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Protein

Ubiquitin ligase-binding protein BUL2

Gene

BUL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1. The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2.10 Publications

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ubiquitin-ubiquitin ligase activity Source: SGD

GO - Biological processi

  • protein monoubiquitination Source: SGD
  • protein polyubiquitination Source: SGD

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-32693-MONOMER
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin ligase-binding protein BUL2
Gene namesi
Name:BUL2
Ordered Locus Names:YML111W
ORF Names:YM8339.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML111W
SGDiS000004579 BUL2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032411 – 920Ubiquitin ligase-binding protein BUL2Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphothreonineCombined sources1
Modified residuei557PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03758
PaxDbiQ03758
PRIDEiQ03758

PTM databases

iPTMnetiQ03758

Interactioni

Subunit structurei

Component of the RSP5-BUL1/2 ubiquitin ligase complex composed of at least RSP5 and BUL1 or BUL2.

Protein-protein interaction databases

BioGridi35093, 158 interactors
DIPiDIP-2237N
IntActiQ03758, 15 interactors
MINTiQ03758
STRINGi4932.YML111W

Structurei

3D structure databases

ProteinModelPortaliQ03758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 133PY-motif5

Domaini

The PY-motif is required for the interaction with RSP5 ubiquitin-ligase and the HSE-mediated gene expression.1 Publication

Sequence similaritiesi

Belongs to the BUL1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010225
HOGENOMiHOG000095282
InParanoidiQ03758
OMAiNEAHINR
OrthoDBiEOG092C0V39

Family and domain databases

InterProiView protein in InterPro
IPR022794 Bul1_C
IPR007519 Bul1_N
PfamiView protein in Pfam
PF04426 Bul1_C, 1 hit
PF04425 Bul1_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD024065 Bul1_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q03758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFTFSTSSR KNGRPPLKSV STEDNIHLLR KRRQQQLSSN STDNSLHPNS
60 70 80 90 100
GQTPRASDSQ DDDIRSASTT NLDRLRQERE ENSLEMDCTQ SRLSHRANML
110 120 130 140 150
VDVLPSFEMY NALHRHIPQG NVDPDRHDFP PSYQEVRTQR MTILPSNDNS
160 170 180 190 200
VERSQLTAVP GSENACNNAT AHSLTNLHPL QTQHLTINST RSGGQSLHSS
210 220 230 240 250
SDTNISQIPF EDDLNDSDNI FIDKLYTLPK LSTPIEIDIR ITKTASIPHE
260 270 280 290 300
RPEEQSILKE YTSGDIIHGY CLIENRSSQP LKFEMFYVTL EAYISVIDRQ
310 320 330 340 350
KGKRTLKRFL RMVDLSASWS YTNITPSTGI NIVPGERDFD DAIIGLSNSR
360 370 380 390 400
ELKPNTKYKK FFMFKLPTQL LDVTCKQEQF SHCLLPPSFG IDKYKNNCKY
410 420 430 440 450
SGIKVNSVLG CGHLGTKGSP ILTLDMADDN LSINYTIDAK IVGKDKRTSK
460 470 480 490 500
LNIMKEKEYN LRVMPFPFAG VTNQQNEKTC LRQLKNLESL IEDRFEALNK
510 520 530 540 550
IFKKLELNEA ISNVDIHDTD ISGTLDGNED LDSDEILRRK LDQLHINNRI
560 570 580 590 600
DDTASQSPSY DSKNMAPKEN LVETELRYKF KNKNKSNSSL FSHFLSSSET
610 620 630 640 650
GSSSTGPHVY NSGLIVLSVK KPQSTLPYWS PSLLRKTNKF EAKSEQEKEN
660 670 680 690 700
WQRLMGMLPE GVKTPLTKLD VHLTCIQSNN SAGHKPPEIS SVTTEFVVIT
710 720 730 740 750
AKSDNSIPIK FCTELLMNEN RLNKLKTKFL TYQKKVHEYR KKFEENHAKL
760 770 780 790 800
NELYNRNRDH FTPKELLFTN FISDQINNDI DSLAGLKVNI IDLHDIFKKQ
810 820 830 840 850
IHTFEEENED IISKKGSSNP PSASSSNNNF LQATFSNGAS TATKFTQQIV
860 870 880 890 900
HEWEKVKPLQ YKRDVTVNLK LNPNIKETLV PNLETCLCCR FYCVRVNIKF
910 920
DNHLGSMKVD IPVDVKKLQI
Length:920
Mass (Da):104,786
Last modified:November 1, 1997 - v1
Checksum:i4134530BF9C1E697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49210 Genomic DNA Translation: CAA89107.1
BK006946 Genomic DNA Translation: DAA09787.1
PIRiS53961
RefSeqiNP_013596.1, NM_001182473.1

Genome annotation databases

EnsemblFungiiYML111W; YML111W; YML111W
GeneIDi854929
KEGGisce:YML111W

Similar proteinsi

Entry informationi

Entry nameiBUL2_YEAST
AccessioniPrimary (citable) accession number: Q03758
Secondary accession number(s): D6W0H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health