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Protein

Ceramide synthase subunit LIP1

Gene

LIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ceramide synthase complex required for synthesis of ceramides.1 Publication

GO - Biological processi

  • ceramide biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-702.
YEAST:MONOMER3O-702.

Chemistry databases

SwissLipidsiSLP:000000917.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase subunit LIP1
Alternative name(s):
LAG1/LAC1-interacting protein 1
Gene namesi
Name:LIP1
Ordered Locus Names:YMR298W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR298W.
SGDiS000004913. LIP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20Cytoplasmic1 PublicationAdd BLAST20
Transmembranei21 – 40Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini41 – 150Lumenal1 PublicationAdd BLAST110

GO - Cellular componenti

  • acyl-CoA ceramide synthase complex Source: SGD
  • endoplasmic reticulum membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033521 – 150Ceramide synthase subunit LIP1Add BLAST150

Proteomic databases

MaxQBiQ03579.
PRIDEiQ03579.

PTM databases

iPTMnetiQ03579.

Interactioni

Subunit structurei

Component of the ceramide synthase complex composed of at least LAC1, LAG1 and LIP1.

Binary interactionsi

WithEntry#Exp.IntActNotes
LAC1P284966EBI-27640,EBI-26585
LAG1P387034EBI-27640,EBI-10035

Protein-protein interaction databases

BioGridi35478. 27 interactors.
DIPiDIP-4392N.
IntActiQ03579. 3 interactors.
MINTiMINT-506475.

Structurei

3D structure databases

ProteinModelPortaliQ03579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LIP1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066058.
InParanoidiQ03579.
OMAiGPSCDKR.
OrthoDBiEOG092C5KTY.

Sequencei

Sequence statusi: Complete.

Q03579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPTPIITT KSAAKPKPKI FNLFRVCFIS LLLIAAVEYF KYGTRINYEW
60 70 80 90 100
FHCTPIKEPQ SGSVIKLWAR GGPSCDKRGE YKTIVKRITR DYEPNDEHLS
110 120 130 140 150
FCIIENDNVP PVHYPIHEDK GEPGYVAYVG YDTDSELVQE LCADSTIYHM
Length:150
Mass (Da):17,207
Last modified:November 1, 1997 - v1
Checksum:i75DBA35225C3065C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80836 Genomic DNA. Translation: CAA56807.1.
BK006946 Genomic DNA. Translation: DAA10199.1.
PIRiS47459.
RefSeqiNP_014027.1. NM_001182807.1.

Genome annotation databases

EnsemblFungiiYMR298W; YMR298W; YMR298W.
GeneIDi855344.
KEGGisce:YMR298W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80836 Genomic DNA. Translation: CAA56807.1.
BK006946 Genomic DNA. Translation: DAA10199.1.
PIRiS47459.
RefSeqiNP_014027.1. NM_001182807.1.

3D structure databases

ProteinModelPortaliQ03579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35478. 27 interactors.
DIPiDIP-4392N.
IntActiQ03579. 3 interactors.
MINTiMINT-506475.

Chemistry databases

SwissLipidsiSLP:000000917.

PTM databases

iPTMnetiQ03579.

Proteomic databases

MaxQBiQ03579.
PRIDEiQ03579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR298W; YMR298W; YMR298W.
GeneIDi855344.
KEGGisce:YMR298W.

Organism-specific databases

EuPathDBiFungiDB:YMR298W.
SGDiS000004913. LIP1.

Phylogenomic databases

HOGENOMiHOG000066058.
InParanoidiQ03579.
OMAiGPSCDKR.
OrthoDBiEOG092C5KTY.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-702.
YEAST:MONOMER3O-702.

Miscellaneous databases

PROiQ03579.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLIP1_YEAST
AccessioniPrimary (citable) accession number: Q03579
Secondary accession number(s): D6W0C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.