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Protein

Inner nuclear membrane protein SRC1

Gene

SRC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in sister chromatid separation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • maintenance of rDNA Source: SGD
  • meiotic attachment of telomere to nuclear envelope Source: GO_Central
  • mitotic sister chromatid segregation Source: SGD
  • nuclear envelope organization Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner nuclear membrane protein SRC1
Alternative name(s):
Helix-extension-helix domain-containing protein 1
Gene namesi
Name:SRC1
Synonyms:HEH1
Ordered Locus Names:YML034W
ORF Names:YML033W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML034W.
SGDiS000004497. SRC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Transmembranei708 – 728HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of nuclear inner membrane Source: GO_Central
  • nuclear envelope Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000721881 – 834Inner nuclear membrane protein SRC1Add BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei394PhosphothreonineCombined sources1
Modified residuei427PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03707.
PRIDEiQ03707.

PTM databases

iPTMnetiQ03707.

Interactioni

Protein-protein interaction databases

BioGridi35136. 163 interactors.
DIPiDIP-4546N.
IntActiQ03707. 10 interactors.
MINTiMINT-552160.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XZRX-ray2.25A170-223[»]
ProteinModelPortaliQ03707.
SMRiQ03707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi117 – 129Poly-AspAdd BLAST13

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068220.
HOGENOMiHOG000142043.
InParanoidiQ03707.
OMAiCWEWIGP.
OrthoDBiEOG092C2JFO.

Family and domain databases

InterProiIPR025856. HeH/LEM_domain.
IPR018996. Inner-Nucl-membr_MAN1.
[Graphical view]
PfamiPF12949. HeH. 1 hit.
PF09402. MSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSDLEYLED GFDPNSMKVA TLRRILVENN VDFPSNARKN ALVGLFDEKV
60 70 80 90 100
KPQIPQLRKM YLNVRPSDEG IVKMDRPSSS PSIASPRRSR RARREKSASP
110 120 130 140 150
MAKQFKKNRI LDDVSNDDDD DDDDDDDNDK KDDPLIVPSG TDTDEVDDEE
160 170 180 190 200
DDVITSSSNK SDTNDFQQNS DTRKKRKDPD SDDWSESNSK ENKIDNKHLN
210 220 230 240 250
LLSSDSEIEQ DYQKAKKRKT SDLNQEHGNG SAILGKLSVK TPIKNTNRKP
260 270 280 290 300
VSMDNFNDSL TSSGTENDPF VPNIRHNPKE LGTANGTGHS TPLSKLKVSA
310 320 330 340 350
SFADKLPQKE VPSTILVPEV EQQEPSQSER TPSLFSSEGS GSESEAPLLP
360 370 380 390 400
EITTPGPHQP MGNTSNNVVE MIDTDSSNLV SDEDEVLVPT RIETPQLPTE
410 420 430 440 450
KDVEKCEARV QELQEEVNEQ LEHENGSEFD VKQGSGKVGN RHKFKRALKF
460 470 480 490 500
LSKSLLALFL FCIFIVIPLL FGLWYREQRL LIGYCGHEVP SHRVSGNSFE
510 520 530 540 550
FIQKLDNLLQ DYRPKCIPCP PNGICYPYLK LKCKPDYKLA PSRLDFLEII
560 570 580 590 600
PAQGKCVKDD KKQQLVSEVV EKSLEFLRAK NAQISCGDGK DDIESGMTED
610 620 630 640 650
ALYQIFNEAR APWIRDDEFE DLWIQVIKDL TEEPEILWRQ LSPTDNNIGG
660 670 680 690 700
NSNNIIKTND VPRQKRHLPE KFISKTRNFR STSKKYIGMK CRFEREIYQT
710 720 730 740 750
YKKFQRPIWL MFLLIVISKV IEIKLKNYYR KKARIEELVT QTMEKLKFQK
760 770 780 790 800
IKSMSDPKEN AYLSIVQLRD IFLSDIVDLK YKNQLWSEVV KYLEHNNSNI
810 820 830
KSNLTEIRGE IMKCWEWIGP MELNEPKDSA ENKI
Length:834
Mass (Da):95,498
Last modified:September 26, 2001 - v2
Checksum:i214CA064ECE160F4
GO

Sequence cautioni

The sequence CAA86621 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA86622 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46659 Genomic DNA. Translation: CAA86621.1. Sequence problems.
Z46659 Genomic DNA. Translation: CAA86622.1. Sequence problems.
BK006946 Genomic DNA. Translation: DAA09865.1.
PIRiS49746.
RefSeqiNP_013679.1. NM_001182391.1.

Genome annotation databases

EnsemblFungiiYML034W; YML034W; YML034W.
GeneIDi854974.
KEGGisce:YML034W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46659 Genomic DNA. Translation: CAA86621.1. Sequence problems.
Z46659 Genomic DNA. Translation: CAA86622.1. Sequence problems.
BK006946 Genomic DNA. Translation: DAA09865.1.
PIRiS49746.
RefSeqiNP_013679.1. NM_001182391.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XZRX-ray2.25A170-223[»]
ProteinModelPortaliQ03707.
SMRiQ03707.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35136. 163 interactors.
DIPiDIP-4546N.
IntActiQ03707. 10 interactors.
MINTiMINT-552160.

PTM databases

iPTMnetiQ03707.

Proteomic databases

MaxQBiQ03707.
PRIDEiQ03707.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML034W; YML034W; YML034W.
GeneIDi854974.
KEGGisce:YML034W.

Organism-specific databases

EuPathDBiFungiDB:YML034W.
SGDiS000004497. SRC1.

Phylogenomic databases

GeneTreeiENSGT00530000068220.
HOGENOMiHOG000142043.
InParanoidiQ03707.
OMAiCWEWIGP.
OrthoDBiEOG092C2JFO.

Enzyme and pathway databases

BioCyciYEAST:G3O-32634-MONOMER.

Miscellaneous databases

PROiQ03707.

Family and domain databases

InterProiIPR025856. HeH/LEM_domain.
IPR018996. Inner-Nucl-membr_MAN1.
[Graphical view]
PfamiPF12949. HeH. 1 hit.
PF09402. MSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRC1_YEAST
AccessioniPrimary (citable) accession number: Q03707
Secondary accession number(s): D6VZE1, Q03712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 26, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.