Q03687 (YMP0_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized membrane protein YMR010W

Gene names

Ordered Locus Names:	YMR010W
ORF Names:	YM8270.13

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Miscellaneous	Present with 937 molecules/cell in log phase SD medium. Ref.4

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: SGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Uncharacterized membrane protein YMR010W		PRO_0000203270
Regions
	Topological domain	1 – 51	51	Extracellular Potential
	Transmembrane	52 – 72	21	Helical; Potential
	Topological domain	73 – 76	4	Cytoplasmic Potential
	Transmembrane	77 – 97	21	Helical; Potential
	Topological domain	98 – 103	6	Extracellular Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Topological domain	125 – 178	54	Cytoplasmic Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Topological domain	200 – 223	24	Extracellular Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Topological domain	245 – 254	10	Cytoplasmic Potential
	Transmembrane	255 – 275	21	Helical; Potential
	Topological domain	276 – 299	24	Extracellular Potential
	Transmembrane	300 – 320	21	Helical; Potential
	Topological domain	321 – 405	85	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q03687 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: AF019859073E134E	FASTA	405	46,872
	10 20 30 40 50 60 MSTTGPLDAT LIRDVAVATA TKASYDMSDT LYSYLPKVDQ FYIPEWLTMQ FIANNLISFT 70 80 90 100 110 120 PLFSYGTTII SIEKCKTALG FSIDICATML IASILRISYY LITPYEITLL RQSLVMIFIQ 130 140 150 160 170 180 LILLRTSLKY RPDEYKYQNL TDVESLSHLI HDIWFEFFSC INRPKFLSED WKNLIKSLSF 190 200 210 220 230 240 TNLLKFSFKI FLAFFYKILK FFDPNFKRIG AFWQWDDDKN FWRFLALFAT VQILVTFFIS 250 260 270 280 290 300 NILNWDSLAQ GLGSIIGSLG LLVESLLPLP QIAILYKLKS VQGFKLILLV SWLCGDTLKI 310 320 330 340 350 360 TYLIFGAKNI SALFVIFALF QMSLDFYIGG QYIYYRYYYP KLRHQHHPND SNSPSDEDES 370 380 390 400 EMYELDLFNT LQKDVEKALK QDSNDTSDSP QDDQVGKSQA QAVTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z48613 Genomic DNA. Translation: CAA88526.1. AY558117 Genomic DNA. Translation: AAS56443.1. BK006946 Genomic DNA. Translation: DAA09908.1.
PIR	S53040.
RefSeq	NP_013723.1. NM_001182506.1.
3D structure databases
ProteinModelPortal	Q03687.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4512N.
IntAct	Q03687. 32 interactions.
MINT	MINT-525880.
STRING	Q03687.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR010W; YMR010W; YMR010W.
GeneID	855022.
KEGG	sce:YMR010W.
NMPDR	fig|4932.3.peg.4767.
Organism-specific databases
CYGD	YMR010w.
SGD	S000004612. YMR010W.
Phylogenomic databases
eggNOG	fuNOG05117.
GeneTree	EFGT00050000006186.
HOGENOM	HBG396015.
OMA	PLFSYGT.
OrthoDB	EOG43V356.
Gene expression databases
ArrayExpress	Q03687.
Genevestigator	Q03687.
GermOnline	YMR010W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR006603. CTNS. [Graphical view]
SMART	SM00679. CTNS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	978210.

Entry information

Entry name

YMP0_YEAST

Accession

Primary (citable) accession number: Q03687
Secondary accession number(s): D6VZI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program