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Protein

Protein GIR2

Gene

GIR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of the GCN2 kinase activity by disrupting the GCN1-GCN2 interaction in amino acid-starved cells (PubMed:19448108).1 Publication

Miscellaneous

Present with 10300 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein kinase inhibitor activity Source: UniProtKB

GO - Biological processi

  • cellular response to amino acid starvation Source: UniProtKB
  • cytoplasmic translation Source: SGD
  • negative regulation of protein complex assembly Source: UniProtKB
  • negative regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of cellular response to amino acid starvation Source: SGD

Keywordsi

Molecular functionRepressor
Biological processStress response

Enzyme and pathway databases

BioCyciYEAST:G3O-29746-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GIR2
Alternative name(s):
DRG family-regulatory protein 2
Genetically interacts with ribosomal genes protein 2
Gene namesi
Name:GIR2
Synonyms:DFRP2
Ordered Locus Names:YDR152W
ORF Names:YD8358.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR152W
SGDiS000002559 GIR2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874951 – 265Protein GIR2Add BLAST265

Proteomic databases

MaxQBiQ03768
PaxDbiQ03768
PRIDEiQ03768

Interactioni

Subunit structurei

Interacts with GCN1; this interaction prevents the interaction of GCN1 with GCN2 protein kinase and GCN2 activation in amino acid-starved cells (PubMed:19448108). Interacts with RBG1 (PubMed:19448108). Associates with ribosomes; the association occurs in a GCN1-dependent manner (PubMed:19448108).1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32205, 54 interactors
DIPiDIP-1751N
IntActiQ03768, 16 interactors
MINTiQ03768
STRINGi4932.YDR152W

Structurei

3D structure databases

DisProtiDP00163
ProteinModelPortaliQ03768
SMRiQ03768
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 159RWDPROSITE-ProRule annotationAdd BLAST151

Sequence similaritiesi

Belongs to the RWDD1/GIR2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000009168
HOGENOMiHOG000191823
InParanoidiQ03768
OMAiIYCGELE
OrthoDBiEOG092C5Q6E

Family and domain databases

InterProiView protein in InterPro
IPR006575 RWD-domain
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF05773 RWD, 1 hit
SMARTiView protein in SMART
SM00591 RWD, 1 hit
SUPFAMiSSF54495 SSF54495, 2 hits
PROSITEiView protein in PROSITE
PS50908 RWD, 1 hit

Sequencei

Sequence statusi: Complete.

Q03768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYKEEQKQE LEVLESIYPD ELRIINDEYP KIKFEVAIKL ELDTGDSTSV
60 70 80 90 100
LTKEHTIIAE FKLPENYPDE PCLISLEAQE VALNDNEEDN EEDEDEVEYD
110 120 130 140 150
DHGNKVLKKF ENLPDLISFK GYLPELTVQL ESQIETDMLL GMQMCFALIS
160 170 180 190 200
SIKERCEQWY SEQLNKLEKQ YELEAQEREK KEQAKFHGTK VTRESYLEWR
210 220 230 240 250
SKFRQELKLD ERDQVRRMKA HHGKLTGKQM FEQGVVGTGD EYMEEDDASV
260
DDVAKGLAKT EIANQ
Length:265
Mass (Da):31,031
Last modified:November 1, 1996 - v1
Checksum:iCE09A067388638ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50046 Genomic DNA Translation: CAA90374.1
AY557681 Genomic DNA Translation: AAS56007.1
BK006938 Genomic DNA Translation: DAA11994.1
PIRiS57978
RefSeqiNP_010436.3, NM_001180459.3

Genome annotation databases

EnsemblFungiiYDR152W; YDR152W; YDR152W
GeneIDi851730
KEGGisce:YDR152W

Similar proteinsi

Entry informationi

Entry nameiGIR2_YEAST
AccessioniPrimary (citable) accession number: Q03768
Secondary accession number(s): D6VSD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health