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Q03680

- BLA1_STRCI

UniProt

Q03680 - BLA1_STRCI

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Protein

Beta-lactamase 1

Gene
blaL
Organism
Streptomyces cacaoi
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Acyl-ester intermediate1 Publication

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase 1 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:blaL
OrganismiStreptomyces cacaoi
Taxonomic identifieri1898 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 325299Beta-lactamase 1PRO_0000017016Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ03680.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni270 – 2723Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03680-1 [UniParc]FASTAAdd to Basket

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MRIRPTRRLL LGAVAPLALV PLVACGQASG SESGQQPGLG GCGTSAHGSA    50
DAHEKEFRAL EKKFDAHPGV YAIDTRDGQE ITHRADERFA YGSTFKALQA 100
GAILAQVLRD GREVRRGAEA DGMDKVVHYG QDAILPNSPV TEKHVADGMS 150
LRELCDAVVA YSDNTAANLL FDQLGGRRGS TRVLKQLGDH TTSMDRYEQE 200
LGSAVPGDPR DTSTPRAFAE DLRAFAVEDG EKAALAPNDR EQLNDWMSGS 250
RTGDALIRAG VPKDWKVEDK SGQVKYGTRN DIAVVRPPGR APIVVSVMSH 300
GDTQDAEPHD ELVAEAGLVV ADGLK 325
Length:325
Mass (Da):34,758
Last modified:February 1, 1994 - v1
Checksum:i8E328575B353ABA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90201 Genomic DNA. Translation: BAA14224.1.
PIRiA37148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90201 Genomic DNA. Translation: BAA14224.1 .
PIRi A37148.

3D structure databases

ProteinModelPortali Q03680.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the gene encoding the active-site serine beta-lactamase from Streptomyces cacaoi."
    Lenzini M.V., Ishihara H., Dusart J., Ogawara H., Joris B., Beeumen J., Frere J.-M., Ghuysen J.-M.
    FEMS Microbiol. Lett. 49:371-376(1988)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KCC S0352.
  2. "Beta-lactamase expression in Streptomyces cacaoi."
    Urabe H., Lenzini M.V., Mukaide M., Dusart J., Nakano M.M., Ghuysen J.-M., Ogawara H.
    J. Bacteriol. 172:6427-6434(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION.
    Strain: KCC S0352.
  3. "The active sites of the beta-lactamases of Streptomyces cacaoi and Streptomyces albus G."
    de Meester F., Joris B., Lenzini M.V., Dehottay P., Erpicium T., Dusart J., Klein D., Ghuysen J.-M., Frere J.-M., van Beeumen J.
    Biochem. J. 244:427-432(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 89-96, ACTIVE SITE SER-93.
  4. "Two different beta-lactamase genes are present in Streptomyces cacaoi."
    Magdalena J., Forsman M., Lenzini M.V., Brans A., Dusart J.
    FEMS Microbiol. Lett. 78:101-105(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPARISON OF BLAU AND BLAL.

Entry informationi

Entry nameiBLA1_STRCI
AccessioniPrimary (citable) accession number: Q03680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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