Putative nucleotide-sugar transporter YMD8 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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Q03697 (YMD8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 81. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Putative nucleotide-sugar transporter YMD8

Gene names

Name:	YMD8
Ordered Locus Names:	YML038C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle › COPI-coated vesicle membrane; Multi-pass membrane protein Ref.4.
Sequence similarities	Belongs to the TPT transporter family. SLC35C subfamily.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cytoplasmic vesicle Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	UDP-glucose transport Inferred from mutant phenotype. Source: SGD
Cellular component	COPI coated vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
AGP1	P25376	1	EBI-27776,EBI-2357
GAP1	P19145	1	EBI-27776,EBI-7314
KEX1	P09620	1	EBI-27776,EBI-9653
PMP2	P40975	1	EBI-27776,EBI-2043041

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 442

442

Putative nucleotide-sugar transporter YMD8

PRO_0000213402

Regions

Topological domain

1 – 3

Cytoplasmic Potential

Transmembrane

4 – 24

Helical; Potential

Topological domain

25 – 32

Extracellular Potential

Transmembrane

33 – 53

Helical; Potential

Topological domain

54 – 76

Cytoplasmic Potential

Transmembrane

77 – 97

Helical; Potential

Topological domain

98 – 107

Extracellular Potential

Transmembrane

108 – 128

Helical; Potential

Topological domain

129 – 132

Cytoplasmic Potential

Transmembrane

133 – 153

Helical; Potential

Topological domain

154 – 166

Extracellular Potential

Transmembrane

167 – 187

Helical; Potential

Topological domain

188 – 254

Cytoplasmic Potential

Transmembrane

255 – 275

Helical; Potential

Topological domain

276 – 301

Extracellular Potential

Transmembrane

302 – 322

Helical; Potential

Topological domain

323 – 329

Cytoplasmic Potential

Transmembrane

330 – 350

Helical; Potential

Topological domain

351 – 355

Extracellular Potential

Transmembrane

356 – 376

Helical; Potential

Topological domain

377 – 442

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q03697 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 37A03543D3AB695E
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FASTA

442

49,615

        10         20         30         40         50         60 
MNRTVFLAFV FGWYFCSIAL SIYNRWMFDP KDGLGIGYPV LVTTFHQATL WLLSGIYIKL 

        70         80         90        100        110        120 
RHKPVKNVLR KNNGFNWSFF LKFLLPTAVA SAGDIGLSNV SFQYVPLTIY TIIKSSSIAF 

       130        140        150        160        170        180 
VLLFGCIFKL EKFHWKLALS VIIMFVGVAL MVFKPSDSTS TKNDQALVIF GSFLVLASSC 

       190        200        210        220        230        240 
LSGLRWVYTQ LMLRNNPIQT NTAAAVEESD GALFTENEDN VDNEPVVNLA NNKMLENFGE 

       250        260        270        280        290        300 
SKPHPIHTIH QLAPIMGITL LLTSLLVEKP FPGIFSSSIF RLDTSNGGVG TETTVLSIVR 

       310        320        330        340        350        360 
GIVLLILPGF AVFLLTICEF SILEQTPVLT VSIVGIVKEL LTVIFGIIIL SERLSGFYNW 

       370        380        390        400        410        420 
LGMLIIMADV CYYNYFRYKQ DLLQKYHSVS TQDNRNELKG FQDFEQLGSK KIAPYSISVD 

       430        440 
LTNQEYELDM IAQNVSRSSQ QV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46659 Genomic DNA. Translation: CAA86617.1. AY692787 Genomic DNA. Translation: AAT92806.1. BK006946 Genomic DNA. Translation: DAA09861.1.
PIR	S49741.
RefSeq	NP_013674.1. NM_001182396.1.
3D structure databases
ProteinModelPortal	Q03697.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1312N.
IntAct	Q03697. 8 interactions.
MINT	MINT-388216.
STRING	Q03697.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YML038C; YML038C; YML038C.
GeneID	854970.
KEGG	sce:YML038C.
NMPDR	fig\|4932.3.peg.4714.
Organism-specific databases
CYGD	YML038c.
SGD	S000004502. YMD8.
Phylogenomic databases
eggNOG	fuNOG06067.
GeneTree	EFGT00050000001385.
HOGENOM	HBG397713.
OMA	MVATETH.
OrthoDB	EOG4GF6Q9.
Gene expression databases
ArrayExpress	Q03697.
Genevestigator	Q03697.
GermOnline	YML038C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004853. DUF250. [Graphical view]
KO	K15280.
Pfam	PF03151. TPT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	978070.

Entry information

Entry name

YMD8_YEAST

Accession

Primary (citable) accession number: Q03697
Secondary accession number(s): D6VZD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents