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Q03518

- TAP1_HUMAN

UniProt

Q03518 - TAP1_HUMAN

Protein

Antigen peptide transporter 1

Gene

TAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi598 – 6058ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ADP binding Source: UniProtKB
    2. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
    3. ATP binding Source: UniProtKB
    4. MHC class Ib protein binding Source: UniProt
    5. peptide antigen binding Source: UniProtKB
    6. peptide transporter activity Source: UniProtKB
    7. protein binding Source: IntAct
    8. protein homodimerization activity Source: UniProtKB
    9. TAP1 binding Source: UniProtKB
    10. TAP2 binding Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of endogenous peptide antigen via MHC class I Source: UniProtKB
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytosol to ER transport Source: UniProtKB
    6. defense response Source: Ensembl
    7. intracellular transport of viral protein in host cell Source: UniProtKB
    8. peptide transport Source: UniProtKB
    9. transmembrane transport Source: RefGenome

    Keywords - Biological processi

    Adaptive immunity, Host-virus interaction, Immunity, Peptide transport, Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi3.6.3.43. 2681.
    ReactomeiREACT_111178. ER-Phagosome pathway.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Protein family/group databases

    TCDBi3.A.1.209.1. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Antigen peptide transporter 1
    Short name:
    APT1
    Alternative name(s):
    ATP-binding cassette sub-family B member 2
    Peptide supply factor 1
    Peptide transporter PSF1
    Short name:
    PSF-1
    Peptide transporter TAP1
    Peptide transporter involved in antigen processing 1
    Really interesting new gene 4 protein
    Gene namesi
    Name:TAP1
    Synonyms:ABCB2, PSF1, RING4, Y3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:43. TAP1.

    Subcellular locationi

    Endoplasmic reticulum membrane; Multi-pass membrane protein
    Note: The transmembrane segments seem to form a pore in the membrane.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. integral component of endoplasmic reticulum membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB
    4. membrane Source: UniProtKB
    5. mitochondrion Source: Ensembl
    6. TAP complex Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi604571. phenotype.
    Orphaneti34592. Immunodeficiency by defective expression of HLA class 1.
    PharmGKBiPA35021.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 808808Antigen peptide transporter 1PRO_0000093326Add
    BLAST

    Proteomic databases

    MaxQBiQ03518.
    PaxDbiQ03518.
    PRIDEiQ03518.

    PTM databases

    PhosphoSiteiQ03518.

    Expressioni

    Inductioni

    By IFNG/IFN-gamma.

    Gene expression databases

    ArrayExpressiQ03518.
    BgeeiQ03518.
    CleanExiHS_TAP1.
    GenevestigatoriQ03518.

    Organism-specific databases

    HPAiCAB009516.

    Interactioni

    Subunit structurei

    Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BNLF2a. Interacts with PSMB5 and PSMB8.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BNLF2aP0C7398EBI-747259,EBI-9346744From a different organism.
    CALRP277972EBI-747259,EBI-1049597
    P4HBP072374EBI-747259,EBI-395883
    PDIA3P301014EBI-747259,EBI-979862
    TAP2Q0351913EBI-747259,EBI-780781
    TAPBPO1553312EBI-747259,EBI-874801
    THOC5Q137694EBI-747259,EBI-5280316

    Protein-protein interaction databases

    BioGridi112753. 24 interactions.
    DIPiDIP-35626N.
    IntActiQ03518. 18 interactions.
    MINTiMINT-1477433.
    STRINGi9606.ENSP00000346206.

    Structurei

    Secondary structure

    1
    808
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi563 – 5708
    Beta strandi580 – 5889
    Beta strandi593 – 5975
    Helixi604 – 6118
    Beta strandi618 – 6247
    Helixi629 – 6313
    Helixi634 – 6407
    Beta strandi641 – 6444
    Beta strandi652 – 6543
    Helixi655 – 6606
    Helixi669 – 67810
    Helixi682 – 6865
    Helixi691 – 6933
    Beta strandi701 – 7033
    Helixi705 – 71713
    Beta strandi722 – 7287
    Turni729 – 7324
    Helixi735 – 74612
    Helixi749 – 7535
    Beta strandi755 – 7595
    Helixi763 – 7675
    Beta strandi770 – 7767
    Beta strandi779 – 7846
    Helixi786 – 7927
    Helixi795 – 8006

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JJ7X-ray2.40A549-808[»]
    ProteinModelPortaliQ03518.
    SMRiQ03518. Positions 234-802.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ03518.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini61 – 7515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 11317LumenalSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini174 – 19320LumenalSequence AnalysisAdd
    BLAST
    Topological domaini215 – 24632CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 28720LumenalSequence AnalysisAdd
    BLAST
    Topological domaini309 – 35850CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini380 – 3889LumenalSequence Analysis
    Topological domaini410 – 47869CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini500 – 5034LumenalSequence Analysis
    Topological domaini525 – 808284CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621Helical; Name=1PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei114 – 13623Helical; Name=2PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei153 – 17321Helical; Name=3PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei194 – 21421Helical; Name=4PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei247 – 26721Helical; Name=5PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=6PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei359 – 37921Helical; Name=7PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei389 – 40921Helical; Name=8PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei479 – 49921Helical; Name=9PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei504 – 52421Helical; Name=10PROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini247 – 530284ABC transmembrane type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini563 – 802240ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni435 – 48046Involved in peptide-binding siteAdd
    BLAST
    Regioni513 – 54735Involved in peptide-binding siteAdd
    BLAST

    Domaini

    The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

    Sequence similaritiesi

    Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOVERGENiHBG008358.
    InParanoidiQ03518.
    KOiK05653.
    OMAiCLGSEIR.
    PhylomeDBiQ03518.
    TreeFamiTF105197.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR013305. ABC_B2.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005293. Ag_transporter2.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    PRINTSiPR01896. TAP1PROTEIN.
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    TIGRFAMsiTIGR00958. 3a01208. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03518-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP    50
    GRDRDGVRVP MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL 100
    PRIFSLLVPT ALPLLRVWAV GLSRWAVLWL GACGVLRATV GSKSENAGAQ 150
    GWLAALKPLA AALGLALPGL ALFRELISWG APGSADSTRL LHWGSHPTAF 200
    VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL GSETRRLSLF 250
    LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 300
    LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE 350
    DTSTLSDSLS ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL 400
    LPKKVGKWYQ LLEVQVRESL AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF 450
    REKLQEIKTL NQKEAVAYAV NSWTTSISGM LLKVGILYIG GQLVTSGAVS 500
    SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE YLDRTPRCPP 550
    SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 600
    GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV 650
    FGRSLQENIA YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG 700
    SQLSGGQRQA VALARALIRK PCVLILDDAT SALDANSQLQ VEQLLYESPE 750
    RYSRSVLLIT QHLSLVEQAD HILFLEGGAI REGGTHQQLM EKKGCYWAMV 800
    QAPADAPE 808
    Length:808
    Mass (Da):87,218
    Last modified:November 25, 2008 - v2
    Checksum:i9CA5FF96FADD6A1B
    GO

    Sequence cautioni

    The sequence CAA47025.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA60785.1 differs from that shown. Reason: Erroneous initiation.

    Polymorphismi

    There are five common alleles; TAP1*01:01 (PSF1A), TAP1*02:01 (PSF1B), TAP1*03:01 (PSF1C), TAP1*01:04 and TAP1*x. The sequence of TAP1*01:01 is shown here.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671P → S.1 Publication
    VAR_016801
    Natural varianti77 – 771G → R.1 Publication
    Corresponds to variant rs57640466 [ dbSNP | Ensembl ].
    VAR_016802
    Natural varianti170 – 1701L → V.
    Corresponds to variant rs2228108 [ dbSNP | Ensembl ].
    VAR_048137
    Natural varianti304 – 3041V → L.
    Corresponds to variant rs36229525 [ dbSNP | Ensembl ].
    VAR_060987
    Natural varianti346 – 3461S → F.
    Corresponds to variant rs2228111 [ dbSNP | Ensembl ].
    VAR_048138
    Natural varianti393 – 3931I → V in allele TAP1*02:01, allele TAP1*03:01, allele TAP1*04:01 and allele TAP1*x. 4 Publications
    Corresponds to variant rs1057141 [ dbSNP | Ensembl ].
    VAR_000092
    Natural varianti430 – 4301A → V in allele TAP1*x. 2 Publications
    Corresponds to variant rs2127679 [ dbSNP | Ensembl ].
    VAR_013151
    Natural varianti479 – 4791G → C.1 Publication
    Corresponds to variant rs2228110 [ dbSNP | Ensembl ].
    VAR_016803
    Natural varianti518 – 5181V → L in allele TAP1*04:01. 3 Publications
    Corresponds to variant rs41550019 [ dbSNP | Ensembl ].
    VAR_013152
    Natural varianti578 – 5781V → I in allele TAP1*x. 1 Publication
    Corresponds to variant rs41561219 [ dbSNP | Ensembl ].
    VAR_013153
    Natural varianti697 – 6971D → G in allele TAP1*02:01, allele TAP1*04:01 and allele TAP1*x. 5 Publications
    Corresponds to variant rs1135216 [ dbSNP | Ensembl ].
    VAR_000093
    Natural varianti708 – 7081R → Q in allele TAP1*04:01. 4 Publications
    Corresponds to variant rs1057149 [ dbSNP | Ensembl ].
    VAR_013154
    Natural varianti719 – 7191R → Q in a lung cancer cell line deficient in MHC class I presentation. 1 Publication
    Corresponds to variant rs121917702 [ dbSNP | Ensembl ].
    VAR_013173
    Natural varianti768 – 7681Q → R.
    Corresponds to variant rs1057149 [ dbSNP | Ensembl ].
    VAR_047514

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57522 mRNA. Translation: CAA40741.1.
    X66401 Genomic DNA. Translation: CAA47025.1. Different initiation.
    X87344 Genomic DNA. Translation: CAA60785.1. Different initiation.
    AL669918 Genomic DNA. Translation: CAI18140.1.
    AL671681 Genomic DNA. Translation: CAI17714.1.
    AL935043 Genomic DNA. Translation: CAI18626.1.
    BX927138 Genomic DNA. Translation: CAQ08449.1.
    CR762476 Genomic DNA. Translation: CAQ08495.1.
    CR933844 Genomic DNA. Translation: CAQ08906.1.
    CR753889 Genomic DNA. Translation: CAQ10287.1.
    CH471081 Genomic DNA. Translation: EAX03647.1.
    BC014081 mRNA. Translation: AAH14081.1.
    L21204 mRNA. Translation: AAC12902.1.
    L21205 mRNA. Translation: AAC12903.1.
    L21206 mRNA. Translation: AAC12904.1.
    L21207 mRNA. Translation: AAC12905.1.
    L21208 mRNA. Translation: AAC12906.1.
    X57521 mRNA. Translation: CAA40740.1.
    S70274 mRNA. Translation: AAD14056.1.
    CCDSiCCDS4758.1.
    PIRiS13427. A41538.
    RefSeqiNP_000584.2. NM_000593.5.
    UniGeneiHs.352018.

    Genome annotation databases

    EnsembliENST00000354258; ENSP00000346206; ENSG00000168394.
    ENST00000383235; ENSP00000372722; ENSG00000206297.
    ENST00000414467; ENSP00000405356; ENSG00000226173.
    ENST00000418205; ENSP00000401149; ENSG00000227816.
    ENST00000424897; ENSP00000413080; ENSG00000230705.
    ENST00000439781; ENSP00000415660; ENSG00000224212.
    ENST00000440894; ENSP00000402316; ENSG00000232367.
    GeneIDi6890.
    KEGGihsa:6890.
    UCSCiuc003ocg.3. human.

    Polymorphism databases

    DMDMi215273957.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    TAP1base

    TAP1 mutation db

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57522 mRNA. Translation: CAA40741.1 .
    X66401 Genomic DNA. Translation: CAA47025.1 . Different initiation.
    X87344 Genomic DNA. Translation: CAA60785.1 . Different initiation.
    AL669918 Genomic DNA. Translation: CAI18140.1 .
    AL671681 Genomic DNA. Translation: CAI17714.1 .
    AL935043 Genomic DNA. Translation: CAI18626.1 .
    BX927138 Genomic DNA. Translation: CAQ08449.1 .
    CR762476 Genomic DNA. Translation: CAQ08495.1 .
    CR933844 Genomic DNA. Translation: CAQ08906.1 .
    CR753889 Genomic DNA. Translation: CAQ10287.1 .
    CH471081 Genomic DNA. Translation: EAX03647.1 .
    BC014081 mRNA. Translation: AAH14081.1 .
    L21204 mRNA. Translation: AAC12902.1 .
    L21205 mRNA. Translation: AAC12903.1 .
    L21206 mRNA. Translation: AAC12904.1 .
    L21207 mRNA. Translation: AAC12905.1 .
    L21208 mRNA. Translation: AAC12906.1 .
    X57521 mRNA. Translation: CAA40740.1 .
    S70274 mRNA. Translation: AAD14056.1 .
    CCDSi CCDS4758.1.
    PIRi S13427. A41538.
    RefSeqi NP_000584.2. NM_000593.5.
    UniGenei Hs.352018.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JJ7 X-ray 2.40 A 549-808 [» ]
    ProteinModelPortali Q03518.
    SMRi Q03518. Positions 234-802.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112753. 24 interactions.
    DIPi DIP-35626N.
    IntActi Q03518. 18 interactions.
    MINTi MINT-1477433.
    STRINGi 9606.ENSP00000346206.

    Chemistry

    DrugBanki DB01259. Lapatinib.

    Protein family/group databases

    TCDBi 3.A.1.209.1. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei Q03518.

    Polymorphism databases

    DMDMi 215273957.

    Proteomic databases

    MaxQBi Q03518.
    PaxDbi Q03518.
    PRIDEi Q03518.

    Protocols and materials databases

    DNASUi 6890.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354258 ; ENSP00000346206 ; ENSG00000168394 .
    ENST00000383235 ; ENSP00000372722 ; ENSG00000206297 .
    ENST00000414467 ; ENSP00000405356 ; ENSG00000226173 .
    ENST00000418205 ; ENSP00000401149 ; ENSG00000227816 .
    ENST00000424897 ; ENSP00000413080 ; ENSG00000230705 .
    ENST00000439781 ; ENSP00000415660 ; ENSG00000224212 .
    ENST00000440894 ; ENSP00000402316 ; ENSG00000232367 .
    GeneIDi 6890.
    KEGGi hsa:6890.
    UCSCi uc003ocg.3. human.

    Organism-specific databases

    CTDi 6890.
    GeneCardsi GC06M032812.
    GC06Mi32796.
    GC06Mj32735.
    GC06Mk32790.
    GC06Ml32966.
    GC06Mm32846.
    GC06Mn32741.
    HGNCi HGNC:43. TAP1.
    HPAi CAB009516.
    MIMi 170260. gene.
    604571. phenotype.
    neXtProti NX_Q03518.
    Orphaneti 34592. Immunodeficiency by defective expression of HLA class 1.
    PharmGKBi PA35021.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1132.
    HOVERGENi HBG008358.
    InParanoidi Q03518.
    KOi K05653.
    OMAi CLGSEIR.
    PhylomeDBi Q03518.
    TreeFami TF105197.

    Enzyme and pathway databases

    BRENDAi 3.6.3.43. 2681.
    Reactomei REACT_111178. ER-Phagosome pathway.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    EvolutionaryTracei Q03518.
    GeneWikii TAP1.
    GenomeRNAii 6890.
    NextBioi 26925.
    PROi Q03518.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03518.
    Bgeei Q03518.
    CleanExi HS_TAP1.
    Genevestigatori Q03518.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR013305. ABC_B2.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005293. Ag_transporter2.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    PRINTSi PR01896. TAP1PROTEIN.
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    TIGRFAMsi TIGR00958. 3a01208. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters."
      Trowsdale J., Hanson I., Mockridge I., Beck S., Townsend A., Kelly A.
      Nature 348:741-744(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
      Beck S., Kelly A., Radley E., Khurshid F., Alderton R.P., Trowsdale J.
      J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
      Beck S., Abdulla S., Alderton R.P., Glynne R.J., Gut I.G., Hosking L.K., Jackson A., Kelly A., Newell W.R., Sanseau P., Radley E., Thorpe K.L., Trowsdale J.
      J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    7. "TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility."
      Jackson D.G., Capra J.D.
      Proc. Natl. Acad. Sci. U.S.A. 90:11079-11083(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-808, VARIANTS VAL-393; LEU-518; GLY-697 AND GLN-708.
      Tissue: Blood.
    8. "A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway."
      Spies T., Bresnahan M., Bahram S., Arnold D., Blanck G., Mellins E., Pious D., Demars R.
      Nature 348:744-747(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-612.
    9. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 691-723, VARIANTS GLY-697 AND GLN-708.
    10. "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."
      Bahram S., Arnold D., Bresnahan M., Strominger J.L., Spies T.
      Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."
      Ahn K., Meyer T.H., Uebel S., Sempe P., Djaballah H., Yang Y., Peterson P.A., Frueh K., Tampe R.
      EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INHIBITION BY ICP47.
    12. "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."
      Nijenhuis M., Hammerling G.J.
      J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PEPTIDE-BINDING SITE.
    13. "Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10."
      Zeidler R., Eissner G., Meissner P., Uebel S., Tampe R., Lazis S., Hammerschmidt W.
      Blood 90:2390-2397(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOWN-REGULATION BY VIRAL IL-10.
    14. "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."
      Ahn K., Gruhler A., Galocha B., Jones T.R., Wiertz E.J.H.J., Ploegh H.L., Peterson P.A., Yang Y., Frueh K.
      Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INHIBITION BY US6 GLYCOPROTEIN.
    15. "Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome."
      Furukawa H., Murata S., Yabe T., Shimbara N., Keicho N., Kashiwase K., Watanabe K., Ishikawa Y., Akaza T., Tadokoro K., Tohma S., Inoue T., Tokunaga K., Yamamoto K., Tanaka K., Juji T.
      J. Clin. Invest. 103:755-758(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN BLS1.
    16. "Adenovirus E19 has two mechanisms for affecting class I MHC expression."
      Bennett E.M., Bennink J.R., Yewdell J.W., Brodsky F.M.
      J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INHIBITION BY E3-19K GLYCOPROTEIN.
    17. "The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."
      Hewitt E.W., Gupta S.S., Lehner P.J.
      EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INHIBITION BY US6 GLYCOPROTEIN.
    18. "Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."
      Begley G.S., Horvath A.R., Taylor J.C., Higgins C.F.
      Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PSMB5 AND PSMB8.
    19. "Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."
      Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E.
      J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EBV BNLF2A.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing."
      Gaudet R., Wiley D.C.
      EMBO J. 20:4964-4972(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 549-808.
    22. "Allelic variants of the human putative peptide transporter involved in antigen processing."
      Colonna M., Bresnahan M., Bahram S., Strominger J.L., Spies T.
      Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-393 AND GLY-697.
    23. "A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer."
      Chen H.L., Gabrilovich D., Tampe R., Girgis K.R., Nadaf S., Carbone D.P.
      Nat. Genet. 13:210-213(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLN-719.
    24. "TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies."
      Tang J., Freedman D.O., Allen S., Karita E., Musonda R., Braga C., Margolick J., Kaslow R.A.
      Hum. Immunol. 62:256-268(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-393; VAL-430; LEU-518; ILE-578; GLY-697 AND GLN-708.
    25. "Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases."
      Lajoie J., Zijenah L.S., Faucher M.C., Ward B.J., Roger M.
      Hum. Immunol. 64:823-829(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-67; ARG-77; VAL-393; VAL-430; CYS-479; LEU-518; GLY-697 AND GLN-708.

    Entry informationi

    Entry nameiTAP1_HUMAN
    AccessioniPrimary (citable) accession number: Q03518
    Secondary accession number(s): Q16149, Q96CP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 159 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-61 is the initiator.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3