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Protein

Protein GIR2

Gene

GIR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of the GCN2 kinase activity by disrupting the GCN1-GCN2 interaction in amino acid-starved cells (PubMed:19448108).1 Publication

GO - Molecular functioni

  • protein kinase inhibitor activity Source: UniProtKB

GO - Biological processi

  • cellular response to amino acid starvation Source: UniProtKB
  • cytoplasmic translation Source: SGD
  • negative regulation of protein complex assembly Source: UniProtKB
  • negative regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of cellular response to amino acid starvation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-29746-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GIR2
Alternative name(s):
DRG family-regulatory protein 2
Genetically interacts with ribosomal genes protein 2
Gene namesi
Name:GIR2
Synonyms:DFRP2
Ordered Locus Names:YDR152W
ORF Names:YD8358.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR152W.
SGDiS000002559. GIR2.

Subcellular locationi

GO - Cellular componenti

  • polysome Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Protein GIR2PRO_0000087495Add
BLAST

Proteomic databases

MaxQBiQ03768.

Interactioni

Subunit structurei

Interacts with GCN1; this interaction prevents the interaction of GCN1 with GCN2 protein kinase and GCN2 activation in amino acid-starved cells (PubMed:19448108). Interacts with RBG1 (PubMed:19448108). Associates with ribosomes; the association occurs in a GCN1-dependent manner (PubMed:19448108).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RBG2P532955EBI-7618,EBI-23421

Protein-protein interaction databases

BioGridi32205. 33 interactions.
DIPiDIP-1751N.
IntActiQ03768. 10 interactions.
MINTiMINT-405801.

Structurei

3D structure databases

DisProtiDP00163.
ProteinModelPortaliQ03768.
SMRiQ03768. Positions 2-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 159151RWDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RWDD1/GIR2 family.Curated
Contains 1 RWD domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000009168.
HOGENOMiHOG000191823.
InParanoidiQ03768.
OMAiPVICLEV.
OrthoDBiEOG092C5Q6E.

Family and domain databases

Gene3Di3.10.110.10. 2 hits.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 2 hits.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYKEEQKQE LEVLESIYPD ELRIINDEYP KIKFEVAIKL ELDTGDSTSV
60 70 80 90 100
LTKEHTIIAE FKLPENYPDE PCLISLEAQE VALNDNEEDN EEDEDEVEYD
110 120 130 140 150
DHGNKVLKKF ENLPDLISFK GYLPELTVQL ESQIETDMLL GMQMCFALIS
160 170 180 190 200
SIKERCEQWY SEQLNKLEKQ YELEAQEREK KEQAKFHGTK VTRESYLEWR
210 220 230 240 250
SKFRQELKLD ERDQVRRMKA HHGKLTGKQM FEQGVVGTGD EYMEEDDASV
260
DDVAKGLAKT EIANQ
Length:265
Mass (Da):31,031
Last modified:November 1, 1996 - v1
Checksum:iCE09A067388638ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50046 Genomic DNA. Translation: CAA90374.1.
AY557681 Genomic DNA. Translation: AAS56007.1.
BK006938 Genomic DNA. Translation: DAA11994.1.
PIRiS57978.
RefSeqiNP_010436.3. NM_001180459.3.

Genome annotation databases

EnsemblFungiiYDR152W; YDR152W; YDR152W.
GeneIDi851730.
KEGGisce:YDR152W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50046 Genomic DNA. Translation: CAA90374.1.
AY557681 Genomic DNA. Translation: AAS56007.1.
BK006938 Genomic DNA. Translation: DAA11994.1.
PIRiS57978.
RefSeqiNP_010436.3. NM_001180459.3.

3D structure databases

DisProtiDP00163.
ProteinModelPortaliQ03768.
SMRiQ03768. Positions 2-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32205. 33 interactions.
DIPiDIP-1751N.
IntActiQ03768. 10 interactions.
MINTiMINT-405801.

Proteomic databases

MaxQBiQ03768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR152W; YDR152W; YDR152W.
GeneIDi851730.
KEGGisce:YDR152W.

Organism-specific databases

EuPathDBiFungiDB:YDR152W.
SGDiS000002559. GIR2.

Phylogenomic databases

GeneTreeiENSGT00390000009168.
HOGENOMiHOG000191823.
InParanoidiQ03768.
OMAiPVICLEV.
OrthoDBiEOG092C5Q6E.

Enzyme and pathway databases

BioCyciYEAST:G3O-29746-MONOMER.

Miscellaneous databases

PROiQ03768.

Family and domain databases

Gene3Di3.10.110.10. 2 hits.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 2 hits.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIR2_YEAST
AccessioniPrimary (citable) accession number: Q03768
Secondary accession number(s): D6VSD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 10300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.