Q03652 (DML1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein DML1

Alternative name(s):
Drosophila melanogaster misato-like protein 1

Gene names

Name:	DML1
Ordered Locus Names:	YMR211W
ORF Names:	YM8261.05

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance. Ref.3
Subcellular location	Mitochondrion Ref.3 Ref.4.
Sequence similarities	Belongs to the misato family.

Ontologies

Keywords
Cellular component	Mitochondrion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial genome maintenance Inferred from mutant phenotype Ref.3. Source: SGD plasmid maintenance Inferred from mutant phenotype Ref.3. Source: SGD protein polymerization Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from direct assay Ref.4. Source: SGD protein complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LPD1	P09624	1	EBI-27461,EBI-5940

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Protein DML1		PRO_0000203331

Sequences

	Sequence		Length	Mass (Da)
	Q03652 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: A24CA4E6BA9DC146	FASTA	475	55,312
	10 20 30 40 50 60 MHEVVTISVS QRANHLTTQF FNIQEGYLQL SKEQQVNDSK IFLNSVVDKV SKTISYAPRA 70 80 90 100 110 120 LLWDARTGNG SLGTYQYSES QDYHFGNEDK FKEQTVIKTH PRIPKSEYQS SLDAGAPLPC 130 140 150 160 170 180 LNRENTMYWS DYSKLIYGPS SFNILRNWYH DTENPNQPDF QNLGERKFDR YSIGYDEFTE 190 200 210 220 230 240 NYLQEFFDGN LHRELEKCDT LQGFNLVSDM ESGWGGFSSA LLVELRNELP KKAVFSWGHN 250 260 270 280 290 300 EDDPFTDDFP MKRLSKKWLP IISNKLRSTI NMMQESDLYF PLYAAPGLTN WETAGKSCRI 310 320 330 340 350 360 FDSINATISQ SNLEQRKTMD YLTTAITLGY SSRNMVTGMV IGDTDYSFCS RVLPFKNSHK 370 380 390 400 410 420 PNSTHIFSKS FIDRGNQTHK HHSEPDSRSK MIEMYTHRYF PSDTIPTEFS NDREFVLELE 430 440 450 460 470 SSEKNRDIFK HWNEFVVRYF KNDSDREELK NELSDYASAY ESGWYEDEDS GDDDM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Preliminary characterisation of DML1, an essential Saccharomyces cerevisiae gene related to misato of Drosophila melanogaster." Gurvitz A., Hartig A., Ruis H., Hamilton B., de Couet H.G. FEMS Yeast Res. 2:123-135(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]	"Assigning function to yeast proteins by integration of technologies." Hazbun T.R., Malmstroem L., Anderson S., Graczyk B.J., Fox B., Riffle M., Sundin B.A., Aranda J.D., McDonald W.H., Chiu C.-H., Snydsman B.E., Bradley P., Muller E.G.D., Fields S., Baker D., Yates J.R. III, Davis T.N. Mol. Cell 12:1353-1365(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49809 Genomic DNA. Translation: CAA89926.1. BK006946 Genomic DNA. Translation: DAA10110.1.
PIR	S55093.
RefSeq	NP_013938.1. NM_001182718.1.
3D structure databases
ProteinModelPortal	Q03652.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1270N.
IntAct	Q03652. 2 interactions.
MINT	MINT-409063.
STRING	4932.YMR211W.
Proteomic databases
PaxDb	Q03652.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR211W; YMR211W; YMR211W.
GeneID	855251.
KEGG	sce:YMR211W.
Organism-specific databases
CYGD	YMR211w.
SGD	S000004824. DML1.
Phylogenomic databases
eggNOG	NOG258372.
HOGENOM	HOG000066051.
OMA	GWGGFSS.
OrthoDB	EOG4HQHSN.
Gene expression databases
Genevestigator	Q03652.
GermOnline	YMR211W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.40.50.1440. 2 hits.
InterPro	IPR019605. Misato_II_myosin-like. IPR003008. Tubulin_FtsZ_GTPase. [Graphical view]
Pfam	PF10644. Misat_Myo_SegII. 1 hit. PF00091. Tubulin. 1 hit. [Graphical view]
SUPFAM	SSF52490. Tubulin_FtsZ. 1 hit.
ProtoNet	Search...
Other
NextBio	978825.

Entry information

Entry name

DML1_YEAST

Accession

Primary (citable) accession number: Q03652
Secondary accession number(s): D6W036

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program