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Q03603

- DGK3_CAEEL

UniProt

Q03603 - DGK3_CAEEL

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Protein
Probable diacylglycerol kinase 3
Gene
dgk-3, F54G8.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Involved in AFD-neuron mediated thermotaxis. Regulates behavior to environmental temperature. Thought to have a role in olfactory adaptation by affecting diacylglycerol levels.2 Publications

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi183 – 194121 Inferred
Add
BLAST
Calcium bindingi228 – 239122 Inferred
Add
BLAST
Zinc fingeri265 – 31652Phorbol-ester/DAG-type 1
Add
BLAST
Zinc fingeri329 – 37547Phorbol-ester/DAG-type 2
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: InterPro
  3. calcium ion binding Source: InterPro
  4. diacylglycerol kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. olfactory behavior Source: UniProtKB
  3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
  4. regulation of long-term neuronal synaptic plasticity Source: WormBase
  5. thermotaxis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable diacylglycerol kinase 3 (EC:2.7.1.107)
Short name:
DAG kinase 3
Alternative name(s):
Diglyceride kinase 3
Short name:
DGK-3
Gene namesi
Name:dgk-3
ORF Names:F54G8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF54G8.2; CE46230; WBGene00000960; dgk-3.

Pathology & Biotechi

Disruption phenotypei

Slow to adapt to new temperature levels. Dgk-3 and dgk-1 double mutant shows defects in olfactory adaptation.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 795795Probable diacylglycerol kinase 3
PRO_0000218471Add
BLAST

Proteomic databases

PaxDbiQ03603.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi6239.F54G8.2.

Structurei

3D structure databases

ProteinModelPortaliQ03603.
SMRiQ03603. Positions 2-75, 159-243, 266-324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 20536EF-hand 1
Add
BLAST
Domaini215 – 25036EF-hand 2
Add
BLAST
Domaini423 – 558136DAGKc
Add
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 2 EF-hand domains.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00750000117569.
HOGENOMiHOG000252931.
InParanoidiQ03603.
OMAiCTVRITH.
OrthoDBiEOG75XGK8.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03603-1 [UniParc]FASTAAdd to Basket

« Hide

MLLSPEQFSR LSEYAAYSRR KLKDMLSDFQ QDGKFYSYLS VDGQTINIDG    50
FRAFLIDYFG ADLPSDLVDQ LFLSFSKPPI KERRTSLFED AISTVRAKFS 100
ESLSGRMAGL NIAGGSGQQT DRSQSSEPQA LVCIPEDDVM GPRVANNDSQ 150
EPRIPLKPLI CTLSLLEADT PENKLDVVFH VYDSDGNGFL DKSEIDGIIE 200
QMMNVARYQQ WDTIELEQVI RQMMVDIDYD NDGIVSFDEW RRGGLTNIPL 250
LVLLGFDTEM KEDGSHVWRL RHFTKPTYCN ACCSILVGWG GKQGLSCSLC 300
KYTVHERCVR SAATNCIRTY SSRQQDKLYH HWQDANATAK CVKCKATVGV 350
FQGKGCRWCH NYVHHRCMSA LAQECDLGAL VHHILPPTHI FPAFLERKTS 400
TSLKNHNFSS HSASLLQAVS PSNDCRPLLV LVNPKSGGKQ GVKILQKFEY 450
LLNPRQVYDL SKTGPEPGLQ LFSTLKNCNI LVCGGDGTIG WVLESMDKMT 500
FPHGRPPVAV LPLGTGNDLA RCLRWGGGYE NENLHKILEQ IEKSSLIDMD 550
RWQIKIEITE NKSARRASEK GDTPPYSIIN NYFSIGVDAS IAHRFHVMRE 600
KFPEKFNSRM RNKLWYFELG TSETLSSSCK NLHEQIDILC DGESIDLGQD 650
ASLEGIALLN IPSIYGGSNL WGRSRKSKGR MPGLFPMKNA EKMQLQTRVQ 700
DIGDGLIELV GLESAMQMGQ IKAGVRGARR LSQCSTVVIQ THKSFPMQID 750
GEPWMQPPCI IQITHKNQAK MLVAAAPRKR SSWMLLKRQS TNDDN 795
Length:795
Mass (Da):89,315
Last modified:May 16, 2012 - v3
Checksum:iA1427D2F9837616A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z19155 Genomic DNA. Translation: CAA79558.3.
PIRiS28273.
RefSeqiNP_499031.3. NM_066630.3.
UniGeneiCel.10418.

Genome annotation databases

EnsemblMetazoaiF54G8.2; F54G8.2; WBGene00000960.
GeneIDi186262.
KEGGicel:CELE_F54G8.2.
UCSCiF54G8.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z19155 Genomic DNA. Translation: CAA79558.3 .
PIRi S28273.
RefSeqi NP_499031.3. NM_066630.3.
UniGenei Cel.10418.

3D structure databases

ProteinModelPortali Q03603.
SMRi Q03603. Positions 2-75, 159-243, 266-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F54G8.2.

Proteomic databases

PaxDbi Q03603.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F54G8.2 ; F54G8.2 ; WBGene00000960 .
GeneIDi 186262.
KEGGi cel:CELE_F54G8.2.
UCSCi F54G8.2. c. elegans.

Organism-specific databases

CTDi 186262.
WormBasei F54G8.2 ; CE46230 ; WBGene00000960 ; dgk-3.

Phylogenomic databases

eggNOGi NOG47311.
GeneTreei ENSGT00750000117569.
HOGENOMi HOG000252931.
InParanoidi Q03603.
OMAi CTVRITH.
OrthoDBi EOG75XGK8.

Miscellaneous databases

NextBioi 931226.
PROi Q03603.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
PROSITEi PS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans."
    Biron D., Shibuya M., Gabel C., Wasserman S.M., Clark D.A., Brown A., Sengupta P., Samuel A.D.
    Nat. Neurosci. 9:1499-1505(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans."
    Matsuki M., Kunitomo H., Iino Y.
    Proc. Natl. Acad. Sci. U.S.A. 103:1112-1117(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiDGK3_CAEEL
AccessioniPrimary (citable) accession number: Q03603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 16, 2012
Last modified: June 11, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi