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Q035U1

- RTPR_LACC3

UniProt

Q035U1 - RTPR_LACC3

Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Enzyme regulationi

    Allosterically regulated by ATP and dNTP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei415 – 4151By similarity
    Active sitei417 – 4171By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Enzyme and pathway databases

    BioCyciLCAS321967:GH4S-2285-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Short name:
    RTPR
    Gene namesi
    Name:rtpR
    Ordered Locus Names:LSEI_2287
    OrganismiLactobacillus casei (strain ATCC 334)
    Taxonomic identifieri321967 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001651: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 748748Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi123 ↔ 426Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi321967.LSEI_2287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ035U1.
    SMRiQ035U1. Positions 8-733.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni151 – 16212Effector region-1By similarityAdd
    BLAST
    Regioni172 – 320149Effector region-2By similarityAdd
    BLAST
    Regioni572 – 63362Adenosylcobalamin-binding-1By similarityAdd
    BLAST
    Regioni692 – 73342Adenosylcobalamin-binding-2By similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG1372.
    HOGENOMiHOG000068540.
    KOiK00527.
    OMAiDSLNNCW.
    OrthoDBiEOG68DCVH.

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q035U1-1 [UniParc]FASTAAdd to Basket

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    MQVMTKPITL APAFIAEVKK EIKPHWGELG WVTYKRTYAR WLPDAQRTEN    50
    WDETVKRVVE GNINLDPRLH TANPDPKVVE TLQKEARNLF KLIYGLAGTP 100
    SGRNLWISGT DYQKRNGDAL NNCWFIAIRP QPYGQSHIVP EDYPASQPAV 150
    SMPYSFMFDE LMKGGGVGFS VTKDNIAKLP PVATKLELTV VIGRNSASYA 200
    DSLKMGAVDR DEWEKAHAGE QADHCALPDT REGWVLANAK VIDHHFAATN 250
    PSGQTKLVLD ITNIRPKGAR IHGFGGTASG PMPLIEMLLD INKLLNARVG 300
    QHLTAVDATD IGNLIGKTVV AGNVRRSAEM SLGSADDEDF ITMKQDQKQL 350
    YHHRWASNNS VAINTQFDAY SPIALAIAKN GEPGIVNLEL SRRFGRIADR 400
    ENAENDPDVE GTNPCGEISL ANGEPCNLFE VFPVVAVEQG WKLKQAFTLA 450
    ARFAKRVTFS HYDWQVSRDI IKKNRRIGVS MSGIQDWFLN DFGRRVVSGF 500
    ESVVDPQTGK MVQKPIYDPE IKQAVDGLYH TVVDADQAYS DALGCEPSRK 550
    HTTVKPSGTV AKLAGVSEGM HFHYAGYLIQ RIRFQGNDPL LPALQACGYH 600
    IEPDVYTKGT MVVEFPIRAA HADDPAFASA GTVSIAEQIA TQAFLQTYWS 650
    DNAVSCTVTF QPKEADQIAG LLSQYRHVIK STSMLPYVGA GFKQAPKEPI 700
    DVKTYKQKCA AIHGSVAAVF AVQNADHDQK DLELVDQTDC AGGACPIK 748
    Length:748
    Mass (Da):82,300
    Last modified:November 14, 2006 - v1
    Checksum:i48F280F385F1DC75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ71031.1.
    RefSeqiYP_807473.1. NC_008526.1.

    Genome annotation databases

    EnsemblBacteriaiABJ71031; ABJ71031; LSEI_2287.
    GeneIDi4420851.
    KEGGilca:LSEI_2287.
    PATRICi22208294. VBILacCas62221_2250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ71031.1 .
    RefSeqi YP_807473.1. NC_008526.1.

    3D structure databases

    ProteinModelPortali Q035U1.
    SMRi Q035U1. Positions 8-733.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321967.LSEI_2287.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ71031 ; ABJ71031 ; LSEI_2287 .
    GeneIDi 4420851.
    KEGGi lca:LSEI_2287.
    PATRICi 22208294. VBILacCas62221_2250.

    Phylogenomic databases

    eggNOGi COG1372.
    HOGENOMi HOG000068540.
    KOi K00527.
    OMAi DSLNNCW.
    OrthoDBi EOG68DCVH.

    Enzyme and pathway databases

    BioCyci LCAS321967:GH4S-2285-MONOMER.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 334.

    Entry informationi

    Entry nameiRTPR_LACC3
    AccessioniPrimary (citable) accession number: Q035U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3