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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi217Copper ACurated1
Metal bindingi252Copper ACurated1
Metal bindingi256Copper ACurated1
Metal bindingi260Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Protein family/group databases

TCDBi3.D.4.6.2 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Synonyms:coxII, ctaB
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB03619 Deoxycholic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000606126 – 303Cytochrome c oxidase subunit 2Add BLAST278

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ctaDP335173EBI-1033998,EBI-1034008

Protein-protein interaction databases

DIPiDIP-38012N
IntActiQ03736, 1 interactor

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 35Combined sources4
Helixi49 – 82Combined sources34
Turni85 – 87Combined sources3
Helixi98 – 127Combined sources30
Beta strandi133 – 141Combined sources9
Beta strandi144 – 148Combined sources5
Turni150 – 152Combined sources3
Beta strandi155 – 158Combined sources4
Helixi164 – 166Combined sources3
Helixi174 – 182Combined sources9
Helixi187 – 189Combined sources3
Turni190 – 192Combined sources3
Beta strandi194 – 196Combined sources3
Beta strandi198 – 201Combined sources4
Beta strandi204 – 215Combined sources12
Beta strandi217 – 221Combined sources5
Helixi222 – 224Combined sources3
Beta strandi226 – 230Combined sources5
Beta strandi236 – 241Combined sources6
Beta strandi246 – 250Combined sources5
Helixi260 – 262Combined sources3
Beta strandi265 – 270Combined sources6
Helixi272 – 281Combined sources10
Helixi282 – 284Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M56X-ray2.30B/H26-289[»]
1M57X-ray3.00B/H26-289[»]
2GSMX-ray2.00B/D26-281[»]
3DTUX-ray2.15B/D26-281[»]
3FYEX-ray2.15B/D26-281[»]
3FYIX-ray2.20B/D26-281[»]
5WEHX-ray3.45B/H26-281[»]
ProteinModelPortaliQ03736
SMRiQ03736
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03736

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA

Family and domain databases

Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSTTLTGC ATGAAGLLAA TAAAAQQQSL EIIGRPQPGG TGFQPSASPV
60 70 80 90 100
ATQIHWLDGF ILVIIAAITI FVTLLILYAV WRFHEKRNKV PARFTHNSPL
110 120 130 140 150
EIAWTIVPIV ILVAIGAFSL PVLFNQQEIP EADVTVKVTG YQWYWGYEYP
160 170 180 190 200
DEEISFESYM IGSPATGGDN RMSPEVEQQL IEAGYSRDEF LLATDTAMVV
210 220 230 240 250
PVNKTVVVQV TGADVIHSWT VPAFGVKQDA VPGRLAQLWF RAEREGIFFG
260 270 280 290 300
QCSELCGISH AYMPITVKVV SEEAYAAWLE QARGGTYELS SVLPATPAGV

SVE
Length:303
Mass (Da):32,931
Last modified:May 27, 2002 - v2
Checksum:i2F363ADA39EFEBF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57680 Genomic DNA Translation: AAA26100.3
PIRiJQ1013
RefSeqiWP_011337012.1, NZ_CP015287.1

Similar proteinsi

Entry informationi

Entry nameiCOX2_RHOSH
AccessioniPrimary (citable) accession number: Q03736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 27, 2002
Last modified: March 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
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Main funding by: National Institutes of Health