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Q03554

- GOT1_YEAST

UniProt

Q03554 - GOT1_YEAST

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Protein

Protein transport protein GOT1

Gene
GOT1, YMR292W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by SFT2.1 Publication

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. protein transport Source: UniProtKB-KW
  3. retrograde transport, endosome to Golgi Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32962-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein GOT1
Alternative name(s):
Golgi transport protein 1
Gene namesi
Name:GOT1
Ordered Locus Names:YMR292W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR292w.
SGDiS000004906. GOT1.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Cytoplasmic Reviewed prediction
Transmembranei9 – 2921Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini30 – 312Lumenal Reviewed prediction
Transmembranei32 – 5221Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini53 – 6715Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei68 – 8821Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini89 – 11224Lumenal Reviewed predictionAdd
BLAST
Transmembranei113 – 13321Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini134 – 1385Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. ER to Golgi transport vesicle Source: SGD
  3. Golgi apparatus Source: SGD
  4. Golgi cis cisterna Source: SGD
  5. Golgi membrane Source: SGD
  6. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Lack of GOT1 is lethal in a strain lacking SFT2.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi73 – 731G → S in got1-1; loss of function. ER-Golgi transport defect when associated with lack of SFT2. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Protein transport protein GOT1PRO_0000218586Add
BLAST

Proteomic databases

MaxQBiQ03554.
PaxDbiQ03554.

Expressioni

Gene expression databases

GenevestigatoriQ03554.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGP1P253761EBI-2057821,EBI-2357
AKR1P390101EBI-2057821,EBI-2421
ARF1P110761EBI-2057821,EBI-2816
CHO1P084561EBI-2057821,EBI-14055
ERG1P324761EBI-2057821,EBI-6545
ERP1Q053591EBI-2057821,EBI-6581
ERP2P397041EBI-2057821,EBI-6587
ERV25P548371EBI-2057821,EBI-6642
ERV29P533371EBI-2057821,EBI-23662
GAP1P191451EBI-2057821,EBI-7314
KRE27P405401EBI-2057821,EBI-24977
MSC7P386941EBI-2057821,EBI-24511
OST1P415431EBI-2057821,EBI-12651
PHO88P382641EBI-2057821,EBI-13350
PHS1P408571EBI-2057821,EBI-26003
PMP2P409751EBI-2057821,EBI-2043041
PMP3P872841EBI-2057821,EBI-13555
RBD2Q122701EBI-2057821,EBI-31471
RTN1Q049471EBI-2057821,EBI-38020
SAC1P323681EBI-2057821,EBI-16210
SEY1Q992871EBI-2057821,EBI-37523
SFT2P381661EBI-2057821,EBI-17046
SPF1P399861EBI-2057821,EBI-3128
SSH1P383531EBI-2057821,EBI-18175
UBP1P250371EBI-2057821,EBI-19819
YCR043CP253611EBI-2057821,EBI-21909
YER053C-AQ3E7B01EBI-2057821,EBI-2047907
YHR080CP388001EBI-2057821,EBI-24597
YOP1Q124021EBI-2057821,EBI-37092

Protein-protein interaction databases

BioGridi35472. 55 interactions.
DIPiDIP-8271N.
IntActiQ03554. 14 interactions.
MINTiMINT-1360157.
STRINGi4932.YMR292W.

Structurei

3D structure databases

ProteinModelPortaliQ03554.

Family & Domainsi

Sequence similaritiesi

Belongs to the GOT1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5120.
GeneTreeiENSGT00390000014507.
HOGENOMiHOG000035939.
OMAiMLLLFDK.
OrthoDBiEOG7HF1XR.

Family and domain databases

InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
[Graphical view]
PfamiPF04178. Got1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03554-1 [UniParc]FASTAAdd to Basket

« Hide

MWLTEAQKFG VAFTFGGFLF FLFGIFTFFD RALLALGNIL FLIGVFLIIG    50
SQKTYIFFTR PNKRRGSLFF LVGAFLILLK WTFLGFIIES LGIIGLFGDF 100
FGVIVQFLRS MPIIGPILSH PAIAPIVDKL AGVRVLPV 138
Length:138
Mass (Da):15,431
Last modified:November 1, 1997 - v1
Checksum:iF078F3725D504B7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80836 Genomic DNA. Translation: CAA56801.1.
BK006946 Genomic DNA. Translation: DAA10193.1.
PIRiS47453.
RefSeqiNP_014020.1. NM_001182800.1.

Genome annotation databases

EnsemblFungiiYMR292W; YMR292W; YMR292W.
GeneIDi855337.
KEGGisce:YMR292W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80836 Genomic DNA. Translation: CAA56801.1 .
BK006946 Genomic DNA. Translation: DAA10193.1 .
PIRi S47453.
RefSeqi NP_014020.1. NM_001182800.1.

3D structure databases

ProteinModelPortali Q03554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35472. 55 interactions.
DIPi DIP-8271N.
IntActi Q03554. 14 interactions.
MINTi MINT-1360157.
STRINGi 4932.YMR292W.

Proteomic databases

MaxQBi Q03554.
PaxDbi Q03554.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR292W ; YMR292W ; YMR292W .
GeneIDi 855337.
KEGGi sce:YMR292W.

Organism-specific databases

CYGDi YMR292w.
SGDi S000004906. GOT1.

Phylogenomic databases

eggNOGi COG5120.
GeneTreei ENSGT00390000014507.
HOGENOMi HOG000035939.
OMAi MLLLFDK.
OrthoDBi EOG7HF1XR.

Enzyme and pathway databases

BioCyci YEAST:G3O-32962-MONOMER.

Miscellaneous databases

NextBioi 979070.

Gene expression databases

Genevestigatori Q03554.

Family and domain databases

InterProi IPR007305. Vesicle_transpt_Got1/SFT2.
[Graphical view ]
Pfami PF04178. Got1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex."
    Conchon S., Cao X., Barlowe C., Pelham H.R.
    EMBO J. 18:3934-3946(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF GLY-73, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiGOT1_YEAST
AccessioniPrimary (citable) accession number: Q03554
Secondary accession number(s): D6W0B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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