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Protein

Trafficking protein particle complex II-specific subunit 130

Gene

TRS130

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchange factor (GEF) for the Golgi YPT1 GTPase. TRS130 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS120. Required for both the cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy through its role in ATG8 and ATG9 trafficking.7 Publications

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • early endosome to Golgi transport Source: SGD
  • intra-Golgi vesicle-mediated transport Source: SGD
  • macroautophagy Source: SGD
  • protein localization by the Cvt pathway Source: SGD
  • regulation of GTPase activity Source: SGD

Keywordsi

Biological processAutophagy, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32900-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex II-specific subunit 130
Short name:
TRAPP II-specific subunit 130
Alternative name(s):
Transport protein particle 130 kDa subunit
Gene namesi
Name:TRS130
Ordered Locus Names:YMR218C
ORF Names:YM8261.12C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR218C
SGDiS000004831 TRS130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935121 – 1102Trafficking protein particle complex II-specific subunit 130Add BLAST1102

Proteomic databases

MaxQBiQ03660
PaxDbiQ03660
PRIDEiQ03660

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS120 and TRS130. Interacts with YPT31 and YPT32.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35396, 119 interactors
DIPiDIP-6482N
IntActiQ03660, 22 interactors
STRINGi4932.YMR218C

Structurei

3D structure databases

ProteinModelPortaliQ03660
SMRiQ03660
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM1 family.Curated

Phylogenomic databases

HOGENOMiHOG000142365
InParanoidiQ03660
KOiK20307
OMAiYANSEVV
OrthoDBiEOG092C0NTV

Family and domain databases

InterProiView protein in InterPro
IPR022233 TRAPP_II_complex_TRAPPC10
PfamiView protein in Pfam
PF12584 TRAPPC10, 1 hit

Sequencei

Sequence statusi: Complete.

Q03660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKEIYCGSV PVSYFDPFDL FESLRPEFQQ ILPLDNIHWK AFDGTVRTVN
60 70 80 90 100
RLPIELIPEG RGEADKSNDE QPFIRFLIVN CISIDQYRAK VRPLVRQWLP
110 120 130 140 150
NLESVSSSTG EKMIYKPIIL LYANSEVVDS NLFKSVSLME KFGKDFPHVQ
160 170 180 190 200
TLEVRSVYRS PKERQEFWNQ FSQKIKASVL SIFQKRLTHL QHSLANLQKG
210 220 230 240 250
NNFEEQLLTR EKLYELYVVF NILEDASLEL QKIKKEILRR NMNMPDGKLQ
260 270 280 290 300
VPFESSSKSD ESLGSIIIEG TLDKFQLHKY FFIRRLRLLK LEDQTLTAFV
310 320 330 340 350
GAFQLIKNFI ESISIEYRKS VRLLEFKHYF ITSMLSYFEF ENVSNPLLCE
360 370 380 390 400
IKAELLMLKR DNWVQGVMAT SGYRLMDKNY PNSDVKYKFD LLKETFVDET
410 420 430 440 450
VFQENFLTLT KEILSLFNKC EGKRQRIVDI LSIEIGLLYY QGKKYEEAVS
460 470 480 490 500
LFLSCYEYYT QTNWNSIGLK ILQVFIDSLS HCPKLDVLQI DGESVSASAV
510 520 530 540 550
LTNAFLNILK LCKDNDSKEI WWKKFMDLQM KNNIHLMYPL DGLFEVTLNS
560 570 580 590 600
KVHLARANVS AIEVNLKSYG FPEDISTKTM RLSLKNMGGD VIVFGASDFL
610 620 630 640 650
LKKGENKLIL ECRDIMYGEF SLLSFEIIVE GITFVKEFPE NQDEFIVVPE
660 670 680 690 700
IYCKESTKVL VKQAHNLNLG EYALELKSVQ SDALESLQVE VEVQKNIGNM
710 720 730 740 750
KNLPVSFSMD EIQARKRYNT PFENVRLEYY LLDQITAFDL IIKTSFTKKN
760 770 780 790 800
DQGTFGETKK VRIQCYLQLS VSVEDIFKKD IFFFKFLLNS SVREEPVILY
810 820 830 840 850
SSELSAPDTR NDYNIRGDYI ATTPALITFD GNESFINCYE ITANNNFDSK
860 870 880 890 900
DIFNLKVRYN TLKEQLDCFI TDAVLIEGDV EWFILFEKWK TFWELEILKK
910 920 930 940 950
LKYDYDAFKE NRIIRLLKTS IDLNKTKSKI RNLCIEKAVL DKILICLNKV
960 970 980 990 1000
SRGIAVCNTD MDEYVRNLVP KQLTVPVQLP GFEQFFHVQF EQMETSHDAL
1010 1020 1030 1040 1050
HDTIATIGNS LSYTVIVENL SGQWGQDVID DGGYIFEILS SNEWLIHGQK
1060 1070 1080 1090 1100
RCAIKEKRKE FEVHLIPLKK GYLNFPRVEI TNINGKSCRV DHSNAFESIL

IF
Length:1,102
Mass (Da):128,131
Last modified:November 1, 1997 - v1
Checksum:i110EA9D95620E727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49809 Genomic DNA Translation: CAA89933.1
BK006946 Genomic DNA Translation: DAA10117.1
PIRiS55100
RefSeqiNP_013945.1, NM_001182725.1

Genome annotation databases

EnsemblFungiiYMR218C; YMR218C; YMR218C
GeneIDi855258
KEGGisce:YMR218C

Similar proteinsi

Entry informationi

Entry nameiTR130_YEAST
AccessioniPrimary (citable) accession number: Q03660
Secondary accession number(s): D6W043
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health