Reviewed, UniProtKB/Swiss-Prot Q03710 (CFAB_PIG)

Names and origin

Protein names

Recommended name:
    Complement factor B
    EC=3.4.21.47
Alternative name(s):
    C3/C5 convertase
    Properdin factor B

Gene names

Name:	CFB
Synonyms:	BF

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	151 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.
Catalytic activity	Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.
Subunit structure	Monomer By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the peptidase S1 family. Contains 3 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Biological process	Complement alternate pathway Immune response Innate immunity
Cellular component	Secreted
Domain	Repeat Sushi
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	complement activation, alternative pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›151	›151	Complement factor B		PRO_0000088663
Regions
	Domain	1 – 61	61	Sushi 2
	Domain	64 – 121	58	Sushi 3
Amino acid modifications
	Glycosylation	23	1	N-linked (GlcNAc...) Potential
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Disulfide bond	4 ↔ 46		By similarity
	Disulfide bond	32 ↔ 59		By similarity
	Disulfide bond	66 ↔ 106		By similarity
	Disulfide bond	92 ↔ 119		By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	151	1

Sequences

	Sequence		Length	Mass (Da)
	Q03710-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BD247E75047E517F	FASTA	151	16,765
	10 20 30 40 50 60 AIRCPRPHDF ENGEYWPRAP YYNLSDEISF HCYDGYTLRG SANRTCQVTG RWDGQTAICD 70 80 90 100 110 120 DGAGYCPNPG IPIGTRKVGT QYRLEDSVTY YCTRGLTLRG SQRRTCQEGG SWSGTEPSCQ 130 140 150 DSFMYDTPAE VAEAFLSSLT ETIEGVDAED G

References

[1]	"Cloning and sequencing of the porcine complement factor B." Peelman L.J., van de Weghe A.R., Coppieters W.R., van Zeveren A.J., Bouquet Y.H. Immunogenetics 34:192-195(1991) [PubMed: 1680099] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M59240 Genomic DNA. Translation: AAA31021.1.
3D structure databases
HSSP	HSSP built from PDB template 1H03 based on UniProtKB P08174.
SMR	Q03710. Positions 1-144.
ModBase	Search...
Protein family/group databases
MEROPS	S01.196.
Phylogenomic databases
HOVERGEN	Q03710.
Enzyme and pathway databases
BRENDA	3.4.21.47. 249.
Family and domain databases
InterPro	IPR016060. Complement_control_module. IPR018114. Peptidase_S1/S6_AS. IPR000436. Sushi_SCR_CCP. [Graphical view]
Gene3D	G3DSA:2.10.70.10. Complement_control_module. 2 hits.
Pfam	PF00084. Sushi. 2 hits. [Graphical view]
SMART	SM00032. CCP. 2 hits. [Graphical view]
PROSITE	PS50923. SUSHI. 2 hits. PS50240. TRYPSIN_DOM. Partial match. PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CFAB_PIG

Accession

Primary (citable) accession number: Q03710

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)