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Q035U1

- RTPR_LACC3

UniProt

Q035U1 - RTPR_LACC3

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Protein
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
Gene
rtpR, LSEI_2287
Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin By similarity.

Enzyme regulationi

Allosterically regulated by ATP and dNTP By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei415 – 4151 By similarity
Active sitei417 – 4171 By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-2285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LSEI_2287
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001651: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi123 ↔ 426Redox-active By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi321967.LSEI_2287.

Structurei

3D structure databases

ProteinModelPortaliQ035U1.
SMRiQ035U1. Positions 8-733.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 16212Effector region-1 By similarity
Add
BLAST
Regioni172 – 320149Effector region-2 By similarity
Add
BLAST
Regioni572 – 63362Adenosylcobalamin-binding-1 By similarity
Add
BLAST
Regioni692 – 73342Adenosylcobalamin-binding-2 By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000068540.
KOiK00527.
OMAiDSLNNCW.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q035U1-1 [UniParc]FASTAAdd to Basket

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MQVMTKPITL APAFIAEVKK EIKPHWGELG WVTYKRTYAR WLPDAQRTEN    50
WDETVKRVVE GNINLDPRLH TANPDPKVVE TLQKEARNLF KLIYGLAGTP 100
SGRNLWISGT DYQKRNGDAL NNCWFIAIRP QPYGQSHIVP EDYPASQPAV 150
SMPYSFMFDE LMKGGGVGFS VTKDNIAKLP PVATKLELTV VIGRNSASYA 200
DSLKMGAVDR DEWEKAHAGE QADHCALPDT REGWVLANAK VIDHHFAATN 250
PSGQTKLVLD ITNIRPKGAR IHGFGGTASG PMPLIEMLLD INKLLNARVG 300
QHLTAVDATD IGNLIGKTVV AGNVRRSAEM SLGSADDEDF ITMKQDQKQL 350
YHHRWASNNS VAINTQFDAY SPIALAIAKN GEPGIVNLEL SRRFGRIADR 400
ENAENDPDVE GTNPCGEISL ANGEPCNLFE VFPVVAVEQG WKLKQAFTLA 450
ARFAKRVTFS HYDWQVSRDI IKKNRRIGVS MSGIQDWFLN DFGRRVVSGF 500
ESVVDPQTGK MVQKPIYDPE IKQAVDGLYH TVVDADQAYS DALGCEPSRK 550
HTTVKPSGTV AKLAGVSEGM HFHYAGYLIQ RIRFQGNDPL LPALQACGYH 600
IEPDVYTKGT MVVEFPIRAA HADDPAFASA GTVSIAEQIA TQAFLQTYWS 650
DNAVSCTVTF QPKEADQIAG LLSQYRHVIK STSMLPYVGA GFKQAPKEPI 700
DVKTYKQKCA AIHGSVAAVF AVQNADHDQK DLELVDQTDC AGGACPIK 748
Length:748
Mass (Da):82,300
Last modified:November 14, 2006 - v1
Checksum:i48F280F385F1DC75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ71031.1.
RefSeqiYP_807473.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ71031; ABJ71031; LSEI_2287.
GeneIDi4420851.
KEGGilca:LSEI_2287.
PATRICi22208294. VBILacCas62221_2250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ71031.1 .
RefSeqi YP_807473.1. NC_008526.1.

3D structure databases

ProteinModelPortali Q035U1.
SMRi Q035U1. Positions 8-733.
ModBasei Search...

Protein-protein interaction databases

STRINGi 321967.LSEI_2287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ71031 ; ABJ71031 ; LSEI_2287 .
GeneIDi 4420851.
KEGGi lca:LSEI_2287.
PATRICi 22208294. VBILacCas62221_2250.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000068540.
KOi K00527.
OMAi DSLNNCW.
OrthoDBi EOG68DCVH.

Enzyme and pathway databases

BioCyci LCAS321967:GH4S-2285-MONOMER.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 334.

Entry informationi

Entry nameiRTPR_LACC3
AccessioniPrimary (citable) accession number: Q035U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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