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Protein

Antigen peptide transporter 1

Gene

TAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi598 – 605ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ADP binding Source: UniProtKB
  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB
  • MHC class Ib protein binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • peptide antigen-transporting ATPase activity Source: Ensembl
  • peptide transporter activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • TAP1 binding Source: UniProtKB
  • TAP2 binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Host-virus interaction, Immunity, Peptide transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168394-MONOMER.
BRENDAi3.6.3.43. 2681.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Protein family/group databases

TCDBi3.A.1.209.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen peptide transporter 1
Short name:
APT1
Alternative name(s):
ATP-binding cassette sub-family B member 2
Peptide supply factor 1
Peptide transporter PSF1
Short name:
PSF-1
Peptide transporter TAP1
Peptide transporter involved in antigen processing 1
Really interesting new gene 4 protein
Gene namesi
Name:TAP1
Synonyms:ABCB2, PSF1, RING4, Y3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:43. TAP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini61 – 75CytoplasmicSequence analysisAdd BLAST15
Transmembranei76 – 96Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini97 – 113LumenalSequence analysisAdd BLAST17
Transmembranei114 – 136Helical; Name=2PROSITE-ProRule annotationAdd BLAST23
Topological domaini137 – 152CytoplasmicSequence analysisAdd BLAST16
Transmembranei153 – 173Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini174 – 193LumenalSequence analysisAdd BLAST20
Transmembranei194 – 214Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini215 – 246CytoplasmicSequence analysisAdd BLAST32
Transmembranei247 – 267Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini268 – 287LumenalSequence analysisAdd BLAST20
Transmembranei288 – 308Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini309 – 358CytoplasmicSequence analysisAdd BLAST50
Transmembranei359 – 379Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini380 – 388LumenalSequence analysis9
Transmembranei389 – 409Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini410 – 478CytoplasmicSequence analysisAdd BLAST69
Transmembranei479 – 499Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini500 – 503LumenalSequence analysis4
Transmembranei504 – 524Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini525 – 808CytoplasmicSequence analysisAdd BLAST284

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: Reactome
  • host cell Source: GOC
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
  • TAP complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Bare lymphocyte syndrome 1 (BLS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.
See also OMIM:604571

Organism-specific databases

DisGeNETi6890.
MalaCardsiTAP1.
MIMi604571. phenotype.
OpenTargetsiENSG00000168394.
ENSG00000206297.
ENSG00000224212.
ENSG00000226173.
ENSG00000227816.
ENSG00000230705.
ENSG00000232367.
Orphaneti34592. Immunodeficiency by defective expression of HLA class 1.
PharmGKBiPA35021.

Chemistry databases

DrugBankiDB01259. Lapatinib.

Polymorphism and mutation databases

BioMutaiTAP1.
DMDMi215273957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933261 – 808Antigen peptide transporter 1Add BLAST808

Proteomic databases

EPDiQ03518.
MaxQBiQ03518.
PaxDbiQ03518.
PeptideAtlasiQ03518.
PRIDEiQ03518.

PTM databases

iPTMnetiQ03518.
PhosphoSitePlusiQ03518.
SwissPalmiQ03518.

Expressioni

Inductioni

By IFNG/IFN-gamma.

Gene expression databases

BgeeiENSG00000168394.
CleanExiHS_TAP1.
ExpressionAtlasiQ03518. baseline and differential.
GenevisibleiQ03518. HS.

Organism-specific databases

HPAiCAB009516.

Interactioni

Subunit structurei

Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BNLF2a. Interacts with herpes simplex virus ICP47 (PubMed:7760936). Interacts with PSMB5 and PSMB8.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BNLF2aP0C7399EBI-747259,EBI-9346744From a different organism.
CALRP277972EBI-747259,EBI-1049597
gNQ77CE46EBI-747259,EBI-11303846From a different organism.
P4HBP072374EBI-747259,EBI-395883
PDIA3P301014EBI-747259,EBI-979862
TAP2Q0351915EBI-747259,EBI-780781
TAPBPO1553314EBI-747259,EBI-874801
THOC5Q137694EBI-747259,EBI-5280316

GO - Molecular functioni

  • MHC class Ib protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • TAP1 binding Source: UniProtKB
  • TAP2 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112753. 40 interactors.
DIPiDIP-35626N.
IntActiQ03518. 41 interactors.
MINTiMINT-1477433.
STRINGi9606.ENSP00000346206.

Structurei

Secondary structure

1808
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi563 – 570Combined sources8
Beta strandi580 – 588Combined sources9
Beta strandi593 – 597Combined sources5
Helixi604 – 611Combined sources8
Beta strandi618 – 624Combined sources7
Helixi629 – 631Combined sources3
Helixi634 – 640Combined sources7
Beta strandi641 – 644Combined sources4
Beta strandi652 – 654Combined sources3
Helixi655 – 660Combined sources6
Helixi669 – 678Combined sources10
Helixi682 – 686Combined sources5
Helixi691 – 693Combined sources3
Beta strandi701 – 703Combined sources3
Helixi705 – 717Combined sources13
Beta strandi722 – 728Combined sources7
Turni729 – 732Combined sources4
Helixi735 – 746Combined sources12
Helixi749 – 753Combined sources5
Beta strandi755 – 759Combined sources5
Helixi763 – 767Combined sources5
Beta strandi770 – 776Combined sources7
Beta strandi779 – 784Combined sources6
Helixi786 – 792Combined sources7
Helixi795 – 800Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJ7X-ray2.40A549-808[»]
ProteinModelPortaliQ03518.
SMRiQ03518.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03518.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 530ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST284
Domaini563 – 802ABC transporterPROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni435 – 480Involved in peptide-binding siteAdd BLAST46
Regioni513 – 547Involved in peptide-binding siteAdd BLAST35

Domaini

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ03518.
KOiK05653.
OMAiCLGEMAI.
OrthoDBiEOG091G05Q9.
PhylomeDBiQ03518.
TreeFamiTF105197.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR013306. Tap1/ABCB2.
[Graphical view]
PANTHERiPTHR24221:SF249. PTHR24221:SF249. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP
60 70 80 90 100
GRDRDGVRVP MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL
110 120 130 140 150
PRIFSLLVPT ALPLLRVWAV GLSRWAVLWL GACGVLRATV GSKSENAGAQ
160 170 180 190 200
GWLAALKPLA AALGLALPGL ALFRELISWG APGSADSTRL LHWGSHPTAF
210 220 230 240 250
VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL GSETRRLSLF
260 270 280 290 300
LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV
310 320 330 340 350
LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE
360 370 380 390 400
DTSTLSDSLS ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL
410 420 430 440 450
LPKKVGKWYQ LLEVQVRESL AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF
460 470 480 490 500
REKLQEIKTL NQKEAVAYAV NSWTTSISGM LLKVGILYIG GQLVTSGAVS
510 520 530 540 550
SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE YLDRTPRCPP
560 570 580 590 600
SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN
610 620 630 640 650
GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV
660 670 680 690 700
FGRSLQENIA YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG
710 720 730 740 750
SQLSGGQRQA VALARALIRK PCVLILDDAT SALDANSQLQ VEQLLYESPE
760 770 780 790 800
RYSRSVLLIT QHLSLVEQAD HILFLEGGAI REGGTHQQLM EKKGCYWAMV

QAPADAPE
Length:808
Mass (Da):87,218
Last modified:November 25, 2008 - v2
Checksum:i9CA5FF96FADD6A1B
GO

Sequence cautioni

The sequence CAA47025 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA60785 differs from that shown. Reason: Erroneous initiation.Curated

Polymorphismi

There are five common alleles; TAP1*01:01 (PSF1A), TAP1*02:01 (PSF1B), TAP1*03:01 (PSF1C), TAP1*01:04 and TAP1*x. The sequence of TAP1*01:01 is shown here.5 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01680167P → S.1 PublicationCorresponds to variant rs375389015dbSNPEnsembl.1
Natural variantiVAR_01680277G → R.1 PublicationCorresponds to variant rs57640466dbSNPEnsembl.1
Natural variantiVAR_048137170L → V.Corresponds to variant rs2228108dbSNPEnsembl.1
Natural variantiVAR_060987304V → L.Corresponds to variant rs36229525dbSNPEnsembl.1
Natural variantiVAR_048138346S → F.Corresponds to variant rs2228111dbSNPEnsembl.1
Natural variantiVAR_000092393I → V in allele TAP1*02:01, allele TAP1*03:01, allele TAP1*04:01 and allele TAP1*x. 4 PublicationsCorresponds to variant rs1057141dbSNPEnsembl.1
Natural variantiVAR_013151430A → V in allele TAP1*x. 2 PublicationsCorresponds to variant rs2127679dbSNPEnsembl.1
Natural variantiVAR_016803479G → C.1 PublicationCorresponds to variant rs2228110dbSNPEnsembl.1
Natural variantiVAR_013152518V → L in allele TAP1*04:01. 3 PublicationsCorresponds to variant rs41550019dbSNPEnsembl.1
Natural variantiVAR_013153578V → I in allele TAP1*x. 1 PublicationCorresponds to variant rs41561219dbSNPEnsembl.1
Natural variantiVAR_000093697D → G in allele TAP1*02:01, allele TAP1*04:01 and allele TAP1*x. 5 PublicationsCorresponds to variant rs1135216dbSNPEnsembl.1
Natural variantiVAR_013154708R → Q in allele TAP1*04:01. 4 PublicationsCorresponds to variant rs1057149dbSNPEnsembl.1
Natural variantiVAR_013173719R → Q in a lung cancer cell line deficient in MHC class I presentation. 1 PublicationCorresponds to variant rs121917702dbSNPEnsembl.1
Natural variantiVAR_047514768Q → R.Corresponds to variant rs1057149dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57522 mRNA. Translation: CAA40741.1.
X66401 Genomic DNA. Translation: CAA47025.1. Different initiation.
X87344 Genomic DNA. Translation: CAA60785.1. Different initiation.
AL669918 Genomic DNA. Translation: CAI18140.1.
AL671681 Genomic DNA. Translation: CAI17714.1.
AL935043 Genomic DNA. Translation: CAI18626.1.
BX927138 Genomic DNA. Translation: CAQ08449.1.
CR762476 Genomic DNA. Translation: CAQ08495.1.
CR933844 Genomic DNA. Translation: CAQ08906.1.
CR753889 Genomic DNA. Translation: CAQ10287.1.
CH471081 Genomic DNA. Translation: EAX03647.1.
BC014081 mRNA. Translation: AAH14081.1.
L21204 mRNA. Translation: AAC12902.1.
L21205 mRNA. Translation: AAC12903.1.
L21206 mRNA. Translation: AAC12904.1.
L21207 mRNA. Translation: AAC12905.1.
L21208 mRNA. Translation: AAC12906.1.
X57521 mRNA. Translation: CAA40740.1.
S70274 mRNA. Translation: AAD14056.1.
CCDSiCCDS4758.1.
PIRiS13427. A41538.
RefSeqiNP_000584.2. NM_000593.5.
NP_001278951.1. NM_001292022.1.
UniGeneiHs.352018.
Hs.731555.

Genome annotation databases

EnsembliENST00000354258; ENSP00000346206; ENSG00000168394.
ENST00000383235; ENSP00000372722; ENSG00000206297.
ENST00000414467; ENSP00000405356; ENSG00000226173.
ENST00000418205; ENSP00000401149; ENSG00000227816.
ENST00000424897; ENSP00000413080; ENSG00000230705.
ENST00000439781; ENSP00000415660; ENSG00000224212.
ENST00000440894; ENSP00000402316; ENSG00000232367.
GeneIDi6890.
KEGGihsa:6890.
UCSCiuc003ocg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

TAP1base

TAP1 mutation db

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57522 mRNA. Translation: CAA40741.1.
X66401 Genomic DNA. Translation: CAA47025.1. Different initiation.
X87344 Genomic DNA. Translation: CAA60785.1. Different initiation.
AL669918 Genomic DNA. Translation: CAI18140.1.
AL671681 Genomic DNA. Translation: CAI17714.1.
AL935043 Genomic DNA. Translation: CAI18626.1.
BX927138 Genomic DNA. Translation: CAQ08449.1.
CR762476 Genomic DNA. Translation: CAQ08495.1.
CR933844 Genomic DNA. Translation: CAQ08906.1.
CR753889 Genomic DNA. Translation: CAQ10287.1.
CH471081 Genomic DNA. Translation: EAX03647.1.
BC014081 mRNA. Translation: AAH14081.1.
L21204 mRNA. Translation: AAC12902.1.
L21205 mRNA. Translation: AAC12903.1.
L21206 mRNA. Translation: AAC12904.1.
L21207 mRNA. Translation: AAC12905.1.
L21208 mRNA. Translation: AAC12906.1.
X57521 mRNA. Translation: CAA40740.1.
S70274 mRNA. Translation: AAD14056.1.
CCDSiCCDS4758.1.
PIRiS13427. A41538.
RefSeqiNP_000584.2. NM_000593.5.
NP_001278951.1. NM_001292022.1.
UniGeneiHs.352018.
Hs.731555.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJ7X-ray2.40A549-808[»]
ProteinModelPortaliQ03518.
SMRiQ03518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112753. 40 interactors.
DIPiDIP-35626N.
IntActiQ03518. 41 interactors.
MINTiMINT-1477433.
STRINGi9606.ENSP00000346206.

Chemistry databases

DrugBankiDB01259. Lapatinib.

Protein family/group databases

TCDBi3.A.1.209.1. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ03518.
PhosphoSitePlusiQ03518.
SwissPalmiQ03518.

Polymorphism and mutation databases

BioMutaiTAP1.
DMDMi215273957.

Proteomic databases

EPDiQ03518.
MaxQBiQ03518.
PaxDbiQ03518.
PeptideAtlasiQ03518.
PRIDEiQ03518.

Protocols and materials databases

DNASUi6890.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354258; ENSP00000346206; ENSG00000168394.
ENST00000383235; ENSP00000372722; ENSG00000206297.
ENST00000414467; ENSP00000405356; ENSG00000226173.
ENST00000418205; ENSP00000401149; ENSG00000227816.
ENST00000424897; ENSP00000413080; ENSG00000230705.
ENST00000439781; ENSP00000415660; ENSG00000224212.
ENST00000440894; ENSP00000402316; ENSG00000232367.
GeneIDi6890.
KEGGihsa:6890.
UCSCiuc003ocg.4. human.

Organism-specific databases

CTDi6890.
DisGeNETi6890.
GeneCardsiTAP1.
HGNCiHGNC:43. TAP1.
HPAiCAB009516.
MalaCardsiTAP1.
MIMi170260. gene.
604571. phenotype.
neXtProtiNX_Q03518.
OpenTargetsiENSG00000168394.
ENSG00000206297.
ENSG00000224212.
ENSG00000226173.
ENSG00000227816.
ENSG00000230705.
ENSG00000232367.
Orphaneti34592. Immunodeficiency by defective expression of HLA class 1.
PharmGKBiPA35021.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ03518.
KOiK05653.
OMAiCLGEMAI.
OrthoDBiEOG091G05Q9.
PhylomeDBiQ03518.
TreeFamiTF105197.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168394-MONOMER.
BRENDAi3.6.3.43. 2681.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiTAP1. human.
EvolutionaryTraceiQ03518.
GeneWikiiTAP1.
GenomeRNAii6890.
PROiQ03518.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168394.
CleanExiHS_TAP1.
ExpressionAtlasiQ03518. baseline and differential.
GenevisibleiQ03518. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_Tap-like.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR013306. Tap1/ABCB2.
[Graphical view]
PANTHERiPTHR24221:SF249. PTHR24221:SF249. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAP1_HUMAN
AccessioniPrimary (citable) accession number: Q03518
Secondary accession number(s): Q16149, Q96CP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 182 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-61 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.