Reviewed, UniProtKB/Swiss-Prot Q03760 (PML39_YEAST)

Names and origin

Protein names

Recommended name:
    Pre-mRNA leakage protein 39
Alternative name(s):
    39 kDa pre-mRNA leakage protein

Gene names

Name:	PML39
Ordered Locus Names:	YML107C
ORF Names:	YM8339.12

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the nuclear retention of improperly spliced pre-mRNAs. Ref.5
Subunit structure	Interacts with MLP1 and MLP2. Ref.5
Subcellular location	Nucleus membrane; Peripheral membrane protein; Lumenal side. Note: Associated with a subset of nuclear pores opposite to the nucleolus. Ref.5 Ref.3
Miscellaneous	Present with 2205 molecules/cell in log phase SD medium. Ref.4

Ontologies

Keywords
Biological process	Transport mRNA transport
Cellular component	Membrane Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW maintenance of RNA location Ref.5 Inferred from mutant phenotype. Source: SGD
Cellular component	nuclear pore Ref.5 Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Pre-mRNA leakage protein 39		PRO_0000203243
Regions
	Compositional bias	134 – 137	4	Poly-Cys

Sequences

	Sequence		Length	Mass (Da)
	Q03760-1 [UniParc]. Last modified September 13, 2005. Version 2. Checksum: 49A05DB003EC4E6B	FASTA	334	39,207
	10 20 30 40 50 60 MEKDALEVRL KSIRHSLDKN TKLLPGKYRN TLGERLITKW RYKKKSHNGS SMLPEKCKSH 70 80 90 100 110 120 VQLYDDLVQE SSKHFVGFRL HDLRALLKRI CSIQNYTRHV LIEWDVRWVN PLTLASKGWE 130 140 150 160 170 180 PYQSASQSQV PFKCCCCHAI MTIPLLKNGD DVADYTMKLN EKIWNSNIIG NHLQKCPWRE 190 200 210 220 230 240 NQVDLNKEYY LSSQNLIREI ERIHTEIDRI VSGSNEFSLK RNSSRIFHYL SEKEIQKLAF 250 260 270 280 290 300 FFDCKDYSLV GLLLLGYTKF QKDDLVQCTA CFHRASLKKL EYTEFNGHAL WCRYYNKELL 310 320 330 PTMLLELIGK EDKLITKLGV GERLNKLEAV LQTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed: 12748633] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Pml39, a novel protein of the nuclear periphery required for nuclear retention of improper messenger ribonucleoparticles." Palancade B., Zuccolo M., Loeillet S., Nicolas A., Doye V. Mol. Biol. Cell 16:5258-5268(2005) [PubMed: 16162818] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MLP1 AND MLP2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z49210 Genomic DNA. Translation: CAA89111.1. Different initiation.
PIR	S53965.
RefSeq	NP_013600.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4523N.
IntAct	Q03760. 1 interaction.
STRING	Q03760.
Genome annotation databases
Ensembl	YML107C; YML107C; YML107C; Saccharomyces cerevisiae. [Genome view]
GeneID	854864.
KEGG	sce:YML107C.
NMPDR	fig|4932.3.peg.4636.
Organism-specific databases
CYGD	YML107c.
SGD	S000004575. PML39.
Phylogenomic databases
OMA	ERIHTEI
OrthoDB	EOG9DZ3BM
Gene expression databases
ArrayExpress	Q03760.
Genevestigator	Q03760.
GermOnline	YML107C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	977786.

Entry information

Entry name

PML39_YEAST

Accession

Primary (citable) accession number: Q03760

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	September 13, 2005
Last modified:	November 24, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)