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Protein

Calmodulin-6

Gene

CAM6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi57 – 682PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 1053PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi130 – 1414PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: TAIR

GO - Biological processi

  • calcium-mediated signaling Source: TAIR

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-6
Short name:
CaM-6
Gene namesi
Name:CAM6
Ordered Locus Names:At5g21274
ORF Names:F13M11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRilocus:1005716170. AT5G21274.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001982821 – 149Calmodulin-6Add BLAST149

Proteomic databases

PaxDbiQ03509.
PRIDEiQ03509.

Expressioni

Gene expression databases

ExpressionAtlasiQ03509. baseline and differential.

Interactioni

Subunit structurei

Interacts with KCBP.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi17520. 3 interactors.
IntActiQ03509. 107 interactors.
STRINGi3702.AT5G21274.1.

Structurei

3D structure databases

ProteinModelPortaliQ03509.
SMRiQ03509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
KOiK02183.
OMAiDEMIREP.
OrthoDBiEOG09360QIJ.
PhylomeDBiQ03509.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q03509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTDDQI SEFKEAFSLF DKDGDGCITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL NLMARKMKDT DSEEELKEAF RVFDKDQNGF
110 120 130 140
ISAAELRHVM TNLGEKLSDE EVDEMIREAD VDGDGQINYE EFVKVMMAK
Length:149
Mass (Da):16,834
Last modified:January 23, 2007 - v2
Checksum:iAA6E088A90AD508A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12024 mRNA. Translation: CAA78059.1.
AC140977 Genomic DNA. Translation: AAO73886.1.
CP002688 Genomic DNA. Translation: AED92947.1.
AY050350 mRNA. Translation: AAK91367.1.
AY094037 mRNA. Translation: AAM16193.1.
PIRiS35187.
RefSeqiNP_850860.1. NM_180529.4.
UniGeneiAt.21106.

Genome annotation databases

EnsemblPlantsiAT5G21274.1; AT5G21274.1; AT5G21274.
GeneIDi832245.
GrameneiAT5G21274.1; AT5G21274.1; AT5G21274.
KEGGiath:AT5G21274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12024 mRNA. Translation: CAA78059.1.
AC140977 Genomic DNA. Translation: AAO73886.1.
CP002688 Genomic DNA. Translation: AED92947.1.
AY050350 mRNA. Translation: AAK91367.1.
AY094037 mRNA. Translation: AAM16193.1.
PIRiS35187.
RefSeqiNP_850860.1. NM_180529.4.
UniGeneiAt.21106.

3D structure databases

ProteinModelPortaliQ03509.
SMRiQ03509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17520. 3 interactors.
IntActiQ03509. 107 interactors.
STRINGi3702.AT5G21274.1.

Proteomic databases

PaxDbiQ03509.
PRIDEiQ03509.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G21274.1; AT5G21274.1; AT5G21274.
GeneIDi832245.
GrameneiAT5G21274.1; AT5G21274.1; AT5G21274.
KEGGiath:AT5G21274.

Organism-specific databases

AraportiAT5G21274.
TAIRilocus:1005716170. AT5G21274.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
KOiK02183.
OMAiDEMIREP.
OrthoDBiEOG09360QIJ.
PhylomeDBiQ03509.

Miscellaneous databases

PROiPR:Q03509.

Gene expression databases

ExpressionAtlasiQ03509. baseline and differential.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCALM6_ARATH
AccessioniPrimary (citable) accession number: Q03509
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.