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Protein

Protein transport protein GOT1

Gene

GOT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by SFT2.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein transport Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32962-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein GOT1
Alternative name(s):
Golgi transport protein 1
Gene namesi
Name:GOT1
Ordered Locus Names:YMR292W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR292W
SGDiS000004906 GOT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini30 – 31LumenalSequence analysis2
Transmembranei32 – 52Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini53 – 67CytoplasmicSequence analysisAdd BLAST15
Transmembranei68 – 88Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini89 – 112LumenalSequence analysisAdd BLAST24
Transmembranei113 – 133Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini134 – 138CytoplasmicSequence analysis5

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Lack of GOT1 is lethal in a strain lacking SFT2.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi73G → S in got1-1; loss of function. ER-Golgi transport defect when associated with lack of SFT2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185861 – 138Protein transport protein GOT1Add BLAST138

Proteomic databases

MaxQBiQ03554
PaxDbiQ03554
PRIDEiQ03554

Interactioni

Protein-protein interaction databases

BioGridi35472, 115 interactors
DIPiDIP-8271N
IntActiQ03554, 15 interactors
MINTiQ03554
STRINGi4932.YMR292W

Structurei

3D structure databases

ProteinModelPortaliQ03554
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GOT1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000014507
HOGENOMiHOG000035939
InParanoidiQ03554
OMAiFYFFARK
OrthoDBiEOG092C5MSJ

Family and domain databases

InterProiView protein in InterPro
IPR007305 Vesicle_transpt_Got1/SFT2
PfamiView protein in Pfam
PF04178 Got1, 1 hit

Sequencei

Sequence statusi: Complete.

Q03554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLTEAQKFG VAFTFGGFLF FLFGIFTFFD RALLALGNIL FLIGVFLIIG
60 70 80 90 100
SQKTYIFFTR PNKRRGSLFF LVGAFLILLK WTFLGFIIES LGIIGLFGDF
110 120 130
FGVIVQFLRS MPIIGPILSH PAIAPIVDKL AGVRVLPV
Length:138
Mass (Da):15,431
Last modified:November 1, 1997 - v1
Checksum:iF078F3725D504B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80836 Genomic DNA Translation: CAA56801.1
BK006946 Genomic DNA Translation: DAA10193.1
PIRiS47453
RefSeqiNP_014020.1, NM_001182800.1

Genome annotation databases

EnsemblFungiiYMR292W; YMR292W; YMR292W
GeneIDi855337
KEGGisce:YMR292W

Similar proteinsi

Entry informationi

Entry nameiGOT1_YEAST
AccessioniPrimary (citable) accession number: Q03554
Secondary accession number(s): D6W0B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health