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Q03579

- LIP1_YEAST

UniProt

Q03579 - LIP1_YEAST

Protein

Ceramide synthase subunit LIP1

Gene

LIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Component of the ceramide synthase complex required for synthesis of ceramides.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. ceramide biosynthetic process Source: SGD

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17699.
    YEAST:MONOMER3O-702.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ceramide synthase subunit LIP1
    Alternative name(s):
    LAG1/LAC1-interacting protein 1
    Gene namesi
    Name:LIP1
    Ordered Locus Names:YMR298W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR298w.
    SGDiS000004913. LIP1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication

    GO - Cellular componenti

    1. acyl-CoA ceramide synthase complex Source: SGD
    2. endoplasmic reticulum membrane Source: SGD
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150Ceramide synthase subunit LIP1PRO_0000203352Add
    BLAST

    Proteomic databases

    MaxQBiQ03579.
    PaxDbiQ03579.
    PeptideAtlasiQ03579.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03579.

    Interactioni

    Subunit structurei

    Component of the ceramide synthase complex composed of at least LAC1, LAG1 and LIP1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LAC1P284966EBI-27640,EBI-26585
    LAG1P387034EBI-27640,EBI-10035

    Protein-protein interaction databases

    BioGridi35478. 25 interactions.
    DIPiDIP-4392N.
    IntActiQ03579. 3 interactions.
    MINTiMINT-506475.
    STRINGi4932.YMR298W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03579.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini41 – 150110Lumenal1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LIP1 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42883.
    HOGENOMiHOG000066058.
    OMAiCADSTIY.
    OrthoDBiEOG7XDBTX.

    Sequencei

    Sequence statusi: Complete.

    Q03579-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQPTPIITT KSAAKPKPKI FNLFRVCFIS LLLIAAVEYF KYGTRINYEW    50
    FHCTPIKEPQ SGSVIKLWAR GGPSCDKRGE YKTIVKRITR DYEPNDEHLS 100
    FCIIENDNVP PVHYPIHEDK GEPGYVAYVG YDTDSELVQE LCADSTIYHM 150
    Length:150
    Mass (Da):17,207
    Last modified:November 1, 1997 - v1
    Checksum:i75DBA35225C3065C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80836 Genomic DNA. Translation: CAA56807.1.
    BK006946 Genomic DNA. Translation: DAA10199.1.
    PIRiS47459.
    RefSeqiNP_014027.1. NM_001182807.1.

    Genome annotation databases

    EnsemblFungiiYMR298W; YMR298W; YMR298W.
    GeneIDi855344.
    KEGGisce:YMR298W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80836 Genomic DNA. Translation: CAA56807.1 .
    BK006946 Genomic DNA. Translation: DAA10199.1 .
    PIRi S47459.
    RefSeqi NP_014027.1. NM_001182807.1.

    3D structure databases

    ProteinModelPortali Q03579.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35478. 25 interactions.
    DIPi DIP-4392N.
    IntActi Q03579. 3 interactions.
    MINTi MINT-506475.
    STRINGi 4932.YMR298W.

    Proteomic databases

    MaxQBi Q03579.
    PaxDbi Q03579.
    PeptideAtlasi Q03579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR298W ; YMR298W ; YMR298W .
    GeneIDi 855344.
    KEGGi sce:YMR298W.

    Organism-specific databases

    CYGDi YMR298w.
    SGDi S000004913. LIP1.

    Phylogenomic databases

    eggNOGi NOG42883.
    HOGENOMi HOG000066058.
    OMAi CADSTIY.
    OrthoDBi EOG7XDBTX.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17699.
    YEAST:MONOMER3O-702.

    Miscellaneous databases

    NextBioi 979088.

    Gene expression databases

    Genevestigatori Q03579.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Lip1p: a novel subunit of acyl-CoA ceramide synthase."
      Vallee B., Riezman H.
      EMBO J. 24:730-741(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH LAC1 AND LAG1.

    Entry informationi

    Entry nameiLIP1_YEAST
    AccessioniPrimary (citable) accession number: Q03579
    Secondary accession number(s): D6W0C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3