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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi217Copper ACurated1
Metal bindingi252Copper ACurated1
Metal bindingi256Copper ACurated1
Metal bindingi260Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Protein family/group databases

TCDBi3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Synonyms:coxII, ctaB
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000606126 – 303Cytochrome c oxidase subunit 2Add BLAST278

Interactioni

Protein-protein interaction databases

DIPiDIP-38012N.
IntActiQ03736. 1 interactor.
STRINGi272943.RSP_1826.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 35Combined sources4
Helixi49 – 82Combined sources34
Turni85 – 87Combined sources3
Helixi98 – 127Combined sources30
Beta strandi133 – 141Combined sources9
Beta strandi144 – 148Combined sources5
Turni150 – 152Combined sources3
Beta strandi155 – 158Combined sources4
Helixi164 – 166Combined sources3
Helixi174 – 182Combined sources9
Helixi187 – 189Combined sources3
Turni190 – 192Combined sources3
Beta strandi194 – 196Combined sources3
Beta strandi198 – 201Combined sources4
Beta strandi204 – 215Combined sources12
Beta strandi217 – 221Combined sources5
Helixi222 – 224Combined sources3
Beta strandi226 – 230Combined sources5
Beta strandi236 – 241Combined sources6
Beta strandi246 – 250Combined sources5
Helixi260 – 262Combined sources3
Beta strandi265 – 270Combined sources6
Helixi272 – 281Combined sources10
Helixi282 – 284Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M56X-ray2.30B/H26-289[»]
1M57X-ray3.00B/H26-289[»]
2GSMX-ray2.00B/D26-281[»]
3DTUX-ray2.15B/D26-281[»]
3FYEX-ray2.15B/D26-281[»]
3FYIX-ray2.20B/D26-281[»]
ProteinModelPortaliQ03736.
SMRiQ03736.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03736.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSTTLTGC ATGAAGLLAA TAAAAQQQSL EIIGRPQPGG TGFQPSASPV
60 70 80 90 100
ATQIHWLDGF ILVIIAAITI FVTLLILYAV WRFHEKRNKV PARFTHNSPL
110 120 130 140 150
EIAWTIVPIV ILVAIGAFSL PVLFNQQEIP EADVTVKVTG YQWYWGYEYP
160 170 180 190 200
DEEISFESYM IGSPATGGDN RMSPEVEQQL IEAGYSRDEF LLATDTAMVV
210 220 230 240 250
PVNKTVVVQV TGADVIHSWT VPAFGVKQDA VPGRLAQLWF RAEREGIFFG
260 270 280 290 300
QCSELCGISH AYMPITVKVV SEEAYAAWLE QARGGTYELS SVLPATPAGV

SVE
Length:303
Mass (Da):32,931
Last modified:May 27, 2002 - v2
Checksum:i2F363ADA39EFEBF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57680 Genomic DNA. Translation: AAA26100.3.
PIRiJQ1013.
RefSeqiWP_011337012.1. NZ_CP015210.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57680 Genomic DNA. Translation: AAA26100.3.
PIRiJQ1013.
RefSeqiWP_011337012.1. NZ_CP015210.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M56X-ray2.30B/H26-289[»]
1M57X-ray3.00B/H26-289[»]
2GSMX-ray2.00B/D26-281[»]
3DTUX-ray2.15B/D26-281[»]
3FYEX-ray2.15B/D26-281[»]
3FYIX-ray2.20B/D26-281[»]
ProteinModelPortaliQ03736.
SMRiQ03736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38012N.
IntActiQ03736. 1 interactor.
STRINGi272943.RSP_1826.

Protein family/group databases

TCDBi3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ03736.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_RHOSH
AccessioniPrimary (citable) accession number: Q03736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 27, 2002
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.