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Protein

Calmodulin-6

Gene

CAM6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi21 – 32121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi57 – 68122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi94 – 105123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi130 – 141124PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: TAIR

GO - Biological processi

  • calcium-mediated signaling Source: TAIR
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-6
Short name:
CaM-6
Gene namesi
Name:CAM6
Ordered Locus Names:At5g21274
ORF Names:F13M11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G21274.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Calmodulin-6PRO_0000198282Add
BLAST

Proteomic databases

PaxDbiQ03509.
PRIDEiQ03509.

Interactioni

Subunit structurei

Interacts with KCBP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
At5g20810Q2V3592EBI-1236097,EBI-1235819
CDKB2-2Q8LG642EBI-1236097,EBI-1235761
CPK3Q424792EBI-1236097,EBI-1235782
F11C1_150Q9SND62EBI-1236097,EBI-1235872
HSP90-2P557372EBI-1236097,EBI-1235834
IAA31D3K0M22EBI-1236097,EBI-1235997
KCBPQ9FHN82EBI-1236097,EBI-1749651
WRKY53Q9SUP62EBI-1236097,EBI-1235980

Protein-protein interaction databases

BioGridi17520. 3 interactions.
IntActiQ03509. 107 interactions.
STRINGi3702.AT5G21274.1.

Structurei

3D structure databases

ProteinModelPortaliQ03509.
SMRiQ03509. Positions 4-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini44 – 7936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 11636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini117 – 14933EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
KOiK02183.
OMAiDEMIREP.
PhylomeDBiQ03509.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTDDQI SEFKEAFSLF DKDGDGCITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL NLMARKMKDT DSEEELKEAF RVFDKDQNGF
110 120 130 140
ISAAELRHVM TNLGEKLSDE EVDEMIREAD VDGDGQINYE EFVKVMMAK
Length:149
Mass (Da):16,834
Last modified:January 23, 2007 - v2
Checksum:iAA6E088A90AD508A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12024 mRNA. Translation: CAA78059.1.
AC140977 Genomic DNA. Translation: AAO73886.1.
CP002688 Genomic DNA. Translation: AED92947.1.
AY050350 mRNA. Translation: AAK91367.1.
AY094037 mRNA. Translation: AAM16193.1.
PIRiS35187.
RefSeqiNP_850860.1. NM_180529.3.
UniGeneiAt.21106.

Genome annotation databases

EnsemblPlantsiAT5G21274.1; AT5G21274.1; AT5G21274.
GeneIDi832245.
GrameneiAT5G21274.1; AT5G21274.1; AT5G21274.
KEGGiath:AT5G21274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12024 mRNA. Translation: CAA78059.1.
AC140977 Genomic DNA. Translation: AAO73886.1.
CP002688 Genomic DNA. Translation: AED92947.1.
AY050350 mRNA. Translation: AAK91367.1.
AY094037 mRNA. Translation: AAM16193.1.
PIRiS35187.
RefSeqiNP_850860.1. NM_180529.3.
UniGeneiAt.21106.

3D structure databases

ProteinModelPortaliQ03509.
SMRiQ03509. Positions 4-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17520. 3 interactions.
IntActiQ03509. 107 interactions.
STRINGi3702.AT5G21274.1.

Proteomic databases

PaxDbiQ03509.
PRIDEiQ03509.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G21274.1; AT5G21274.1; AT5G21274.
GeneIDi832245.
GrameneiAT5G21274.1; AT5G21274.1; AT5G21274.
KEGGiath:AT5G21274.

Organism-specific databases

TAIRiAT5G21274.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
KOiK02183.
OMAiDEMIREP.
PhylomeDBiQ03509.

Miscellaneous databases

PROiQ03509.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calmodulin isoforms in Arabidopsis encoded by multiple divergent mRNAs."
    Gawienowski M.C., Szymanski D., Perera I.Y., Zielinski R.E.
    Plant Mol. Biol. 22:215-225(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Interaction of a kinesin-like protein with calmodulin isoforms from Arabidopsis."
    Reddy V.S., Safadi F., Zielinski R.E., Reddy A.S.
    J. Biol. Chem. 274:31727-31733(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KCBP.
  6. "Calmodulins and related potential calcium sensors of Arabidopsis."
    McCormack E., Braam J.
    New Phytol. 159:585-598(2003)
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiCALM6_ARATH
AccessioniPrimary (citable) accession number: Q03509
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: March 16, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.