Q03518 (TAP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Antigen peptide transporter 1
Short name=APT1

Alternative name(s):
ATP-binding cassette sub-family B member 2
Peptide supply factor 1
Peptide transporter PSF1
Short name=PSF-1
Peptide transporter TAP1
Peptide transporter involved in antigen processing 1
Really interesting new gene 4 protein

Gene names

Name:	TAP1
Synonyms:	ABCB2, PSF1, RING4, Y3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	808 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
Subunit structure	Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BNLF2a. Interacts with PSMB5 and PSMB8. Ref.18 Ref.19
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: The transmembrane segments seem to form a pore in the membrane.
Induction	By IFNG/IFN-gamma. Ref.13
Domain	The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.
Polymorphism	There are five common alleles; TAP1*01:01 (PSF1A), TAP1*02:01 (PSF1B), TAP1*03:01 (PSF1C), TAP1*01:04 and TAP1*x. The sequence of TAP1*01:01 is shown here.
Involvement in disease	Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.
Caution	It is uncertain whether Met-1 or Met-61 is the initiator.
Sequence caution	The sequence CAA47025.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA60785.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Adaptive immunity Host-virus interaction Immunity Peptide transport Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I Inferred from mutant phenotype PubMed 11133832. Source: UniProtKB antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome cytosol to ER transport Inferred from mutant phenotype PubMed 7538543. Source: UniProtKB defense response Inferred from electronic annotation. Source: Compara intracellular transport of viral proteins in host cell Inferred from mutant phenotype PubMed 7538543. Source: UniProtKB positive regulation of T cell mediated cytotoxicity Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	TAP complex Inferred from direct assay PubMed 11133832PubMed 15518576. Source: UniProtKB cytosol Non-traceable author statement PubMed 11133832. Source: UniProtKB mitochondrion Inferred from electronic annotation. Source: Compara plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	ADP binding Inferred from direct assay Ref.21. Source: UniProtKB ATP binding Inferred from direct assay PubMed 11133832PubMed 7673167. Source: UniProtKB MHC class I protein binding Inferred from Biological aspect of Ancestor. Source: RefGenome TAP1 binding Inferred from sequence or structural similarity. Source: UniProtKB TAP2 binding Inferred from Biological aspect of Ancestor. Source: RefGenome oligopeptide-transporting ATPase activity Inferred from Biological aspect of Ancestor. Source: RefGenome peptide antigen binding Non-traceable author statement PubMed 11133832. Source: UniProtKB protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB tapasin binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CALR	P27797	2	EBI-747259,EBI-1049597
P4HB	P07237	4	EBI-747259,EBI-395883
PDIA3	P30101	4	EBI-747259,EBI-979862
TAP2	Q03519	6	EBI-747259,EBI-780781
TAPBP	O15533	7	EBI-747259,EBI-874801

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 808

808

Antigen peptide transporter 1

PRO_0000093326

Regions

Topological domain

61 – 75

15

Cytoplasmic Potential

Transmembrane

76 – 96

21

Helical; Name=1; Potential

Topological domain

97 – 113

17

Lumenal Potential

Transmembrane

114 – 136

23

Helical; Name=2; Potential

Topological domain

137 – 152

16

Cytoplasmic Potential

Transmembrane

153 – 173

21

Helical; Name=3; Potential

Topological domain

174 – 193

20

Lumenal Potential

Transmembrane

194 – 214

21

Helical; Name=4; Potential

Topological domain

215 – 246

32

Cytoplasmic Potential

Transmembrane

247 – 267

21

Helical; Name=5; Potential

Topological domain

268 – 287

20

Lumenal Potential

Transmembrane

288 – 308

21

Helical; Name=6; Potential

Topological domain

309 – 358

50

Cytoplasmic Potential

Transmembrane

359 – 379

21

Helical; Name=7; Potential

Topological domain

380 – 388

9

Lumenal Potential

Transmembrane

389 – 409

21

Helical; Name=8; Potential

Topological domain

410 – 478

69

Cytoplasmic Potential

Transmembrane

479 – 499

21

Helical; Name=9; Potential

Topological domain

500 – 503

4

Lumenal Potential

Transmembrane

504 – 524

21

Helical; Name=10; Potential

Topological domain

525 – 808

284

Cytoplasmic Potential

Domain

247 – 530

284

ABC transmembrane type-1

Domain

563 – 802

240

ABC transporter

Nucleotide binding

598 – 605

8

ATP Potential

Region

435 – 480

46

Involved in peptide-binding site

Region

513 – 547

35

Involved in peptide-binding site

Natural variations

Natural variant

67

1

P → S. Ref.25

VAR_016801

Natural variant

77

1

G → R. Ref.25
Corresponds to variant rs57640466 [ dbSNP | Ensembl ].

VAR_016802

Natural variant

170

1

L → V.
Corresponds to variant rs2228108 [ dbSNP | Ensembl ].

VAR_048137

Natural variant

304

1

V → L.
Corresponds to variant rs36229525 [ dbSNP | Ensembl ].

VAR_060987

Natural variant

346

1

S → F.
Corresponds to variant rs2228111 [ dbSNP | Ensembl ].

VAR_048138

Natural variant

393

1

I → V in allele TAP1*02:01, allele TAP1*03:01, allele TAP1*04:01 and allele TAP1*x. Ref.7 Ref.22 Ref.24 Ref.25
Corresponds to variant rs1057141 [ dbSNP | Ensembl ].

VAR_000092

Natural variant

430

1

A → V in allele TAP1*x. Ref.24 Ref.25
Corresponds to variant rs2127679 [ dbSNP | Ensembl ].

VAR_013151

Natural variant

479

1

G → C. Ref.25
Corresponds to variant rs2228110 [ dbSNP | Ensembl ].

VAR_016803

Natural variant

518

1

V → L in allele TAP1*04:01. Ref.7 Ref.24 Ref.25
Corresponds to variant rs41550019 [ dbSNP | Ensembl ].

VAR_013152

Natural variant

578

1

V → I in allele TAP1*x. Ref.24
Corresponds to variant rs41561219 [ dbSNP | Ensembl ].

VAR_013153

Natural variant

697

1

D → G in allele TAP1*02:01, allele TAP1*04:01 and allele TAP1*x. Ref.7 Ref.9 Ref.22 Ref.24 Ref.25
Corresponds to variant rs1135216 [ dbSNP | Ensembl ].

VAR_000093

Natural variant

708

1

R → Q in allele TAP1*04:01. Ref.7 Ref.9 Ref.24 Ref.25
Corresponds to variant rs1057149 [ dbSNP | Ensembl ].

VAR_013154

Natural variant

719

1

R → Q in a lung cancer cell line deficient in MHC class I presentation. Ref.23

VAR_013173

Natural variant

768

1

Q → R.
Corresponds to variant rs1057149 [ dbSNP | Ensembl ].

VAR_047514

Secondary structure

1

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808

Helix Strand Turn

Details...

Beta strand

563 – 570

8

Beta strand

580 – 588

9

Beta strand

593 – 597

5

Helix

604 – 611

8

Beta strand

618 – 624

7

Helix

629 – 631

3

Helix

634 – 640

7

Beta strand

641 – 644

4

Beta strand

652 – 654

3

Helix

655 – 660

6

Helix

669 – 678

10

Helix

682 – 686

5

Helix

691 – 693

3

Beta strand

701 – 703

3

Helix

705 – 717

13

Beta strand

722 – 728

7

Turn

729 – 732

4

Helix

735 – 746

12

Helix

749 – 753

5

Beta strand

755 – 759

5

Helix

763 – 767

5

Beta strand

770 – 776

7

Beta strand

779 – 784

6

Helix

786 – 792

7

Helix

795 – 800

6

Sequences

	Sequence		Length	Mass (Da)
	Q03518 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 9CA5FF96FADD6A1B	FASTA	808	87,218
	10 20 30 40 50 60 MAELLASAGS ACSWDFPRAP PSFPPPAASR GGLGGTRSFR PHRGAESPRP GRDRDGVRVP 70 80 90 100 110 120 MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV 130 140 150 160 170 180 GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG 190 200 210 220 230 240 APGSADSTRL LHWGSHPTAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL 250 260 270 280 290 300 GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV 310 320 330 340 350 360 LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS 370 380 390 400 410 420 ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL 430 440 450 460 470 480 AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM 490 500 510 520 530 540 LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE 550 560 570 580 590 600 YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN 610 620 630 640 650 660 GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA 670 680 690 700 710 720 YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK 730 740 750 760 770 780 PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI 790 800 REGGTHQQLM EKKGCYWAMV QAPADAPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters." Trowsdale J., Hanson I., Mockridge I., Beck S., Townsend A., Kelly A. Nature 348:741-744(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing." Beck S., Kelly A., Radley E., Khurshid F., Alderton R.P., Trowsdale J. J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC." Beck S., Abdulla S., Alderton R.P., Glynne R.J., Gut I.G., Hosking L.K., Jackson A., Kelly A., Newell W.R., Sanseau P., Radley E., Thorpe K.L., Trowsdale J. J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[7]	"TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility." Jackson D.G., Capra J.D. Proc. Natl. Acad. Sci. U.S.A. 90:11079-11083(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-808, VARIANTS VAL-393; LEU-518; GLY-697 AND GLN-708. Tissue: Blood.
[8]	"A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway." Spies T., Bresnahan M., Bahram S., Arnold D., Blanck G., Mellins E., Pious D., Demars R. Nature 348:744-747(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-612.
[9]	"New allelic polymorphisms in TAP genes." Szafer F., Oksenberg J.R., Steinman L. Immunogenetics 39:374-374(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 691-723, VARIANTS GLY-697 AND GLN-708.
[10]	"Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region." Bahram S., Arnold D., Bresnahan M., Strominger J.L., Spies T. Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47." Ahn K., Meyer T.H., Uebel S., Sempe P., Djaballah H., Yang Y., Peterson P.A., Frueh K., Tampe R. EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract] Cited for: INHIBITION BY ICP47.
[12]	"Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site." Nijenhuis M., Hammerling G.J. J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PEPTIDE-BINDING SITE.
[13]	"Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10." Zeidler R., Eissner G., Meissner P., Uebel S., Tampe R., Lazis S., Hammerschmidt W. Blood 90:2390-2397(1997) [PubMed] [Europe PMC] [Abstract] Cited for: DOWN-REGULATION BY VIRAL IL-10.
[14]	"The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP." Ahn K., Gruhler A., Galocha B., Jones T.R., Wiertz E.J.H.J., Ploegh H.L., Peterson P.A., Yang Y., Frueh K. Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract] Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[15]	"Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome." Furukawa H., Murata S., Yabe T., Shimbara N., Keicho N., Kashiwase K., Watanabe K., Ishikawa Y., Akaza T., Tadokoro K., Tohma S., Inoue T., Tokunaga K., Yamamoto K., Tanaka K., Juji T. J. Clin. Invest. 103:755-758(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN BLS1.
[16]	"Adenovirus E19 has two mechanisms for affecting class I MHC expression." Bennett E.M., Bennink J.R., Yewdell J.W., Brodsky F.M. J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INHIBITION BY E3-19K GLYCOPROTEIN.
[17]	"The human cytomegalovirus gene product US6 inhibits ATP binding by TAP." Hewitt E.W., Gupta S.S., Lehner P.J. EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INHIBITION BY US6 GLYCOPROTEIN.
[18]	"Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome." Begley G.S., Horvath A.R., Taylor J.C., Higgins C.F. Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PSMB5 AND PSMB8.
[19]	"Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation." Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E. J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EBV BNLF2A.
[20]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[21]	"Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing." Gaudet R., Wiley D.C. EMBO J. 20:4964-4972(2001) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 549-808.
[22]	"Allelic variants of the human putative peptide transporter involved in antigen processing." Colonna M., Bresnahan M., Bahram S., Strominger J.L., Spies T. Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS VAL-393 AND GLY-697.
[23]	"A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer." Chen H.L., Gabrilovich D., Tampe R., Girgis K.R., Nadaf S., Carbone D.P. Nat. Genet. 13:210-213(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLN-719.
[24]	"TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies." Tang J., Freedman D.O., Allen S., Karita E., Musonda R., Braga C., Margolick J., Kaslow R.A. Hum. Immunol. 62:256-268(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS VAL-393; VAL-430; LEU-518; ILE-578; GLY-697 AND GLN-708.
[25]	"Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases." Lajoie J., Zijenah L.S., Faucher M.C., Ward B.J., Roger M. Hum. Immunol. 64:823-829(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS SER-67; ARG-77; VAL-393; VAL-430; CYS-479; LEU-518; GLY-697 AND GLN-708.
+	Additional computationally mapped references.

Web resources

TAP1base

TAP1 mutation db

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X57522 mRNA. Translation: CAA40741.1.
X66401 Genomic DNA. Translation: CAA47025.1. Different initiation.
X87344 Genomic DNA. Translation: CAA60785.1. Different initiation.
AL669918 Genomic DNA. Translation: CAI18140.1.
AL671681 Genomic DNA. Translation: CAI17714.1.
AL935043 Genomic DNA. Translation: CAI18626.1.
BX927138 Genomic DNA. Translation: CAQ08449.1.
CR762476 Genomic DNA. Translation: CAQ08495.1.
CR933844 Genomic DNA. Translation: CAQ08906.1.
CR753889 Genomic DNA. Translation: CAQ10287.1.
CH471081 Genomic DNA. Translation: EAX03647.1.
BC014081 mRNA. Translation: AAH14081.1.
L21204 mRNA. Translation: AAC12902.1.
L21205 mRNA. Translation: AAC12903.1.
L21206 mRNA. Translation: AAC12904.1.
L21207 mRNA. Translation: AAC12905.1.
L21208 mRNA. Translation: AAC12906.1.
X57521 mRNA. Translation: CAA40740.1.
S70274 mRNA. Translation: AAD14056.1.

IPI

IPI00646625.

PIR

A41538. S13427.

RefSeq

NP_000584.2. NM_000593.5.

UniGene

Hs.352018.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JJ7	X-ray	2.40	A	549-808	[»]

ProteinModelPortal

Q03518.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-35626N.

IntAct

Q03518. 13 interactions.

MINT

MINT-1477433.

STRING

9606.ENSP00000346206.

Protein family/group databases

TCDB

3.A.1.209.1. ATP-binding cassette (ABC) superfamily.

PTM databases

PhosphoSite

Q03518.

Polymorphism databases

DMDM

215273957.

Proteomic databases

PaxDb

Q03518.

PRIDE

Q03518.

Protocols and materials databases

DNASU

6890.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000354258; ENSP00000346206; ENSG00000168394.
ENST00000383235; ENSP00000372722; ENSG00000206297.
ENST00000414467; ENSP00000405356; ENSG00000226173.
ENST00000418205; ENSP00000401149; ENSG00000227816.
ENST00000424897; ENSP00000413080; ENSG00000230705.
ENST00000439781; ENSP00000415660; ENSG00000224212.
ENST00000440894; ENSP00000402316; ENSG00000232367.

GeneID

6890.

KEGG

hsa:6890.

UCSC

uc003ocg.3. human.

Organism-specific databases

CTD

6890.

GeneCards

GC06M032812.

HGNC

HGNC:43. TAP1.

HPA

CAB009516.

MIM

170260. gene.
604571. phenotype.

neXtProt

NX_Q03518.

Orphanet

34592. Immunodeficiency by defective expression of HLA class 1.

PharmGKB

PA35021.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1132.

HOVERGEN

HBG008358.

InParanoid

Q03518.

KO

K05653.

OMA

LPLLRVW.

OrthoDB

EOG4KPT98.

PhylomeDB

Q03518.

Enzyme and pathway databases

BRENDA

3.6.3.43. 2681.

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

Q03518.

Bgee

Q03518.

CleanEx

HS_TAP1.

Genevestigator

Q03518.

GermOnline

ENSG00000168394. Homo sapiens.

Family and domain databases

InterPro

IPR003593. AAA+_ATPase.
IPR013305. ABC_B2.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR005293. Ag_transporter2.
[Graphical view]

Pfam

PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]

PRINTS

PR01896. TAP1PROTEIN.

SMART

SM00382. AAA. 1 hit.
[Graphical view]

SUPFAM

SSF90123. ABC_TM_1. 1 hit.

TIGRFAMs

TIGR00958. 3a01208. 1 hit.

PROSITE

PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q03518.

GenomeRNAi

6890.

NextBio

26925.

SOURCE

Search...

Entry information

Entry name

TAP1_HUMAN

Accession

Primary (citable) accession number: Q03518
Secondary accession number(s): Q16149, Q96CP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 146 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.