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Q03631

- WAR1_YEAST

UniProt

Q03631 - WAR1_YEAST

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Protein

Weak acid resistance protein 1

Gene

WAR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

transcription factor which binds to a weak acid response element (WARE) to mediate stress induction of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi76 – 10934Zn(2)-C6 fungal-typeAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: SGD
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: SGD
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32668-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Weak acid resistance protein 1
Gene namesi
Name:WAR1
Ordered Locus Names:YML076C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML076c.
SGDiS000004541. WAR1.

Subcellular locationi

Nucleus 3 Publications

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi368 – 3681S → L: Causes hyperactivity with constitutive induction of PDR12. 1 Publication
Mutagenesisi452 – 4521Y → C: Causes hyperactivity with constitutive induction of PDR12. 1 Publication
Mutagenesisi463 – 4631Y → C: Causes hyperactivity with constitutive induction of PDR12. 1 Publication
Mutagenesisi640 – 6401A → T: Causes hyperactivity with constitutive induction of PDR12. 1 Publication
Mutagenesisi703 – 7031S → P: Causes hyperactivitywith constitutive induction of PDR12. 1 Publication
Mutagenesisi762 – 7621K → R or N: Causes hyperactivity with constitutive induction of PDR12. 2 Publications
Mutagenesisi763 – 7631F → M: Causes hyperactivity with constitutive induction of PDR12. 1 Publication
Mutagenesisi764 – 7641Missing: Causes hypersensitivity to sorbate through its inability to induce PDR12. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 944944Weak acid resistance protein 1PRO_0000115004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylation is required for PDR12 induction.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03631.
PaxDbiQ03631.
PeptideAtlasiQ03631.
PRIDEiQ03631.

Expressioni

Gene expression databases

GenevestigatoriQ03631.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi35065. 16 interactions.
MINTiMINT-2734616.
STRINGi4932.YML076C.

Structurei

3D structure databases

ProteinModelPortaliQ03631.
SMRiQ03631. Positions 74-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG46074.
HOGENOMiHOG000142350.
InParanoidiQ03631.
OMAiNQTRKRR.
OrthoDBiEOG7Q2NDP.

Family and domain databases

InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03631-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTQIAITGV AVGKEINNDN SKTDQKVSLP KADVPCIDKA TQTIIEGCSK
60 70 80 90 100
DDPRLSYPTK LETTEKGKTK RNSFACVCCH SLKQKCEPSD VNDIYRKPCR
110 120 130 140 150
RCLKHKKLCK FDLSKRTRKR KPRSRSPTPF ESPMVNVSTK SKGPTDSEES
160 170 180 190 200
SLKDGTSYLA SFPSDPNAKQ FPNSRTVLPG LQQSLSDLWS TLSQPPSYGA
210 220 230 240 250
REAETTSTGE ITTNNHTKSN GSVPTNPAVL ASNDEHTNIS DAPVIYSTYN
260 270 280 290 300
SPVPISSAPT SINSEALFKH RPKIVGDEET QNVKVKRQKK SYSRHMTRSF
310 320 330 340 350
RKQLQSLIIS QKGKIRDISM KLDTWSKQWN DLVEKSMFLP TIADPVSVGI
360 370 380 390 400
ISHEEATLRL HLYKTEISYL SKLPFIKVEE NVSVDELRKK KPILFSVIMS
410 420 430 440 450
CVSIVLTPKQ TTRGTIMKLD SFVLNLITNQ IFKANNKSIE IIESLSTLCL
460 470 480 490 500
WYNFFEWSSK TRYHIFNYIC CCLTRDLGPT YVNRSFGMFS DEDPKRFKSP
510 520 530 540 550
LELYSNGASL TLLVYISALN ISIFLRQSIQ ARWSHVTEKA CEDLVKETKK
560 570 580 590 600
SRHYDNDKLL LDSADDPILV QFAKMNHVLE NIHTHLHERD LNDDEFDDPI
610 620 630 640 650
FTKKYLNKLM EKYHKQLQEI FTKLDRNRPR VIAFYYSVEA YLYQYKLAVF
660 670 680 690 700
IGEMSHTINE KVELPREIMD DFVKCYHCCK SALEEFSKLE PILITSLPLF
710 720 730 740 750
HTSRIIYTVG MLLLKLRYSV VAIPSFHDLM PLTDDAIALV IGVNNLLEKT
760 770 780 790 800
SELYPFNNSL YKFRYVIALF CQTYANKVID VADRYNAERE KLKEKQVIDE
810 820 830 840 850
VSNGHDGTKP INAYVTESQK MPTEEDPIID NNTNQNITAV PDEMLPVYSR
860 870 880 890 900
VRDDTAAMNL NINSTSYMNE SPHEHRESMT GTTLLPPPFI SNDVTNSADS
910 920 930 940
TNIKPSPSSS VDNLNDYLTD INSLAWGVNS LNDEFWTDLF MNDI
Length:944
Mass (Da):107,561
Last modified:November 1, 1997 - v1
Checksum:i020A56745DF52CCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46373 Genomic DNA. Translation: CAA86502.1.
BK006946 Genomic DNA. Translation: DAA09821.1.
PIRiS48821.
RefSeqiNP_013635.1. NM_001182435.1.

Genome annotation databases

EnsemblFungiiYML076C; YML076C; YML076C.
GeneIDi854899.
KEGGisce:YML076C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46373 Genomic DNA. Translation: CAA86502.1 .
BK006946 Genomic DNA. Translation: DAA09821.1 .
PIRi S48821.
RefSeqi NP_013635.1. NM_001182435.1.

3D structure databases

ProteinModelPortali Q03631.
SMRi Q03631. Positions 74-116.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35065. 16 interactions.
MINTi MINT-2734616.
STRINGi 4932.YML076C.

Proteomic databases

MaxQBi Q03631.
PaxDbi Q03631.
PeptideAtlasi Q03631.
PRIDEi Q03631.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML076C ; YML076C ; YML076C .
GeneIDi 854899.
KEGGi sce:YML076C.

Organism-specific databases

CYGDi YML076c.
SGDi S000004541. WAR1.

Phylogenomic databases

eggNOGi NOG46074.
HOGENOMi HOG000142350.
InParanoidi Q03631.
OMAi NQTRKRR.
OrthoDBi EOG7Q2NDP.

Enzyme and pathway databases

BioCyci YEAST:G3O-32668-MONOMER.

Miscellaneous databases

NextBioi 977873.

Gene expression databases

Genevestigatori Q03631.

Family and domain databases

InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
SMARTi SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "War1p, a novel transcription factor controlling weak acid stress response in yeast."
    Kren A., Mamnun Y.M., Bauer B.E., Schueller C., Wolfger H., Hatzixanthis K., Mollapour M., Gregori C., Piper P.W., Kuchler K.
    Mol. Cell. Biol. 23:1775-1785(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, PHOSPHORYLATION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae."
    Schueller C., Mamnun Y.M., Mollapour M., Krapf G., Schuster M., Bauer B.E., Piper P.W., Kuchler K.
    Mol. Biol. Cell 15:706-720(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "A new physiological role for Pdr12p in Saccharomyces cerevisiae: export of aromatic and branched-chain organic acids produced in amino acid catabolism."
    Hazelwood L.A., Tai S.L., Boer V.M., de Winde J.H., Pronk J.T., Daran J.-M.
    FEMS Yeast Res. 6:937-945(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "A genetic screen identifies mutations in the yeast WAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation."
    Gregori C., Bauer B.E., Schwartz C., Kren A., Schueller C., Kuchler K.
    FEBS J. 274:3094-3107(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-762; PHE-763 AND ARG-764.
  9. "Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation."
    Gregori C., Schueller C., Frohner I.E., Ammerer G., Kuchler K.
    J. Biol. Chem. 283:25752-25764(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF SER-368; TYR-452; TYR-463; ALA-640; SER-703 AND LYS-762.
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWAR1_YEAST
AccessioniPrimary (citable) accession number: Q03631
Secondary accession number(s): D6W0K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3