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Q03587 (RPOB_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit B
EC=2.7.7.6
Gene names
Name:rpoB
Ordered Locus Names:Ta0390
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length1195 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Cofactor

Zinc.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11951195DNA-directed RNA polymerase subunit B
PRO_0000048098

Regions

Zinc finger1135 – 116127 Potential

Sequences

Sequence LengthMass (Da)Tools
Q03587 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 7C1A575F218CF43E

FASTA1,195134,690
        10         20         30         40         50         60 
MKEIVDAYFK KYGIVNHQLD SMNSFYATPD NPNSVMQQIV DETKVSDDAD PGYFVLDPAK 

        70         80         90        100        110        120 
TGGHDIRIYY GRVRENGHYV GEQTIFIGKP EIKEASGASN QITPNEARLR DLNYLAPVTL 

       130        140        150        160        170        180 
KLRIVEDGIE KGSEIIKVGD LPVMVRSKIC TLSEENLDQY IEKNNGPIGL SRREKLQYVG 

       190        200        210        220        230        240 
EDPDDPGGYF IIGGSERVIV SLEDLAPNKI MVEWEDRYES KVEVSKVFSQ RGGFRALTSM 

       250        260        270        280        290        300 
EKGTDGTINV SIPSVAGTVP LVILMKALGL ERDVDVHDAI ASVPEMEPII YSNIEDSKNP 

       310        320        330        340        350        360 
KVLPPNGVNT TEDAISYLEK RFAAGQAKEF RDKKISQMLD HSLLPHLGDS PSDRIRKAIY 

       370        380        390        400        410        420 
LGRMARSLLE LSLGIRKEDD KDHLANKRIK LAGDLMDELF RSAFQSVMKD LKYQLEKTYN 

       430        440        450        460        470        480 
RKRGIKIRPA VRQDLLTQRV LHAMSTGNWI GGRTGVSQLL DRVSNLSTIS HLRRIISPLT 

       490        500        510        520        530        540 
RTQPHFEARD LHPTQWGRIC PNETPEGQNC GLVKNAALLI NVTQGIDPDS VMEILKGMDV 

       550        560        570        580        590        600 
REVLEESPKK GRVYLNGDFI GYHDDPRYLV SRIREERRSG RMSDEVNVRY DDNTNEVIVN 

       610        620        630        640        650        660 
SDRGRLRRPL LILKDGKTVL DRTMIERLKH GEISFEDLVK QGAIEWLDAE EEEDTYVAVY 

       670        680        690        700        710        720 
AYDIPEKCPH CNSYLYRSMV DWVNPGESEI TLECGFCHQR FNVPSKLSKE NTHLEIDPAM 

       730        740        750        760        770        780 
ILGVVASIIP YPEHNSSPRI TIASAMAKQS LGFAQSNVRI RPDTRGHLLH YPQVPLVRTR 

       790        800        810        820        830        840 
VMDYIHYDRR PAGQNFVVAV LSYEGYNIQD ALVINKAAIE RGLGRSTFFR TYSAEERRYP 

       850        860        870        880        890        900 
GGQEDKFEIP THDIIGARAE EYYKNLDDSG IIFPEAYVEG SDVLIGKTSP PRFLEEGEER 

       910        920        930        940        950        960 
LGPQRRRESS VTMRPNESGY VDNVFLTVSE SNSRVVKIKV RSERIPELGD KFASRHGQKG 

       970        980        990       1000       1010       1020 
VVGLVVPQED MPFTEDGIIP DLIFNPHSIP SRMTVGHILE MIGGKIASRT GRFIDGTIFS 

      1030       1040       1050       1060       1070       1080 
GEPEKSLRDA LVKYGFRKSS TEVMYDGITG RRFKADIFVG VIYYQKLHHM VAGKFHARSR 

      1090       1100       1110       1120       1130       1140 
GPVQILTRQP TEGRSRQGGL RFGEMERDTL IAHGAAMVIK DRLLDQSDGT VLYVCGNPSC 

      1150       1160       1170       1180       1190 
GHIAIYDRRK GTLRCPVCGN TGNIYPIETS YAFKLMRDEL ISLGVVMRLM LGDMK

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the genes encoding the subunits H, B, A' and A'' of the DNA-dependent RNA polymerase and the initiator tRNA from Thermoplasma acidophilum."
Klenk H.-P., Renner O., Schwass V., Zillig W.
Nucleic Acids Res. 20:5226-5226(1992) [PubMed: 1408839] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[2]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed: 11029001] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X68198 Genomic DNA. Translation: CAA48280.1.
AL445064 Genomic DNA. Translation: CAC11534.1.
PIRS26722.
RefSeqNP_393870.1. NC_002578.1.

3D structure databases

ProteinModelPortalQ03587.
ModBaseSearch...

Proteomic databases

PRIDEQ03587.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1456006.
GenomeReviewsGene locus Ta0390 in contig AL139299_GR.
KEGGtac:Ta0390.
NMPDRfig|273075.1.peg.392.

Phylogenomic databases

HOGENOMHBG317648.
OMAHNSSPRI.
PhylomeDBQ03587.
ProtClustDBPRK08565.

Enzyme and pathway databases

BioCycTACI273075:TA0390-MONOMER.

Family and domain databases

InterProIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR019969. DNA-dir_RNA_pol_su_B_arc.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007647. RNA_pol_Rpb2_5.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
Gene3DG3DSA:2.40.270.10. G3DSA:2.40.270.10. 2 hits.
G3DSA:2.40.50.150. Ribosomal_L2. 1 hit.
KOK13798.
PANTHERPTHR20856. RNA_pol_I_sub2. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF04567. RNA_pol_Rpb2_5. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR03670. RpoB_arch. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_THEAC
AccessionPrimary (citable) accession number: Q03587
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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