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Q03736 (COX2_RHOSH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene names
Name:ctaC
Synonyms:coxII, ctaB
OrganismRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifier1063 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 303278Cytochrome c oxidase subunit 2
PRO_0000006061

Regions

Transmembrane60 – 8021Helical; Potential
Transmembrane104 – 12421Helical; Potential

Sites

Metal binding2171Copper A Probable
Metal binding2521Copper A Probable
Metal binding2561Copper A Probable
Metal binding2601Copper A Probable

Secondary structure

.............................................. 303
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q03736 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: 2F363ADA39EFEBF8

FASTA30332,931
        10         20         30         40         50         60 
MRHSTTLTGC ATGAAGLLAA TAAAAQQQSL EIIGRPQPGG TGFQPSASPV ATQIHWLDGF 

        70         80         90        100        110        120 
ILVIIAAITI FVTLLILYAV WRFHEKRNKV PARFTHNSPL EIAWTIVPIV ILVAIGAFSL 

       130        140        150        160        170        180 
PVLFNQQEIP EADVTVKVTG YQWYWGYEYP DEEISFESYM IGSPATGGDN RMSPEVEQQL 

       190        200        210        220        230        240 
IEAGYSRDEF LLATDTAMVV PVNKTVVVQV TGADVIHSWT VPAFGVKQDA VPGRLAQLWF 

       250        260        270        280        290        300 
RAEREGIFFG QCSELCGISH AYMPITVKVV SEEAYAAWLE QARGGTYELS SVLPATPAGV 


SVE 

« Hide

References

[1]"The gene encoding cytochrome c oxidase subunit II from Rhodobacter sphaeroides; comparison of the deduced amino acid sequence with sequences of corresponding peptides from other species."
Cao J., Shapleigh J., Gennis R., Revzin A., Ferguson-Miller S.
Gene 101:133-137(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Hiser C., Ferguson-Miller S.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57680 Genomic DNA. Translation: AAA26100.3.
PIRJQ1013.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1M56X-ray2.30B/H26-289[»]
1M57X-ray3.00B/H26-289[»]
2GSMX-ray2.00B/D26-281[»]
3DTUX-ray2.15B/D26-281[»]
3FYEX-ray2.15B/D26-281[»]
3FYIX-ray2.20B/D26-281[»]
ProteinModelPortalQ03736.
SMRQ03736. Positions 30-289.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-38012N.
IntActQ03736. 1 interaction.

Protein family/group databases

TCDB3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ03736.

Entry information

Entry nameCOX2_RHOSH
AccessionPrimary (citable) accession number: Q03736
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 27, 2002
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references