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Q03554

- GOT1_YEAST

UniProt

Q03554 - GOT1_YEAST

Protein

Protein transport protein GOT1

Gene

GOT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by SFT2.1 Publication

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. protein transport Source: UniProtKB-KW
    3. retrograde transport, endosome to Golgi Source: SGD

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32962-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein GOT1
    Alternative name(s):
    Golgi transport protein 1
    Gene namesi
    Name:GOT1
    Ordered Locus Names:YMR292W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR292w.
    SGDiS000004906. GOT1.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. ER to Golgi transport vesicle Source: SGD
    3. Golgi apparatus Source: SGD
    4. Golgi cis cisterna Source: SGD
    5. Golgi membrane Source: SGD
    6. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Lack of GOT1 is lethal in a strain lacking SFT2.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi73 – 731G → S in got1-1; loss of function. ER-Golgi transport defect when associated with lack of SFT2. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Protein transport protein GOT1PRO_0000218586Add
    BLAST

    Proteomic databases

    MaxQBiQ03554.
    PaxDbiQ03554.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03554.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGP1P253761EBI-2057821,EBI-2357
    AKR1P390101EBI-2057821,EBI-2421
    ARF1P110761EBI-2057821,EBI-2816
    CHO1P084561EBI-2057821,EBI-14055
    ERG1P324761EBI-2057821,EBI-6545
    ERP1Q053591EBI-2057821,EBI-6581
    ERP2P397041EBI-2057821,EBI-6587
    ERV25P548371EBI-2057821,EBI-6642
    ERV29P533371EBI-2057821,EBI-23662
    GAP1P191451EBI-2057821,EBI-7314
    KRE27P405401EBI-2057821,EBI-24977
    MSC7P386941EBI-2057821,EBI-24511
    OST1P415431EBI-2057821,EBI-12651
    PHO88P382641EBI-2057821,EBI-13350
    PHS1P408571EBI-2057821,EBI-26003
    PMP2P409751EBI-2057821,EBI-2043041
    PMP3P872841EBI-2057821,EBI-13555
    RBD2Q122701EBI-2057821,EBI-31471
    RTN1Q049471EBI-2057821,EBI-38020
    SAC1P323681EBI-2057821,EBI-16210
    SEY1Q992871EBI-2057821,EBI-37523
    SFT2P381661EBI-2057821,EBI-17046
    SPF1P399861EBI-2057821,EBI-3128
    SSH1P383531EBI-2057821,EBI-18175
    UBP1P250371EBI-2057821,EBI-19819
    YCR043CP253611EBI-2057821,EBI-21909
    YER053C-AQ3E7B01EBI-2057821,EBI-2047907
    YHR080CP388001EBI-2057821,EBI-24597
    YOP1Q124021EBI-2057821,EBI-37092

    Protein-protein interaction databases

    BioGridi35472. 55 interactions.
    DIPiDIP-8271N.
    IntActiQ03554. 14 interactions.
    MINTiMINT-1360157.
    STRINGi4932.YMR292W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03554.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini30 – 312LumenalSequence Analysis
    Topological domaini53 – 6715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini89 – 11224LumenalSequence AnalysisAdd
    BLAST
    Topological domaini134 – 1385CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei32 – 5221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321Helical; Name=4Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GOT1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5120.
    GeneTreeiENSGT00390000014507.
    HOGENOMiHOG000035939.
    OMAiMLLLFDK.
    OrthoDBiEOG7HF1XR.

    Family and domain databases

    InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
    [Graphical view]
    PfamiPF04178. Got1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03554-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWLTEAQKFG VAFTFGGFLF FLFGIFTFFD RALLALGNIL FLIGVFLIIG    50
    SQKTYIFFTR PNKRRGSLFF LVGAFLILLK WTFLGFIIES LGIIGLFGDF 100
    FGVIVQFLRS MPIIGPILSH PAIAPIVDKL AGVRVLPV 138
    Length:138
    Mass (Da):15,431
    Last modified:November 1, 1997 - v1
    Checksum:iF078F3725D504B7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80836 Genomic DNA. Translation: CAA56801.1.
    BK006946 Genomic DNA. Translation: DAA10193.1.
    PIRiS47453.
    RefSeqiNP_014020.1. NM_001182800.1.

    Genome annotation databases

    EnsemblFungiiYMR292W; YMR292W; YMR292W.
    GeneIDi855337.
    KEGGisce:YMR292W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80836 Genomic DNA. Translation: CAA56801.1 .
    BK006946 Genomic DNA. Translation: DAA10193.1 .
    PIRi S47453.
    RefSeqi NP_014020.1. NM_001182800.1.

    3D structure databases

    ProteinModelPortali Q03554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35472. 55 interactions.
    DIPi DIP-8271N.
    IntActi Q03554. 14 interactions.
    MINTi MINT-1360157.
    STRINGi 4932.YMR292W.

    Proteomic databases

    MaxQBi Q03554.
    PaxDbi Q03554.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR292W ; YMR292W ; YMR292W .
    GeneIDi 855337.
    KEGGi sce:YMR292W.

    Organism-specific databases

    CYGDi YMR292w.
    SGDi S000004906. GOT1.

    Phylogenomic databases

    eggNOGi COG5120.
    GeneTreei ENSGT00390000014507.
    HOGENOMi HOG000035939.
    OMAi MLLLFDK.
    OrthoDBi EOG7HF1XR.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32962-MONOMER.

    Miscellaneous databases

    NextBioi 979070.

    Gene expression databases

    Genevestigatori Q03554.

    Family and domain databases

    InterProi IPR007305. Vesicle_transpt_Got1/SFT2.
    [Graphical view ]
    Pfami PF04178. Got1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex."
      Conchon S., Cao X., Barlowe C., Pelham H.R.
      EMBO J. 18:3934-3946(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF GLY-73, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiGOT1_YEAST
    AccessioniPrimary (citable) accession number: Q03554
    Secondary accession number(s): D6W0B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3