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Q03526

- ITK_MOUSE

UniProt

Q03526 - ITK_MOUSE

Protein

Tyrosine-protein kinase ITK/TSK

Gene

Itk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi127 – 1271ZincBy similarity
    Metal bindingi138 – 1381ZincBy similarity
    Metal bindingi139 – 1391ZincBy similarity
    Metal bindingi149 – 1491ZincBy similarity
    Binding sitei396 – 3961ATPPROSITE-ProRule annotation
    Active sitei487 – 4871Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri119 – 15537Btk-typePROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi374 – 3829ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of phospholipase C activity Source: UniProtKB
    2. adaptive immune response Source: UniProtKB
    3. cytokine production Source: UniProtKB
    4. interferon-gamma production Source: MGI
    5. interleukin-4 production Source: MGI
    6. intracellular signal transduction Source: InterPro
    7. NK T cell differentiation Source: MGI
    8. peptidyl-tyrosine phosphorylation Source: GOC
    9. T cell receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 3474.
    ReactomeiREACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_225768. Generation of second messenger molecules.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase ITK/TSK (EC:2.7.10.2)
    Alternative name(s):
    IL-2-inducible T-cell kinase
    Kinase EMT
    Kinase TLK
    T-cell-specific kinase
    Gene namesi
    Name:Itk
    Synonyms:Emt, Tlk, Tsk
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96621. Itk.

    Subcellular locationi

    Cytoplasm
    Note: Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.By similarity

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    Mice display decreased mature thymocytes and elicit profound defect in CD4+ and CD8+ T-cell development. Additionally, they show a strong decrease of cytokine production in response to TCR receptor stimulation.4 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 625625Tyrosine-protein kinase ITK/TSKPRO_0000088107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei186 – 1861Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei517 – 5171Phosphotyrosine; by LCKBy similarity
    Modified residuei570 – 5701PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated at Tyr-517 in the activation loop of the kinase domain by LCK. Subsequent autophosphorylation at Tyr-186 leads to the kinase activation. The autophosphorylated Tyr-186 lies within the substrate binding sequence of the SH3 domain By similarity.By similarity
    Ubiquitinated.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ03526.

    PTM databases

    PhosphoSiteiQ03526.

    Expressioni

    Tissue specificityi

    Is detected in the thymus, lymph node and very faintly in the spleen, but is not detected in the liver, lung, kidney, heart, brain, intestine or testis. Expressed in T-lymphocytes and mast cells. It may also be expressed in natural killer cells.

    Developmental stagei

    Is present in the fetal thymus as early as day 14 of gestation. The levels are 5- to 10-fold higher in thymocytes than in peripheral T-cells, and increase in the thymus during development from neonate to adult.

    Inductioni

    Through a myriad of surface receptors including the TCR/CD3 signaling complex, coreceptors, or chemokine receptors.

    Gene expression databases

    ArrayExpressiQ03526.
    BgeeiQ03526.
    CleanExiMM_ITK.
    GenevestigatoriQ03526.

    Interactioni

    Subunit structurei

    Homooligomerizes; this association negatively regulates kinase activity. Interacts with PPIA/CYPA; this interaction regulates TCR signal strength via a proline-directed conformational switch in ITK. Interacts with THEMIS By similarity. Interacts with FASLG. Interacts with VAV1; this interaction is important for VAV1 localization and TCR-induced actin polarization.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi200840. 5 interactions.
    DIPiDIP-29283N.
    IntActiQ03526. 4 interactions.
    MINTiMINT-84965.

    Structurei

    Secondary structure

    1
    625
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi178 – 1803
    Beta strandi181 – 1866
    Beta strandi192 – 1954
    Beta strandi200 – 2023
    Beta strandi203 – 2053
    Beta strandi211 – 2144
    Beta strandi215 – 2184
    Beta strandi220 – 2223
    Beta strandi224 – 2263
    Beta strandi229 – 2346
    Helixi240 – 2423
    Beta strandi243 – 2464
    Beta strandi248 – 2503
    Helixi252 – 26211
    Beta strandi268 – 2725
    Turni275 – 2773
    Beta strandi279 – 2857
    Beta strandi290 – 2923
    Beta strandi294 – 3029
    Beta strandi305 – 3073
    Beta strandi310 – 3134
    Beta strandi318 – 3203
    Helixi321 – 33010
    Beta strandi335 – 3373
    Beta strandi338 – 3425

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AWJNMR-A160-236[»]
    1LUINMR-A238-344[»]
    1LUKNMR-A238-344[»]
    1LUMNMR-A238-344[»]
    1LUNNMR-A238-344[»]
    2ETZNMR-A238-344[»]
    2EU0NMR-A238-344[»]
    2K79NMR-A177-237[»]
    B238-344[»]
    2K7ANMR-A177-237[»]
    B238-344[»]
    2RN8NMR-A177-238[»]
    2RNANMR-A177-238[»]
    3S9KX-ray2.35A236-344[»]
    ProteinModelPortaliQ03526.
    SMRiQ03526. Positions 5-623.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ03526.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 117114PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini177 – 23761SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini245 – 34399SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini368 – 620253Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The N-terminal PH domain allows ITK to be recruited to the plasma membrane by an activated PI3 kinase. This domain contains also a proline-rich region (PRR). The adjoining domain is a SH3 domain, which binds to PRR (from itself or from other proteins). Next, a SH2 domain is required for binding tyrosine-phosphorylated substrates. In the C-terminal region, the kinase domain is required for tyrosine phosphorylation By similarity.By similarity

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.PROSITE-ProRule annotation
    Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri119 – 15537Btk-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    SH2 domain, SH3 domain, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00640000091251.
    HOGENOMiHOG000233859.
    HOVERGENiHBG008761.
    InParanoidiQ03526.
    KOiK07363.
    OMAiRRNEEYC.
    PhylomeDBiQ03526.
    TreeFamiTF351634.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view]
    PfamiPF00779. BTK. 1 hit.
    PF00169. PH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00402. TECBTKDOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03526-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT    50
    LKGSIELSRI KCVEIVKSDI SIPCHYKYPF QTLVYLQVVH DNYLLYVFAP 100
    DCESRQRWVL TLKEETRNNN SLVSKYHPNF WMDGRWRCCS QLEKPAVGCA 150
    PYDPSKNASK KPLPPTPEDN RRSFQEPEET LVIALYDYQT NDPQELALRC 200
    DEEYYLLDSS EIHWWRVQDK NGHEGYAPSS YLVEKSPNNL ETYEWYNKSI 250
    SRDKAEKLLL DTGKEGAFMV RDSRTPGTYT VSVFTKAIIS ENPCIKHYHI 300
    KETNDSPKRY YVAEKYVFDS IPLLIQYHQY NGGGLVTRLR YPVCSWRQKA 350
    PVTAGLRYGK WVIQPSELTF VQEIGSGQFG LVHLGYWLNK DKVAIKTIQE 400
    GAMSEEDFIE EAEVMMKLSH PKLVQLYGVC LEQAPICLVF EFMEHGCLSD 450
    YLRSQRGLFA AETLLGMCLD VCEGMAYLEK ACVIHRDLAA RNCLVGENQV 500
    IKVSDFGMTR FVLDDQYTSS TGTKFPVKWA SPEVFSFSRY SSKSDVWSFG 550
    VLMWEVFSEG KIPYENRSNS EVVEDISTGF RLYKPRLASC HVYQIMNHCW 600
    KEKPEDRPPF SQLLSQLAEI AEAGL 625
    Length:625
    Mass (Da):72,292
    Last modified:February 1, 1995 - v1
    Checksum:iF7A4A18A8A1AADDC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 876Missing(PubMed:8421704)Curated
    Sequence conflicti82 – 876Missing(PubMed:8476425)Curated
    Sequence conflicti82 – 876Missing1 PublicationCurated
    Sequence conflicti535 – 5351F → S in L10628. (PubMed:8476425)Curated
    Sequence conflicti540 – 5401Y → C in L10628. (PubMed:8476425)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00619 mRNA. Translation: AAA39337.1.
    L05631 mRNA. Translation: AAA40518.1.
    L10628 mRNA. No translation available.
    D14042 mRNA. Translation: BAA03129.1.
    CCDSiCCDS70169.1.
    PIRiA43030.
    RefSeqiNP_001268894.1. NM_001281965.1.
    NP_001268895.1. NM_001281966.1.
    NP_001268897.1. NM_001281968.1.
    NP_034713.2. NM_010583.3.
    UniGeneiMm.339927.

    Genome annotation databases

    EnsembliENSMUST00000109237; ENSMUSP00000104860; ENSMUSG00000020395.
    GeneIDi16428.
    KEGGimmu:16428.
    UCSCiuc011xtn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00619 mRNA. Translation: AAA39337.1 .
    L05631 mRNA. Translation: AAA40518.1 .
    L10628 mRNA. No translation available.
    D14042 mRNA. Translation: BAA03129.1 .
    CCDSi CCDS70169.1.
    PIRi A43030.
    RefSeqi NP_001268894.1. NM_001281965.1.
    NP_001268895.1. NM_001281966.1.
    NP_001268897.1. NM_001281968.1.
    NP_034713.2. NM_010583.3.
    UniGenei Mm.339927.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AWJ NMR - A 160-236 [» ]
    1LUI NMR - A 238-344 [» ]
    1LUK NMR - A 238-344 [» ]
    1LUM NMR - A 238-344 [» ]
    1LUN NMR - A 238-344 [» ]
    2ETZ NMR - A 238-344 [» ]
    2EU0 NMR - A 238-344 [» ]
    2K79 NMR - A 177-237 [» ]
    B 238-344 [» ]
    2K7A NMR - A 177-237 [» ]
    B 238-344 [» ]
    2RN8 NMR - A 177-238 [» ]
    2RNA NMR - A 177-238 [» ]
    3S9K X-ray 2.35 A 236-344 [» ]
    ProteinModelPortali Q03526.
    SMRi Q03526. Positions 5-623.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200840. 5 interactions.
    DIPi DIP-29283N.
    IntActi Q03526. 4 interactions.
    MINTi MINT-84965.

    PTM databases

    PhosphoSitei Q03526.

    Proteomic databases

    PRIDEi Q03526.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109237 ; ENSMUSP00000104860 ; ENSMUSG00000020395 .
    GeneIDi 16428.
    KEGGi mmu:16428.
    UCSCi uc011xtn.1. mouse.

    Organism-specific databases

    CTDi 3702.
    MGIi MGI:96621. Itk.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00640000091251.
    HOGENOMi HOG000233859.
    HOVERGENi HBG008761.
    InParanoidi Q03526.
    KOi K07363.
    OMAi RRNEEYC.
    PhylomeDBi Q03526.
    TreeFami TF351634.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 3474.
    Reactomei REACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_225768. Generation of second messenger molecules.

    Miscellaneous databases

    EvolutionaryTracei Q03526.
    NextBioi 289653.
    PROi Q03526.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03526.
    Bgeei Q03526.
    CleanExi MM_ITK.
    Genevestigatori Q03526.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view ]
    Pfami PF00779. BTK. 1 hit.
    PF00169. PH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00402. TECBTKDOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2."
      Siliciano J.D., Morrow T.A., Desiderio S.V.
      Proc. Natl. Acad. Sci. U.S.A. 89:11194-11198(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymocyte.
    2. "Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk."
      Heyeck S.D., Berg L.J.
      Proc. Natl. Acad. Sci. U.S.A. 90:669-673(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymocyte.
    3. "Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells."
      Yamada N., Kawakami Y., Kimura H., Fukamachi H., Baier G., Altman A., Kato T., Inagaki Y., Kawakami T.
      Biochem. Biophys. Res. Commun. 192:231-240(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CBA/J.
      Tissue: Mast cell.
    4. Ogata M., Sawada M., Fujiwara H., Hamaoka T.
      Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk."
      Liao X.C., Littman D.R.
      Immunity 3:757-769(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    6. "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling."
      Fu G., Vallee S., Rybakin V., McGuire M.V., Ampudia J., Brockmeyer C., Salek M., Fallen P.R., Hoerter J.A.H., Munshi A., Huang Y.H., Hu J., Fox H.S., Sauer K., Acuto O., Gascoigne N.R.J.
      Nat. Immunol. 10:848-856(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH THEMIS.
    7. "Regulatory intramolecular association in a tyrosine kinase of the Tec family."
      Andreotti A.H., Bunnell S.C., Feng S., Berg L.J., Schreiber S.L.
      Nature 385:93-97(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 160-236.
    8. "CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line."
      August A., Gibson S., Kawakami Y., Kawakami T., Mills G.B., Dupont B.
      Proc. Natl. Acad. Sci. U.S.A. 91:9347-9351(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    9. "CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK."
      King P.D., Sadra A., Han A., Liu X.-R., Sunder-Plassmann R., Reinherz E.L., Dupont B.
      Int. Immunol. 8:1707-1714(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    10. "Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain."
      Ching K.A., Kawakami Y., Kawakami T., Tsoukas C.D.
      J. Immunol. 163:6006-6013(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    11. "Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity."
      Schaeffer E.M., Debnath J., Yap G., McVicar D., Liao X.C., Littman D.R., Sher A., Varmus H.E., Lenardo M.J., Schwartzberg P.L.
      Science 284:638-641(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    12. "Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk."
      Broussard C., Fleischacker C., Horai R., Chetana M., Venegas A.M., Sharp L.L., Hedrick S.M., Fowlkes B.J., Schwartzberg P.L.
      Immunity 25:93-104(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    13. "Disrupting the intermolecular self-association of Itk enhances T cell signaling."
      Min L., Wu W., Joseph R.E., Fulton D.B., Berg L., Andreotti A.H.
      J. Immunol. 184:4228-4235(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    14. "Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell."
      Qi Q., Xia M., Bai Y., Yu S., Cantorna M., August A.
      J. Biol. Chem. 286:138-146(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INVARIANT NKT CELL MATURATION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiITK_MOUSE
    AccessioniPrimary (citable) accession number: Q03526
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 154 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3