Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Colicin-E7 immunity protein

Gene

imm

Organism
Escherichia coli
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBacteriocin immunity

Protein family/group databases

TCDBi8.B.24.5.5 the colicin immunity protein (colip) functional family

Names & Taxonomyi

Protein namesi
Recommended name:
Colicin-E7 immunity protein
Alternative name(s):
ImmE7
Microcin-E7 immunity protein
Gene namesi
Name:imm
Synonyms:ceiE7
Encoded oniPlasmid ColE70 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187081 – 87Colicin-E7 immunity proteinAdd BLAST87

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

DIPiDIP-16989N
IntActiQ03708, 3 interactors

Structurei

Secondary structure

187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Helixi12 – 25Combined sources14
Beta strandi28 – 31Combined sources4
Helixi32 – 45Combined sources14
Turni48 – 51Combined sources4
Helixi52 – 55Combined sources4
Beta strandi59 – 61Combined sources3
Helixi65 – 78Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AYIX-ray2.00A1-87[»]
1CEIX-ray1.80A1-87[»]
1MZ8X-ray2.00A/C1-87[»]
1UJZX-ray2.10A1-87[»]
1UNKX-ray1.80A/B/C/D1-87[»]
1ZNVX-ray2.00A/C1-87[»]
2ERHX-ray2.00A1-87[»]
2JAZX-ray2.03A/C1-87[»]
2JB0X-ray1.91A1-87[»]
2JBGX-ray2.20A/C1-87[»]
2K0DNMR-X2-87[»]
4F37X-ray2.57A/B2-87[»]
5WNWX-ray1.79C6-45[»]
7CEIX-ray2.30A1-87[»]
ProteinModelPortaliQ03708
SMRiQ03708
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03708

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd16363 Col_Im_like, 1 hit
Gene3Di1.10.1200.20, 1 hit
InterProiView protein in InterPro
IPR035900 Colicin_E_sf
IPR000290 Colicin_pyocin
PfamiView protein in Pfam
PF01320 Colicin_Pyocin, 1 hit
PRINTSiPR01299 PYOCIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007225 Colicin_pyocin, 1 hit
SUPFAMiSSF47345 SSF47345, 1 hit

Sequencei

Sequence statusi: Complete.

Q03708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKNSISDY TEAEFVQLLK EIEKENVAAT DDVLDVLLEH FVKITEHPDG
60 70 80
TDLIYYPSDN RDDSPEGIVK EIKEWRAANG KPGFKQG
Length:87
Mass (Da):9,895
Last modified:November 1, 1997 - v2
Checksum:i2CA7D97057529335
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4K → E in AAA23071 (PubMed:2045785).Curated1
Sequence conflicti27V → E in AAA23071 (PubMed:2045785).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57540 Genomic DNA Translation: AAA23071.1
X63620 Genomic DNA Translation: CAA45165.1
PIRiS27394
RefSeqiWP_001560791.1, NZ_NSMJ01000297.1
YP_009060494.1, NC_024962.1

Genome annotation databases

GeneIDi20467019

Similar proteinsi

Entry informationi

Entry nameiIMM7_ECOLX
AccessioniPrimary (citable) accession number: Q03708
Secondary accession number(s): Q47113
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health