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Protein

Cyclic nucleotide-gated cation channel

Gene

tax-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal thermosensation and chemosensation sensory behavior (PubMed:8893027). Required, downstream of receptor-type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons (PubMed:21173231). Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons (PubMed:23664973). Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation (PubMed:9486798). In ASI and ASJ sensory neurons, controls behavioral response to P.aeruginosa by up-regulating the transcription of daf-7, a member of the TGF-beta family (PubMed:25303524). In AWB and AWC sensory neurons, mediates the recognition of food oders which subsequently allows for the detection of preferred food sources (PubMed:25009271).6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei560 – 5601cAMPSequence analysis
Binding sitei575 – 5751cAMPSequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi501 – 623123cAMPBy similarityAdd
BLAST

GO - Molecular functioni

  • cGMP binding Source: UniProtKB
  • intracellular cAMP activated cation channel activity Source: WormBase
  • intracellular cGMP activated cation channel activity Source: WormBase
  • voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

  • aerotaxis Source: WormBase
  • calcium-mediated signaling Source: UniProtKB
  • cation transmembrane transport Source: WormBase
  • chemosensory behavior Source: UniProtKB
  • chemotaxis Source: CACAO
  • detection of carbon dioxide Source: UniProtKB
  • detection of chemical stimulus involved in sensory perception Source: UniProtKB
  • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: UniProtKB
  • multicellular organismal reproductive process Source: WormBase
  • negative regulation of cGMP-mediated signaling Source: WormBase
  • neuron projection morphogenesis Source: WormBase
  • olfactory behavior Source: WormBase
  • phototransduction Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of growth rate Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • regulation of axon extension Source: WormBase
  • regulation of membrane potential Source: GO_Central
  • regulation of neuron differentiation Source: WormBase
  • response to hyperoxia Source: WormBase
  • response to oxygen levels Source: WormBase
  • thermosensory behavior Source: UniProtKB
  • thermotaxis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Chemotaxis, Ion transport, Neurogenesis, Transport

Keywords - Ligandi

cGMP, cGMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-2485179. Activation of the phototransduction cascade.
R-CEL-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-CEL-5620916. VxPx cargo-targeting to cilium.

Protein family/group databases

TCDBi1.A.1.5.20. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated cation channel
Alternative name(s):
Abnormal chemotaxis protein 4
Gene namesi
Name:tax-4
ORF Names:ZC84.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZC84.2; CE27352; WBGene00006526; tax-4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 120120CytoplasmicSequence analysisAdd
BLAST
Transmembranei121 – 14121Helical; Name=H1Sequence analysisAdd
BLAST
Topological domaini142 – 20160ExtracellularSequence analysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=H2Sequence analysisAdd
BLAST
Topological domaini223 – 25129CytoplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=H3Sequence analysisAdd
BLAST
Topological domaini273 – 30937ExtracellularSequence analysisAdd
BLAST
Transmembranei310 – 33021Helical; Name=H4Sequence analysisAdd
BLAST
Topological domaini331 – 38656CytoplasmicSequence analysisAdd
BLAST
Transmembranei387 – 40721Helical; Name=H5Sequence analysisAdd
BLAST
Topological domaini408 – 547140ExtracellularSequence analysisAdd
BLAST
Transmembranei548 – 56821Helical; Name=H6Sequence analysisAdd
BLAST
Topological domaini569 – 733165CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • ciliary inversin compartment Source: WormBase
  • dendrite Source: WormBase
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: GOC
  • nonmotile primary cilium Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Cyclic nucleotide-gated cation channelPRO_0000219328Add
BLAST

Proteomic databases

PaxDbiQ03611.

Expressioni

Tissue specificityi

Expressed at the sensory endings of thermosensory, gustatory, and olfactory neurons.

Gene expression databases

BgeeiWBGene00006526.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZC84.2.

Structurei

3D structure databases

ProteinModelPortaliQ03611.
SMRiQ03611. Positions 419-607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000007898.
InParanoidiQ03611.
KOiK04950.
OMAiQYMELRK.
OrthoDBiEOG091G03EW.
PhylomeDBiQ03611.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAEPAPDP TNPSTSGLAP TTNGIGSPPP TASAATKFSI LTKFLRRKNQ
60 70 80 90 100
VHTTTAQQNE FMQKYMPNGN SNAVQPAATG GQPASSDGGS AIEVPPPKES
110 120 130 140 150
YAVRIRKYLA NYTQDPSTDN FYYWTCVVTV AYIYNLLFVI ARQVFNDLIG
160 170 180 190 200
PSSQSLCRFY NGTLNSTTQV ECTYNMLTNM KEMPTYSQYP DLGWSKYWHF
210 220 230 240 250
RMLWVFFDLL MDCVYLIDTF LNYRMGYMDQ GLVVREAEKV TKAYWQSKQY
260 270 280 290 300
RIDGISLIPL DYILGWPIPY INWRGLPILR LNRLIRYKRV RNCLERTETR
310 320 330 340 350
SSMPNAFRVV VVVWYIVIII HWNACLYFWI SEWIGLGTDA WVYGHLNKQS
360 370 380 390 400
LPDDITDTLL RRYVYSFYWS TLILTTIGEV PSPVRNIEYA FVTLDLMCGV
410 420 430 440 450
LIFATIVGNV GSMISNMSAA RTEFQNKMDG IKQYMELRKV SKQLEIRVIK
460 470 480 490 500
WFDYLWTNKQ SLSDQQVLKV LPDKLQAEIA MQVHFETLRK VRIFQDCEAG
510 520 530 540 550
LLAELVLKLQ LQVFSPGDFI CKKGDIGREM YIVKRGRLQV VDDDGKKVFV
560 570 580 590 600
TLQEGSVFGE LSILNIAGSK NGNRRTANVR SVGYTDLFVL SKTDLWNALR
610 620 630 640 650
EYPDARKLLL AKGREILKKD NLLDENAPEE QKTVEEIAEH LNNAVKVLQT
660 670 680 690 700
RMARLIVEHS STEGKLMKRI EMLEKHLSRY KALARRQKTM HGVSIDGGDI
710 720 730
STDGVDERVR PPRLRQTKTI DLPTGTESES LLK
Length:733
Mass (Da):83,893
Last modified:August 2, 2002 - v3
Checksum:i1EC7EB0179F9355E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86922 mRNA. Translation: BAA13180.1.
Z19157 Genomic DNA. Translation: CAB63418.2.
PIRiS28292.
RefSeqiNP_499033.1. NM_066632.4.
UniGeneiCel.19693.

Genome annotation databases

EnsemblMetazoaiZC84.2; ZC84.2; WBGene00006526.
GeneIDi176297.
KEGGicel:CELE_ZC84.2.
UCSCiZC84.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86922 mRNA. Translation: BAA13180.1.
Z19157 Genomic DNA. Translation: CAB63418.2.
PIRiS28292.
RefSeqiNP_499033.1. NM_066632.4.
UniGeneiCel.19693.

3D structure databases

ProteinModelPortaliQ03611.
SMRiQ03611. Positions 419-607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZC84.2.

Protein family/group databases

TCDBi1.A.1.5.20. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

PaxDbiQ03611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZC84.2; ZC84.2; WBGene00006526.
GeneIDi176297.
KEGGicel:CELE_ZC84.2.
UCSCiZC84.2. c. elegans.

Organism-specific databases

CTDi176297.
WormBaseiZC84.2; CE27352; WBGene00006526; tax-4.

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000007898.
InParanoidiQ03611.
KOiK04950.
OMAiQYMELRK.
OrthoDBiEOG091G03EW.
PhylomeDBiQ03611.

Enzyme and pathway databases

ReactomeiR-CEL-2485179. Activation of the phototransduction cascade.
R-CEL-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-CEL-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

PROiQ03611.

Gene expression databases

BgeeiWBGene00006526.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNG_CAEEL
AccessioniPrimary (citable) accession number: Q03611
Secondary accession number(s): P90800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 2, 2002
Last modified: September 7, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.