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Q03579 (LIP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ceramide synthase subunit LIP1
Alternative name(s):
LAG1/LAC1-interacting protein 1
Gene names
Name:LIP1
Ordered Locus Names:YMR298W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the ceramide synthase complex required for synthesis of ceramides. Ref.3

Subunit structure

Component of the ceramide synthase complex composed of at least LAC1, LAG1 and LIP1.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein Ref.3.

Sequence similarities

Belongs to the LIP1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LAC1P284966EBI-27640,EBI-26585
LAG1P387034EBI-27640,EBI-10035

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 150150Ceramide synthase subunit LIP1
PRO_0000203352

Regions

Topological domain1 – 2020Cytoplasmic Ref.3
Transmembrane21 – 4020Helical; Signal-anchor for type II membrane protein; Potential
Topological domain41 – 150110Lumenal Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q03579 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 75DBA35225C3065C

FASTA15017,207
        10         20         30         40         50         60 
MSQPTPIITT KSAAKPKPKI FNLFRVCFIS LLLIAAVEYF KYGTRINYEW FHCTPIKEPQ 

        70         80         90        100        110        120 
SGSVIKLWAR GGPSCDKRGE YKTIVKRITR DYEPNDEHLS FCIIENDNVP PVHYPIHEDK 

       130        140        150 
GEPGYVAYVG YDTDSELVQE LCADSTIYHM 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Lip1p: a novel subunit of acyl-CoA ceramide synthase."
Vallee B., Riezman H.
EMBO J. 24:730-741(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH LAC1 AND LAG1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80836 Genomic DNA. Translation: CAA56807.1.
BK006946 Genomic DNA. Translation: DAA10199.1.
PIRS47459.
RefSeqNP_014027.1. NM_001182807.1.

3D structure databases

ProteinModelPortalQ03579.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35478. 25 interactions.
DIPDIP-4392N.
IntActQ03579. 3 interactions.
MINTMINT-506475.
STRING4932.YMR298W.

Proteomic databases

MaxQBQ03579.
PaxDbQ03579.
PeptideAtlasQ03579.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR298W; YMR298W; YMR298W.
GeneID855344.
KEGGsce:YMR298W.

Organism-specific databases

CYGDYMR298w.
SGDS000004913. LIP1.

Phylogenomic databases

eggNOGNOG42883.
HOGENOMHOG000066058.
OMACADSTIY.
OrthoDBEOG7XDBTX.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-17699.
YEAST:MONOMER3O-702.

Gene expression databases

GenevestigatorQ03579.

Family and domain databases

ProtoNetSearch...

Other

NextBio979088.

Entry information

Entry nameLIP1_YEAST
AccessionPrimary (citable) accession number: Q03579
Secondary accession number(s): D6W0C5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families