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Protein
Submitted name:

Factor I C3b/C4b inactivator (Serine protease)

Gene

cfi

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS01.199

Names & Taxonomyi

Protein namesi
Submitted name:
Factor I C3b/C4b inactivator (Serine protease)Imported
Gene namesi
Name:cfiImported
Synonyms:factor IImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254048 cfi

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500416388721 – 613Sequence analysisAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi139 ↔ 203PROSITE-ProRule annotation
Disulfide bondi152 ↔ 213PROSITE-ProRule annotation
Disulfide bondi186 ↔ 196PROSITE-ProRule annotation
Disulfide bondi220 ↔ 232PROSITE-ProRule annotation
Disulfide bondi227 ↔ 245PROSITE-ProRule annotation
Disulfide bondi239 ↔ 254PROSITE-ProRule annotation
Disulfide bondi263 ↔ 281PROSITE-ProRule annotation
Disulfide bondi275 ↔ 290PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ03711
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 214SRCRInterPro annotationAdd BLAST103
Domaini370 – 604Peptidase S1InterPro annotationAdd BLAST235

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili300 – 320Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG005311
KOiK01333

Family and domain databases

CDDicd00112 LDLa, 2 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di3.10.250.10, 1 hit
InterProiView protein in InterPro
IPR003884 FacI_MAC
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 2 hits
PF00530 SRCR, 1 hit
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00057 FIMAC, 1 hit
SM00192 LDLa, 2 hits
SM00202 SR, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 1 hit
SSF57424 SSF57424, 2 hits
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 2 hits
PS50287 SRCR_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q03711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLCCVLIL FCHFYVNTFS SAVSGAGDAR PNTCEFNALS CHKVFCAPWQ
60 70 80 90 100
RCVAGVCRCK LPYQCPKNAT TEVCTDGKRK LQSYCQLKSV ECSNPLNSKY
110 120 130 140 150
RFSSEAPCTE TFTLTQNGEP GKGIIKVKLP TFEQELFLCG KQWSNREANV
160 170 180 190 200
VCRQLGSTKG ADASASDKVF SLVTEKPPEH CIQATCRGLE NSLAECALRK
210 220 230 240 250
LPMQDNQVAK VTCYTENKDC GFGEFTCSNG KCIPSELACD SKNDCGDLSD
260 270 280 290 300
ELCCKSCNAG FHCRSDTCIP EQYRCNGELD CIGGEDESNC TVEQEQKSEK
310 320 330 340 350
QEEVEQKQTS EKQEEDLVQE SKATQVEEKA KIVNYDIDAE RRLLMKSLPE
360 370 380 390 400
LSCGVPPQTA ALTLTRKKRV IGGTNAVKNQ FPWQVAIKDG TAVNCGGIYI
410 420 430 440 450
GGCWVLTAAH CVRSNQPQRY LIMLELLDRL SYDKDLDSFP VKSVIVHELY
460 470 480 490 500
NPNTYENDIA LLEVKNIYNN PKCMQADNNM VPACVPWSPF QFKAGDTCTV
510 520 530 540 550
SGWGREKGMS RVFHLKWGHI NLMDNCTRVY KERFLDKMEC ARTYDGSIDA
560 570 580 590 600
CKGDSGGPLV CYDVNKVAYV WGIVSWGENC GVPGYPGVYT KVANYFEWIA
610
HQVGRSLMSK YNV
Length:613
Mass (Da):68,308
Last modified:November 1, 1996 - v1
Checksum:iD66E626CEEF617E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59958 mRNA Translation: CAA42582.1
PIRiI51601 S15468
RefSeqiNP_001095259.1, NM_001101789.1
UniGeneiXl.1143

Genome annotation databases

GeneIDi399318
KEGGixla:399318

Similar proteinsi

Entry informationi

Entry nameiQ03711_XENLA
AccessioniPrimary (citable) accession number: Q03711
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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