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Protein

Luminal-binding protein 1

Gene

BIP1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Luminal-binding protein 1
Short name:
BiP 1
Alternative name(s):
78 kDa glucose-regulated protein homolog 1
Short name:
GRP-78-1
Gene namesi
Name:BIP1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 290›290Luminal-binding protein 1PRO_0000078666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ03681.
ProMEXiQ03681.

Structurei

3D structure databases

ProteinModelPortaliQ03681.
SMRiQ03681. Positions 1-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi287 – 2904Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q03681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KVQQLLKDYF DGKEPNKGVN PDEAVAYGAA VQGGILSGEG GDETKDILLL
60 70 80 90 100
DVAPLTLGIE TVGGVMTKLI PRNTVIPTKK SQVFTTYQDQ QTTVSIQVFE
110 120 130 140 150
GERSLTKDCR LLGKFDLTGI APAPRGTPQI EVTFEVDANG ILNVKAEDKG
160 170 180 190 200
TGKSEKITIT NDKGRLSQEE IERMVREAEE FAEEDKKVKE RIDARNSLET
210 220 230 240 250
YVYNMKNQIN DKDKLADKLE SDEKEKIETA TKEALEWLDD NQSAEKEDYE
260 270 280 290
EKLKEVEAIC NPIITAVYQR SGGAPGGGSS EEEEDGHDEL
Length:290
Mass (Da):32,032
Last modified:February 1, 1995 - v1
Checksum:iE80F65136E64BF89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60060 mRNA. Translation: CAA42662.1.
PIRiS21877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60060 mRNA. Translation: CAA42662.1.
PIRiS21877.

3D structure databases

ProteinModelPortaliQ03681.
SMRiQ03681. Positions 1-209.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ03681.
ProMEXiQ03681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The tobacco luminal binding protein is encoded by a multigene family."
    Denecke J., Goldman M.H., Demolder J., Seurinck J., Botterman J.
    Plant Cell 3:1025-1035(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Erratum
    Denecke J., Goldman M.H., Demolder J., Seurinck J., Botterman J.
    Plant Cell 3:1251-1251(1990)

Entry informationi

Entry nameiBIP1_TOBAC
AccessioniPrimary (citable) accession number: Q03681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.