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Q03518

- TAP1_HUMAN

UniProt

Q03518 - TAP1_HUMAN

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Protein
Antigen peptide transporter 1
Gene
TAP1, ABCB2, PSF1, RING4, Y3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi598 – 6058ATP Reviewed prediction

GO - Molecular functioni

  1. ADP binding Source: UniProtKB
  2. ATP binding Source: UniProtKB
  3. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
  4. MHC class Ib protein binding Source: UniProt
  5. TAP1 binding Source: UniProtKB
  6. TAP2 binding Source: UniProtKB
  7. peptide antigen binding Source: UniProtKB
  8. peptide transporter activity Source: UniProtKB
  9. protein binding Source: IntAct
  10. protein homodimerization activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. antigen processing and presentation of endogenous peptide antigen via MHC class I Source: UniProtKB
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytosol to ER transport Source: UniProtKB
  6. defense response Source: Ensembl
  7. intracellular transport of viral protein in host cell Source: UniProtKB
  8. peptide transport Source: UniProtKB
  9. transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Host-virus interaction, Immunity, Peptide transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.43. 2681.
ReactomeiREACT_111178. ER-Phagosome pathway.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Protein family/group databases

TCDBi3.A.1.209.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen peptide transporter 1
Short name:
APT1
Alternative name(s):
ATP-binding cassette sub-family B member 2
Peptide supply factor 1
Peptide transporter PSF1
Short name:
PSF-1
Peptide transporter TAP1
Peptide transporter involved in antigen processing 1
Really interesting new gene 4 protein
Gene namesi
Name:TAP1
Synonyms:ABCB2, PSF1, RING4, Y3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:43. TAP1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein
Note: The transmembrane segments seem to form a pore in the membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini61 – 7515Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei76 – 9621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini97 – 11317Lumenal Reviewed prediction
Add
BLAST
Transmembranei114 – 13623Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini137 – 15216Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei153 – 17321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini174 – 19320Lumenal Reviewed prediction
Add
BLAST
Transmembranei194 – 21421Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini215 – 24632Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei247 – 26721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini268 – 28720Lumenal Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini309 – 35850Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei359 – 37921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini380 – 3889Lumenal Reviewed prediction
Transmembranei389 – 40921Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini410 – 47869Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei479 – 49921Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini500 – 5034Lumenal Reviewed prediction
Transmembranei504 – 52421Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini525 – 808284Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. TAP complex Source: UniProtKB
  2. endoplasmic reticulum membrane Source: Reactome
  3. integral component of endoplasmic reticulum membrane Source: UniProtKB
  4. integral component of membrane Source: UniProtKB
  5. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi604571. phenotype.
Orphaneti34592. Immunodeficiency by defective expression of HLA class 1.
PharmGKBiPA35021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808Antigen peptide transporter 1
PRO_0000093326Add
BLAST

Proteomic databases

MaxQBiQ03518.
PaxDbiQ03518.
PRIDEiQ03518.

PTM databases

PhosphoSiteiQ03518.

Expressioni

Inductioni

By IFNG/IFN-gamma.1 Publication

Gene expression databases

ArrayExpressiQ03518.
BgeeiQ03518.
CleanExiHS_TAP1.
GenevestigatoriQ03518.

Organism-specific databases

HPAiCAB009516.

Interactioni

Subunit structurei

Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BNLF2a. Interacts with PSMB5 and PSMB8.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BNLF2aP0C7398EBI-747259,EBI-9346744From a different organism.
CALRP277972EBI-747259,EBI-1049597
P4HBP072374EBI-747259,EBI-395883
PDIA3P301014EBI-747259,EBI-979862
TAP2Q0351913EBI-747259,EBI-780781
TAPBPO1553312EBI-747259,EBI-874801
THOC5Q137694EBI-747259,EBI-5280316

Protein-protein interaction databases

BioGridi112753. 24 interactions.
DIPiDIP-35626N.
IntActiQ03518. 18 interactions.
MINTiMINT-1477433.
STRINGi9606.ENSP00000346206.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi563 – 5708
Beta strandi580 – 5889
Beta strandi593 – 5975
Helixi604 – 6118
Beta strandi618 – 6247
Helixi629 – 6313
Helixi634 – 6407
Beta strandi641 – 6444
Beta strandi652 – 6543
Helixi655 – 6606
Helixi669 – 67810
Helixi682 – 6865
Helixi691 – 6933
Beta strandi701 – 7033
Helixi705 – 71713
Beta strandi722 – 7287
Turni729 – 7324
Helixi735 – 74612
Helixi749 – 7535
Beta strandi755 – 7595
Helixi763 – 7675
Beta strandi770 – 7767
Beta strandi779 – 7846
Helixi786 – 7927
Helixi795 – 8006

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JJ7X-ray2.40A549-808[»]
ProteinModelPortaliQ03518.
SMRiQ03518. Positions 234-802.

Miscellaneous databases

EvolutionaryTraceiQ03518.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini247 – 530284ABC transmembrane type-1
Add
BLAST
Domaini563 – 802240ABC transporter
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni435 – 48046Involved in peptide-binding site
Add
BLAST
Regioni513 – 54735Involved in peptide-binding site
Add
BLAST

Domaini

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
HOVERGENiHBG008358.
InParanoidiQ03518.
KOiK05653.
OMAiCLGSEIR.
PhylomeDBiQ03518.
TreeFamiTF105197.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_B2.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005293. Ag_transporter2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSiPR01896. TAP1PROTEIN.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00958. 3a01208. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03518-1 [UniParc]FASTAAdd to Basket

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MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP    50
GRDRDGVRVP MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL 100
PRIFSLLVPT ALPLLRVWAV GLSRWAVLWL GACGVLRATV GSKSENAGAQ 150
GWLAALKPLA AALGLALPGL ALFRELISWG APGSADSTRL LHWGSHPTAF 200
VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL GSETRRLSLF 250
LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 300
LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE 350
DTSTLSDSLS ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL 400
LPKKVGKWYQ LLEVQVRESL AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF 450
REKLQEIKTL NQKEAVAYAV NSWTTSISGM LLKVGILYIG GQLVTSGAVS 500
SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE YLDRTPRCPP 550
SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 600
GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV 650
FGRSLQENIA YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG 700
SQLSGGQRQA VALARALIRK PCVLILDDAT SALDANSQLQ VEQLLYESPE 750
RYSRSVLLIT QHLSLVEQAD HILFLEGGAI REGGTHQQLM EKKGCYWAMV 800
QAPADAPE 808
Length:808
Mass (Da):87,218
Last modified:November 25, 2008 - v2
Checksum:i9CA5FF96FADD6A1B
GO

Sequence cautioni

The sequence CAA47025.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA60785.1 differs from that shown. Reason: Erroneous initiation.

Polymorphismi

There are five common alleles; TAP1*01:01 (PSF1A), TAP1*02:01 (PSF1B), TAP1*03:01 (PSF1C), TAP1*01:04 and TAP1*x. The sequence of TAP1*01:01 is shown here.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671P → S.1 Publication
VAR_016801
Natural varianti77 – 771G → R.1 Publication
Corresponds to variant rs57640466 [ dbSNP | Ensembl ].
VAR_016802
Natural varianti170 – 1701L → V.
Corresponds to variant rs2228108 [ dbSNP | Ensembl ].
VAR_048137
Natural varianti304 – 3041V → L.
Corresponds to variant rs36229525 [ dbSNP | Ensembl ].
VAR_060987
Natural varianti346 – 3461S → F.
Corresponds to variant rs2228111 [ dbSNP | Ensembl ].
VAR_048138
Natural varianti393 – 3931I → V in allele TAP1*02:01, allele TAP1*03:01, allele TAP1*04:01 and allele TAP1*x. 4 Publications
Corresponds to variant rs1057141 [ dbSNP | Ensembl ].
VAR_000092
Natural varianti430 – 4301A → V in allele TAP1*x. 2 Publications
Corresponds to variant rs2127679 [ dbSNP | Ensembl ].
VAR_013151
Natural varianti479 – 4791G → C.1 Publication
Corresponds to variant rs2228110 [ dbSNP | Ensembl ].
VAR_016803
Natural varianti518 – 5181V → L in allele TAP1*04:01. 3 Publications
Corresponds to variant rs41550019 [ dbSNP | Ensembl ].
VAR_013152
Natural varianti578 – 5781V → I in allele TAP1*x. 1 Publication
Corresponds to variant rs41561219 [ dbSNP | Ensembl ].
VAR_013153
Natural varianti697 – 6971D → G in allele TAP1*02:01, allele TAP1*04:01 and allele TAP1*x. 5 Publications
Corresponds to variant rs1135216 [ dbSNP | Ensembl ].
VAR_000093
Natural varianti708 – 7081R → Q in allele TAP1*04:01. 4 Publications
Corresponds to variant rs1057149 [ dbSNP | Ensembl ].
VAR_013154
Natural varianti719 – 7191R → Q in a lung cancer cell line deficient in MHC class I presentation. 1 Publication
Corresponds to variant rs121917702 [ dbSNP | Ensembl ].
VAR_013173
Natural varianti768 – 7681Q → R.
Corresponds to variant rs1057149 [ dbSNP | Ensembl ].
VAR_047514

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57522 mRNA. Translation: CAA40741.1.
X66401 Genomic DNA. Translation: CAA47025.1. Different initiation.
X87344 Genomic DNA. Translation: CAA60785.1. Different initiation.
AL669918 Genomic DNA. Translation: CAI18140.1.
AL671681 Genomic DNA. Translation: CAI17714.1.
AL935043 Genomic DNA. Translation: CAI18626.1.
BX927138 Genomic DNA. Translation: CAQ08449.1.
CR762476 Genomic DNA. Translation: CAQ08495.1.
CR933844 Genomic DNA. Translation: CAQ08906.1.
CR753889 Genomic DNA. Translation: CAQ10287.1.
CH471081 Genomic DNA. Translation: EAX03647.1.
BC014081 mRNA. Translation: AAH14081.1.
L21204 mRNA. Translation: AAC12902.1.
L21205 mRNA. Translation: AAC12903.1.
L21206 mRNA. Translation: AAC12904.1.
L21207 mRNA. Translation: AAC12905.1.
L21208 mRNA. Translation: AAC12906.1.
X57521 mRNA. Translation: CAA40740.1.
S70274 mRNA. Translation: AAD14056.1.
CCDSiCCDS4758.1.
PIRiS13427. A41538.
RefSeqiNP_000584.2. NM_000593.5.
UniGeneiHs.352018.

Genome annotation databases

EnsembliENST00000354258; ENSP00000346206; ENSG00000168394.
ENST00000383235; ENSP00000372722; ENSG00000206297.
ENST00000414467; ENSP00000405356; ENSG00000226173.
ENST00000418205; ENSP00000401149; ENSG00000227816.
ENST00000424897; ENSP00000413080; ENSG00000230705.
ENST00000439781; ENSP00000415660; ENSG00000224212.
ENST00000440894; ENSP00000402316; ENSG00000232367.
GeneIDi6890.
KEGGihsa:6890.
UCSCiuc003ocg.3. human.

Polymorphism databases

DMDMi215273957.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

TAP1base

TAP1 mutation db

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57522 mRNA. Translation: CAA40741.1 .
X66401 Genomic DNA. Translation: CAA47025.1 . Different initiation.
X87344 Genomic DNA. Translation: CAA60785.1 . Different initiation.
AL669918 Genomic DNA. Translation: CAI18140.1 .
AL671681 Genomic DNA. Translation: CAI17714.1 .
AL935043 Genomic DNA. Translation: CAI18626.1 .
BX927138 Genomic DNA. Translation: CAQ08449.1 .
CR762476 Genomic DNA. Translation: CAQ08495.1 .
CR933844 Genomic DNA. Translation: CAQ08906.1 .
CR753889 Genomic DNA. Translation: CAQ10287.1 .
CH471081 Genomic DNA. Translation: EAX03647.1 .
BC014081 mRNA. Translation: AAH14081.1 .
L21204 mRNA. Translation: AAC12902.1 .
L21205 mRNA. Translation: AAC12903.1 .
L21206 mRNA. Translation: AAC12904.1 .
L21207 mRNA. Translation: AAC12905.1 .
L21208 mRNA. Translation: AAC12906.1 .
X57521 mRNA. Translation: CAA40740.1 .
S70274 mRNA. Translation: AAD14056.1 .
CCDSi CCDS4758.1.
PIRi S13427. A41538.
RefSeqi NP_000584.2. NM_000593.5.
UniGenei Hs.352018.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JJ7 X-ray 2.40 A 549-808 [» ]
ProteinModelPortali Q03518.
SMRi Q03518. Positions 234-802.
ModBasei Search...

Protein-protein interaction databases

BioGridi 112753. 24 interactions.
DIPi DIP-35626N.
IntActi Q03518. 18 interactions.
MINTi MINT-1477433.
STRINGi 9606.ENSP00000346206.

Protein family/group databases

TCDBi 3.A.1.209.1. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei Q03518.

Polymorphism databases

DMDMi 215273957.

Proteomic databases

MaxQBi Q03518.
PaxDbi Q03518.
PRIDEi Q03518.

Protocols and materials databases

DNASUi 6890.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354258 ; ENSP00000346206 ; ENSG00000168394 .
ENST00000383235 ; ENSP00000372722 ; ENSG00000206297 .
ENST00000414467 ; ENSP00000405356 ; ENSG00000226173 .
ENST00000418205 ; ENSP00000401149 ; ENSG00000227816 .
ENST00000424897 ; ENSP00000413080 ; ENSG00000230705 .
ENST00000439781 ; ENSP00000415660 ; ENSG00000224212 .
ENST00000440894 ; ENSP00000402316 ; ENSG00000232367 .
GeneIDi 6890.
KEGGi hsa:6890.
UCSCi uc003ocg.3. human.

Organism-specific databases

CTDi 6890.
GeneCardsi GC06M032812.
GC06Mi32796.
GC06Mj32735.
GC06Mk32790.
GC06Ml32966.
GC06Mm32846.
GC06Mn32741.
HGNCi HGNC:43. TAP1.
HPAi CAB009516.
MIMi 170260. gene.
604571. phenotype.
neXtProti NX_Q03518.
Orphaneti 34592. Immunodeficiency by defective expression of HLA class 1.
PharmGKBi PA35021.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
HOVERGENi HBG008358.
InParanoidi Q03518.
KOi K05653.
OMAi CLGSEIR.
PhylomeDBi Q03518.
TreeFami TF105197.

Enzyme and pathway databases

BRENDAi 3.6.3.43. 2681.
Reactomei REACT_111178. ER-Phagosome pathway.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

EvolutionaryTracei Q03518.
GeneWikii TAP1.
GenomeRNAii 6890.
NextBioi 26925.
PROi Q03518.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q03518.
Bgeei Q03518.
CleanExi HS_TAP1.
Genevestigatori Q03518.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR013305. ABC_B2.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005293. Ag_transporter2.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
PRINTSi PR01896. TAP1PROTEIN.
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsi TIGR00958. 3a01208. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters."
    Trowsdale J., Hanson I., Mockridge I., Beck S., Townsend A., Kelly A.
    Nature 348:741-744(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
    Beck S., Kelly A., Radley E., Khurshid F., Alderton R.P., Trowsdale J.
    J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
    Beck S., Abdulla S., Alderton R.P., Glynne R.J., Gut I.G., Hosking L.K., Jackson A., Kelly A., Newell W.R., Sanseau P., Radley E., Thorpe K.L., Trowsdale J.
    J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  7. "TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility."
    Jackson D.G., Capra J.D.
    Proc. Natl. Acad. Sci. U.S.A. 90:11079-11083(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-808, VARIANTS VAL-393; LEU-518; GLY-697 AND GLN-708.
    Tissue: Blood.
  8. "A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway."
    Spies T., Bresnahan M., Bahram S., Arnold D., Blanck G., Mellins E., Pious D., Demars R.
    Nature 348:744-747(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-612.
  9. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 691-723, VARIANTS GLY-697 AND GLN-708.
  10. "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."
    Bahram S., Arnold D., Bresnahan M., Strominger J.L., Spies T.
    Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."
    Ahn K., Meyer T.H., Uebel S., Sempe P., Djaballah H., Yang Y., Peterson P.A., Frueh K., Tampe R.
    EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITION BY ICP47.
  12. "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."
    Nijenhuis M., Hammerling G.J.
    J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PEPTIDE-BINDING SITE.
  13. "Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10."
    Zeidler R., Eissner G., Meissner P., Uebel S., Tampe R., Lazis S., Hammerschmidt W.
    Blood 90:2390-2397(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOWN-REGULATION BY VIRAL IL-10.
  14. "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."
    Ahn K., Gruhler A., Galocha B., Jones T.R., Wiertz E.J.H.J., Ploegh H.L., Peterson P.A., Yang Y., Frueh K.
    Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITION BY US6 GLYCOPROTEIN.
  15. "Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome."
    Furukawa H., Murata S., Yabe T., Shimbara N., Keicho N., Kashiwase K., Watanabe K., Ishikawa Y., Akaza T., Tadokoro K., Tohma S., Inoue T., Tokunaga K., Yamamoto K., Tanaka K., Juji T.
    J. Clin. Invest. 103:755-758(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BLS1.
  16. "Adenovirus E19 has two mechanisms for affecting class I MHC expression."
    Bennett E.M., Bennink J.R., Yewdell J.W., Brodsky F.M.
    J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITION BY E3-19K GLYCOPROTEIN.
  17. "The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."
    Hewitt E.W., Gupta S.S., Lehner P.J.
    EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITION BY US6 GLYCOPROTEIN.
  18. "Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."
    Begley G.S., Horvath A.R., Taylor J.C., Higgins C.F.
    Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PSMB5 AND PSMB8.
  19. "Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."
    Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E.
    J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EBV BNLF2A.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing."
    Gaudet R., Wiley D.C.
    EMBO J. 20:4964-4972(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 549-808.
  22. "Allelic variants of the human putative peptide transporter involved in antigen processing."
    Colonna M., Bresnahan M., Bahram S., Strominger J.L., Spies T.
    Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-393 AND GLY-697.
  23. "A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer."
    Chen H.L., Gabrilovich D., Tampe R., Girgis K.R., Nadaf S., Carbone D.P.
    Nat. Genet. 13:210-213(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-719.
  24. "TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies."
    Tang J., Freedman D.O., Allen S., Karita E., Musonda R., Braga C., Margolick J., Kaslow R.A.
    Hum. Immunol. 62:256-268(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-393; VAL-430; LEU-518; ILE-578; GLY-697 AND GLN-708.
  25. "Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases."
    Lajoie J., Zijenah L.S., Faucher M.C., Ward B.J., Roger M.
    Hum. Immunol. 64:823-829(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SER-67; ARG-77; VAL-393; VAL-430; CYS-479; LEU-518; GLY-697 AND GLN-708.

Entry informationi

Entry nameiTAP1_HUMAN
AccessioniPrimary (citable) accession number: Q03518
Secondary accession number(s): Q16149, Q96CP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-61 is the initiator.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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