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Q03630

- BET5_YEAST

UniProt

Q03630 - BET5_YEAST

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Protein
Trafficking protein particle complex subunit BET5
Gene
BET5, YML077W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.4 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. autophagy Source: UniProtKB-KW
  3. regulation of Rab GTPase activity Source: GOC
Complete GO annotation...

Keywords - Biological processi

Autophagy, ER-Golgi transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32669-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit BET5
Short name:
TRAPP subunit BET5
Alternative name(s):
Transport protein particle 18 kDa subunit
Gene namesi
Name:BET5
Ordered Locus Names:YML077W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML077w.
SGDiS000004542. BET5.

Subcellular locationi

Golgi apparatuscis-Golgi network. Endoplasmic reticulum. Preautophagosomal structure 2 Publications

GO - Cellular componenti

  1. TRAPPI protein complex Source: SGD
  2. TRAPPII protein complex Source: SGD
  3. TRAPPIII protein complex Source: SGD
  4. cis-Golgi network Source: InterPro
  5. endoplasmic reticulum Source: UniProtKB-SubCell
  6. pre-autophagosomal structure Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Trafficking protein particle complex subunit BET5
PRO_0000211565Add
BLAST

Proteomic databases

MaxQBiQ03630.
PaxDbiQ03630.

Expressioni

Gene expression databases

GenevestigatoriQ03630.

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BET3P3614910EBI-3580,EBI-3567

Protein-protein interaction databases

BioGridi35064. 40 interactions.
DIPiDIP-4528N.
IntActiQ03630. 5 interactions.
MINTiMINT-478474.
STRINGi4932.YML077W.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 95
Beta strandi11 – 133
Beta strandi15 – 173
Helixi37 – 448
Helixi48 – 5710
Beta strandi67 – 715
Beta strandi76 – 805
Beta strandi87 – 915
Beta strandi94 – 974
Helixi100 – 11617
Helixi143 – 15210

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CUEX-ray3.70C/I/O/U1-159[»]
ProteinModelPortaliQ03630.
SMRiQ03630. Positions 1-156.

Miscellaneous databases

EvolutionaryTraceiQ03630.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG237222.
GeneTreeiENSGT00510000047863.
HOGENOMiHOG000172118.
OMAiFYETPAN.
OrthoDBiEOG71CFZH.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view]
PANTHERiPTHR23249. PTHR23249. 1 hit.
PfamiPF04099. Sybindin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03630-1 [UniParc]FASTAAdd to Basket

« Hide

MGIYSFWIFD RHCNCIFDRE WTLASNSASG TINSKQNEED AKLLYGMIFS    50
LRSITQKLSK GSVKNDIRSI STGKYRVHTY CTASGLWFVL LSDFKQQSYT 100
QVLQYIYSHI YVKYVSNNLL SPYDFAENEN EMRGQGTRKI TNRNFISVLE 150
SFLAPMVNQ 159
Length:159
Mass (Da):18,434
Last modified:November 1, 1997 - v1
Checksum:i4821217270F516E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46373 Genomic DNA. Translation: CAA86501.1.
AY557760 Genomic DNA. Translation: AAS56086.1.
BK006946 Genomic DNA. Translation: DAA09820.1.
PIRiS48820.
RefSeqiNP_013634.1. NM_001182436.1.

Genome annotation databases

EnsemblFungiiYML077W; YML077W; YML077W.
GeneIDi854898.
KEGGisce:YML077W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46373 Genomic DNA. Translation: CAA86501.1 .
AY557760 Genomic DNA. Translation: AAS56086.1 .
BK006946 Genomic DNA. Translation: DAA09820.1 .
PIRi S48820.
RefSeqi NP_013634.1. NM_001182436.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CUE X-ray 3.70 C/I/O/U 1-159 [» ]
ProteinModelPortali Q03630.
SMRi Q03630. Positions 1-156.
ModBasei Search...

Protein-protein interaction databases

BioGridi 35064. 40 interactions.
DIPi DIP-4528N.
IntActi Q03630. 5 interactions.
MINTi MINT-478474.
STRINGi 4932.YML077W.

Proteomic databases

MaxQBi Q03630.
PaxDbi Q03630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML077W ; YML077W ; YML077W .
GeneIDi 854898.
KEGGi sce:YML077W.

Organism-specific databases

CYGDi YML077w.
SGDi S000004542. BET5.

Phylogenomic databases

eggNOGi NOG237222.
GeneTreei ENSGT00510000047863.
HOGENOMi HOG000172118.
OMAi FYETPAN.
OrthoDBi EOG71CFZH.

Enzyme and pathway databases

BioCyci YEAST:G3O-32669-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q03630.
NextBioi 977870.
PROi Q03630.

Gene expression databases

Genevestigatori Q03630.

Family and domain databases

InterProi IPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view ]
PANTHERi PTHR23249. PTHR23249. 1 hit.
Pfami PF04099. Sybindin. 1 hit.
[Graphical view ]
SUPFAMi SSF64356. SSF64356. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "A high copy suppressor screen reveals genetic interactions between BET3 and a new gene. Evidence for a novel complex in ER-to-Golgi transport."
    Jiang Y., Scarpa A., Zhang L., Stone S., Feliciano E., Ferro-Novick S.
    Genetics 149:833-841(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion."
    Sacher M., Jiang Y., Barrowman J., Scarpa A., Burston J., Zhang L., Schieltz D., Yates J.R. III, Abeliovich H., Ferro-Novick S.
    EMBO J. 17:2494-2503(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TRAPP II COMPLEX.
  6. "TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport."
    Sacher M., Barrowman J., Wang W., Horecka J., Zhang Y., Pypaert M., Ferro-Novick S.
    Mol. Cell 7:433-442(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE TRAPP II COMPLEX, IDENTIFICATION IN THE TRAPP II COMPLEX, FUNCTION OF THE TRAPP I COMPLEX, IDENTIFICATION IN THE TRAPP I COMPLEX, SUBCELLULAR LOCATION.
  7. "Molecular architecture of the TRAPPII complex and implications for vesicle tethering."
    Yip C.K., Berscheminski J., Walz T.
    Nat. Struct. Mol. Biol. 17:1298-1304(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TRAP II COMPLEX, FUNCTION OF THE TRAP II COMPLEX.
  8. Cited for: IDENTIFICATION IN THE TRAPP III COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE TRAPP III COMPLEX.

Entry informationi

Entry nameiBET5_YEAST
AccessioniPrimary (citable) accession number: Q03630
Secondary accession number(s): D6W0K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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