Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q03730

- YMB8_YEAST

UniProt

Q03730 - YMB8_YEAST

Protein

Uncharacterized vacuolar membrane protein YML018C

Gene

YML018C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32622-MONOMER.

    Protein family/group databases

    TCDBi2.A.7.24.5. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized vacuolar membrane protein YML018C
    Gene namesi
    Ordered Locus Names:YML018C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML018c.
    SGDiS000004480. YML018C.

    Subcellular locationi

    Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Uncharacterized vacuolar membrane protein YML018CPRO_0000203261Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei93 – 931Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ03730.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03730.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATG27P469891EBI-27739,EBI-26164
    COT1P327981EBI-27739,EBI-5006
    FET5P435611EBI-27739,EBI-6891
    FTH1P383101EBI-27739,EBI-20959
    PMC1P389291EBI-27739,EBI-3097
    RBD2Q122701EBI-27739,EBI-31471
    SFT2P381661EBI-27739,EBI-17046
    TVP15Q038601EBI-27739,EBI-37537

    Protein-protein interaction databases

    BioGridi35151. 14 interactions.
    DIPiDIP-4953N.
    IntActiQ03730. 23 interactions.
    MINTiMINT-548702.
    STRINGi4932.YML018C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03730.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 468VacuolarSequence Analysis
    Topological domaini68 – 13265CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini154 – 1563VacuolarSequence Analysis
    Topological domaini177 – 1826CytoplasmicSequence Analysis
    Topological domaini201 – 21919VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini241 – 25717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini279 – 29214VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini314 – 3218CytoplasmicSequence Analysis
    Topological domaini343 – 3453VacuolarSequence Analysis
    Topological domaini367 – 39327CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei157 – 17620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei220 – 24021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei322 – 34221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPT transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    GeneTreeiENSGT00390000005949.
    HOGENOMiHOG000176279.
    KOiK15289.
    OMAiFFILHWT.
    OrthoDBiEOG7QVMD1.

    Family and domain databases

    InterProiIPR013657. UAA.
    [Graphical view]
    PfamiPF08449. UAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03730-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSKDQTSFN KRWTLGLLML GLVIILWVLS SFLINLIFED DSYRKPFFIT    50
    YTNTAAFIFY LFPTAKAVVV NYKDTGRANV HRELIMEEEG TGSDSNRSVD 100
    MTSPLLTNLE AGTHANQKKR LTLYETIKLS AEFCILWFTA NLVTNASLAF 150
    TSVASQTILS TTSSFFTLFI GAICHVESLS KSKVLGSFIS FVGIIMVTKS 200
    DSHQRYQRHI ADVSGDDNDA VQVLIGNLLA LAGAVLYGVY STLLKREVGD 250
    ETRVNMKIFF GFVGLFNLLF LWPSLIVLDF FGWEPFSLPK DPKVVVIIFV 300
    NCLITFVSDF CWAKAMLLTS PLTVTVGLSI TIPLAMFGDV IFKHKTMSAL 350
    YLFGATLILG SFFIINKSSE EEHFENSITA SNYESVEVPA ANN 393
    Length:393
    Mass (Da):43,749
    Last modified:November 1, 1997 - v1
    Checksum:iDEC5C3EEF293F5ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti257 – 2571K → R in AAT92742. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46659 Genomic DNA. Translation: CAA86637.1.
    AY692723 Genomic DNA. Translation: AAT92742.1.
    BK006946 Genomic DNA. Translation: DAA09880.1.
    PIRiS49759.
    RefSeqiNP_013694.1. NM_001182376.1.

    Genome annotation databases

    EnsemblFungiiYML018C; YML018C; YML018C.
    GeneIDi854990.
    KEGGisce:YML018C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46659 Genomic DNA. Translation: CAA86637.1 .
    AY692723 Genomic DNA. Translation: AAT92742.1 .
    BK006946 Genomic DNA. Translation: DAA09880.1 .
    PIRi S49759.
    RefSeqi NP_013694.1. NM_001182376.1.

    3D structure databases

    ProteinModelPortali Q03730.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35151. 14 interactions.
    DIPi DIP-4953N.
    IntActi Q03730. 23 interactions.
    MINTi MINT-548702.
    STRINGi 4932.YML018C.

    Protein family/group databases

    TCDBi 2.A.7.24.5. the drug/metabolite transporter (dmt) superfamily.

    Proteomic databases

    PaxDbi Q03730.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML018C ; YML018C ; YML018C .
    GeneIDi 854990.
    KEGGi sce:YML018C.

    Organism-specific databases

    CYGDi YML018c.
    SGDi S000004480. YML018C.

    Phylogenomic databases

    eggNOGi COG0697.
    GeneTreei ENSGT00390000005949.
    HOGENOMi HOG000176279.
    KOi K15289.
    OMAi FFILHWT.
    OrthoDBi EOG7QVMD1.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32622-MONOMER.

    Miscellaneous databases

    NextBioi 978127.
    PROi Q03730.

    Gene expression databases

    Genevestigatori Q03730.

    Family and domain databases

    InterProi IPR013657. UAA.
    [Graphical view ]
    Pfami PF08449. UAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYMB8_YEAST
    AccessioniPrimary (citable) accession number: Q03730
    Secondary accession number(s): D6VZF6, Q6B2K7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2010 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3