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Q03680

- BLA1_STRCI

UniProt

Q03680 - BLA1_STRCI

Protein

Beta-lactamase 1

Gene

blaL

Organism
Streptomyces cacaoi
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931Acyl-ester intermediate1 PublicationPROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase 1 (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    Gene namesi
    Name:blaL
    OrganismiStreptomyces cacaoi
    Taxonomic identifieri1898 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 325299Beta-lactamase 1PRO_0000017016Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ03680.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni270 – 2723Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q03680-1 [UniParc]FASTAAdd to Basket

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    MRIRPTRRLL LGAVAPLALV PLVACGQASG SESGQQPGLG GCGTSAHGSA    50
    DAHEKEFRAL EKKFDAHPGV YAIDTRDGQE ITHRADERFA YGSTFKALQA 100
    GAILAQVLRD GREVRRGAEA DGMDKVVHYG QDAILPNSPV TEKHVADGMS 150
    LRELCDAVVA YSDNTAANLL FDQLGGRRGS TRVLKQLGDH TTSMDRYEQE 200
    LGSAVPGDPR DTSTPRAFAE DLRAFAVEDG EKAALAPNDR EQLNDWMSGS 250
    RTGDALIRAG VPKDWKVEDK SGQVKYGTRN DIAVVRPPGR APIVVSVMSH 300
    GDTQDAEPHD ELVAEAGLVV ADGLK 325
    Length:325
    Mass (Da):34,758
    Last modified:February 1, 1994 - v1
    Checksum:i8E328575B353ABA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90201 Genomic DNA. Translation: BAA14224.1.
    PIRiA37148.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90201 Genomic DNA. Translation: BAA14224.1 .
    PIRi A37148.

    3D structure databases

    ProteinModelPortali Q03680.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the gene encoding the active-site serine beta-lactamase from Streptomyces cacaoi."
      Lenzini M.V., Ishihara H., Dusart J., Ogawara H., Joris B., Beeumen J., Frere J.-M., Ghuysen J.-M.
      FEMS Microbiol. Lett. 49:371-376(1988)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: KCC S0352.
    2. "Beta-lactamase expression in Streptomyces cacaoi."
      Urabe H., Lenzini M.V., Mukaide M., Dusart J., Nakano M.M., Ghuysen J.-M., Ogawara H.
      J. Bacteriol. 172:6427-6434(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION.
      Strain: KCC S0352.
    3. "The active sites of the beta-lactamases of Streptomyces cacaoi and Streptomyces albus G."
      de Meester F., Joris B., Lenzini M.V., Dehottay P., Erpicium T., Dusart J., Klein D., Ghuysen J.-M., Frere J.-M., van Beeumen J.
      Biochem. J. 244:427-432(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 89-96, ACTIVE SITE SER-93.
    4. "Two different beta-lactamase genes are present in Streptomyces cacaoi."
      Magdalena J., Forsman M., Lenzini M.V., Brans A., Dusart J.
      FEMS Microbiol. Lett. 78:101-105(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPARISON OF BLAU AND BLAL.

    Entry informationi

    Entry nameiBLA1_STRCI
    AccessioniPrimary (citable) accession number: Q03680
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3