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Protein

Ceramide synthase subunit LIP1

Gene

LIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ceramide synthase complex required for synthesis of ceramides.1 Publication

GO - Biological processi

  • ceramide biosynthetic process Source: SGD

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-702
YEAST:MONOMER3O-702

Chemistry databases

SwissLipidsiSLP:000000917

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase subunit LIP1
Alternative name(s):
LAG1/LAC1-interacting protein 1
Gene namesi
Name:LIP1
Ordered Locus Names:YMR298W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR298W
SGDiS000004913 LIP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20Cytoplasmic1 PublicationAdd BLAST20
Transmembranei21 – 40Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini41 – 150Lumenal1 PublicationAdd BLAST110

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033521 – 150Ceramide synthase subunit LIP1Add BLAST150

Proteomic databases

MaxQBiQ03579
PaxDbiQ03579
PRIDEiQ03579

PTM databases

iPTMnetiQ03579

Interactioni

Subunit structurei

Component of the ceramide synthase complex composed of at least LAC1, LAG1 and LIP1.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35478, 218 interactors
DIPiDIP-4392N
IntActiQ03579, 5 interactors
STRINGi4932.YMR298W

Structurei

3D structure databases

ProteinModelPortaliQ03579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LIP1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066058
InParanoidiQ03579
OMAiGPSCDKR
OrthoDBiEOG092C5KTY

Sequencei

Sequence statusi: Complete.

Q03579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPTPIITT KSAAKPKPKI FNLFRVCFIS LLLIAAVEYF KYGTRINYEW
60 70 80 90 100
FHCTPIKEPQ SGSVIKLWAR GGPSCDKRGE YKTIVKRITR DYEPNDEHLS
110 120 130 140 150
FCIIENDNVP PVHYPIHEDK GEPGYVAYVG YDTDSELVQE LCADSTIYHM
Length:150
Mass (Da):17,207
Last modified:November 1, 1997 - v1
Checksum:i75DBA35225C3065C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80836 Genomic DNA Translation: CAA56807.1
BK006946 Genomic DNA Translation: DAA10199.1
PIRiS47459
RefSeqiNP_014027.1, NM_001182807.1

Genome annotation databases

EnsemblFungiiYMR298W; YMR298W; YMR298W
GeneIDi855344
KEGGisce:YMR298W

Similar proteinsi

Entry informationi

Entry nameiLIP1_YEAST
AccessioniPrimary (citable) accession number: Q03579
Secondary accession number(s): D6W0C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health