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Protein
Submitted name:

Factor I C3b/C4b inactivator (Serine protease)

Gene

cfi

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS01.199.

Names & Taxonomyi

Protein namesi
Submitted name:
Factor I C3b/C4b inactivator (Serine protease)Imported
Gene namesi
Name:cfiImported
Synonyms:factor IImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254048. cfi.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500416388721 – 613Sequence analysisAdd BLAST593

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ03711.

Structurei

3D structure databases

ProteinModelPortaliQ03711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 214SRCRInterPro annotationAdd BLAST103
Domaini370 – 604Peptidase S1InterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation
Contains 1 peptidase S1 domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG005311.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.10.250.10. 1 hit.
4.10.400.10. 2 hits.
InterProiIPR003884. FacI_MAC.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 2 hits.
PF00530. SRCR. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00057. FIMAC. 1 hit.
SM00192. LDLa. 2 hits.
SM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 2 hits.
PROSITEiPS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
PS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLCCVLIL FCHFYVNTFS SAVSGAGDAR PNTCEFNALS CHKVFCAPWQ
60 70 80 90 100
RCVAGVCRCK LPYQCPKNAT TEVCTDGKRK LQSYCQLKSV ECSNPLNSKY
110 120 130 140 150
RFSSEAPCTE TFTLTQNGEP GKGIIKVKLP TFEQELFLCG KQWSNREANV
160 170 180 190 200
VCRQLGSTKG ADASASDKVF SLVTEKPPEH CIQATCRGLE NSLAECALRK
210 220 230 240 250
LPMQDNQVAK VTCYTENKDC GFGEFTCSNG KCIPSELACD SKNDCGDLSD
260 270 280 290 300
ELCCKSCNAG FHCRSDTCIP EQYRCNGELD CIGGEDESNC TVEQEQKSEK
310 320 330 340 350
QEEVEQKQTS EKQEEDLVQE SKATQVEEKA KIVNYDIDAE RRLLMKSLPE
360 370 380 390 400
LSCGVPPQTA ALTLTRKKRV IGGTNAVKNQ FPWQVAIKDG TAVNCGGIYI
410 420 430 440 450
GGCWVLTAAH CVRSNQPQRY LIMLELLDRL SYDKDLDSFP VKSVIVHELY
460 470 480 490 500
NPNTYENDIA LLEVKNIYNN PKCMQADNNM VPACVPWSPF QFKAGDTCTV
510 520 530 540 550
SGWGREKGMS RVFHLKWGHI NLMDNCTRVY KERFLDKMEC ARTYDGSIDA
560 570 580 590 600
CKGDSGGPLV CYDVNKVAYV WGIVSWGENC GVPGYPGVYT KVANYFEWIA
610
HQVGRSLMSK YNV
Length:613
Mass (Da):68,308
Last modified:November 1, 1996 - v1
Checksum:iD66E626CEEF617E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59958 mRNA. Translation: CAA42582.1.
PIRiI51601. S15468.
RefSeqiNP_001095259.1. NM_001101789.1.
UniGeneiXl.1143.

Genome annotation databases

GeneIDi399318.
KEGGixla:399318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59958 mRNA. Translation: CAA42582.1.
PIRiI51601. S15468.
RefSeqiNP_001095259.1. NM_001101789.1.
UniGeneiXl.1143.

3D structure databases

ProteinModelPortaliQ03711.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.199.

Proteomic databases

PRIDEiQ03711.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399318.
KEGGixla:399318.

Organism-specific databases

CTDi399318.
XenbaseiXB-GENE-6254048. cfi.

Phylogenomic databases

HOVERGENiHBG005311.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.10.250.10. 1 hit.
4.10.400.10. 2 hits.
InterProiIPR003884. FacI_MAC.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 2 hits.
PF00530. SRCR. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00057. FIMAC. 1 hit.
SM00192. LDLa. 2 hits.
SM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 2 hits.
PROSITEiPS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
PS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ03711_XENLA
AccessioniPrimary (citable) accession number: Q03711
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.