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Protein

Trafficking protein particle complex subunit BET5

Gene

BET5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.4 Publications

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • ER to Golgi vesicle-mediated transport Source: SGD

Keywordsi

Biological processAutophagy, ER-Golgi transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32669-MONOMER
ReactomeiR-SCE-204005 COPII-mediated vesicle transport
R-SCE-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit BET5
Short name:
TRAPP subunit BET5
Alternative name(s):
Transport protein particle 18 kDa subunit
Gene namesi
Name:BET5
Ordered Locus Names:YML077W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML077W
SGDiS000004542 BET5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115651 – 159Trafficking protein particle complex subunit BET5Add BLAST159

Proteomic databases

MaxQBiQ03630
PaxDbiQ03630
PRIDEiQ03630

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BET3P3614911EBI-3580,EBI-3567

Protein-protein interaction databases

BioGridi35064, 450 interactors
DIPiDIP-4528N
IntActiQ03630, 7 interactors
STRINGi4932.YML077W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CUEX-ray3.70C/I/O/U1-159[»]
ProteinModelPortaliQ03630
SMRiQ03630
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03630

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00510000047863
HOGENOMiHOG000172118
InParanoidiQ03630
KOiK20300
OMAiNVLHQIY
OrthoDBiEOG092C5E92

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR007233 TRAPPC
PANTHERiPTHR23249 PTHR23249, 1 hit
PfamiView protein in Pfam
PF04099 Sybindin, 1 hit
SMARTiView protein in SMART
SM01399 Sybindin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit

Sequencei

Sequence statusi: Complete.

Q03630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIYSFWIFD RHCNCIFDRE WTLASNSASG TINSKQNEED AKLLYGMIFS
60 70 80 90 100
LRSITQKLSK GSVKNDIRSI STGKYRVHTY CTASGLWFVL LSDFKQQSYT
110 120 130 140 150
QVLQYIYSHI YVKYVSNNLL SPYDFAENEN EMRGQGTRKI TNRNFISVLE

SFLAPMVNQ
Length:159
Mass (Da):18,434
Last modified:November 1, 1997 - v1
Checksum:i4821217270F516E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46373 Genomic DNA Translation: CAA86501.1
AY557760 Genomic DNA Translation: AAS56086.1
BK006946 Genomic DNA Translation: DAA09820.1
PIRiS48820
RefSeqiNP_013634.1, NM_001182436.1

Genome annotation databases

EnsemblFungiiYML077W; YML077W; YML077W
GeneIDi854898
KEGGisce:YML077W

Similar proteinsi

Entry informationi

Entry nameiBET5_YEAST
AccessioniPrimary (citable) accession number: Q03630
Secondary accession number(s): D6W0K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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