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Q03680 (BLA1_STRCI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase 1

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:blaL
OrganismStreptomyces cacaoi
Taxonomic identifier1898 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 325299Beta-lactamase 1
PRO_0000017016

Regions

Region270 – 2723Substrate binding By similarity

Sites

Active site931Acyl-ester intermediate Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q03680 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 8E328575B353ABA3

FASTA32534,758
        10         20         30         40         50         60 
MRIRPTRRLL LGAVAPLALV PLVACGQASG SESGQQPGLG GCGTSAHGSA DAHEKEFRAL 

        70         80         90        100        110        120 
EKKFDAHPGV YAIDTRDGQE ITHRADERFA YGSTFKALQA GAILAQVLRD GREVRRGAEA 

       130        140        150        160        170        180 
DGMDKVVHYG QDAILPNSPV TEKHVADGMS LRELCDAVVA YSDNTAANLL FDQLGGRRGS 

       190        200        210        220        230        240 
TRVLKQLGDH TTSMDRYEQE LGSAVPGDPR DTSTPRAFAE DLRAFAVEDG EKAALAPNDR 

       250        260        270        280        290        300 
EQLNDWMSGS RTGDALIRAG VPKDWKVEDK SGQVKYGTRN DIAVVRPPGR APIVVSVMSH 

       310        320 
GDTQDAEPHD ELVAEAGLVV ADGLK 

« Hide

References

[1]"Nucleotide sequence of the gene encoding the active-site serine beta-lactamase from Streptomyces cacaoi."
Lenzini M.V., Ishihara H., Dusart J., Ogawara H., Joris B., Beeumen J., Frere J.-M., Ghuysen J.-M.
FEMS Microbiol. Lett. 49:371-376(1988)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: KCC S0352.
[2]"Beta-lactamase expression in Streptomyces cacaoi."
Urabe H., Lenzini M.V., Mukaide M., Dusart J., Nakano M.M., Ghuysen J.-M., Ogawara H.
J. Bacteriol. 172:6427-6434(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION.
Strain: KCC S0352.
[3]"The active sites of the beta-lactamases of Streptomyces cacaoi and Streptomyces albus G."
de Meester F., Joris B., Lenzini M.V., Dehottay P., Erpicium T., Dusart J., Klein D., Ghuysen J.-M., Frere J.-M., van Beeumen J.
Biochem. J. 244:427-432(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 89-96, ACTIVE SITE SER-93.
[4]"Two different beta-lactamase genes are present in Streptomyces cacaoi."
Magdalena J., Forsman M., Lenzini M.V., Brans A., Dusart J.
FEMS Microbiol. Lett. 78:101-105(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPARISON OF BLAU AND BLAL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D90201 Genomic DNA. Translation: BAA14224.1.
PIRA37148.

3D structure databases

ProteinModelPortalQ03680.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLA1_STRCI
AccessionPrimary (citable) accession number: Q03680
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families