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Q03730

- YMB8_YEAST

UniProt

Q03730 - YMB8_YEAST

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Protein

Uncharacterized vacuolar membrane protein YML018C

Gene

YML018C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32622-MONOMER.

Protein family/group databases

TCDBi2.A.7.24.5. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized vacuolar membrane protein YML018C
Gene namesi
Ordered Locus Names:YML018C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML018c.
SGDiS000004480. YML018C.

Subcellular locationi

Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Topological domaini39 – 468VacuolarSequence Analysis
Transmembranei47 – 6721HelicalSequence AnalysisAdd
BLAST
Topological domaini68 – 13265CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Topological domaini154 – 1563VacuolarSequence Analysis
Transmembranei157 – 17620HelicalSequence AnalysisAdd
BLAST
Topological domaini177 – 1826CytoplasmicSequence Analysis
Transmembranei183 – 20018HelicalSequence AnalysisAdd
BLAST
Topological domaini201 – 21919VacuolarSequence AnalysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence AnalysisAdd
BLAST
Topological domaini241 – 25717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence AnalysisAdd
BLAST
Topological domaini279 – 29214VacuolarSequence AnalysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence AnalysisAdd
BLAST
Topological domaini314 – 3218CytoplasmicSequence Analysis
Transmembranei322 – 34221HelicalSequence AnalysisAdd
BLAST
Topological domaini343 – 3453VacuolarSequence Analysis
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Topological domaini367 – 39327CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Uncharacterized vacuolar membrane protein YML018CPRO_0000203261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 931Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ03730.

Expressioni

Gene expression databases

GenevestigatoriQ03730.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG27P469891EBI-27739,EBI-26164
COT1P327981EBI-27739,EBI-5006
FET5P435611EBI-27739,EBI-6891
FTH1P383101EBI-27739,EBI-20959
PMC1P389291EBI-27739,EBI-3097
RBD2Q122701EBI-27739,EBI-31471
SFT2P381661EBI-27739,EBI-17046
TVP15Q038601EBI-27739,EBI-37537

Protein-protein interaction databases

BioGridi35151. 14 interactions.
DIPiDIP-4953N.
IntActiQ03730. 23 interactions.
MINTiMINT-548702.
STRINGi4932.YML018C.

Structurei

3D structure databases

ProteinModelPortaliQ03730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPT transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00390000005949.
HOGENOMiHOG000176279.
InParanoidiQ03730.
KOiK15289.
OMAiFFILHWT.
OrthoDBiEOG7QVMD1.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03730-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSKDQTSFN KRWTLGLLML GLVIILWVLS SFLINLIFED DSYRKPFFIT
60 70 80 90 100
YTNTAAFIFY LFPTAKAVVV NYKDTGRANV HRELIMEEEG TGSDSNRSVD
110 120 130 140 150
MTSPLLTNLE AGTHANQKKR LTLYETIKLS AEFCILWFTA NLVTNASLAF
160 170 180 190 200
TSVASQTILS TTSSFFTLFI GAICHVESLS KSKVLGSFIS FVGIIMVTKS
210 220 230 240 250
DSHQRYQRHI ADVSGDDNDA VQVLIGNLLA LAGAVLYGVY STLLKREVGD
260 270 280 290 300
ETRVNMKIFF GFVGLFNLLF LWPSLIVLDF FGWEPFSLPK DPKVVVIIFV
310 320 330 340 350
NCLITFVSDF CWAKAMLLTS PLTVTVGLSI TIPLAMFGDV IFKHKTMSAL
360 370 380 390
YLFGATLILG SFFIINKSSE EEHFENSITA SNYESVEVPA ANN
Length:393
Mass (Da):43,749
Last modified:November 1, 1997 - v1
Checksum:iDEC5C3EEF293F5ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571K → R in AAT92742. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46659 Genomic DNA. Translation: CAA86637.1.
AY692723 Genomic DNA. Translation: AAT92742.1.
BK006946 Genomic DNA. Translation: DAA09880.1.
PIRiS49759.
RefSeqiNP_013694.1. NM_001182376.1.

Genome annotation databases

EnsemblFungiiYML018C; YML018C; YML018C.
GeneIDi854990.
KEGGisce:YML018C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46659 Genomic DNA. Translation: CAA86637.1 .
AY692723 Genomic DNA. Translation: AAT92742.1 .
BK006946 Genomic DNA. Translation: DAA09880.1 .
PIRi S49759.
RefSeqi NP_013694.1. NM_001182376.1.

3D structure databases

ProteinModelPortali Q03730.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35151. 14 interactions.
DIPi DIP-4953N.
IntActi Q03730. 23 interactions.
MINTi MINT-548702.
STRINGi 4932.YML018C.

Protein family/group databases

TCDBi 2.A.7.24.5. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PaxDbi Q03730.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML018C ; YML018C ; YML018C .
GeneIDi 854990.
KEGGi sce:YML018C.

Organism-specific databases

CYGDi YML018c.
SGDi S000004480. YML018C.

Phylogenomic databases

eggNOGi COG0697.
GeneTreei ENSGT00390000005949.
HOGENOMi HOG000176279.
InParanoidi Q03730.
KOi K15289.
OMAi FFILHWT.
OrthoDBi EOG7QVMD1.

Enzyme and pathway databases

BioCyci YEAST:G3O-32622-MONOMER.

Miscellaneous databases

NextBioi 978127.
PROi Q03730.

Gene expression databases

Genevestigatori Q03730.

Family and domain databases

InterProi IPR013657. UAA.
[Graphical view ]
Pfami PF08449. UAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYMB8_YEAST
AccessioniPrimary (citable) accession number: Q03730
Secondary accession number(s): D6VZF6, Q6B2K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2010 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3