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Q03554 (GOT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein transport protein GOT1
Alternative name(s):
Golgi transport protein 1
Gene names
Name:GOT1
Ordered Locus Names:YMR292W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by SFT2. Ref.3

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein Ref.3.

Disruption phenotype

Lack of GOT1 is lethal in a strain lacking SFT2. Ref.3

Sequence similarities

Belongs to the GOT1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Protein transport protein GOT1
PRO_0000218586

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Name=1; Potential
Topological domain30 – 312Lumenal Potential
Transmembrane32 – 5221Helical; Name=2; Potential
Topological domain53 – 6715Cytoplasmic Potential
Transmembrane68 – 8821Helical; Name=3; Potential
Topological domain89 – 11224Lumenal Potential
Transmembrane113 – 13321Helical; Name=4; Potential
Topological domain134 – 1385Cytoplasmic Potential

Experimental info

Mutagenesis731G → S in got1-1; loss of function. ER-Golgi transport defect when associated with lack of SFT2. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q03554 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: F078F3725D504B7D

FASTA13815,431
        10         20         30         40         50         60 
MWLTEAQKFG VAFTFGGFLF FLFGIFTFFD RALLALGNIL FLIGVFLIIG SQKTYIFFTR 

        70         80         90        100        110        120 
PNKRRGSLFF LVGAFLILLK WTFLGFIIES LGIIGLFGDF FGVIVQFLRS MPIIGPILSH 

       130 
PAIAPIVDKL AGVRVLPV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex."
Conchon S., Cao X., Barlowe C., Pelham H.R.
EMBO J. 18:3934-3946(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF GLY-73, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80836 Genomic DNA. Translation: CAA56801.1.
BK006946 Genomic DNA. Translation: DAA10193.1.
PIRS47453.
RefSeqNP_014020.1. NM_001182800.1.

3D structure databases

ProteinModelPortalQ03554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35472. 55 interactions.
DIPDIP-8271N.
IntActQ03554. 14 interactions.
MINTMINT-1360157.
STRING4932.YMR292W.

Proteomic databases

MaxQBQ03554.
PaxDbQ03554.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR292W; YMR292W; YMR292W.
GeneID855337.
KEGGsce:YMR292W.

Organism-specific databases

CYGDYMR292w.
SGDS000004906. GOT1.

Phylogenomic databases

eggNOGCOG5120.
GeneTreeENSGT00390000014507.
HOGENOMHOG000035939.
OMAMLLLFDK.
OrthoDBEOG7HF1XR.

Enzyme and pathway databases

BioCycYEAST:G3O-32962-MONOMER.

Gene expression databases

GenevestigatorQ03554.

Family and domain databases

InterProIPR007305. Vesicle_transpt_Got1/SFT2.
[Graphical view]
PfamPF04178. Got1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio979070.

Entry information

Entry nameGOT1_YEAST
AccessionPrimary (citable) accession number: Q03554
Secondary accession number(s): D6W0B9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families