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Protein

Transport/processing ATP-binding protein ComA

Gene

comA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei17 – 171PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi517 – 5248ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Competence, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-48-MONOMER.

Protein family/group databases

MEROPSiC39.001.
TCDBi3.A.1.112.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Transport/processing ATP-binding protein ComA (EC:3.4.22.-)
Gene namesi
Name:comA
Ordered Locus Names:SP_0042
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei166 – 18621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei205 – 22521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei237 – 25721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei282 – 30221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei306 – 32621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei397 – 41721HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Transport/processing ATP-binding protein ComAPRO_0000092234Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02000419.

Structurei

3D structure databases

ProteinModelPortaliQ03727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 138128Peptidase C39PROSITE-ProRule annotationAdd
BLAST
Domaini168 – 450283ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 717234ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation
Contains 1 peptidase C39 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108JJA. Bacteria.
COG2274. LUCA.
HOGENOMiHOG000097319.
KOiK12292.
OMAiLMKGEMT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005897. Pept_C39_ABC_bacteriocin.
IPR005074. Peptidase_C39.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR01193. bacteriocin_ABC. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGKRHYRP QVDQMDCGVA SLAMVFGYYG SYYFLAHLRE LAKTTMDGTT
60 70 80 90 100
ALGLVKVAEE IGFETRAIKA DMTLFDLPDL TFPFVAHVLK EGKLLHYYVV
110 120 130 140 150
TGQDKDSIHI ADPDPGVKLT KLPRERFEEE WTGVTLFMAP SPDYKPHKEQ
160 170 180 190 200
KNGLLSFIPI LVKQRGLIAN IVLATLLVTV INIVGSYYLQ SIIDTYVPDQ
210 220 230 240 250
MRSTLGIISI GLVIVYIFQQ ILSYAQEYLL LVLGQRLSID VILSYIKHVF
260 270 280 290 300
HLPMSFFATR RTGEIVSRFT DANSIIDALA STILSIFLDV STVVIISLVL
310 320 330 340 350
FSQNTNLFFM TLLALPIYTV IIFAFMKPFE KMNRDTMEAN AVLSSSIIED
360 370 380 390 400
INGIETIKSL TSESQRYQKI DKEFVDYLKK SFTYSRAESQ QKALKKVAHL
410 420 430 440 450
LLNVGILWMG AVLVMDGKMS LGQLITYNTL LVYFTNPLEN IINLQTKLQT
460 470 480 490 500
AQVANNRLNE VYLVASEFEE KKTVEDLSLM KGDMTFKQVH YKYGYGRDVL
510 520 530 540 550
SDINLTVPQG SKVAFVGISG SGKTTLAKMM VNFYDPSQGE ISLGSVNLNQ
560 570 580 590 600
IDKKALRQYI NYLSQQPYVF NGTILENLLL GAKEGTTQED ILRAVELAEI
610 620 630 640 650
REDIERMPLN YQTELTSDGA GISGGQRQRI ALARALLTDA PVLILDEATS
660 670 680 690 700
SLDILTEKRI VDNLIALDKT LIFIAHRLTI AERTEKVVVL DQGKIVEEGK
710
HADLLAQGGF YAHLVNS
Length:717
Mass (Da):80,404
Last modified:September 26, 2001 - v3
Checksum:i06A51085A902F608
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181F → L in AAA69510 (PubMed:1987129).Curated
Sequence conflicti545 – 5451S → G in AAA69510 (PubMed:1987129).Curated
Sequence conflicti564 – 5641S → P in AAA69510 (PubMed:1987129).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36180 Genomic DNA. Translation: AAA69510.1.
AE005672 Genomic DNA. Translation: AAK74231.1.
PIRiA39203.
C97877.
F95004.
RefSeqiWP_000668284.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74231; AAK74231; SP_0042.
KEGGispn:SP_0042.
PATRICi19704411. VBIStrPne105772_0050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36180 Genomic DNA. Translation: AAA69510.1.
AE005672 Genomic DNA. Translation: AAK74231.1.
PIRiA39203.
C97877.
F95004.
RefSeqiWP_000668284.1. NZ_AKVY01000001.1.

3D structure databases

ProteinModelPortaliQ03727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02000419.

Protein family/group databases

MEROPSiC39.001.
TCDBi3.A.1.112.1. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK74231; AAK74231; SP_0042.
KEGGispn:SP_0042.
PATRICi19704411. VBIStrPne105772_0050.

Phylogenomic databases

eggNOGiENOG4108JJA. Bacteria.
COG2274. LUCA.
HOGENOMiHOG000097319.
KOiK12292.
OMAiLMKGEMT.

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-48-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005897. Pept_C39_ABC_bacteriocin.
IPR005074. Peptidase_C39.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR01193. bacteriocin_ABC. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOMA_STRPN
AccessioniPrimary (citable) accession number: Q03727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 26, 2001
Last modified: September 7, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.