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Reviewed, UniProtKB/Swiss-Prot Q03518 (TAP1_HUMAN)

Last modified July 7, 2009. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Antigen peptide transporter 1
      Short name=APT1
Alternative name(s):
    Peptide transporter TAP1
    ATP-binding cassette sub-family B member 2
    Peptide supply factor 1
    Peptide transporter PSF1
      Short name=PSF-1
    Peptide transporter involved in antigen processing 1
Gene names
Name: TAP1
Synonyms: ABCB2, PSF1, RING4, Y3
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length808 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Subunit structure

Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BNLF2a.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: The transmembrane segments seem to form a pore in the membrane.

Induction

By interferon gamma.

Domain

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Polymorphism

There are five common alleles; TAP1*0101 (PSF1A), TAP1*0201 (PSF1B), TAP1*0301 (PSF1C), TAP1*0104 and TAP1*x. The sequence of TAP1*0101 is shown here.

Involvement in disease

Defects in TAP1 are a cause of bare lymphocyte syndrome type 1 (BLS1) [MIM:604571]; also called HLA class I deficiency. BLS1 is a class I antigen deficiency that is not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. Ref.15

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Caution

It is uncertain whether Met-1 or Met-61 is the initiator.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 808808Antigen peptide transporter 1
PRO_0000093326

Regions

Topological domain61 – 7515Cytoplasmic Potential
Transmembrane76 – 96211 Potential
Topological domain97 – 11317Lumenal Potential
Transmembrane114 – 136232 Potential
Topological domain137 – 15216Cytoplasmic Potential
Transmembrane153 – 173213 Potential
Topological domain174 – 19320Lumenal Potential
Transmembrane194 – 214214 Potential
Topological domain215 – 24632Cytoplasmic Potential
Transmembrane247 – 267215 Potential
Topological domain268 – 28720Lumenal Potential
Transmembrane288 – 308216 Potential
Topological domain309 – 35850Cytoplasmic Potential
Transmembrane359 – 379217 Potential
Topological domain380 – 3889Lumenal Potential
Transmembrane389 – 409218 Potential
Topological domain410 – 47869Cytoplasmic Potential
Transmembrane479 – 499219 Potential
Topological domain500 – 5034Lumenal Potential
Transmembrane504 – 5242110 Potential
Topological domain525 – 808284Cytoplasmic Potential
Domain247 – 530284ABC transmembrane type-1
Domain563 – 802240ABC transporter
Nucleotide binding598 – 6058ATP Potential
Region435 – 48046Involved in peptide-binding site
Region513 – 54735Involved in peptide-binding site

Natural variations

Natural variant671P → S Ref.24
VAR_016801
Natural variant771G → R Ref.24
VAR_016802
Natural variant1701L → V: dbSNP rs2228108.
VAR_048137
Natural variant3461S → F: dbSNP rs2228111.
VAR_048138
Natural variant3931I → V in allele TAP1*0201, allele TAP1*0301, allele TAP1*0401 and allele TAP1*x. dbSNP rs1057141. Ref.24 Ref.7 Ref.21 Ref.23
VAR_000092
Natural variant4301A → V in allele TAP1*x. dbSNP rs2127679. Ref.24 Ref.23
VAR_013151
Natural variant4791G → C: dbSNP rs2228110. Ref.24
VAR_016803
Natural variant5181V → L in allele TAP1*0401. Ref.24 Ref.7 Ref.23
VAR_013152
Natural variant5781V → I in allele TAP1*x. Ref.23
VAR_013153
Natural variant6971D → G in allele TAP1*0201, allele TAP1*0401 and allele TAP1*x. dbSNP rs1135216. Ref.24 Ref.7 Ref.21 Ref.23 Ref.9
VAR_000093
Natural variant7081R → Q in allele TAP1*0401. dbSNP rs1057149. Ref.24 Ref.7 Ref.23 Ref.9
VAR_013154
Natural variant7191R → Q in a lung cancer cell line deficient in MHC class I presentation.
VAR_013173
Natural variant7681Q → R: dbSNP rs1057149.
VAR_047514

Secondary structure

................................................ 808
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q03518-1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 9CA5FF96FADD6A1B

FASTA80887,218
        10         20         30         40         50         60 
MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP GRDRDGVRVP 

        70         80         90        100        110        120 
MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 

       130        140        150        160        170        180 
GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG 

       190        200        210        220        230        240 
APGSADSTRL LHWGSHPTAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 

       250        260        270        280        290        300 
GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 

       310        320        330        340        350        360 
LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS 

       370        380        390        400        410        420 
ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL 

       430        440        450        460        470        480 
AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM 

       490        500        510        520        530        540 
LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE 

       550        560        570        580        590        600 
YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 

       610        620        630        640        650        660 
GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 

       670        680        690        700        710        720 
YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK 

       730        740        750        760        770        780 
PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 

       790        800 
REGGTHQQLM EKKGCYWAMV QAPADAPE 

« Hide

References

« Hide 'large scale' references
[1]"Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters."
Trowsdale J., Hanson I., Mockridge I., Beck S., Townsend A., Kelly A.
Nature 348:741-744(1990) [PubMed: 2259383] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
Beck S., Kelly A., Radley E., Khurshid F., Alderton R.P., Trowsdale J.
J. Mol. Biol. 228:433-441(1992) [PubMed: 1453454] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
Beck S., Abdulla S., Alderton R.P., Glynne R.J., Gut I.G., Hosking L.K., Jackson A., Kelly A., Newell W.R., Sanseau P., Radley E., Thorpe K.L., Trowsdale J.
J. Mol. Biol. 255:1-13(1996) [PubMed: 8568858] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[7]"TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility."
Jackson D.G., Capra J.D.
Proc. Natl. Acad. Sci. U.S.A. 90:11079-11083(1993) [PubMed: 8248212] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-808, VARIANTS VAL-393; LEU-518; GLY-697 AND GLN-708.
Tissue: Blood.
[8]"A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway."
Spies T., Bresnahan M., Bahram S., Arnold D., Blanck G., Mellins E., Pious D., Demars R.
Nature 348:744-747(1990) [PubMed: 2259384] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-612.
[9]"New allelic polymorphisms in TAP genes."
Szafer F., Oksenberg J.R., Steinman L.
Immunogenetics 39:374-374(1994) [PubMed: 8168860] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 691-723, VARIANTS GLY-697 AND GLN-708.
[10]"Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."
Bahram S., Arnold D., Bresnahan M., Strominger J.L., Spies T.
Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed: 1946428] [Abstract]
Cited for: TISSUE SPECIFICITY.
[11]"Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."
Ahn K., Meyer T.H., Uebel S., Sempe P., Djaballah H., Yang Y., Peterson P.A., Frueh K., Tampe R.
EMBO J. 15:3247-3255(1996) [PubMed: 8670825] [Abstract]
Cited for: INHIBITION BY ICP47.
[12]"Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."
Nijenhuis M., Hammerling G.J.
J. Immunol. 157:5467-5477(1996) [PubMed: 8955196] [Abstract]
Cited for: PEPTIDE-BINDING SITE.
[13]"Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10."
Zeidler R., Eissner G., Meissner P., Uebel S., Tampe R., Lazis S., Hammerschmidt W.
Blood 90:2390-2397(1997) [PubMed: 9310490] [Abstract]
Cited for: DOWN-REGULATION BY VIRAL IL-10.
[14]"The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."
Ahn K., Gruhler A., Galocha B., Jones T.R., Wiertz E.J.H.J., Ploegh H.L., Peterson P.A., Yang Y., Frueh K.
Immunity 6:613-621(1997) [PubMed: 9175839] [Abstract]
Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[15]"Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome."
Furukawa H., Murata S., Yabe T., Shimbara N., Keicho N., Kashiwase K., Watanabe K., Ishikawa Y., Akaza T., Tadokoro K., Tohma S., Inoue T., Tokunaga K., Yamamoto K., Tanaka K., Juji T.
J. Clin. Invest. 103:755-758(1999) [PubMed: 10074494] [Abstract]
Cited for: INVOLVEMENT IN BLS1.
[16]"Adenovirus E19 has two mechanisms for affecting class I MHC expression."
Bennett E.M., Bennink J.R., Yewdell J.W., Brodsky F.M.
J. Immunol. 162:5049-5052(1999) [PubMed: 10227971] [Abstract]
Cited for: INHIBITION BY E3-19K GLYCOPROTEIN.
[17]"The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."
Hewitt E.W., Gupta S.S., Lehner P.J.
EMBO J. 20:387-396(2001) [PubMed: 11157746] [Abstract]
Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[18]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[19]"Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."
Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E.
J. Immunol. 182:2313-2324(2009) [PubMed: 19201886] [Abstract]
Cited for: INTERACTION WITH EBV BNLF2A.
[20]"Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing."
Gaudet R., Wiley D.C.
EMBO J. 20:4964-4972(2001) [PubMed: 11532960] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 549-808.
[21]"Allelic variants of the human putative peptide transporter involved in antigen processing."
Colonna M., Bresnahan M., Bahram S., Strominger J.L., Spies T.
Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed: 1570316] [Abstract]
Cited for: VARIANTS VAL-393 AND GLY-697.
[22]"A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer."
Chen H.L., Gabrilovich D., Tampe R., Girgis K.R., Nadaf S., Carbone D.P.
Nat. Genet. 13:210-213(1996) [PubMed: 8640228] [Abstract]
Cited for: VARIANT GLN-719.
[23]"TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies."
Tang J., Freedman D.O., Allen S., Karita E., Musonda R., Braga C., Margolick J., Kaslow R.A.
Hum. Immunol. 62:256-268(2001) [PubMed: 11250043] [Abstract]
Cited for: VARIANTS VAL-393; VAL-430; LEU-518; ILE-578; GLY-697 AND GLN-708.
[24]"Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases."
Lajoie J., Zijenah L.S., Faucher M.C., Ward B.J., Roger M.
Hum. Immunol. 64:823-829(2003) [PubMed: 12878362] [Abstract]
Cited for: VARIANTS SER-67; ARG-77; VAL-393; VAL-430; CYS-479; LEU-518; GLY-697 AND GLN-708.
+Additional computationally mapped references.

Web resources

TAP1base

TAP1 mutation db

Cross-references

Sequence databases

X57522 mRNA. Translation: CAA40741.1.
X66401 Genomic DNA. Translation: CAA47025.1. Different initiation.
X87344 Genomic DNA. Translation: CAA60785.1. Different initiation.
AL669918 Genomic DNA. Translation: CAI18140.1.
AL671681 Genomic DNA. Translation: CAI17714.1.
AL935043 Genomic DNA. Translation: CAI18626.1.
BX927138 Genomic DNA. Translation: CAQ08449.1.
CR762476 Genomic DNA. Translation: CAQ08495.1.
CR933844 Genomic DNA. Translation: CAQ08906.1.
CR753889 Genomic DNA. Translation: CAQ10287.1.
CH471081 Genomic DNA. Translation: EAX03647.1.
BC014081 mRNA. Translation: AAH14081.1.
L21204 mRNA. Translation: AAC12902.1.
L21205 mRNA. Translation: AAC12903.1.
L21206 mRNA. Translation: AAC12904.1.
L21207 mRNA. Translation: AAC12905.1.
L21208 mRNA. Translation: AAC12906.1.
X57521 mRNA. Translation: CAA40740.1.
S70274 mRNA. Translation: AAD14056.1.
IPIIPI00646625.
PIRA41538. S13427.
RefSeqNP_000584.2.
UniGeneHs.352018

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1JJ7X-ray2.40A549-808[»]
ModBaseSearch...

Protein-protein interaction databases

IntActQ03518. 12 interactions.

Protein family/group databases

TCDB3.A.1.209.1. ATP-binding cassette (ABC) superfamily.

Proteomic databases

PRIDEQ03518.

Genome annotation databases

EnsemblENSG00000168394. Homo sapiens. [Contig view]
ENSG00000206233. Homo sapiens. [Contig view]
ENSG00000206297. Homo sapiens. [Contig view]
GeneID6890.
KEGGhsa:6890.
UCSCuc003ocg.1. human.

Organism-specific databases

GeneCardsGC06M032920.
H-InvDBHIX0005760.
HIX0057922.
HIX0078577.
HIX0078746.
HGNCHGNC:43. TAP1.
MIM170260. gene.
604571. phenotype.
Orphanet843. Bronchopneumopathy, chronic, due to TAP deficiency.
34592. Immunodeficiency by defective expression of HLA class 1.
PharmGKBPA29020.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ03518.
OMAQ03518. CLGEMAI.

Enzyme and pathway databases

BRENDA3.6.3.43. 247.

Gene expression databases

ArrayExpressQ03518.
CleanExHS_TAP1.
GermOnlineENSG00000168394. Homo sapiens.

Family and domain databases

InterProIPR013305. ABC_B2.
IPR001140. ABC_TM_transpt.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR005293. Ag_transporter2.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSPR01896. TAP1PROTEIN.
ProDomPD000006. ABC_transporter. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00958. 3a01208. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameTAP1_HUMAN
AccessionPrimary (citable) accession number: Q03518
Secondary accession number(s): Q16149, Q96CP4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: July 7, 2009
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents