Reviewed, UniProtKB/Swiss-Prot Q03518 (TAP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Antigen peptide transporter 1
      Short name=APT1
Alternative name(s):
    Peptide transporter TAP1
    ATP-binding cassette sub-family B member 2
    Peptide supply factor 1
    Peptide transporter PSF1
      Short name=PSF-1
    Peptide transporter involved in antigen processing 1

Gene names

Name:	TAP1
Synonyms:	ABCB2, PSF1, RING4, Y3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	808 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
Subunit structure	Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BNLF2a.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: The transmembrane segments seem to form a pore in the membrane.
Induction	By interferon gamma.
Domain	The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.
Polymorphism	There are five common alleles; TAP1*0101 (PSF1A), TAP1*0201 (PSF1B), TAP1*0301 (PSF1C), TAP1*0104 and TAP1*x. The sequence of TAP1*0101 is shown here.
Involvement in disease	Defects in TAP1 are a cause of bare lymphocyte syndrome type 1 (BLS1) [MIM:604571]; also called HLA class I deficiency. BLS1 is a class I antigen deficiency that is not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. Ref.15
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.
Caution	It is uncertain whether Met-1 or Met-61 is the initiator.

Ontologies

Keywords
Biological process	Host-virus interaction Immune response Peptide transport Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	immune response Inferred from electronic annotation. Source: UniProtKB-KW oligopeptide transport Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Ref.10 Non-traceable author statement. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro oligopeptide transporter activity Inferred from electronic annotation. Source: UniProtKB-KW protein heterodimerization activity Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CALR	P27797	1	EBI-747259,EBI-1049597
P4HB	P07237	3	EBI-747259,EBI-395883
PDIA3	P30101	3	EBI-747259,EBI-979862
TAP2	Q03519	2	EBI-747259,EBI-780781
TAPBP	O15533	4	EBI-747259,EBI-874801

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 808

808

Antigen peptide transporter 1

PRO_0000093326

Regions

Topological domain

61 – 75

15

Cytoplasmic Potential

Transmembrane

76 – 96

21

1 Potential

Topological domain

97 – 113

17

Lumenal Potential

Transmembrane

114 – 136

23

2 Potential

Topological domain

137 – 152

16

Cytoplasmic Potential

Transmembrane

153 – 173

21

3 Potential

Topological domain

174 – 193

20

Lumenal Potential

Transmembrane

194 – 214

21

4 Potential

Topological domain

215 – 246

32

Cytoplasmic Potential

Transmembrane

247 – 267

21

5 Potential

Topological domain

268 – 287

20

Lumenal Potential

Transmembrane

288 – 308

21

6 Potential

Topological domain

309 – 358

50

Cytoplasmic Potential

Transmembrane

359 – 379

21

7 Potential

Topological domain

380 – 388

9

Lumenal Potential

Transmembrane

389 – 409

21

8 Potential

Topological domain

410 – 478

69

Cytoplasmic Potential

Transmembrane

479 – 499

21

9 Potential

Topological domain

500 – 503

4

Lumenal Potential

Transmembrane

504 – 524

21

10 Potential

Topological domain

525 – 808

284

Cytoplasmic Potential

Domain

247 – 530

284

ABC transmembrane type-1

Domain

563 – 802

240

ABC transporter

Nucleotide binding

598 – 605

8

ATP Potential

Region

435 – 480

46

Involved in peptide-binding site

Region

513 – 547

35

Involved in peptide-binding site

Natural variations

Natural variant

67

1

P → S Ref.24

VAR_016801

Natural variant

77

1

G → R Ref.24

VAR_016802

Natural variant

170

1

L → V: dbSNP rs2228108.

VAR_048137

Natural variant

346

1

S → F: dbSNP rs2228111.

VAR_048138

Natural variant

393

1

I → V in allele TAP1*0201, allele TAP1*0301, allele TAP1*0401 and allele TAP1*x. dbSNP rs1057141. Ref.24 Ref.7 Ref.21 Ref.23

VAR_000092

Natural variant

430

1

A → V in allele TAP1*x. dbSNP rs2127679. Ref.24 Ref.23

VAR_013151

Natural variant

479

1

G → C: dbSNP rs2228110. Ref.24

VAR_016803

Natural variant

518

1

V → L in allele TAP1*0401. Ref.24 Ref.7 Ref.23

VAR_013152

Natural variant

578

1

V → I in allele TAP1*x. Ref.23

VAR_013153

Natural variant

697

1

D → G in allele TAP1*0201, allele TAP1*0401 and allele TAP1*x. dbSNP rs1135216. Ref.24 Ref.7 Ref.21 Ref.23 Ref.9

VAR_000093

Natural variant

708

1

R → Q in allele TAP1*0401. dbSNP rs1057149. Ref.24 Ref.7 Ref.23 Ref.9

VAR_013154

Natural variant

719

1

R → Q in a lung cancer cell line deficient in MHC class I presentation.

VAR_013173

Natural variant

768

1

Q → R: dbSNP rs1057149.

VAR_047514

Secondary structure

1

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808

Helix Strand Turn

Details...

Beta strand

563 – 570

8

Beta strand

580 – 588

9

Beta strand

593 – 597

5

Helix

604 – 611

8

Beta strand

618 – 624

7

Helix

629 – 631

3

Helix

634 – 640

7

Beta strand

641 – 644

4

Beta strand

652 – 654

3

Helix

655 – 660

6

Helix

669 – 678

10

Helix

682 – 686

5

Helix

691 – 693

3

Beta strand

701 – 703

3

Helix

705 – 717

13

Beta strand

722 – 728

7

Turn

729 – 732

4

Helix

735 – 746

12

Helix

749 – 753

5

Beta strand

755 – 759

5

Helix

763 – 767

5

Beta strand

770 – 776

7

Beta strand

779 – 784

6

Helix

786 – 792

7

Helix

795 – 800

6

Sequences

	Sequence		Length	Mass (Da)
	Q03518-1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 9CA5FF96FADD6A1B	FASTA	808	87,218
	10 20 30 40 50 60 MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP GRDRDGVRVP 70 80 90 100 110 120 MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 130 140 150 160 170 180 GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG 190 200 210 220 230 240 APGSADSTRL LHWGSHPTAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 250 260 270 280 290 300 GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 310 320 330 340 350 360 LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS 370 380 390 400 410 420 ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL 430 440 450 460 470 480 AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM 490 500 510 520 530 540 LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE 550 560 570 580 590 600 YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 610 620 630 640 650 660 GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 670 680 690 700 710 720 YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK 730 740 750 760 770 780 PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 790 800 REGGTHQQLM EKKGCYWAMV QAPADAPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters." Trowsdale J., Hanson I., Mockridge I., Beck S., Townsend A., Kelly A. Nature 348:741-744(1990) [PubMed: 2259383] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing." Beck S., Kelly A., Radley E., Khurshid F., Alderton R.P., Trowsdale J. J. Mol. Biol. 228:433-441(1992) [PubMed: 1453454] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC." Beck S., Abdulla S., Alderton R.P., Glynne R.J., Gut I.G., Hosking L.K., Jackson A., Kelly A., Newell W.R., Sanseau P., Radley E., Thorpe K.L., Trowsdale J. J. Mol. Biol. 255:1-13(1996) [PubMed: 8568858] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[7]	"TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility." Jackson D.G., Capra J.D. Proc. Natl. Acad. Sci. U.S.A. 90:11079-11083(1993) [PubMed: 8248212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-808, VARIANTS VAL-393; LEU-518; GLY-697 AND GLN-708. Tissue: Blood.
[8]	"A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway." Spies T., Bresnahan M., Bahram S., Arnold D., Blanck G., Mellins E., Pious D., Demars R. Nature 348:744-747(1990) [PubMed: 2259384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-612.
[9]	"New allelic polymorphisms in TAP genes." Szafer F., Oksenberg J.R., Steinman L. Immunogenetics 39:374-374(1994) [PubMed: 8168860] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 691-723, VARIANTS GLY-697 AND GLN-708.
[10]	"Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region." Bahram S., Arnold D., Bresnahan M., Strominger J.L., Spies T. Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed: 1946428] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47." Ahn K., Meyer T.H., Uebel S., Sempe P., Djaballah H., Yang Y., Peterson P.A., Frueh K., Tampe R. EMBO J. 15:3247-3255(1996) [PubMed: 8670825] [Abstract] Cited for: INHIBITION BY ICP47.
[12]	"Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site." Nijenhuis M., Hammerling G.J. J. Immunol. 157:5467-5477(1996) [PubMed: 8955196] [Abstract] Cited for: PEPTIDE-BINDING SITE.
[13]	"Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10." Zeidler R., Eissner G., Meissner P., Uebel S., Tampe R., Lazis S., Hammerschmidt W. Blood 90:2390-2397(1997) [PubMed: 9310490] [Abstract] Cited for: DOWN-REGULATION BY VIRAL IL-10.
[14]	"The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP." Ahn K., Gruhler A., Galocha B., Jones T.R., Wiertz E.J.H.J., Ploegh H.L., Peterson P.A., Yang Y., Frueh K. Immunity 6:613-621(1997) [PubMed: 9175839] [Abstract] Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[15]	"Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome." Furukawa H., Murata S., Yabe T., Shimbara N., Keicho N., Kashiwase K., Watanabe K., Ishikawa Y., Akaza T., Tadokoro K., Tohma S., Inoue T., Tokunaga K., Yamamoto K., Tanaka K., Juji T. J. Clin. Invest. 103:755-758(1999) [PubMed: 10074494] [Abstract] Cited for: INVOLVEMENT IN BLS1.
[16]	"Adenovirus E19 has two mechanisms for affecting class I MHC expression." Bennett E.M., Bennink J.R., Yewdell J.W., Brodsky F.M. J. Immunol. 162:5049-5052(1999) [PubMed: 10227971] [Abstract] Cited for: INHIBITION BY E3-19K GLYCOPROTEIN.
[17]	"The human cytomegalovirus gene product US6 inhibits ATP binding by TAP." Hewitt E.W., Gupta S.S., Lehner P.J. EMBO J. 20:387-396(2001) [PubMed: 11157746] [Abstract] Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[18]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[19]	"Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation." Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E. J. Immunol. 182:2313-2324(2009) [PubMed: 19201886] [Abstract] Cited for: INTERACTION WITH EBV BNLF2A.
[20]	"Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing." Gaudet R., Wiley D.C. EMBO J. 20:4964-4972(2001) [PubMed: 11532960] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 549-808.
[21]	"Allelic variants of the human putative peptide transporter involved in antigen processing." Colonna M., Bresnahan M., Bahram S., Strominger J.L., Spies T. Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed: 1570316] [Abstract] Cited for: VARIANTS VAL-393 AND GLY-697.
[22]	"A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer." Chen H.L., Gabrilovich D., Tampe R., Girgis K.R., Nadaf S., Carbone D.P. Nat. Genet. 13:210-213(1996) [PubMed: 8640228] [Abstract] Cited for: VARIANT GLN-719.
[23]	"TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies." Tang J., Freedman D.O., Allen S., Karita E., Musonda R., Braga C., Margolick J., Kaslow R.A. Hum. Immunol. 62:256-268(2001) [PubMed: 11250043] [Abstract] Cited for: VARIANTS VAL-393; VAL-430; LEU-518; ILE-578; GLY-697 AND GLN-708.
[24]	"Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases." Lajoie J., Zijenah L.S., Faucher M.C., Ward B.J., Roger M. Hum. Immunol. 64:823-829(2003) [PubMed: 12878362] [Abstract] Cited for: VARIANTS SER-67; ARG-77; VAL-393; VAL-430; CYS-479; LEU-518; GLY-697 AND GLN-708.
+	Additional computationally mapped references.

Web resources

TAP1base

TAP1 mutation db

Cross-references

Sequence databases

EMBLGenBankDDBJ

X57522 mRNA. Translation: CAA40741.1.
X66401 Genomic DNA. Translation: CAA47025.1. Different initiation.
X87344 Genomic DNA. Translation: CAA60785.1. Different initiation.
AL669918 Genomic DNA. Translation: CAI18140.1.
AL671681 Genomic DNA. Translation: CAI17714.1.
AL935043 Genomic DNA. Translation: CAI18626.1.
BX927138 Genomic DNA. Translation: CAQ08449.1.
CR762476 Genomic DNA. Translation: CAQ08495.1.
CR933844 Genomic DNA. Translation: CAQ08906.1.
CR753889 Genomic DNA. Translation: CAQ10287.1.
CH471081 Genomic DNA. Translation: EAX03647.1.
BC014081 mRNA. Translation: AAH14081.1.
L21204 mRNA. Translation: AAC12902.1.
L21205 mRNA. Translation: AAC12903.1.
L21206 mRNA. Translation: AAC12904.1.
L21207 mRNA. Translation: AAC12905.1.
L21208 mRNA. Translation: AAC12906.1.
X57521 mRNA. Translation: CAA40740.1.
S70274 mRNA. Translation: AAD14056.1.

IPI

IPI00646625.

PIR

A41538. S13427.

RefSeq

NP_000584.2.

UniGene

Hs.352018

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JJ7	X-ray	2.40	A	549-808	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q03518. 12 interactions.

Protein family/group databases

TCDB

3.A.1.209.1. ATP-binding cassette (ABC) superfamily.

Proteomic databases

PRIDE

Q03518.

Genome annotation databases

Ensembl

ENSG00000168394. Homo sapiens. [Contig view]
ENSG00000206233. Homo sapiens. [Contig view]
ENSG00000206297. Homo sapiens. [Contig view]

GeneID

6890.

KEGG

hsa:6890.

UCSC

uc003ocg.1. human.

Organism-specific databases

GeneCards

GC06M032920.

H-InvDB

HIX0005760.
HIX0057922.
HIX0078577.
HIX0078746.

HGNC

HGNC:43. TAP1.

MIM

170260. gene.
604571. phenotype.

Orphanet

843. Bronchopneumopathy, chronic, due to TAP deficiency.
34592. Immunodeficiency by defective expression of HLA class 1.

PharmGKB

PA29020.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q03518.

OMA

Q03518. CLGEMAI.

Enzyme and pathway databases

BRENDA

3.6.3.43. 247.

Gene expression databases

ArrayExpress

Q03518.

CleanEx

HS_TAP1.

GermOnline

ENSG00000168394. Homo sapiens.

Family and domain databases

InterPro

IPR013305. ABC_B2.
IPR001140. ABC_TM_transpt.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR005293. Ag_transporter2.
IPR003593. ATPase_AAA+_core.
[Graphical view]

Pfam

PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]

PRINTS

PR01896. TAP1PROTEIN.

ProDom

PD000006. ABC_transporter. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00382. AAA. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00958. 3a01208. 1 hit.

PROSITE

PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

ProtoNet

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Other Resources

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Entry information

Entry name

TAP1_HUMAN

Accession

Primary (citable) accession number: Q03518
Secondary accession number(s): Q16149, Q96CP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 25, 2008
Last modified:	July 7, 2009
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)