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Q03519

- TAP2_HUMAN

UniProt

Q03519 - TAP2_HUMAN

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Protein

Antigen peptide transporter 2

Gene
TAP2, ABCB3, PSF2, RING11, Y1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi503 – 5108ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. MHC class Ib protein binding Source: UniProt
  3. peptide antigen-transporting ATPase activity Source: UniProtKB
  4. protein binding Source: IntAct
  5. TAP1 binding Source: UniProtKB
  6. tapasin binding Source: UniProtKB
  7. transporter activity Source: MGI

GO - Biological processi

  1. antigen processing and presentation of endogenous peptide antigen via MHC class I Source: UniProtKB
  2. antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent Source: UniProtKB
  3. antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: RefGenome
  4. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  5. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  6. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: RefGenome
  7. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  8. cytosol to ER transport Source: UniProtKB
  9. intracellular transport of viral protein in host cell Source: UniProtKB
  10. peptide antigen transport Source: UniProtKB
  11. positive regulation of antigen processing and presentation of peptide antigen via MHC class I Source: RefGenome
  12. transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Host-virus interaction, Immunity, Peptide transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.43. 2681.
ReactomeiREACT_111178. ER-Phagosome pathway.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Protein family/group databases

TCDBi3.A.1.209.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen peptide transporter 2
Short name:
APT2
Alternative name(s):
ATP-binding cassette sub-family B member 3
Peptide supply factor 2
Peptide transporter PSF2
Short name:
PSF-2
Peptide transporter TAP2
Peptide transporter involved in antigen processing 2
Really interesting new gene 11 protein
Gene namesi
Name:TAP2
Synonyms:ABCB3, PSF2, RING11, Y1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:44. TAP2.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein
Note: The transmembrane segments seem to form a pore in the membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Lumenal Reviewed prediction
Transmembranei7 – 2721Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini28 – 5629Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei57 – 7721Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini78 – 9821Lumenal Reviewed predictionAdd
BLAST
Transmembranei99 – 11921Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini120 – 14829Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei149 – 16921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini170 – 18718Lumenal Reviewed predictionAdd
BLAST
Transmembranei188 – 20821Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini209 – 26658Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei267 – 28721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini288 – 2936Lumenal Reviewed prediction
Transmembranei294 – 31421Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini315 – 37460Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei375 – 39521Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini396 – 40813Lumenal Reviewed predictionAdd
BLAST
Transmembranei409 – 42921Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini430 – 686257Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. integral component of endoplasmic reticulum membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB
  4. TAP complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi604571. phenotype.
Orphaneti34592. Immunodeficiency by defective expression of HLA class 1.
PharmGKBiPA35022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Antigen peptide transporter 2PRO_0000093329Add
BLAST

Proteomic databases

MaxQBiQ03519.
PaxDbiQ03519.
PRIDEiQ03519.

PTM databases

PhosphoSiteiQ03519.

Expressioni

Inductioni

By IFNG/IFN-gamma.

Gene expression databases

ArrayExpressiQ03519.
BgeeiQ03519.
CleanExiHS_TAP2.
GenevestigatoriQ03519.

Organism-specific databases

HPAiHPA001312.

Interactioni

Subunit structurei

Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BNLF2aP0C7396EBI-780781,EBI-9346744From a different organism.
TAP1Q0351813EBI-780781,EBI-747259
TAPBPO155338EBI-780781,EBI-874801

Protein-protein interaction databases

BioGridi112754. 13 interactions.
DIPiDIP-322N.
IntActiQ03519. 7 interactions.
MINTiMINT-2838244.
STRINGi9606.ENSP00000372726.

Structurei

3D structure databases

ProteinModelPortaliQ03519.
SMRiQ03519. Positions 140-685.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini152 – 435284ABC transmembrane type-1Add
BLAST
Domaini468 – 686219ABC transporterAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni301 – 38989Involved in peptide-binding siteAdd
BLAST
Regioni414 – 43320Involved in peptide-binding siteAdd
BLAST

Domaini

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
HOVERGENiHBG008358.
InParanoidiQ03519.
KOiK05654.
OMAiLINDIAM.
PhylomeDBiQ03519.
TreeFamiTF105197.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013306. ABC_B3.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005293. Ag_transporter2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSiPR01897. TAP2PROTEIN.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q03519-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW    50
GLLKLRGLLG FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS 100
WLLVGYGAAG LSWSLWAVLS PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP 150
LLVAAFFFLV LAVLGETLIP HYSGRVIDIL GGDFDPHAFA SAIFFMCLFS 200
FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF FQETKTGELN 250
SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 300
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH 350
EVCRYKEALE QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ 400
DGELTQGSLL SFMIYQESVG SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ 450
PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR PDRPVLKGLT FTLRPGEVTA 500
LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC YLHSQVVSVG 550
QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 600
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS 650
RGDRTVLVIA HRLQTVQRAH QILVLQEGKL QKLAQL 686
Length:686
Mass (Da):75,664
Last modified:June 1, 1994 - v1
Checksum:iE7E4A7F6A2A3B48B
GO
Isoform 2 (identifier: Q03519-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     645-686: LQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL → KTLWKFMIF

Show »
Length:653
Mass (Da):72,003
Checksum:iAA79C3E9C6FE31AB
GO

Polymorphismi

4 common alleles are officially recognized: TAP2*01:01 (TAP2A or PSF2A or RING11A), TAP2*01:02 (TAP2E), TAP2*01:03 (TAP2F), and TAP2*02:01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have been identified: TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02:02), TAP2*02D, TAP2*02E, TAP2*02F, TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01:01.
The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with susceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva, cornea and mouth due to exocrine glands dysfunction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561R → K.
Corresponds to variant rs17220192 [ dbSNP | Ensembl ].
VAR_036873
Natural varianti374 – 3741A → T in allele TAP2*01F, allele TAP2*01G, allele TAP2*01H, allele TAP2*02B and allele TAP2*02D. 2 Publications
Corresponds to variant rs111303994 [ dbSNP | Ensembl ].
VAR_014997
Natural varianti379 – 3791V → I in allele TAP2*01D, allele TAP2*01E, allele TAP2*01G, allele TAP2*02C and allele TAP2*02F. 3 Publications
Corresponds to variant rs1800454 [ dbSNP | Ensembl ].
VAR_000094
Natural varianti467 – 4671V → I in allele TAP2*01F and allele TAP2*02D. 2 Publications
Corresponds to variant rs150253319 [ dbSNP | Ensembl ].
VAR_014998
Natural varianti513 – 5131A → S Rare polymorphism. 1 Publication
VAR_014999
Natural varianti565 – 5651A → T in allele TAP2*01:02, allele TAP2*01D, allele TAP2*02E and allele TAP2*02F. 1 Publication
Corresponds to variant rs2228396 [ dbSNP | Ensembl ].
VAR_000095
Natural varianti577 – 5771M → V in allele TAP2*BKY2. 1 Publication
Corresponds to variant rs2228391 [ dbSNP | Ensembl ].
VAR_015000
Natural varianti651 – 6511R → C in allele TAP2*01:03 and allele TAP2*01G. 1 Publication
Corresponds to variant rs4148876 [ dbSNP | Ensembl ].
VAR_000096
Natural varianti665 – 6651T → A in allele TAP2*02:01, allele TAP2*02B, allele TAP2*02C, allele TAP2*02D, allele TAP2*02E, allele TAP2*02F, allele TAP2*04A and allele TAP2*Bky2. 2 Publications
Corresponds to variant rs241447 [ dbSNP | Ensembl ].
VAR_000097
Natural varianti686 – 6861L → LQEGQDLYSRLVQQRLMD in allele TAP2*02:01, allele TAP2*02B, allele TAP2*02C, allele TAP2*02D, allele TAP2*02E, allele TAP2*02F, allele TAP2*03A and allele TAP2*BKY2.
VAR_000098

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei645 – 68642LQDWN…KLAQL → KTLWKFMIF in isoform 2. VSP_038904Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti345 – 3451F → I in BAD97020. 1 Publication
Sequence conflicti520 – 5201Y → N in BAD97020. 1 Publication
Sequence conflicti655 – 6551T → A in BAD97020. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66401 Genomic DNA. Translation: CAA47027.1.
M84748 mRNA. No translation available.
M74447 mRNA. Translation: AAA59841.1.
Z22935 mRNA. Translation: CAA80522.1.
Z22936 mRNA. Translation: CAA80523.1.
AB073779 mRNA. Translation: BAB71769.1.
AF105151 mRNA. Translation: AAD12059.1.
X87344 Genomic DNA. Translation: CAA60788.1.
AK222823 mRNA. Translation: BAD96543.1.
AK223300 mRNA. Translation: BAD97020.1.
BX296564 Genomic DNA. No translation available.
CR788227 Genomic DNA. No translation available.
BX682530 Genomic DNA. Translation: CAI41935.1.
CR762476 Genomic DNA. Translation: CAQ08491.1.
CR753889 Genomic DNA. Translation: CAQ10283.1.
CT009502 Genomic DNA. Translation: CAQ07778.1.
BC002751 mRNA. No translation available.
U07844 mRNA. Translation: AAA79901.1.
AH007554 Genomic DNA. Translation: AAD23381.1.
L09191 mRNA. Translation: AAA58648.1.
L10287 mRNA. Translation: AAA58649.1.
CCDSiCCDS4755.1. [Q03519-2]
PIRiB41538.
RefSeqiNP_000535.3. NM_000544.3.
NP_001276972.1. NM_001290043.1. [Q03519-1]
NP_061313.2. NM_018833.2. [Q03519-2]
UniGeneiHs.502.

Genome annotation databases

EnsembliENST00000374897; ENSP00000364032; ENSG00000204267. [Q03519-1]
ENST00000374899; ENSP00000364034; ENSG00000204267. [Q03519-2]
ENST00000383118; ENSP00000372599; ENSG00000206235. [Q03519-1]
ENST00000383119; ENSP00000372600; ENSG00000206235. [Q03519-2]
ENST00000383239; ENSP00000372726; ENSG00000206299. [Q03519-1]
ENST00000383240; ENSP00000372727; ENSG00000206299. [Q03519-2]
ENST00000414145; ENSP00000401377; ENSG00000228582. [Q03519-2]
ENST00000419142; ENSP00000390013; ENSG00000237599.
ENST00000426977; ENSP00000387553; ENSG00000232326. [Q03519-2]
ENST00000439425; ENSP00000396156; ENSG00000225967. [Q03519-2]
ENST00000443713; ENSP00000394101; ENSG00000228582. [Q03519-1]
ENST00000451907; ENSP00000392172; ENSG00000223481. [Q03519-2]
ENST00000452371; ENSP00000406540; ENSG00000223481.
ENST00000455842; ENSP00000393580; ENSG00000225967.
ENST00000457634; ENSP00000416471; ENSG00000232326.
GeneIDi6891.
KEGGihsa:6891.
UCSCiuc003occ.3. human. [Q03519-1]

Polymorphism databases

DMDMi549044.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

TAP2base

TAP2 mutation db

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66401 Genomic DNA. Translation: CAA47027.1 .
M84748 mRNA. No translation available.
M74447 mRNA. Translation: AAA59841.1 .
Z22935 mRNA. Translation: CAA80522.1 .
Z22936 mRNA. Translation: CAA80523.1 .
AB073779 mRNA. Translation: BAB71769.1 .
AF105151 mRNA. Translation: AAD12059.1 .
X87344 Genomic DNA. Translation: CAA60788.1 .
AK222823 mRNA. Translation: BAD96543.1 .
AK223300 mRNA. Translation: BAD97020.1 .
BX296564 Genomic DNA. No translation available.
CR788227 Genomic DNA. No translation available.
BX682530 Genomic DNA. Translation: CAI41935.1 .
CR762476 Genomic DNA. Translation: CAQ08491.1 .
CR753889 Genomic DNA. Translation: CAQ10283.1 .
CT009502 Genomic DNA. Translation: CAQ07778.1 .
BC002751 mRNA. No translation available.
U07844 mRNA. Translation: AAA79901.1 .
AH007554 Genomic DNA. Translation: AAD23381.1 .
L09191 mRNA. Translation: AAA58648.1 .
L10287 mRNA. Translation: AAA58649.1 .
CCDSi CCDS4755.1. [Q03519-2 ]
PIRi B41538.
RefSeqi NP_000535.3. NM_000544.3.
NP_001276972.1. NM_001290043.1. [Q03519-1 ]
NP_061313.2. NM_018833.2. [Q03519-2 ]
UniGenei Hs.502.

3D structure databases

ProteinModelPortali Q03519.
SMRi Q03519. Positions 140-685.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112754. 13 interactions.
DIPi DIP-322N.
IntActi Q03519. 7 interactions.
MINTi MINT-2838244.
STRINGi 9606.ENSP00000372726.

Protein family/group databases

TCDBi 3.A.1.209.1. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei Q03519.

Polymorphism databases

DMDMi 549044.

Proteomic databases

MaxQBi Q03519.
PaxDbi Q03519.
PRIDEi Q03519.

Protocols and materials databases

DNASUi 6891.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374897 ; ENSP00000364032 ; ENSG00000204267 . [Q03519-1 ]
ENST00000374899 ; ENSP00000364034 ; ENSG00000204267 . [Q03519-2 ]
ENST00000383118 ; ENSP00000372599 ; ENSG00000206235 . [Q03519-1 ]
ENST00000383119 ; ENSP00000372600 ; ENSG00000206235 . [Q03519-2 ]
ENST00000383239 ; ENSP00000372726 ; ENSG00000206299 . [Q03519-1 ]
ENST00000383240 ; ENSP00000372727 ; ENSG00000206299 . [Q03519-2 ]
ENST00000414145 ; ENSP00000401377 ; ENSG00000228582 . [Q03519-2 ]
ENST00000419142 ; ENSP00000390013 ; ENSG00000237599 .
ENST00000426977 ; ENSP00000387553 ; ENSG00000232326 . [Q03519-2 ]
ENST00000439425 ; ENSP00000396156 ; ENSG00000225967 . [Q03519-2 ]
ENST00000443713 ; ENSP00000394101 ; ENSG00000228582 . [Q03519-1 ]
ENST00000451907 ; ENSP00000392172 ; ENSG00000223481 . [Q03519-2 ]
ENST00000452371 ; ENSP00000406540 ; ENSG00000223481 .
ENST00000455842 ; ENSP00000393580 ; ENSG00000225967 .
ENST00000457634 ; ENSP00000416471 ; ENSG00000232326 .
GeneIDi 6891.
KEGGi hsa:6891.
UCSCi uc003occ.3. human. [Q03519-1 ]

Organism-specific databases

CTDi 6891.
GeneCardsi GC06M032789.
GC06Mi32773.
GC06Mj32703.
GC06Mk32767.
GC06Ml32943.
GC06Mm32815.
GC06Mn32718.
GC06Mo32879.
H-InvDB HIX0005757.
HIX0166631.
HIX0166883.
HIX0167147.
HGNCi HGNC:44. TAP2.
HPAi HPA001312.
MIMi 170261. gene.
604571. phenotype.
neXtProti NX_Q03519.
Orphaneti 34592. Immunodeficiency by defective expression of HLA class 1.
PharmGKBi PA35022.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
HOVERGENi HBG008358.
InParanoidi Q03519.
KOi K05654.
OMAi LINDIAM.
PhylomeDBi Q03519.
TreeFami TF105197.

Enzyme and pathway databases

BRENDAi 3.6.3.43. 2681.
Reactomei REACT_111178. ER-Phagosome pathway.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

GeneWikii TAP2.
GenomeRNAii 6891.
NextBioi 26929.
PROi Q03519.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q03519.
Bgeei Q03519.
CleanExi HS_TAP2.
Genevestigatori Q03519.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013306. ABC_B3.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005293. Ag_transporter2.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
PRINTSi PR01897. TAP2PROTEIN.
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsi TIGR00958. 3a01208. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
    Beck S., Kelly A., Radley E., Khurshid F., Alderton R.P., Trowsdale J.
    J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE TAP2*01:01) (ISOFORM 1).
  2. "Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex."
    Powis S.H., Mockridge I., Kelly A., Kerr L.-A., Glynne R.J., Gileadi U., Beck S., Trowsdale J.
    Proc. Natl. Acad. Sci. U.S.A. 89:1463-1467(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*01:01/TAP2*02:01) (ISOFORM 1).
  3. "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."
    Bahram S., Arnold D., Bresnahan M., Strominger J.L., Spies T.
    Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*02:01) (ISOFORM 1).
  4. "Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2."
    Powis S.H., Tonks S., Mockridge I., Kelly A.P., Bodmer J.G., Trowsdale J.
    Immunogenetics 37:373-380(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*01:02) (ISOFORM 1).
  5. "Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome."
    Kumagai S., Kanagawa S., Morinobu A., Takada M., Nakamura K., Sugai S., Maruya E., Saji H.
    Arthritis Rheum. 40:1685-1692(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*BKY2) (ISOFORM 1), VARIANT TAP2*BKY2 VAL-577.
    Tissue: Blood.
  6. "Novel splicing of the human MHC-encoded peptide transporter confers unique properties."
    Yan G., Shi L., Faustman D.
    J. Immunol. 162:852-859(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-379.
    Tissue: Spleen.
  7. "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
    Beck S., Abdulla S., Alderton R.P., Glynne R.J., Gut I.G., Hosking L.K., Jackson A., Kelly A., Newell W.R., Sanseau P., Radley E., Thorpe K.L., Trowsdale J.
    J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE TAP2*01:01) (ISOFORM 1).
  8. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE TAP2*BKY2) (ISOFORM 1).
    Tissue: Liver and Synovium.
  9. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES TAP2*03A AND TAP2*BKY2).
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  11. "Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain."
    Cano P., Baxter-Lowe L.A.
    Tissue Antigens 45:139-142(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-686 (ALLELE TAP2*01:03) (ISOFORM 1).
    Tissue: Blood.
  12. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-686 (ISOFORM 1), VARIANTS THR-374 AND ILE-467.
  13. Singal D.P., Ye M., D'Souza M.
    Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 517-645 (ALLELE TAP2*01:01/TAP2*01:02) (ISOFORM 1).
  14. "Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis."
    Singal D.P., Ye M., Qiu X., D'Souza M.
    Clin. Exp. Rheumatol. 12:29-33(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 517-645 (ALLELE TAP2*01:01/TAP2*01:02) (ISOFORM 1).
  15. "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."
    Nijenhuis M., Hammerling G.J.
    J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PEPTIDE-BINDING SITE.
  16. "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."
    Ahn K., Meyer T.H., Uebel S., Sempe P., Djaballah H., Yang Y., Peterson P.A., Frueh K., Tampe R.
    EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITION BY ICP47.
  17. "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."
    Ahn K., Gruhler A., Galocha B., Jones T.R., Wiertz E.J.H.J., Ploegh H.L., Peterson P.A., Yang Y., Frueh K.
    Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITION BY US6 GLYCOPROTEIN.
  18. "The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."
    Hewitt E.W., Gupta S.S., Lehner P.J.
    EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITION BY US6 GLYCOPROTEIN.
  19. "Adenovirus E19 has two mechanisms for affecting class I MHC expression."
    Bennett E.M., Bennink J.R., Yewdell J.W., Brodsky F.M.
    J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITION BY E3-19K GLYCOPROTEIN.
  20. "Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."
    Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E.
    J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EBV BNLF2A.
  21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "Allelic variants of the human putative peptide transporter involved in antigen processing."
    Colonna M., Bresnahan M., Bahram S., Strominger J.L., Spies T.
    Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ILE-379 AND ALA-665.
  23. Cited for: INVOLVEMENT IN BLS1.
  24. "Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans."
    Tang J., Freedman D.O., Allen S., Karita E., Musonda R., Braga C., Jamieson B.D., Louie L., Kaslow R.A.
    Genes Immun. 2:32-40(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS THR-374; ILE-379; ILE-467; SER-513 THR-565; CYS-651; ALA-665 AND GLN-GLU-GLY-GLN-ASP-LEU-TYR-SER-ARG-LEU-VAL-GLN-GLN-ARG-LEU-MET-ASP-686 INS, DEFINITION OF ALLELES.

Entry informationi

Entry nameiTAP2_HUMAN
AccessioniPrimary (citable) accession number: Q03519
Secondary accession number(s): B0V2J8
, O95410, Q53FI6, Q5HY71, Q96PT8, Q9UQ83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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