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Q035U1 (RTPR_LACC3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Short name=RTPR
EC=1.17.4.2
Gene names
Name:rtpR
Ordered Locus Names:LSEI_2287
OrganismLactobacillus casei (strain ATCC 334) [Complete proteome] [HAMAP]
Taxonomic identifier321967 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length748 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactor

Adenosylcobalamin By similarity.

Enzyme regulation

Allosterically regulated by ATP and dNTP By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the class II ribonucleoside-triphosphate reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 748748Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326538

Regions

Region151 – 16212Effector region-1 By similarity
Region172 – 320149Effector region-2 By similarity
Region572 – 63362Adenosylcobalamin-binding-1 By similarity
Region692 – 73342Adenosylcobalamin-binding-2 By similarity

Sites

Active site4151 By similarity
Active site4171 By similarity

Amino acid modifications

Disulfide bond123 ↔ 426Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q035U1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 48F280F385F1DC75

FASTA74882,300
        10         20         30         40         50         60 
MQVMTKPITL APAFIAEVKK EIKPHWGELG WVTYKRTYAR WLPDAQRTEN WDETVKRVVE 

        70         80         90        100        110        120 
GNINLDPRLH TANPDPKVVE TLQKEARNLF KLIYGLAGTP SGRNLWISGT DYQKRNGDAL 

       130        140        150        160        170        180 
NNCWFIAIRP QPYGQSHIVP EDYPASQPAV SMPYSFMFDE LMKGGGVGFS VTKDNIAKLP 

       190        200        210        220        230        240 
PVATKLELTV VIGRNSASYA DSLKMGAVDR DEWEKAHAGE QADHCALPDT REGWVLANAK 

       250        260        270        280        290        300 
VIDHHFAATN PSGQTKLVLD ITNIRPKGAR IHGFGGTASG PMPLIEMLLD INKLLNARVG 

       310        320        330        340        350        360 
QHLTAVDATD IGNLIGKTVV AGNVRRSAEM SLGSADDEDF ITMKQDQKQL YHHRWASNNS 

       370        380        390        400        410        420 
VAINTQFDAY SPIALAIAKN GEPGIVNLEL SRRFGRIADR ENAENDPDVE GTNPCGEISL 

       430        440        450        460        470        480 
ANGEPCNLFE VFPVVAVEQG WKLKQAFTLA ARFAKRVTFS HYDWQVSRDI IKKNRRIGVS 

       490        500        510        520        530        540 
MSGIQDWFLN DFGRRVVSGF ESVVDPQTGK MVQKPIYDPE IKQAVDGLYH TVVDADQAYS 

       550        560        570        580        590        600 
DALGCEPSRK HTTVKPSGTV AKLAGVSEGM HFHYAGYLIQ RIRFQGNDPL LPALQACGYH 

       610        620        630        640        650        660 
IEPDVYTKGT MVVEFPIRAA HADDPAFASA GTVSIAEQIA TQAFLQTYWS DNAVSCTVTF 

       670        680        690        700        710        720 
QPKEADQIAG LLSQYRHVIK STSMLPYVGA GFKQAPKEPI DVKTYKQKCA AIHGSVAAVF 

       730        740 
AVQNADHDQK DLELVDQTDC AGGACPIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000423 Genomic DNA. Translation: ABJ71031.1.
RefSeqYP_807473.1. NC_008526.1.

3D structure databases

ProteinModelPortalQ035U1.
SMRQ035U1. Positions 8-733.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321967.LSEI_2287.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ71031; ABJ71031; LSEI_2287.
GeneID4420851.
KEGGlca:LSEI_2287.
PATRIC22208294. VBILacCas62221_2250.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1372.
HOGENOMHOG000068540.
KOK00527.
OMADSLNNCW.
OrthoDBEOG68DCVH.

Enzyme and pathway databases

BioCycLCAS321967:GH4S-2285-MONOMER.

Family and domain databases

InterProIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsTIGR02505. RTPR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRTPR_LACC3
AccessionPrimary (citable) accession number: Q035U1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families