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Protein

Uncharacterized vacuolar membrane protein YML018C

Gene

YML018C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32622-MONOMER.

Protein family/group databases

TCDBi2.A.7.24.5. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized vacuolar membrane protein YML018C
Gene namesi
Ordered Locus Names:YML018C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML018C.
SGDiS000004480. YML018C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 46VacuolarSequence analysis8
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 132CytoplasmicSequence analysisAdd BLAST65
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 156VacuolarSequence analysis3
Transmembranei157 – 176HelicalSequence analysisAdd BLAST20
Topological domaini177 – 182CytoplasmicSequence analysis6
Transmembranei183 – 200HelicalSequence analysisAdd BLAST18
Topological domaini201 – 219VacuolarSequence analysisAdd BLAST19
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 257CytoplasmicSequence analysisAdd BLAST17
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 292VacuolarSequence analysisAdd BLAST14
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 321CytoplasmicSequence analysis8
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 345VacuolarSequence analysis3
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 393CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032611 – 393Uncharacterized vacuolar membrane protein YML018CAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ03730.

PTM databases

iPTMnetiQ03730.

Interactioni

Protein-protein interaction databases

BioGridi35151. 13 interactors.
DIPiDIP-4953N.
IntActiQ03730. 23 interactors.
MINTiMINT-548702.

Structurei

3D structure databases

ProteinModelPortaliQ03730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPT transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000005949.
HOGENOMiHOG000176279.
InParanoidiQ03730.
KOiK15289.
OMAiYLLFEAK.
OrthoDBiEOG092C3OW1.

Sequencei

Sequence statusi: Complete.

Q03730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSKDQTSFN KRWTLGLLML GLVIILWVLS SFLINLIFED DSYRKPFFIT
60 70 80 90 100
YTNTAAFIFY LFPTAKAVVV NYKDTGRANV HRELIMEEEG TGSDSNRSVD
110 120 130 140 150
MTSPLLTNLE AGTHANQKKR LTLYETIKLS AEFCILWFTA NLVTNASLAF
160 170 180 190 200
TSVASQTILS TTSSFFTLFI GAICHVESLS KSKVLGSFIS FVGIIMVTKS
210 220 230 240 250
DSHQRYQRHI ADVSGDDNDA VQVLIGNLLA LAGAVLYGVY STLLKREVGD
260 270 280 290 300
ETRVNMKIFF GFVGLFNLLF LWPSLIVLDF FGWEPFSLPK DPKVVVIIFV
310 320 330 340 350
NCLITFVSDF CWAKAMLLTS PLTVTVGLSI TIPLAMFGDV IFKHKTMSAL
360 370 380 390
YLFGATLILG SFFIINKSSE EEHFENSITA SNYESVEVPA ANN
Length:393
Mass (Da):43,749
Last modified:November 1, 1997 - v1
Checksum:iDEC5C3EEF293F5ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257K → R in AAT92742 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46659 Genomic DNA. Translation: CAA86637.1.
AY692723 Genomic DNA. Translation: AAT92742.1.
BK006946 Genomic DNA. Translation: DAA09880.1.
PIRiS49759.
RefSeqiNP_013694.1. NM_001182376.1.

Genome annotation databases

EnsemblFungiiYML018C; YML018C; YML018C.
GeneIDi854990.
KEGGisce:YML018C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46659 Genomic DNA. Translation: CAA86637.1.
AY692723 Genomic DNA. Translation: AAT92742.1.
BK006946 Genomic DNA. Translation: DAA09880.1.
PIRiS49759.
RefSeqiNP_013694.1. NM_001182376.1.

3D structure databases

ProteinModelPortaliQ03730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35151. 13 interactors.
DIPiDIP-4953N.
IntActiQ03730. 23 interactors.
MINTiMINT-548702.

Protein family/group databases

TCDBi2.A.7.24.5. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ03730.

Proteomic databases

PRIDEiQ03730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML018C; YML018C; YML018C.
GeneIDi854990.
KEGGisce:YML018C.

Organism-specific databases

EuPathDBiFungiDB:YML018C.
SGDiS000004480. YML018C.

Phylogenomic databases

GeneTreeiENSGT00390000005949.
HOGENOMiHOG000176279.
InParanoidiQ03730.
KOiK15289.
OMAiYLLFEAK.
OrthoDBiEOG092C3OW1.

Enzyme and pathway databases

BioCyciYEAST:G3O-32622-MONOMER.

Miscellaneous databases

PROiQ03730.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiYMB8_YEAST
AccessioniPrimary (citable) accession number: Q03730
Secondary accession number(s): D6VZF6, Q6B2K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2010 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.