Aspartyl-tRNA synthetase, cytoplasmic - Caenorhabditis elegans

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Reviewed, UniProtKB/Swiss-Prot Q03577 (SYDC_CAEEL)

Last modified February 9, 2010. Version 75. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase, cytoplasmic
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase
      Short name=AspRS

Gene names

Name:	drs-1
ORF Names:	B0464.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

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Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase receptor-mediated endocytosis Inferred from mutant phenotype. Source: WormBase reproduction Inferred from mutant phenotype. Source: WormBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 531

531

Aspartyl-tRNA synthetase, cytoplasmic

PRO_0000111013

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Sequences

Sequence

Length

Mass (Da)

Tools

Q03577-1 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 094E3207DC102733
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FASTA

531

59,939

        10         20         30         40         50         60 
MADAAEGEQP KLSKKELNKL ARKAKKDEKA GEKGGNQQQA AAMDQEDASK DFYGSYGLVN 

        70         80         90        100        110        120 
SKEKKVLNFL KVKEINVSNA TKDVWVRGRI HTTRSKGKNC FLVLRQGVYT VQVAMFMNEK 

       130        140        150        160        170        180 
ISKQMLKFVS SISKESIVDV YATINKVDNP IESCTQKDVE LLAQQVFVVS TSAPKLPLQI 

       190        200        210        220        230        240 
EDASRRAPTD EEKASEQENQ LAVVNLDTRL DNRVIDLRTP TSHAIFRIQA GICNQFRNIL 

       250        260        270        280        290        300 
DVRGFVEIMA PKIISAPSEG GANVFEVSYF KGSAYLAQSP QLYKQMAIAG DFEKVYTIGP 

       310        320        330        340        350        360 
VFRAEDSNTH RHMTEFVGLD LEMAFNFHYH EVMETIAEVL TQMFKGLQQN YQDEIAAVGN 

       370        380        390        400        410        420 
QYPAEPFQFC EPPLILKYPD AITLLRENGI EIGDEDDLST PVEKFLGKLV KEKYSTDFYV 

       430        440        450        460        470        480 
LDKFPLSVRP FYTMPDAHDE RYSNSYDMFM RGEEILSGAQ RIHDADMLVE RAKHHQVDLA 

       490        500        510        520        530 
KIQSYIDSFK YGCPPHAGGG IGLERVTMLF LGLHNIRLAS LFPRDPKRLT P

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References

[1]

"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans."
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L.

Wohldman P.
Nature 368:32-38(1994) [PubMed: 7906398] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

[2]

"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	Z19152 Genomic DNA. Translation: CAA79536.1.
PIR	S28278.
RefSeq	NP_499089.1.
UniGene	Cel.7882
3D structure databases
SMR	Q03577. Positions 46-531.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03577.
Genome annotation databases
Ensembl	B0464.1.1; B0464.1.1; B0464.1; Caenorhabditis elegans. [Genome view] B0464.1.2; B0464.1.2; B0464.1; Caenorhabditis elegans. [Genome view]
GeneID	176334.
KEGG	cel:B0464.1.
UCSC	B0464.1.1. c. elegans.
Organism-specific databases
CTD	176334.
WormBase	WBGene00001094. drs-1.
WormPep	B0464.1. CE00015. [WorfDB]
Phylogenomic databases
eggNOG	meNOG04046.
HOGENOM	HBG745843.
InParanoid	Q03577.
OMA	RNPKQSN.
PhylomeDB	Q03577.
Enzyme and pathway databases
BRENDA	6.1.1.12. 672.
Gene expression databases
ArrayExpress	Q03577.
Family and domain databases
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-dom. IPR002312. Asp-tRNA-synth_IIb. IPR004523. Asp-tRNA-synth_IIb_arc/euk. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00458. aspS_arch. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	892140.

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Entry information

Entry name

SYDC_CAEEL

Accession

Primary (citable) accession number: Q03577

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	February 9, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project

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Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents