##gff-version 3 Q03519 UniProtKB Chain 1 686 . . . ID=PRO_0000093329;Note=Antigen peptide transporter 2 Q03519 UniProtKB Topological domain 1 6 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Transmembrane 7 27 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Topological domain 28 56 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Transmembrane 57 77 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Topological domain 78 98 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Transmembrane 99 119 . . . Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Topological domain 120 148 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Transmembrane 149 169 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Topological domain 170 187 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Transmembrane 188 208 . . . Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Topological domain 209 266 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Transmembrane 267 287 . . . Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Topological domain 288 293 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Transmembrane 294 314 . . . Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Topological domain 315 374 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Transmembrane 375 395 . . . Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Topological domain 396 408 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Transmembrane 409 429 . . . Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Topological domain 430 686 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q03519 UniProtKB Domain 152 435 . . . Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 Q03519 UniProtKB Domain 468 686 . . . Note=ABC transporter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Q03519 UniProtKB Region 301 389 . . . Note=Part of the peptide-binding site;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8955196;Dbxref=PMID:8955196 Q03519 UniProtKB Region 414 433 . . . Note=Part of the peptide-binding site;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8955196;Dbxref=PMID:8955196 Q03519 UniProtKB Binding site 503 510 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 Q03519 UniProtKB Site 16 16 . . . Note=Inter-subunit salt bridge with TAPBP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26611325;Dbxref=PMID:26611325 Q03519 UniProtKB Alternative sequence 645 686 . . . ID=VSP_038904;Note=In isoform 2. LQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL->KTLWKFMIF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9916708;Dbxref=PMID:9916708 Q03519 UniProtKB Natural variant 56 56 . . . ID=VAR_036873;Note=R->K;Dbxref=dbSNP:rs17220192 Q03519 UniProtKB Natural variant 374 374 . . . ID=VAR_014997;Note=In allele TAP2*01F%2C allele TAP2*01G%2C allele TAP2*01H%2C allele TAP2*02B and allele TAP2*02D. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11294565,ECO:0000269|PubMed:9672156;Dbxref=dbSNP:rs111303994,PMID:11294565,PMID:9672156 Q03519 UniProtKB Natural variant 379 379 . . . ID=VAR_000094;Note=In allele TAP2*01D%2C allele TAP2*01E%2C allele TAP2*01G%2C allele TAP2*02C and allele TAP2*02F. V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11294565,ECO:0000269|PubMed:1570316,ECO:0000269|PubMed:9916708;Dbxref=dbSNP:rs1800454,PMID:11294565,PMID:1570316,PMID:9916708 Q03519 UniProtKB Natural variant 467 467 . . . ID=VAR_014998;Note=In allele TAP2*01F and allele TAP2*02D. V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11294565,ECO:0000269|PubMed:9672156;Dbxref=dbSNP:rs150253319,PMID:11294565,PMID:9672156 Q03519 UniProtKB Natural variant 513 513 . . . ID=VAR_014999;Note=A->S Q03519 UniProtKB Natural variant 565 565 . . . ID=VAR_000095;Note=In allele TAP2*01:02%2C allele TAP2*01D%2C allele TAP2*02E and allele TAP2*02F. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11294565;Dbxref=dbSNP:rs2228396,PMID:11294565 Q03519 UniProtKB Natural variant 577 577 . . . ID=VAR_015000;Note=In allele TAP2*BKY2. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9324024;Dbxref=dbSNP:rs2228391,PMID:9324024 Q03519 UniProtKB Natural variant 651 651 . . . ID=VAR_000096;Note=In allele TAP2*01:03 and allele TAP2*01G. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11294565;Dbxref=dbSNP:rs4148876,PMID:11294565 Q03519 UniProtKB Natural variant 665 665 . . . ID=VAR_000097;Note=In allele TAP2*02:01%2C allele TAP2*02B%2C allele TAP2*02C%2C allele TAP2*02D%2C allele TAP2*02E%2C allele TAP2*02F%2C allele TAP2*04A and allele TAP2*Bky2. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11294565,ECO:0000269|PubMed:1570316;Dbxref=dbSNP:rs241447,PMID:11294565,PMID:1570316 Q03519 UniProtKB Natural variant 686 686 . . . ID=VAR_000098;Note=In allele TAP2*02:01%2C allele TAP2*02B%2C allele TAP2*02C%2C allele TAP2*02D%2C allele TAP2*02E%2C allele TAP2*02F%2C allele TAP2*03A and allele TAP2*BKY2. L->LQEGQDLYSRLVQQRLMD Q03519 UniProtKB Mutagenesis 16 16 . . . Note=Complete loss of interaction with TAPBP%2C resulting in impaired PLC assembly and antigen presentation. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26611325;Dbxref=PMID:26611325 Q03519 UniProtKB Mutagenesis 638 638 . . . Note=Inactive in peptide transport when associated with 'A-734' of TAP1. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25377891;Dbxref=PMID:25377891 Q03519 UniProtKB Sequence conflict 345 345 . . . Note=F->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q03519 UniProtKB Sequence conflict 520 520 . . . Note=Y->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q03519 UniProtKB Sequence conflict 655 655 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305