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Q03579

- LIP1_YEAST

UniProt

Q03579 - LIP1_YEAST

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Protein

Ceramide synthase subunit LIP1

Gene

LIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the ceramide synthase complex required for synthesis of ceramides.1 Publication

GO - Biological processi

  1. ceramide biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17699.
YEAST:MONOMER3O-702.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase subunit LIP1
Alternative name(s):
LAG1/LAC1-interacting protein 1
Gene namesi
Name:LIP1
Ordered Locus Names:YMR298W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR298w.
SGDiS000004913. LIP1.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication

GO - Cellular componenti

  1. acyl-CoA ceramide synthase complex Source: SGD
  2. endoplasmic reticulum membrane Source: SGD
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Ceramide synthase subunit LIP1PRO_0000203352Add
BLAST

Proteomic databases

MaxQBiQ03579.
PaxDbiQ03579.
PeptideAtlasiQ03579.

Expressioni

Gene expression databases

GenevestigatoriQ03579.

Interactioni

Subunit structurei

Component of the ceramide synthase complex composed of at least LAC1, LAG1 and LIP1.

Binary interactionsi

WithEntry#Exp.IntActNotes
LAC1P284966EBI-27640,EBI-26585
LAG1P387034EBI-27640,EBI-10035

Protein-protein interaction databases

BioGridi35478. 25 interactions.
DIPiDIP-4392N.
IntActiQ03579. 3 interactions.
MINTiMINT-506475.
STRINGi4932.YMR298W.

Structurei

3D structure databases

ProteinModelPortaliQ03579.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Cytoplasmic1 PublicationAdd
BLAST
Topological domaini41 – 150110Lumenal1 PublicationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4020Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the LIP1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42883.
HOGENOMiHOG000066058.
InParanoidiQ03579.
OMAiCADSTIY.
OrthoDBiEOG7XDBTX.

Sequencei

Sequence statusi: Complete.

Q03579-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQPTPIITT KSAAKPKPKI FNLFRVCFIS LLLIAAVEYF KYGTRINYEW
60 70 80 90 100
FHCTPIKEPQ SGSVIKLWAR GGPSCDKRGE YKTIVKRITR DYEPNDEHLS
110 120 130 140 150
FCIIENDNVP PVHYPIHEDK GEPGYVAYVG YDTDSELVQE LCADSTIYHM
Length:150
Mass (Da):17,207
Last modified:November 1, 1997 - v1
Checksum:i75DBA35225C3065C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80836 Genomic DNA. Translation: CAA56807.1.
BK006946 Genomic DNA. Translation: DAA10199.1.
PIRiS47459.
RefSeqiNP_014027.1. NM_001182807.1.

Genome annotation databases

EnsemblFungiiYMR298W; YMR298W; YMR298W.
GeneIDi855344.
KEGGisce:YMR298W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80836 Genomic DNA. Translation: CAA56807.1 .
BK006946 Genomic DNA. Translation: DAA10199.1 .
PIRi S47459.
RefSeqi NP_014027.1. NM_001182807.1.

3D structure databases

ProteinModelPortali Q03579.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35478. 25 interactions.
DIPi DIP-4392N.
IntActi Q03579. 3 interactions.
MINTi MINT-506475.
STRINGi 4932.YMR298W.

Proteomic databases

MaxQBi Q03579.
PaxDbi Q03579.
PeptideAtlasi Q03579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR298W ; YMR298W ; YMR298W .
GeneIDi 855344.
KEGGi sce:YMR298W.

Organism-specific databases

CYGDi YMR298w.
SGDi S000004913. LIP1.

Phylogenomic databases

eggNOGi NOG42883.
HOGENOMi HOG000066058.
InParanoidi Q03579.
OMAi CADSTIY.
OrthoDBi EOG7XDBTX.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17699.
YEAST:MONOMER3O-702.

Miscellaneous databases

NextBioi 979088.

Gene expression databases

Genevestigatori Q03579.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Lip1p: a novel subunit of acyl-CoA ceramide synthase."
    Vallee B., Riezman H.
    EMBO J. 24:730-741(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH LAC1 AND LAG1.

Entry informationi

Entry nameiLIP1_YEAST
AccessioniPrimary (citable) accession number: Q03579
Secondary accession number(s): D6W0C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3