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Q03630

- BET5_YEAST

UniProt

Q03630 - BET5_YEAST

Protein

Trafficking protein particle complex subunit BET5

Gene

BET5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.4 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. ER to Golgi vesicle-mediated transport Source: SGD
    3. positive regulation of Rab GTPase activity Source: GOC

    Keywords - Biological processi

    Autophagy, ER-Golgi transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32669-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trafficking protein particle complex subunit BET5
    Short name:
    TRAPP subunit BET5
    Alternative name(s):
    Transport protein particle 18 kDa subunit
    Gene namesi
    Name:BET5
    Ordered Locus Names:YML077W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML077w.
    SGDiS000004542. BET5.

    Subcellular locationi

    GO - Cellular componenti

    1. cis-Golgi network Source: InterPro
    2. endoplasmic reticulum Source: UniProtKB-SubCell
    3. pre-autophagosomal structure Source: UniProtKB-SubCell
    4. TRAPPIII protein complex Source: SGD
    5. TRAPPII protein complex Source: SGD
    6. TRAPPI protein complex Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 159159Trafficking protein particle complex subunit BET5PRO_0000211565Add
    BLAST

    Proteomic databases

    MaxQBiQ03630.
    PaxDbiQ03630.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03630.

    Interactioni

    Subunit structurei

    Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BET3P3614910EBI-3580,EBI-3567

    Protein-protein interaction databases

    BioGridi35064. 40 interactions.
    DIPiDIP-4528N.
    IntActiQ03630. 5 interactions.
    MINTiMINT-478474.
    STRINGi4932.YML077W.

    Structurei

    Secondary structure

    1
    159
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 95
    Beta strandi11 – 133
    Beta strandi15 – 173
    Helixi37 – 448
    Helixi48 – 5710
    Beta strandi67 – 715
    Beta strandi76 – 805
    Beta strandi87 – 915
    Beta strandi94 – 974
    Helixi100 – 11617
    Helixi143 – 15210

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CUEX-ray3.70C/I/O/U1-159[»]
    ProteinModelPortaliQ03630.
    SMRiQ03630. Positions 1-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ03630.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG237222.
    GeneTreeiENSGT00510000047863.
    HOGENOMiHOG000172118.
    OMAiFYETPAN.
    OrthoDBiEOG71CFZH.

    Family and domain databases

    InterProiIPR011012. Longin-like_dom.
    IPR007233. Sybindin.
    [Graphical view]
    PANTHERiPTHR23249. PTHR23249. 1 hit.
    PfamiPF04099. Sybindin. 1 hit.
    [Graphical view]
    SUPFAMiSSF64356. SSF64356. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q03630-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGIYSFWIFD RHCNCIFDRE WTLASNSASG TINSKQNEED AKLLYGMIFS    50
    LRSITQKLSK GSVKNDIRSI STGKYRVHTY CTASGLWFVL LSDFKQQSYT 100
    QVLQYIYSHI YVKYVSNNLL SPYDFAENEN EMRGQGTRKI TNRNFISVLE 150
    SFLAPMVNQ 159
    Length:159
    Mass (Da):18,434
    Last modified:November 1, 1997 - v1
    Checksum:i4821217270F516E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46373 Genomic DNA. Translation: CAA86501.1.
    AY557760 Genomic DNA. Translation: AAS56086.1.
    BK006946 Genomic DNA. Translation: DAA09820.1.
    PIRiS48820.
    RefSeqiNP_013634.1. NM_001182436.1.

    Genome annotation databases

    EnsemblFungiiYML077W; YML077W; YML077W.
    GeneIDi854898.
    KEGGisce:YML077W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46373 Genomic DNA. Translation: CAA86501.1 .
    AY557760 Genomic DNA. Translation: AAS56086.1 .
    BK006946 Genomic DNA. Translation: DAA09820.1 .
    PIRi S48820.
    RefSeqi NP_013634.1. NM_001182436.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CUE X-ray 3.70 C/I/O/U 1-159 [» ]
    ProteinModelPortali Q03630.
    SMRi Q03630. Positions 1-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35064. 40 interactions.
    DIPi DIP-4528N.
    IntActi Q03630. 5 interactions.
    MINTi MINT-478474.
    STRINGi 4932.YML077W.

    Proteomic databases

    MaxQBi Q03630.
    PaxDbi Q03630.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML077W ; YML077W ; YML077W .
    GeneIDi 854898.
    KEGGi sce:YML077W.

    Organism-specific databases

    CYGDi YML077w.
    SGDi S000004542. BET5.

    Phylogenomic databases

    eggNOGi NOG237222.
    GeneTreei ENSGT00510000047863.
    HOGENOMi HOG000172118.
    OMAi FYETPAN.
    OrthoDBi EOG71CFZH.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32669-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q03630.
    NextBioi 977870.
    PROi Q03630.

    Gene expression databases

    Genevestigatori Q03630.

    Family and domain databases

    InterProi IPR011012. Longin-like_dom.
    IPR007233. Sybindin.
    [Graphical view ]
    PANTHERi PTHR23249. PTHR23249. 1 hit.
    Pfami PF04099. Sybindin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64356. SSF64356. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "A high copy suppressor screen reveals genetic interactions between BET3 and a new gene. Evidence for a novel complex in ER-to-Golgi transport."
      Jiang Y., Scarpa A., Zhang L., Stone S., Feliciano E., Ferro-Novick S.
      Genetics 149:833-841(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion."
      Sacher M., Jiang Y., Barrowman J., Scarpa A., Burston J., Zhang L., Schieltz D., Yates J.R. III, Abeliovich H., Ferro-Novick S.
      EMBO J. 17:2494-2503(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE TRAPP II COMPLEX.
    6. "TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport."
      Sacher M., Barrowman J., Wang W., Horecka J., Zhang Y., Pypaert M., Ferro-Novick S.
      Mol. Cell 7:433-442(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE TRAPP II COMPLEX, IDENTIFICATION IN THE TRAPP II COMPLEX, FUNCTION OF THE TRAPP I COMPLEX, IDENTIFICATION IN THE TRAPP I COMPLEX, SUBCELLULAR LOCATION.
    7. "Molecular architecture of the TRAPPII complex and implications for vesicle tethering."
      Yip C.K., Berscheminski J., Walz T.
      Nat. Struct. Mol. Biol. 17:1298-1304(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE TRAP II COMPLEX, FUNCTION OF THE TRAP II COMPLEX.
    8. Cited for: IDENTIFICATION IN THE TRAPP III COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE TRAPP III COMPLEX.

    Entry informationi

    Entry nameiBET5_YEAST
    AccessioniPrimary (citable) accession number: Q03630
    Secondary accession number(s): D6W0K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3