Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q035U1

- RTPR_LACC3

UniProt

Q035U1 - RTPR_LACC3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Enzyme regulationi

Allosterically regulated by ATP and dNTP.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei415 – 4151By similarity
Active sitei417 – 4171By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-2285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LSEI_2287
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001651: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi123 ↔ 426Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi321967.LSEI_2287.

Structurei

3D structure databases

ProteinModelPortaliQ035U1.
SMRiQ035U1. Positions 8-733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 16212Effector region-1By similarityAdd
BLAST
Regioni172 – 320149Effector region-2By similarityAdd
BLAST
Regioni572 – 63362Adenosylcobalamin-binding-1By similarityAdd
BLAST
Regioni692 – 73342Adenosylcobalamin-binding-2By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000068540.
KOiK00527.
OMAiDSLNNCW.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q035U1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVMTKPITL APAFIAEVKK EIKPHWGELG WVTYKRTYAR WLPDAQRTEN
60 70 80 90 100
WDETVKRVVE GNINLDPRLH TANPDPKVVE TLQKEARNLF KLIYGLAGTP
110 120 130 140 150
SGRNLWISGT DYQKRNGDAL NNCWFIAIRP QPYGQSHIVP EDYPASQPAV
160 170 180 190 200
SMPYSFMFDE LMKGGGVGFS VTKDNIAKLP PVATKLELTV VIGRNSASYA
210 220 230 240 250
DSLKMGAVDR DEWEKAHAGE QADHCALPDT REGWVLANAK VIDHHFAATN
260 270 280 290 300
PSGQTKLVLD ITNIRPKGAR IHGFGGTASG PMPLIEMLLD INKLLNARVG
310 320 330 340 350
QHLTAVDATD IGNLIGKTVV AGNVRRSAEM SLGSADDEDF ITMKQDQKQL
360 370 380 390 400
YHHRWASNNS VAINTQFDAY SPIALAIAKN GEPGIVNLEL SRRFGRIADR
410 420 430 440 450
ENAENDPDVE GTNPCGEISL ANGEPCNLFE VFPVVAVEQG WKLKQAFTLA
460 470 480 490 500
ARFAKRVTFS HYDWQVSRDI IKKNRRIGVS MSGIQDWFLN DFGRRVVSGF
510 520 530 540 550
ESVVDPQTGK MVQKPIYDPE IKQAVDGLYH TVVDADQAYS DALGCEPSRK
560 570 580 590 600
HTTVKPSGTV AKLAGVSEGM HFHYAGYLIQ RIRFQGNDPL LPALQACGYH
610 620 630 640 650
IEPDVYTKGT MVVEFPIRAA HADDPAFASA GTVSIAEQIA TQAFLQTYWS
660 670 680 690 700
DNAVSCTVTF QPKEADQIAG LLSQYRHVIK STSMLPYVGA GFKQAPKEPI
710 720 730 740
DVKTYKQKCA AIHGSVAAVF AVQNADHDQK DLELVDQTDC AGGACPIK
Length:748
Mass (Da):82,300
Last modified:November 14, 2006 - v1
Checksum:i48F280F385F1DC75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ71031.1.
RefSeqiWP_011674848.1. NC_008526.1.
YP_807473.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ71031; ABJ71031; LSEI_2287.
GeneIDi4420851.
KEGGilca:LSEI_2287.
PATRICi22208294. VBILacCas62221_2250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ71031.1 .
RefSeqi WP_011674848.1. NC_008526.1.
YP_807473.1. NC_008526.1.

3D structure databases

ProteinModelPortali Q035U1.
SMRi Q035U1. Positions 8-733.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321967.LSEI_2287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ71031 ; ABJ71031 ; LSEI_2287 .
GeneIDi 4420851.
KEGGi lca:LSEI_2287.
PATRICi 22208294. VBILacCas62221_2250.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000068540.
KOi K00527.
OMAi DSLNNCW.
OrthoDBi EOG68DCVH.

Enzyme and pathway databases

BioCyci LCAS321967:GH4S-2285-MONOMER.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 334.

Entry informationi

Entry nameiRTPR_LACC3
AccessioniPrimary (citable) accession number: Q035U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3