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Protein

Rhizopuspepsin-4

Gene
N/A
Organism
Rhizopus niveus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108PROSITE-ProRule annotation1
Active sitei291PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhizopuspepsin-4 (EC:3.4.23.21)
Alternative name(s):
Aspartate protease
OrganismiRhizopus niveus
Taxonomic identifieri4844 [NCBI]
Taxonomic lineageiEukaryotaFungiMucoromycotaMucoromycotinaMucoralesMucorineaeRhizopodaceaeRhizopus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002588922 – 74Activation peptideSequence analysisAdd BLAST53
ChainiPRO_000002589075 – 398Rhizopuspepsin-4Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi121 ↔ 124By similarity
Disulfide bondi325 ↔ 358By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PRIDEiQ03700.

Structurei

3D structure databases

ProteinModelPortaliQ03700.
SMRiQ03700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 394Peptidase A1PROSITE-ProRule annotationAdd BLAST305

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 67Poly-Ser10
Compositional biasi237 – 240Poly-Gly4

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd06097. Aspergillopepsin_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR034163. Aspergillopepsin-like_cat_dom.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTLISSCV ALACMALAVE AAPSGKKINV PLSKNANYKP NAKRAIEKAN
60 70 80 90 100
AKYARFRSSS SSSSSSSCGS AGTESSGSVP VTDDGNDIEY YGEVTVGTPG
110 120 130 140 150
IKLKLDFDTG SSDLWFASTL CTNCGSSQTK YDPSQSSTYA KDGRTWSISY
160 170 180 190 200
GDGSSASGIL GKDTVNLGGL KIKNQIIELA KREASSFSSG PSDGLLGLGF
210 220 230 240 250
DSITTVSGVQ TPMDNLISQG LISNPVFGVY LGKESNGGGG EYIFGGYDSS
260 270 280 290 300
KFSGDLTTIA VDNSNGWYGI TIDGASISGS QVSDSFSAIL DTGTTLLILP
310 320 330 340 350
SNVASSVAQA YNANDNGDGT YNINCDTSEL QPLVFTIGGS TFEVPTDSLI
360 370 380 390
FEQDGNTCVA GFGYGQDDFA IFGDVFLKNN YVVFNPQVPQ VQIAPISN
Length:398
Mass (Da):41,409
Last modified:November 1, 1995 - v1
Checksum:i70CA63FEFB5C05D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56992 Genomic DNA. Translation: CAA40309.1.

Similar proteinsi

Entry informationi

Entry nameiCARP4_RHINI
AccessioniPrimary (citable) accession number: Q03700
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 15, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families