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Protein

Colicin-E7 immunity protein

Gene

imm

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Bacteriocin immunity

Protein family/group databases

TCDBi8.B.24.5.5. the colicin immunity protein (colip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Colicin-E7 immunity protein
Alternative name(s):
ImmE7
Microcin-E7 immunity protein
Gene namesi
Name:imm
Synonyms:ceiE7
Encoded oniPlasmid ColE70 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187081 – 87Colicin-E7 immunity proteinAdd BLAST87

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
colE7Q471122EBI-1035025,EBI-1035016

Protein-protein interaction databases

DIPiDIP-16989N.
IntActiQ03708. 1 interactor.
MINTiMINT-95483.

Structurei

Secondary structure

187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Helixi12 – 25Combined sources14
Beta strandi28 – 31Combined sources4
Helixi32 – 45Combined sources14
Turni48 – 51Combined sources4
Helixi52 – 55Combined sources4
Beta strandi59 – 61Combined sources3
Helixi65 – 78Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AYIX-ray2.00A1-87[»]
1CEIX-ray1.80A1-87[»]
1MZ8X-ray2.00A/C1-87[»]
1UJZX-ray2.10A1-87[»]
1UNKX-ray1.80A/B/C/D1-87[»]
1ZNVX-ray2.00A/C1-87[»]
2ERHX-ray2.00A1-87[»]
2JAZX-ray2.03A/C1-87[»]
2JB0X-ray1.91A1-87[»]
2JBGX-ray2.20A/C1-87[»]
2K0DNMR-X2-51[»]
X65-87[»]
4F37X-ray2.57A/B2-87[»]
5INAX-ray1.79C6-45[»]
7CEIX-ray2.30A1-87[»]
ProteinModelPortaliQ03708.
SMRiQ03708.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03708.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1200.20. 1 hit.
InterProiIPR023802. Colicin/pyocin_immunity_dom.
IPR000290. Colicin_pyocin.
[Graphical view]
PfamiPF01320. Colicin_Pyocin. 1 hit.
[Graphical view]
PRINTSiPR01299. PYOCIN.
ProDomiPD007225. Colicin_pyocin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47345. SSF47345. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKNSISDY TEAEFVQLLK EIEKENVAAT DDVLDVLLEH FVKITEHPDG
60 70 80
TDLIYYPSDN RDDSPEGIVK EIKEWRAANG KPGFKQG
Length:87
Mass (Da):9,895
Last modified:November 1, 1997 - v2
Checksum:i2CA7D97057529335
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4K → E in AAA23071 (PubMed:2045785).Curated1
Sequence conflicti27V → E in AAA23071 (PubMed:2045785).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57540 Genomic DNA. Translation: AAA23071.1.
X63620 Genomic DNA. Translation: CAA45165.1.
PIRiS27394.
RefSeqiWP_001560791.1. NZ_LJYD01000044.1.
YP_009060494.1. NC_024962.1.

Genome annotation databases

GeneIDi20467019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57540 Genomic DNA. Translation: AAA23071.1.
X63620 Genomic DNA. Translation: CAA45165.1.
PIRiS27394.
RefSeqiWP_001560791.1. NZ_LJYD01000044.1.
YP_009060494.1. NC_024962.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AYIX-ray2.00A1-87[»]
1CEIX-ray1.80A1-87[»]
1MZ8X-ray2.00A/C1-87[»]
1UJZX-ray2.10A1-87[»]
1UNKX-ray1.80A/B/C/D1-87[»]
1ZNVX-ray2.00A/C1-87[»]
2ERHX-ray2.00A1-87[»]
2JAZX-ray2.03A/C1-87[»]
2JB0X-ray1.91A1-87[»]
2JBGX-ray2.20A/C1-87[»]
2K0DNMR-X2-51[»]
X65-87[»]
4F37X-ray2.57A/B2-87[»]
5INAX-ray1.79C6-45[»]
7CEIX-ray2.30A1-87[»]
ProteinModelPortaliQ03708.
SMRiQ03708.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-16989N.
IntActiQ03708. 1 interactor.
MINTiMINT-95483.

Protein family/group databases

TCDBi8.B.24.5.5. the colicin immunity protein (colip) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20467019.

Miscellaneous databases

EvolutionaryTraceiQ03708.

Family and domain databases

Gene3Di1.10.1200.20. 1 hit.
InterProiIPR023802. Colicin/pyocin_immunity_dom.
IPR000290. Colicin_pyocin.
[Graphical view]
PfamiPF01320. Colicin_Pyocin. 1 hit.
[Graphical view]
PRINTSiPR01299. PYOCIN.
ProDomiPD007225. Colicin_pyocin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47345. SSF47345. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIMM7_ECOLX
AccessioniPrimary (citable) accession number: Q03708
Secondary accession number(s): Q47113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.