Q03519 (TAP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Antigen peptide transporter 2
Short name=APT2

Alternative name(s):
ATP-binding cassette sub-family B member 3
Peptide supply factor 2
Peptide transporter PSF2
Short name=PSF-2
Peptide transporter TAP2
Peptide transporter involved in antigen processing 2
Really interesting new gene 11 protein

Gene names

Name:	TAP2
Synonyms:	ABCB3, PSF2, RING11, Y1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	686 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Subunit structure	Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a. Ref.20
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: The transmembrane segments seem to form a pore in the membrane.
Induction	By IFNG/IFN-gamma.
Domain	The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.
Polymorphism	4 common alleles are officially recognized: TAP2*01:01 (TAP2A or PSF2A or RING11A), TAP2*01:02 (TAP2E), TAP2*01:03 (TAP2F), and TAP2*02:01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have been identified: TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02:02), TAP2*02D, TAP2*02E, TAP2*02F, TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01:01. The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with susceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva, cornea and mouth due to exocrine glands dysfunction.
Involvement in disease	Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Adaptive immunity Host-virus interaction Immunity Peptide transport Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Inferred from Biological aspect of Ancestor. Source: RefGenome antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent Inferred from mutant phenotype PubMed 1538751. Source: UniProtKB antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Inferred from Biological aspect of Ancestor. Source: RefGenome cytosol to ER transport Inferred from mutant phenotype PubMed 7538543. Source: UniProtKB intracellular transport of viral proteins in host cell Inferred from mutant phenotype PubMed 7538543. Source: UniProtKB peptide antigen transport Inferred from direct assay PubMed 8496691. Source: UniProtKB positive regulation of T cell mediated cytotoxicity Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of antigen processing and presentation of peptide antigen via MHC class I Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	TAP complex Inferred from direct assay PubMed 15518576PubMed 17947644. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	ATP binding Inferred from direct assay PubMed 7673167. Source: UniProtKB MHC class I protein binding Inferred from Biological aspect of Ancestor. Source: RefGenome TAP1 binding Inferred from Biological aspect of Ancestor. Source: RefGenome TAP2 binding Inferred from Biological aspect of Ancestor. Source: RefGenome oligopeptide-transporting ATPase activity Inferred from Biological aspect of Ancestor. Source: RefGenome peptide antigen binding Inferred from Biological aspect of Ancestor. Source: RefGenome peptide antigen-transporting ATPase activity Inferred from mutant phenotype PubMed 1538751. Source: UniProtKB tapasin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TAP1	Q03518	6	EBI-780781,EBI-747259
TAPBP	O15533	3	EBI-780781,EBI-874801

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q03519-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q03519-2)

The sequence of this isoform differs from the canonical sequence as follows:
     645-686: LQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL → KTLWKFMIF

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 686	686	Antigen peptide transporter 2		PRO_0000093329
Regions
	Topological domain	1 – 6	6	Lumenal Potential
	Transmembrane	7 – 27	21	Helical; Name=1; Potential
	Topological domain	28 – 56	29	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 98	21	Lumenal Potential
	Transmembrane	99 – 119	21	Helical; Name=3; Potential
	Topological domain	120 – 148	29	Cytoplasmic Potential
	Transmembrane	149 – 169	21	Helical; Name=4; Potential
	Topological domain	170 – 187	18	Lumenal Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 266	58	Cytoplasmic Potential
	Transmembrane	267 – 287	21	Helical; Name=6; Potential
	Topological domain	288 – 293	6	Lumenal Potential
	Transmembrane	294 – 314	21	Helical; Name=7; Potential
	Topological domain	315 – 374	60	Cytoplasmic Potential
	Transmembrane	375 – 395	21	Helical; Name=8; Potential
	Topological domain	396 – 408	13	Lumenal Potential
	Transmembrane	409 – 429	21	Helical; Name=9; Potential
	Topological domain	430 – 686	257	Cytoplasmic Potential
	Domain	152 – 435	284	ABC transmembrane type-1
	Domain	468 – 686	219	ABC transporter
	Nucleotide binding	503 – 510	8	ATP Potential
	Region	301 – 389	89	Involved in peptide-binding site
	Region	414 – 433	20	Involved in peptide-binding site
Natural variations
	Alternative sequence	645 – 686	42	LQDWN…KLAQL → KTLWKFMIF in isoform 2.		VSP_038904
	Natural variant	56	1	R → K. Corresponds to variant rs17220192 [ dbSNP | Ensembl ].		VAR_036873
	Natural variant	374	1	A → T in allele TAP2*01F, allele TAP2*01G, allele TAP2*01H, allele TAP2*02B and allele TAP2*02D. Ref.12 Ref.24		VAR_014997
	Natural variant	379	1	V → I in allele TAP2*01D, allele TAP2*01E, allele TAP2*01G, allele TAP2*02C and allele TAP2*02F. Ref.6 Ref.22 Ref.24 Corresponds to variant rs1800454 [ dbSNP | Ensembl ].		VAR_000094
	Natural variant	467	1	V → I in allele TAP2*01F and allele TAP2*02D. Ref.12 Ref.24		VAR_014998
	Natural variant	513	1	A → S Rare polymorphism. Ref.24		VAR_014999
	Natural variant	565	1	A → T in allele TAP2*01:02, allele TAP2*01D, allele TAP2*02E and allele TAP2*02F. Ref.24 Corresponds to variant rs2228396 [ dbSNP | Ensembl ].		VAR_000095
	Natural variant	577	1	M → V in allele TAP2*BKY2. Ref.5 Corresponds to variant rs2228391 [ dbSNP | Ensembl ].		VAR_015000
	Natural variant	651	1	R → C in allele TAP2*01:03 and allele TAP2*01G. Ref.24 Corresponds to variant rs4148876 [ dbSNP | Ensembl ].		VAR_000096
	Natural variant	665	1	T → A in allele TAP2*02:01, allele TAP2*02B, allele TAP2*02C, allele TAP2*02D, allele TAP2*02E, allele TAP2*02F, allele TAP2*04A and allele TAP2*Bky2. Ref.22 Ref.24 Corresponds to variant rs241447 [ dbSNP | Ensembl ].		VAR_000097
	Natural variant	686	1	L → LQEGQDLYSRLVQQRLMD in allele TAP2*02:01, allele TAP2*02B, allele TAP2*02C, allele TAP2*02D, allele TAP2*02E, allele TAP2*02F, allele TAP2*03A and allele TAP2*BKY2.		VAR_000098
Experimental info
	Sequence conflict	345	1	F → I in BAD97020. Ref.8
	Sequence conflict	520	1	Y → N in BAD97020. Ref.8
	Sequence conflict	655	1	T → A in BAD97020. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: E7E4A7F6A2A3B48B	FASTA	686	75,664
	10 20 30 40 50 60 MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 70 80 90 100 110 120 FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 130 140 150 160 170 180 PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 190 200 210 220 230 240 GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 250 260 270 280 290 300 FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 310 320 330 340 350 360 PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 370 380 390 400 410 420 QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 430 440 450 460 470 480 SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 490 500 510 520 530 540 PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 550 560 570 580 590 600 YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 610 620 630 640 650 660 GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS RGDRTVLVIA 670 680 HRLQTVQRAH QILVLQEGKL QKLAQL
	Isoform 2 [UniParc]. Checksum: AA79C3E9C6FE31AB	FASTA	653	72,003
	10 20 30 40 50 60 MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 70 80 90 100 110 120 FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 130 140 150 160 170 180 PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 190 200 210 220 230 240 GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 250 260 270 280 290 300 FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 310 320 330 340 350 360 PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 370 380 390 400 410 420 QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 430 440 450 460 470 480 SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 490 500 510 520 530 540 PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 550 560 570 580 590 600 YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 610 620 630 640 650 GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQAKTLWKF MIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing." Beck S., Kelly A., Radley E., Khurshid F., Alderton R.P., Trowsdale J. J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE TAP2*01:01) (ISOFORM 1).
[2]	"Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex." Powis S.H., Mockridge I., Kelly A., Kerr L.-A., Glynne R.J., Gileadi U., Beck S., Trowsdale J. Proc. Natl. Acad. Sci. U.S.A. 89:1463-1467(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*01:01/TAP2*02:01) (ISOFORM 1).
[3]	"Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region." Bahram S., Arnold D., Bresnahan M., Strominger J.L., Spies T. Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*02:01) (ISOFORM 1).
[4]	"Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2." Powis S.H., Tonks S., Mockridge I., Kelly A.P., Bodmer J.G., Trowsdale J. Immunogenetics 37:373-380(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*01:02) (ISOFORM 1).
[5]	"Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome." Kumagai S., Kanagawa S., Morinobu A., Takada M., Nakamura K., Sugai S., Maruya E., Saji H. Arthritis Rheum. 40:1685-1692(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*BKY2) (ISOFORM 1), VARIANT TAP2*BKY2 VAL-577. Tissue: Blood.
[6]	"Novel splicing of the human MHC-encoded peptide transporter confers unique properties." Yan G., Shi L., Faustman D. J. Immunol. 162:852-859(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-379. Tissue: Spleen.
[7]	"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC." Beck S., Abdulla S., Alderton R.P., Glynne R.J., Gut I.G., Hosking L.K., Jackson A., Kelly A., Newell W.R., Sanseau P., Radley E., Thorpe K.L., Trowsdale J. J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE TAP2*01:01) (ISOFORM 1).
[8]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE TAP2*BKY2) (ISOFORM 1). Tissue: Liver and Synovium.
[9]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES TAP2*03A AND TAP2*BKY2).
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[11]	"Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain." Cano P., Baxter-Lowe L.A. Tissue Antigens 45:139-142(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-686 (ALLELE TAP2*01:03) (ISOFORM 1). Tissue: Blood.
[12]	"New TAP2 polymorphisms in Africans." Tang J., Allen S., Karita E., Musonda R., Kaslow R.A. Tissue Antigens 51:556-562(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-686 (ISOFORM 1), VARIANTS THR-374 AND ILE-467.
[13]	Singal D.P., Ye M., D'Souza M. Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 517-645 (ALLELE TAP2*01:01/TAP2*01:02) (ISOFORM 1).
[14]	"Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis." Singal D.P., Ye M., Qiu X., D'Souza M. Clin. Exp. Rheumatol. 12:29-33(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 517-645 (ALLELE TAP2*01:01/TAP2*01:02) (ISOFORM 1).
[15]	"Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site." Nijenhuis M., Hammerling G.J. J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PEPTIDE-BINDING SITE.
[16]	"Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47." Ahn K., Meyer T.H., Uebel S., Sempe P., Djaballah H., Yang Y., Peterson P.A., Frueh K., Tampe R. EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract] Cited for: INHIBITION BY ICP47.
[17]	"The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP." Ahn K., Gruhler A., Galocha B., Jones T.R., Wiertz E.J.H.J., Ploegh H.L., Peterson P.A., Yang Y., Frueh K. Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract] Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[18]	"The human cytomegalovirus gene product US6 inhibits ATP binding by TAP." Hewitt E.W., Gupta S.S., Lehner P.J. EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[19]	"Adenovirus E19 has two mechanisms for affecting class I MHC expression." Bennett E.M., Bennink J.R., Yewdell J.W., Brodsky F.M. J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INHIBITION BY E3-19K GLYCOPROTEIN.
[20]	"Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation." Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E. J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EBV BNLF2A.
[21]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[22]	"Allelic variants of the human putative peptide transporter involved in antigen processing." Colonna M., Bresnahan M., Bahram S., Strominger J.L., Spies T. Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ILE-379 AND ALA-665.
[23]	"Homozygous human TAP peptide transporter mutation in HLA class I deficiency." de la Salle H., Hanau D., Fricker D., Urlacher A., Kelly A., Salamero J., Powis S.H., Donato L., Bausinger H., Laforet M., Jeras M., Spehner D., Bieber T., Falkenrodt A., Cazenave J.-P., Trowsdale J., Tongio M.-M. Science 265:237-241(1994) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN BLS1.
[24]	"Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans." Tang J., Freedman D.O., Allen S., Karita E., Musonda R., Braga C., Jamieson B.D., Louie L., Kaslow R.A. Genes Immun. 2:32-40(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS THR-374; ILE-379; ILE-467; SER-513 THR-565; CYS-651; ALA-665 AND GLN-GLU-GLY-GLN-ASP-LEU-TYR-SER-ARG-LEU-VAL-GLN-GLN-ARG-LEU-MET-ASP-686 INS, DEFINITION OF ALLELES.
+	Additional computationally mapped references.

Web resources

TAP2base

TAP2 mutation db

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases
EMBL GenBank DDBJ	X66401 Genomic DNA. Translation: CAA47027.1. M84748 mRNA. No translation available. M74447 mRNA. Translation: AAA59841.1. Z22935 mRNA. Translation: CAA80522.1. Z22936 mRNA. Translation: CAA80523.1. AB073779 mRNA. Translation: BAB71769.1. AF105151 mRNA. Translation: AAD12059.1. X87344 Genomic DNA. Translation: CAA60788.1. AK222823 mRNA. Translation: BAD96543.1. AK223300 mRNA. Translation: BAD97020.1. BX296564 Genomic DNA. No translation available. CR788227 Genomic DNA. No translation available. BX682530 Genomic DNA. Translation: CAI41935.1. CR762476 Genomic DNA. Translation: CAQ08491.1. CR753889 Genomic DNA. Translation: CAQ10283.1. CT009502 Genomic DNA. Translation: CAQ07778.1. BC002751 mRNA. No translation available. U07844 mRNA. Translation: AAA79901.1. AH007554 Genomic DNA. Translation: AAD23381.1. L09191 mRNA. Translation: AAA58648.1. L10287 mRNA. Translation: AAA58649.1.
IPI	IPI00001382. IPI00328112. IPI00892682.
PIR	B41538.
RefSeq	NP_000535.3. NM_000544.3. NP_061313.2. NM_018833.2.
UniGene	Hs.502.
3D structure databases
ProteinModelPortal	Q03519.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-322N.
IntAct	Q03519. 6 interactions.
MINT	MINT-2838244.
STRING	9606.ENSP00000372726.
Protein family/group databases
TCDB	3.A.1.209.1. ATP-binding cassette (ABC) superfamily.
PTM databases
PhosphoSite	Q03519.
Polymorphism databases
DMDM	549044.
Proteomic databases
PaxDb	Q03519.
PRIDE	Q03519.
Protocols and materials databases
DNASU	6891.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374897; ENSP00000364032; ENSG00000204267. ENST00000374899; ENSP00000364034; ENSG00000204267. ENST00000383118; ENSP00000372599; ENSG00000206235. ENST00000383119; ENSP00000372600; ENSG00000206235. ENST00000383239; ENSP00000372726; ENSG00000206299. ENST00000383240; ENSP00000372727; ENSG00000206299. ENST00000414145; ENSP00000401377; ENSG00000228582. ENST00000419142; ENSP00000390013; ENSG00000237599. ENST00000426977; ENSP00000387553; ENSG00000232326. ENST00000439425; ENSP00000396156; ENSG00000225967. ENST00000443713; ENSP00000394101; ENSG00000228582. ENST00000451907; ENSP00000392172; ENSG00000223481. ENST00000452371; ENSP00000406540; ENSG00000223481. ENST00000455842; ENSP00000393580; ENSG00000225967. ENST00000457634; ENSP00000416471; ENSG00000232326.
GeneID	6891.
KEGG	hsa:6891.
UCSC	uc003occ.3. human.
Organism-specific databases
CTD	6891.
GeneCards	GC06M032789.
H-InvDB	HIX0005757. HIX0166631. HIX0166883. HIX0167147.
HGNC	HGNC:44. TAP2.
HPA	HPA001312.
MIM	170261. gene. 604571. phenotype.
neXtProt	NX_Q03519.
Orphanet	34592. Immunodeficiency by defective expression of HLA class 1. 572. Immunodeficiency by defective expression of HLA class 2.
PharmGKB	PA35022.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1132.
HOVERGEN	HBG008358.
InParanoid	Q03519.
KO	K05654.
OrthoDB	EOG4KD6M6.
PhylomeDB	Q03519.
Enzyme and pathway databases
BRENDA	3.6.3.43. 2681.
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q03519.
Bgee	Q03519.
CleanEx	HS_TAP2.
Genevestigator	Q03519.
GermOnline	ENSG00000204267. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR013306. ABC_B3. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR005293. Ag_transporter2. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
PRINTS	PR01897. TAP2PROTEIN.
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
TIGRFAMs	TIGR00958. 3a01208. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6891.
NextBio	26929.
SOURCE	Search...

Entry information

Entry name

TAP2_HUMAN

Accession

Primary (citable) accession number: Q03519
Secondary accession number(s): B0V2J8 , O95410, Q53FI6, Q5HY71, Q96PT8, Q9UQ83

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 147 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.