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Q03519 (TAP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 157. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Antigen peptide transporter 2

Short name=APT2
Alternative name(s):
ATP-binding cassette sub-family B member 3
Peptide supply factor 2
Peptide transporter PSF2
Short name=PSF-2
Peptide transporter TAP2
Peptide transporter involved in antigen processing 2
Really interesting new gene 11 protein
Gene names
Name:TAP2
Synonyms:ABCB3, PSF2, RING11, Y1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length686 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Subunit structure

Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a. Ref.20

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: The transmembrane segments seem to form a pore in the membrane.

Induction

By IFNG/IFN-gamma.

Domain

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Polymorphism

4 common alleles are officially recognized: TAP2*01:01 (TAP2A or PSF2A or RING11A), TAP2*01:02 (TAP2E), TAP2*01:03 (TAP2F), and TAP2*02:01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have been identified: TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02:02), TAP2*02D, TAP2*02E, TAP2*02F, TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01:01.

The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with susceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva, cornea and mouth due to exocrine glands dysfunction.

Involvement in disease

Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processAdaptive immunity
Host-virus interaction
Immunity
Peptide transport
Protein transport
Transport
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I

Inferred from direct assay PubMed 8496691. Source: UniProtKB

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

Inferred from Biological aspect of Ancestor. Source: RefGenome

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

Inferred from mutant phenotype PubMed 1538751. Source: UniProtKB

antigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Inferred from Biological aspect of Ancestor. Source: RefGenome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cytosol to ER transport

Inferred from mutant phenotype PubMed 7538543. Source: UniProtKB

intracellular transport of viral protein in host cell

Inferred from mutant phenotype PubMed 7538543. Source: UniProtKB

oligopeptide transmembrane transport

Inferred from Biological aspect of Ancestor. Source: GOC

peptide antigen transport

Inferred from direct assay PubMed 8496691. Source: UniProtKB

peptide transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of T cell mediated cytotoxicity

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of antigen processing and presentation of peptide antigen via MHC class I

Inferred from Biological aspect of Ancestor. Source: RefGenome

transmembrane transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentTAP complex

Inferred from direct assay PubMed 15518576PubMed 17947644. Source: UniProtKB

endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

integral component of endoplasmic reticulum membrane

Inferred from direct assay PubMed 7673167. Source: UniProtKB

integral component of membrane

Inferred from direct assay Ref.15. Source: UniProtKB

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionATP binding

Inferred from direct assay PubMed 7673167. Source: UniProtKB

MHC class I protein binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

TAP1 binding

Inferred from physical interaction PubMed 1538751PubMed 15518576. Source: UniProtKB

TAP2 binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

oligopeptide-transporting ATPase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

peptide antigen binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

peptide antigen-transporting ATPase activity

Inferred from mutant phenotype PubMed 1538751. Source: UniProtKB

tapasin binding

Inferred from sequence or structural similarity. Source: UniProtKB

transporter activity

Inferred from direct assay PubMed 10835348. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TAP1Q035187EBI-780781,EBI-747259
TAPBPO155333EBI-780781,EBI-874801

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q03519-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q03519-2)

The sequence of this isoform differs from the canonical sequence as follows:
     645-686: LQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL → KTLWKFMIF

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 686686Antigen peptide transporter 2
PRO_0000093329

Regions

Topological domain1 – 66Lumenal Potential
Transmembrane7 – 2721Helical; Name=1; Potential
Topological domain28 – 5629Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 9821Lumenal Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 14829Cytoplasmic Potential
Transmembrane149 – 16921Helical; Name=4; Potential
Topological domain170 – 18718Lumenal Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 26658Cytoplasmic Potential
Transmembrane267 – 28721Helical; Name=6; Potential
Topological domain288 – 2936Lumenal Potential
Transmembrane294 – 31421Helical; Name=7; Potential
Topological domain315 – 37460Cytoplasmic Potential
Transmembrane375 – 39521Helical; Name=8; Potential
Topological domain396 – 40813Lumenal Potential
Transmembrane409 – 42921Helical; Name=9; Potential
Topological domain430 – 686257Cytoplasmic Potential
Domain152 – 435284ABC transmembrane type-1
Domain468 – 686219ABC transporter
Nucleotide binding503 – 5108ATP Potential
Region301 – 38989Involved in peptide-binding site
Region414 – 43320Involved in peptide-binding site

Natural variations

Alternative sequence645 – 68642LQDWN…KLAQL → KTLWKFMIF in isoform 2.
VSP_038904
Natural variant561R → K.
Corresponds to variant rs17220192 [ dbSNP | Ensembl ].
VAR_036873
Natural variant3741A → T in allele TAP2*01F, allele TAP2*01G, allele TAP2*01H, allele TAP2*02B and allele TAP2*02D. Ref.12 Ref.24
Corresponds to variant rs111303994 [ dbSNP | Ensembl ].
VAR_014997
Natural variant3791V → I in allele TAP2*01D, allele TAP2*01E, allele TAP2*01G, allele TAP2*02C and allele TAP2*02F. Ref.6 Ref.22 Ref.24
Corresponds to variant rs1800454 [ dbSNP | Ensembl ].
VAR_000094
Natural variant4671V → I in allele TAP2*01F and allele TAP2*02D. Ref.12 Ref.24
Corresponds to variant rs150253319 [ dbSNP | Ensembl ].
VAR_014998
Natural variant5131A → S Rare polymorphism. Ref.24
VAR_014999
Natural variant5651A → T in allele TAP2*01:02, allele TAP2*01D, allele TAP2*02E and allele TAP2*02F. Ref.24
Corresponds to variant rs2228396 [ dbSNP | Ensembl ].
VAR_000095
Natural variant5771M → V in allele TAP2*BKY2. Ref.5
Corresponds to variant rs2228391 [ dbSNP | Ensembl ].
VAR_015000
Natural variant6511R → C in allele TAP2*01:03 and allele TAP2*01G. Ref.24
Corresponds to variant rs4148876 [ dbSNP | Ensembl ].
VAR_000096
Natural variant6651T → A in allele TAP2*02:01, allele TAP2*02B, allele TAP2*02C, allele TAP2*02D, allele TAP2*02E, allele TAP2*02F, allele TAP2*04A and allele TAP2*Bky2. Ref.22 Ref.24
Corresponds to variant rs241447 [ dbSNP | Ensembl ].
VAR_000097
Natural variant6861L → LQEGQDLYSRLVQQRLMD in allele TAP2*02:01, allele TAP2*02B, allele TAP2*02C, allele TAP2*02D, allele TAP2*02E, allele TAP2*02F, allele TAP2*03A and allele TAP2*BKY2.
VAR_000098

Experimental info

Sequence conflict3451F → I in BAD97020. Ref.8
Sequence conflict5201Y → N in BAD97020. Ref.8
Sequence conflict6551T → A in BAD97020. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: E7E4A7F6A2A3B48B

FASTA68675,664
        10         20         30         40         50         60 
MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 

        70         80         90        100        110        120 
FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 

       130        140        150        160        170        180 
PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 

       190        200        210        220        230        240 
GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 

       250        260        270        280        290        300 
FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 

       310        320        330        340        350        360 
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 

       370        380        390        400        410        420 
QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 

       430        440        450        460        470        480 
SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 

       490        500        510        520        530        540 
PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 

       550        560        570        580        590        600 
YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 

       610        620        630        640        650        660 
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS RGDRTVLVIA 

       670        680 
HRLQTVQRAH QILVLQEGKL QKLAQL 

« Hide

Isoform 2 [UniParc].

Checksum: AA79C3E9C6FE31AB
Show »

FASTA65372,003

References

« Hide 'large scale' references
[1]"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
Beck S., Kelly A., Radley E., Khurshid F., Alderton R.P., Trowsdale J.
J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE TAP2*01:01) (ISOFORM 1).
[2]"Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex."
Powis S.H., Mockridge I., Kelly A., Kerr L.-A., Glynne R.J., Gileadi U., Beck S., Trowsdale J.
Proc. Natl. Acad. Sci. U.S.A. 89:1463-1467(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*01:01/TAP2*02:01) (ISOFORM 1).
[3]"Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."
Bahram S., Arnold D., Bresnahan M., Strominger J.L., Spies T.
Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*02:01) (ISOFORM 1).
[4]"Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2."
Powis S.H., Tonks S., Mockridge I., Kelly A.P., Bodmer J.G., Trowsdale J.
Immunogenetics 37:373-380(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*01:02) (ISOFORM 1).
[5]"Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome."
Kumagai S., Kanagawa S., Morinobu A., Takada M., Nakamura K., Sugai S., Maruya E., Saji H.
Arthritis Rheum. 40:1685-1692(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*BKY2) (ISOFORM 1), VARIANT TAP2*BKY2 VAL-577.
Tissue: Blood.
[6]"Novel splicing of the human MHC-encoded peptide transporter confers unique properties."
Yan G., Shi L., Faustman D.
J. Immunol. 162:852-859(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-379.
Tissue: Spleen.
[7]"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
Beck S., Abdulla S., Alderton R.P., Glynne R.J., Gut I.G., Hosking L.K., Jackson A., Kelly A., Newell W.R., Sanseau P., Radley E., Thorpe K.L., Trowsdale J.
J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE TAP2*01:01) (ISOFORM 1).
[8]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE TAP2*BKY2) (ISOFORM 1).
Tissue: Liver and Synovium.
[9]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES TAP2*03A AND TAP2*BKY2).
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[11]"Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain."
Cano P., Baxter-Lowe L.A.
Tissue Antigens 45:139-142(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-686 (ALLELE TAP2*01:03) (ISOFORM 1).
Tissue: Blood.
[12]"New TAP2 polymorphisms in Africans."
Tang J., Allen S., Karita E., Musonda R., Kaslow R.A.
Tissue Antigens 51:556-562(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-686 (ISOFORM 1), VARIANTS THR-374 AND ILE-467.
[13]Singal D.P., Ye M., D'Souza M.
Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 517-645 (ALLELE TAP2*01:01/TAP2*01:02) (ISOFORM 1).
[14]"Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis."
Singal D.P., Ye M., Qiu X., D'Souza M.
Clin. Exp. Rheumatol. 12:29-33(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 517-645 (ALLELE TAP2*01:01/TAP2*01:02) (ISOFORM 1).
[15]"Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."
Nijenhuis M., Hammerling G.J.
J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PEPTIDE-BINDING SITE.
[16]"Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."
Ahn K., Meyer T.H., Uebel S., Sempe P., Djaballah H., Yang Y., Peterson P.A., Frueh K., Tampe R.
EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INHIBITION BY ICP47.
[17]"The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."
Ahn K., Gruhler A., Galocha B., Jones T.R., Wiertz E.J.H.J., Ploegh H.L., Peterson P.A., Yang Y., Frueh K.
Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[18]"The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."
Hewitt E.W., Gupta S.S., Lehner P.J.
EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[19]"Adenovirus E19 has two mechanisms for affecting class I MHC expression."
Bennett E.M., Bennink J.R., Yewdell J.W., Brodsky F.M.
J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INHIBITION BY E3-19K GLYCOPROTEIN.
[20]"Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."
Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E.
J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EBV BNLF2A.
[21]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[22]"Allelic variants of the human putative peptide transporter involved in antigen processing."
Colonna M., Bresnahan M., Bahram S., Strominger J.L., Spies T.
Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ILE-379 AND ALA-665.
[23]"Homozygous human TAP peptide transporter mutation in HLA class I deficiency."
de la Salle H., Hanau D., Fricker D., Urlacher A., Kelly A., Salamero J., Powis S.H., Donato L., Bausinger H., Laforet M., Jeras M., Spehner D., Bieber T., Falkenrodt A., Cazenave J.-P., Trowsdale J., Tongio M.-M.
Science 265:237-241(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN BLS1.
[24]"Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans."
Tang J., Freedman D.O., Allen S., Karita E., Musonda R., Braga C., Jamieson B.D., Louie L., Kaslow R.A.
Genes Immun. 2:32-40(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS THR-374; ILE-379; ILE-467; SER-513 THR-565; CYS-651; ALA-665 AND GLN-GLU-GLY-GLN-ASP-LEU-TYR-SER-ARG-LEU-VAL-GLN-GLN-ARG-LEU-MET-ASP-686 INS, DEFINITION OF ALLELES.
+Additional computationally mapped references.

Web resources

TAP2base

TAP2 mutation db

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66401 Genomic DNA. Translation: CAA47027.1.
M84748 mRNA. No translation available.
M74447 mRNA. Translation: AAA59841.1.
Z22935 mRNA. Translation: CAA80522.1.
Z22936 mRNA. Translation: CAA80523.1.
AB073779 mRNA. Translation: BAB71769.1.
AF105151 mRNA. Translation: AAD12059.1.
X87344 Genomic DNA. Translation: CAA60788.1.
AK222823 mRNA. Translation: BAD96543.1.
AK223300 mRNA. Translation: BAD97020.1.
BX296564 Genomic DNA. No translation available.
CR788227 Genomic DNA. No translation available.
BX682530 Genomic DNA. Translation: CAI41935.1.
CR762476 Genomic DNA. Translation: CAQ08491.1.
CR753889 Genomic DNA. Translation: CAQ10283.1.
CT009502 Genomic DNA. Translation: CAQ07778.1.
BC002751 mRNA. No translation available.
U07844 mRNA. Translation: AAA79901.1.
AH007554 Genomic DNA. Translation: AAD23381.1.
L09191 mRNA. Translation: AAA58648.1.
L10287 mRNA. Translation: AAA58649.1.
PIRB41538.
RefSeqNP_000535.3. NM_000544.3.
NP_061313.2. NM_018833.2.
UniGeneHs.502.

3D structure databases

ProteinModelPortalQ03519.
SMRQ03519. Positions 140-685.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112754. 14 interactions.
DIPDIP-322N.
IntActQ03519. 6 interactions.
MINTMINT-2838244.
STRING9606.ENSP00000372726.

Protein family/group databases

TCDB3.A.1.209.1. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSiteQ03519.

Polymorphism databases

DMDM549044.

Proteomic databases

PaxDbQ03519.
PRIDEQ03519.

Protocols and materials databases

DNASU6891.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374897; ENSP00000364032; ENSG00000204267. [Q03519-1]
ENST00000374899; ENSP00000364034; ENSG00000204267. [Q03519-2]
ENST00000383118; ENSP00000372599; ENSG00000206235. [Q03519-1]
ENST00000383119; ENSP00000372600; ENSG00000206235. [Q03519-2]
ENST00000383239; ENSP00000372726; ENSG00000206299. [Q03519-1]
ENST00000383240; ENSP00000372727; ENSG00000206299. [Q03519-2]
ENST00000414145; ENSP00000401377; ENSG00000228582. [Q03519-2]
ENST00000419142; ENSP00000390013; ENSG00000237599.
ENST00000426977; ENSP00000387553; ENSG00000232326. [Q03519-2]
ENST00000439425; ENSP00000396156; ENSG00000225967. [Q03519-2]
ENST00000443713; ENSP00000394101; ENSG00000228582. [Q03519-1]
ENST00000451907; ENSP00000392172; ENSG00000223481. [Q03519-2]
ENST00000452371; ENSP00000406540; ENSG00000223481.
ENST00000455842; ENSP00000393580; ENSG00000225967.
ENST00000457634; ENSP00000416471; ENSG00000232326.
GeneID6891.
KEGGhsa:6891.
UCSCuc003occ.3. human. [Q03519-1]

Organism-specific databases

CTD6891.
GeneCardsGC06M032789.
GC06Mi32773.
GC06Mj32703.
GC06Mk32767.
GC06Ml32943.
GC06Mm32815.
GC06Mn32718.
GC06Mo32879.
H-InvDBHIX0005757.
HIX0166631.
HIX0166883.
HIX0167147.
HGNCHGNC:44. TAP2.
HPAHPA001312.
MIM170261. gene.
604571. phenotype.
neXtProtNX_Q03519.
Orphanet34592. Immunodeficiency by defective expression of HLA class 1.
PharmGKBPA35022.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1132.
HOVERGENHBG008358.
InParanoidQ03519.
KOK05654.
OMAPFNDISA.
PhylomeDBQ03519.
TreeFamTF105197.

Enzyme and pathway databases

BRENDA3.6.3.43. 2681.
ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ03519.
BgeeQ03519.
CleanExHS_TAP2.
GenevestigatorQ03519.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013306. ABC_B3.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005293. Ag_transporter2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSPR01897. TAP2PROTEIN.
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsTIGR00958. 3a01208. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAP2.
GenomeRNAi6891.
NextBio26929.
PROQ03519.
SOURCESearch...

Entry information

Entry nameTAP2_HUMAN
AccessionPrimary (citable) accession number: Q03519
Secondary accession number(s): B0V2J8 expand/collapse secondary AC list , O95410, Q53FI6, Q5HY71, Q96PT8, Q9UQ83
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM