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Q03736

- COX2_RHOSH

UniProt

Q03736 - COX2_RHOSH

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Protein

Cytochrome c oxidase subunit 2

Gene
ctaC, coxII, ctaB
Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi217 – 2171Copper A Inferred
Metal bindingi252 – 2521Copper A Inferred
Metal bindingi256 – 2561Copper A Inferred
Metal bindingi260 – 2601Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Protein family/group databases

TCDBi3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Synonyms:coxII, ctaB
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021Helical; Reviewed predictionAdd
BLAST
Transmembranei104 – 12421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 303278Cytochrome c oxidase subunit 2PRO_0000006061Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-38012N.
IntActiQ03736. 1 interaction.

Structurei

Secondary structure

1
303
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 354
Helixi49 – 8234
Turni85 – 873
Helixi98 – 12730
Beta strandi133 – 1419
Beta strandi144 – 1485
Turni150 – 1523
Beta strandi155 – 1584
Helixi164 – 1663
Helixi174 – 1829
Helixi187 – 1893
Turni190 – 1923
Beta strandi194 – 1963
Beta strandi198 – 2014
Beta strandi204 – 21512
Beta strandi217 – 2215
Helixi222 – 2243
Beta strandi226 – 2305
Beta strandi236 – 2416
Beta strandi246 – 2505
Helixi260 – 2623
Beta strandi265 – 2706
Helixi272 – 28110
Helixi282 – 2843

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M56X-ray2.30B/H26-289[»]
1M57X-ray3.00B/H26-289[»]
2GSMX-ray2.00B/D26-281[»]
3DTUX-ray2.15B/D26-281[»]
3FYEX-ray2.15B/D26-281[»]
3FYIX-ray2.20B/D26-281[»]
ProteinModelPortaliQ03736.
SMRiQ03736. Positions 30-289.

Miscellaneous databases

EvolutionaryTraceiQ03736.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03736-1 [UniParc]FASTAAdd to Basket

« Hide

MRHSTTLTGC ATGAAGLLAA TAAAAQQQSL EIIGRPQPGG TGFQPSASPV    50
ATQIHWLDGF ILVIIAAITI FVTLLILYAV WRFHEKRNKV PARFTHNSPL 100
EIAWTIVPIV ILVAIGAFSL PVLFNQQEIP EADVTVKVTG YQWYWGYEYP 150
DEEISFESYM IGSPATGGDN RMSPEVEQQL IEAGYSRDEF LLATDTAMVV 200
PVNKTVVVQV TGADVIHSWT VPAFGVKQDA VPGRLAQLWF RAEREGIFFG 250
QCSELCGISH AYMPITVKVV SEEAYAAWLE QARGGTYELS SVLPATPAGV 300
SVE 303
Length:303
Mass (Da):32,931
Last modified:May 27, 2002 - v2
Checksum:i2F363ADA39EFEBF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57680 Genomic DNA. Translation: AAA26100.3.
PIRiJQ1013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57680 Genomic DNA. Translation: AAA26100.3 .
PIRi JQ1013.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M56 X-ray 2.30 B/H 26-289 [» ]
1M57 X-ray 3.00 B/H 26-289 [» ]
2GSM X-ray 2.00 B/D 26-281 [» ]
3DTU X-ray 2.15 B/D 26-281 [» ]
3FYE X-ray 2.15 B/D 26-281 [» ]
3FYI X-ray 2.20 B/D 26-281 [» ]
ProteinModelPortali Q03736.
SMRi Q03736. Positions 30-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-38012N.
IntActi Q03736. 1 interaction.

Protein family/group databases

TCDBi 3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q03736.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The gene encoding cytochrome c oxidase subunit II from Rhodobacter sphaeroides; comparison of the deduced amino acid sequence with sequences of corresponding peptides from other species."
    Cao J., Shapleigh J., Gennis R., Revzin A., Ferguson-Miller S.
    Gene 101:133-137(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Hiser C., Ferguson-Miller S.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiCOX2_RHOSH
AccessioniPrimary (citable) accession number: Q03736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 27, 2002
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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