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Q03707

- SRC1_YEAST

UniProt

Q03707 - SRC1_YEAST

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Protein

Inner nuclear membrane protein SRC1

Gene

SRC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in sister chromatid separation.1 Publication

GO - Biological processi

  1. maintenance of rDNA Source: SGD
  2. mitotic sister chromatid segregation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner nuclear membrane protein SRC1
Alternative name(s):
Helix-extension-helix domain-containing protein 1
Gene namesi
Name:SRC1
Synonyms:HEH1
Ordered Locus Names:YML034W
ORF Names:YML033W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML034w1.
SGDiS000004497. SRC1.

Subcellular locationi

Nucleus inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Targeting to the inner nuclear membrane requires the SRP1 and KAP95 karyopherins and the Ran cycle.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST
Transmembranei708 – 72821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of nuclear inner membrane Source: InterPro
  2. nuclear envelope Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Inner nuclear membrane protein SRC1PRO_0000072188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781Phosphoserine1 Publication
Modified residuei80 – 801Phosphoserine2 Publications
Modified residuei85 – 851Phosphoserine2 Publications
Modified residuei181 – 1811Phosphoserine1 Publication
Modified residuei203 – 2031Phosphoserine1 Publication
Modified residuei204 – 2041Phosphoserine2 Publications
Modified residuei206 – 2061Phosphoserine2 Publications
Modified residuei301 – 3011Phosphoserine1 Publication
Modified residuei394 – 3941Phosphothreonine2 Publications
Modified residuei427 – 4271Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03707.
PaxDbiQ03707.
PeptideAtlasiQ03707.

Expressioni

Gene expression databases

GenevestigatoriQ03707.

Interactioni

Protein-protein interaction databases

BioGridi35136. 163 interactions.
DIPiDIP-4546N.
IntActiQ03707. 8 interactions.
MINTiMINT-552160.
STRINGi4932.YML034W.

Structurei

3D structure databases

ProteinModelPortaliQ03707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi117 – 12913Poly-AspAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292066.
GeneTreeiENSGT00530000068220.
HOGENOMiHOG000142043.
InParanoidiQ03707.
OMAiHENGSEF.
OrthoDBiEOG7GBG5Q.

Family and domain databases

InterProiIPR025856. HeH/LEM_domain.
IPR018996. Inner-Nucl-membr_MAN1.
[Graphical view]
PfamiPF12949. HeH. 1 hit.
PF09402. MSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03707-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSDLEYLED GFDPNSMKVA TLRRILVENN VDFPSNARKN ALVGLFDEKV
60 70 80 90 100
KPQIPQLRKM YLNVRPSDEG IVKMDRPSSS PSIASPRRSR RARREKSASP
110 120 130 140 150
MAKQFKKNRI LDDVSNDDDD DDDDDDDNDK KDDPLIVPSG TDTDEVDDEE
160 170 180 190 200
DDVITSSSNK SDTNDFQQNS DTRKKRKDPD SDDWSESNSK ENKIDNKHLN
210 220 230 240 250
LLSSDSEIEQ DYQKAKKRKT SDLNQEHGNG SAILGKLSVK TPIKNTNRKP
260 270 280 290 300
VSMDNFNDSL TSSGTENDPF VPNIRHNPKE LGTANGTGHS TPLSKLKVSA
310 320 330 340 350
SFADKLPQKE VPSTILVPEV EQQEPSQSER TPSLFSSEGS GSESEAPLLP
360 370 380 390 400
EITTPGPHQP MGNTSNNVVE MIDTDSSNLV SDEDEVLVPT RIETPQLPTE
410 420 430 440 450
KDVEKCEARV QELQEEVNEQ LEHENGSEFD VKQGSGKVGN RHKFKRALKF
460 470 480 490 500
LSKSLLALFL FCIFIVIPLL FGLWYREQRL LIGYCGHEVP SHRVSGNSFE
510 520 530 540 550
FIQKLDNLLQ DYRPKCIPCP PNGICYPYLK LKCKPDYKLA PSRLDFLEII
560 570 580 590 600
PAQGKCVKDD KKQQLVSEVV EKSLEFLRAK NAQISCGDGK DDIESGMTED
610 620 630 640 650
ALYQIFNEAR APWIRDDEFE DLWIQVIKDL TEEPEILWRQ LSPTDNNIGG
660 670 680 690 700
NSNNIIKTND VPRQKRHLPE KFISKTRNFR STSKKYIGMK CRFEREIYQT
710 720 730 740 750
YKKFQRPIWL MFLLIVISKV IEIKLKNYYR KKARIEELVT QTMEKLKFQK
760 770 780 790 800
IKSMSDPKEN AYLSIVQLRD IFLSDIVDLK YKNQLWSEVV KYLEHNNSNI
810 820 830
KSNLTEIRGE IMKCWEWIGP MELNEPKDSA ENKI
Length:834
Mass (Da):95,498
Last modified:September 26, 2001 - v2
Checksum:i214CA064ECE160F4
GO

Sequence cautioni

The sequence CAA86621.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAA86622.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46659 Genomic DNA. Translation: CAA86621.1. Sequence problems.
Z46659 Genomic DNA. Translation: CAA86622.1. Sequence problems.
BK006946 Genomic DNA. Translation: DAA09865.1.
PIRiS49746.
RefSeqiNP_013679.1. NM_001182391.1.

Genome annotation databases

EnsemblFungiiYML034W; YML034W; YML034W.
GeneIDi854974.
KEGGisce:YML034W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46659 Genomic DNA. Translation: CAA86621.1 . Sequence problems.
Z46659 Genomic DNA. Translation: CAA86622.1 . Sequence problems.
BK006946 Genomic DNA. Translation: DAA09865.1 .
PIRi S49746.
RefSeqi NP_013679.1. NM_001182391.1.

3D structure databases

ProteinModelPortali Q03707.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35136. 163 interactions.
DIPi DIP-4546N.
IntActi Q03707. 8 interactions.
MINTi MINT-552160.
STRINGi 4932.YML034W.

Proteomic databases

MaxQBi Q03707.
PaxDbi Q03707.
PeptideAtlasi Q03707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML034W ; YML034W ; YML034W .
GeneIDi 854974.
KEGGi sce:YML034W.

Organism-specific databases

CYGDi YML034w1.
SGDi S000004497. SRC1.

Phylogenomic databases

eggNOGi NOG292066.
GeneTreei ENSGT00530000068220.
HOGENOMi HOG000142043.
InParanoidi Q03707.
OMAi HENGSEF.
OrthoDBi EOG7GBG5Q.

Enzyme and pathway databases

BioCyci YEAST:G3O-32634-MONOMER.

Miscellaneous databases

NextBioi 978082.

Gene expression databases

Genevestigatori Q03707.

Family and domain databases

InterProi IPR025856. HeH/LEM_domain.
IPR018996. Inner-Nucl-membr_MAN1.
[Graphical view ]
Pfami PF12949. HeH. 1 hit.
PF09402. MSC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "SRC1: an intron-containing yeast gene involved in sister chromatid segregation."
    Rodriguez-Navarro S., Igual J.C., Perez-Ortin J.E.
    Yeast 19:43-54(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION OF INTRON.
  4. "Karyopherin-mediated import of integral inner nuclear membrane proteins."
    King M.C., Lusk C.P., Blobel G.
    Nature 442:1003-1007(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80; SER-85; SER-204 AND SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301; THR-394 AND SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78; SER-80; SER-85; SER-181; SER-203; SER-204; SER-206 AND THR-394, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSRC1_YEAST
AccessioniPrimary (citable) accession number: Q03707
Secondary accession number(s): D6VZE1, Q03712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 26, 2001
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3