Reviewed, UniProtKB/Swiss-Prot Q036B8 (ADD_LACC3)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	LSEI_2207

Organism

Lactobacillus casei (strain ATCC 334) [Complete proteome] [HAMAP]

Taxonomic identifier

321967 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Adenosine deaminase HAMAP MF_00540		PRO_1000017665
Sites
	Active site	199	1	Potential
	Active site	246	1	Potential
	Active site	279	1	Potential
	Active site	280	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q036B8-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 4193949F6BE2F803	FASTA	339	36,961
	10 20 30 40 50 60 MDFQTLHQLS KTELHCHLDG SLSLSCIRQL AKMIDRKLPA TDDELRRLVQ APADSENLGD 70 80 90 100 110 120 YLKAFDFVAP LLQTKKALQL AAYDVVEQAA EENVRYIEIR FAPVFSLAGG LSLVEATQAV 130 140 150 160 170 180 IEGLHQGMAT YDIMAKALVC GMRQLPNTDN QTMFKTTAPL LGSTLVGGDF AGNEADFPTN 190 200 210 220 230 240 VCAPAIKTAQ SLGVPLTFHA GECHCPQNIG EAVRLGIPRI GHATACFDQP ALIEKIVETG 250 260 270 280 290 300 TTVELCLTSN LQTKAARTLA EFPYQALKKA GAKITINTDN RTVSNTTLTQ EYQRYQQAFG 310 320 330 TTAADFLAFN LNAIDAAFIP DADKKSLRDQ LHQDYATYC

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000423 Genomic DNA. Translation: ABJ70954.1.
RefSeq	YP_807396.1.
3D structure databases
SMR	Q036B8. Positions 8-335.
ModBase	Search...
Protein-protein interaction databases
STRING	Q036B8.
Genome annotation databases
GeneID	4420754.
GenomeReviews	Gene locus LSEI_2207 in contig CP000423_GR.
KEGG	lca:LSEI_2207.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	FLKKLDW.
PhylomeDB	Q036B8.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_LACC3

Accession

Primary (citable) accession number: Q036B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	February 9, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)