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Reviewed, UniProtKB/Swiss-Prot Q03509 (CALM6_ARATH)

Last modified June 16, 2009. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Calmodulin-6
      Short name=CaM-6
Gene names
Name: CAM6
Ordered Locus Names: At5g21274
ORF Names: F13M11.?
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length149 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Calmodulin mediates the control of a large number of enzymes and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Miscellaneous

This protein has four functional calcium-binding sites.

Sequence similarities

Belongs to the calmodulin family.

Contains 4 EF-hand domains.

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Ontologies

Keywords
   DomainRepeat
   LigandCalcium
   PTMAcetylation
Methylation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcalcium-mediated signaling Ref.1

Traceable author statement. Source: TAIR

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

O221791EBI-1236097,EBI-1238013
P274501EBI-1236097,EBI-1238108
Q29Q721EBI-1236097,EBI-1238714
Q2V3592EBI-1236097,EBI-1235819
Q391301EBI-1236097,EBI-1749651
Q3EAG31EBI-1236097,EBI-1238312
Q3EBV71EBI-1236097,EBI-1235683
Q4PSE31EBI-1236097,EBI-1238507
Q7X9H61EBI-1236097,EBI-1238497
Q7X9N21EBI-1236097,EBI-622264
Q84JC21EBI-1236097,EBI-1238377
Q8H1D61EBI-1236097,EBI-1238166
Q8LPR41EBI-1236097,EBI-1238087
Q8VZ701EBI-1236097,EBI-1238078
Q93Z301EBI-1236097,EBI-1237782
Q9FGX21EBI-1236097,EBI-942623
Q9FGZ51EBI-1236097,EBI-622281
Q9FIW61EBI-1236097,EBI-1237967
Q9FL191EBI-1236097,EBI-622440
Q9FLL01EBI-1236097,EBI-1238516
Q9FLV41EBI-1236097,EBI-1238700
Q9FUD31EBI-1236097,EBI-942633
Q9LUI61EBI-1236097,EBI-1238581
Q9LW661EBI-1236097,EBI-1238066
Q9LX561EBI-1236097,EBI-1235891
Q9SGN71EBI-1236097,EBI-1238190
Q9SJX81EBI-1236097,EBI-1238001
Q9SKN21EBI-1236097,EBI-1237944
Q9SL701EBI-1236097,EBI-1238421
ABF4Q9M7Q21EBI-1236097,EBI-1237867
AGL21Q9SZJ61EBI-1236097,EBI-621986
AGL61Q4PSU41EBI-1236097,EBI-1237976
AGL80Q9FJK31EBI-1236097,EBI-622424
ALDH3F1Q70E961EBI-1236097,EBI-1237774
ANP3O220421EBI-1236097,EBI-1239058
APK2aO498391EBI-1236097,EBI-1238631
ASK6Q390101EBI-1236097,EBI-1238323
At1g08320Q56W431EBI-1236097,EBI-1237844
At1g27190O045671EBI-1236097,EBI-1238687
At1g54610Q9ZVM91EBI-1236097,EBI-1235713
At1g58110Q84WC81EBI-1236097,EBI-1237819
At1g60040Q9ZUI91EBI-1236097,EBI-622185
At1g68380/T2E12_7Q9M9C31EBI-1236097,EBI-1238618
At1g77145O806511EBI-1236097,EBI-1238133
At1g80120Q9SSC71EBI-1236097,EBI-1238625
At3g02880Q9M8T01EBI-1236097,EBI-1238677
At3g17600Q2VW982EBI-1236097,EBI-1235997
At3g19100Q9LJL91EBI-1236097,EBI-1238393
AT4g02410O812921EBI-1236097,EBI-1237950
AT4g02640O227631EBI-1236097,EBI-969959
At4g18630/F28A21_40Q8GYP41EBI-1236097,EBI-1239007
AT4g34380Q9SZ031EBI-1236097,EBI-1238343
At4g37240/C7A10_120Q8LE561EBI-1236097,EBI-1237996
At4g39540/F23K16_170Q8GY881EBI-1236097,EBI-1238334
At5g38800Q9FMC21EBI-1236097,EBI-1237855
At5g49760/K2I5_13Q8GZ991EBI-1236097,EBI-1238218
AtMg00870P925251EBI-1236097,EBI-1238547
BZIP61Q9M2K41EBI-1236097,EBI-1237830
CAM7P592201EBI-1236097,EBI-1236031
CDKB2-2Q8LG642EBI-1236097,EBI-1235761
CIPK24Q9LDI31EBI-1236097,EBI-537551
CIPK6O655541EBI-1236097,EBI-537615
CKI1Q390501EBI-1236097,EBI-1237881
CML45Q93Z271EBI-1236097,EBI-1235938
CML9Q9S7441EBI-1236097,EBI-1236048
CPK3Q424792EBI-1236097,EBI-1235782
CPK30Q9SSF81EBI-1236097,EBI-1235738
CRK40Q9SYS31EBI-1236097,EBI-1238119
CRK9O654691EBI-1236097,EBI-1238158
CYP19-3Q388671EBI-1236097,EBI-1235851
CYP705A20Q9LJY71EBI-1236097,EBI-1237907
CYP78A9Q9SLP11EBI-1236097,EBI-1238437
dl4570wO235521EBI-1236097,EBI-1235805
F11C1_150Q9SND62EBI-1236097,EBI-1235872
F14F8_210Q9LFU31EBI-1236097,EBI-1237805
F18O21_230Q9LYL61EBI-1236097,EBI-1238139
FBW2Q9ZPE41EBI-1236097,EBI-604740
FBX14Q8RWQ81EBI-1236097,EBI-1235922
HSP81-2P557372EBI-1236097,EBI-1235834
LRR-RLKQ3ECN41EBI-1236097,EBI-1238268
LRR-RLKQ8VYG71EBI-1236097,EBI-1238236
LRR-RLKQ9LSI91EBI-1236097,EBI-1238253
LRR-RLKQ9M9C51EBI-1236097,EBI-1238661
MHKP432941EBI-1236097,EBI-1238022
MPK18Q9C5C01EBI-1236097,EBI-1238534
NEK7Q9LHI71EBI-1236097,EBI-1238055
PCKAQ9T0741EBI-1236097,EBI-1238593
PEPKR2Q8W4901EBI-1236097,EBI-1238381
PFK2Q9FIK01EBI-1236097,EBI-1238609
PFK3Q94AA41EBI-1236097,EBI-1238600
psbAP837551EBI-1236097,EBI-1236013
PUB7Q9CAG51EBI-1236097,EBI-1239045
RKF3P930501EBI-1236097,EBI-1238281
SCL21Q9S7H51EBI-1236097,EBI-1238472
SCL4Q9FL031EBI-1236097,EBI-1238466
SHP1Q5XXJ31EBI-1236097,EBI-1237985
T12C14_120Q9LZP81EBI-1236097,EBI-942845
T20L15_160Q9LZV71EBI-1236097,EBI-1238200
T4M14.10Q9LQ651EBI-1236097,EBI-942986
TT16Q8RYD91EBI-1236097,EBI-621993
WAKL21Q8GYF51EBI-1236097,EBI-1238355
WRKY43Q8GY111EBI-1236097,EBI-1235953
WRKY53Q9SUP62EBI-1236097,EBI-1235980

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 149148Calmodulin-6
PRO_0000198282

Regions

Domain8 – 4336EF-hand 1
Domain44 – 7936EF-hand 2
Domain81 – 11636EF-hand 3
Domain117 – 14933EF-hand 4
Calcium binding21 – 32121 By similarity
Calcium binding57 – 68122 By similarity
Calcium binding94 – 105123 By similarity
Calcium binding130 – 141124 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1161N6,N6,N6-trimethyllysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q03509-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: AA6E088A90AD508A

FASTA14916,834
        10         20         30         40         50         60 
MADQLTDDQI SEFKEAFSLF DKDGDGCITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 

        70         80         90        100        110        120 
NGTIDFPEFL NLMARKMKDT DSEEELKEAF RVFDKDQNGF ISAAELRHVM TNLGEKLSDE 

       130        140 
EVDEMIREAD VDGDGQINYE EFVKVMMAK

« Hide

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References

« Hide 'large scale' references
[1]"Calmodulin isoforms in Arabidopsis encoded by multiple divergent mRNAs."
Gawienowski M.C., Szymanski D., Perera I.Y., Zielinski R.E.
Plant Mol. Biol. 22:215-225(1993) [PubMed: 8507825] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. expand/collapse author list , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
Nature 408:823-826(2000) [PubMed: 11130714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Calmodulins and related potential calcium sensors of Arabidopsis."
McCormack E., Braam J.
New Phytol. 159:585-598(2003)
Cited for: GENE FAMILY, NOMENCLATURE.

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Cross-references

Sequence databases

Z12024 mRNA. Translation: CAA78059.1.
AC140977 Genomic DNA. Translation: AAO73886.1.
AY050350 mRNA. Translation: AAK91367.1.
AY094037 mRNA. Translation: AAM16193.1.
IPIIPI00520449.
PIRS35187.
RefSeqNP_850860.1.
UniGeneAt.21106

3D structure databases

HSSPHSSP built from PDB template 1F70 based on UniProtKB P02593.
SMRQ03509. Positions 1-148.
ModBaseSearch...

Protein-protein interaction databases

IntActQ03509. 104 interactions.

Proteomic databases

PRIDEQ03509.

Genome annotation databases

GeneID832245.
GenomeReviewsGene locus AT5G21274 in contig BA000015_GR.
KEGGath:AT5G21274.
NMPDRfig|3702.1.peg.24337.

Organism-specific databases

TAIRAt5g21274.

Phylogenomic databases

OMAQ03509. DEQIAEF.

Family and domain databases

InterProIPR011992. EF-Hand_type.
IPR018248. EF_hand.
IPR018247. EF_HAND_1.
IPR018249. EF_HAND_2.
IPR002048. EF_hand_Ca_bd.
[Graphical view]
Gene3DG3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PfamPF00036. efhand. 4 hits.
[Graphical view]
ProDomPD000012. EF-hand. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00054. EFh. 4 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCALM6_ARATH
AccessionPrimary (citable) accession number: Q03509
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents