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Protein

Beta-glucosidase

Gene

bglA

Organism
Bacillus circulans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166Proton donorSequence analysis1
Active sitei355NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase (EC:3.2.1.21)
Alternative name(s):
Amygdalase
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:bglA
OrganismiBacillus circulans
Taxonomic identifieri1397 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000638702 – 450Beta-glucosidaseAdd BLAST449

Interactioni

Protein-protein interaction databases

MINTiMINT-8328760.

Structurei

Secondary structure

1450
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi11 – 15Combined sources5
Helixi18 – 21Combined sources4
Helixi34 – 40Combined sources7
Turni42 – 44Combined sources3
Helixi46 – 48Combined sources3
Turni51 – 55Combined sources5
Helixi61 – 71Combined sources11
Beta strandi74 – 79Combined sources6
Helixi82 – 85Combined sources4
Beta strandi89 – 92Combined sources4
Helixi95 – 110Combined sources16
Beta strandi114 – 122Combined sources9
Helixi126 – 129Combined sources4
Turni130 – 132Combined sources3
Helixi133 – 135Combined sources3
Helixi138 – 154Combined sources17
Turni155 – 157Combined sources3
Beta strandi160 – 165Combined sources6
Helixi167 – 175Combined sources9
Helixi187 – 210Combined sources24
Beta strandi215 – 220Combined sources6
Beta strandi225 – 231Combined sources7
Helixi233 – 244Combined sources12
Turni245 – 247Combined sources3
Helixi248 – 255Combined sources8
Helixi261 – 269Combined sources9
Helixi280 – 284Combined sources5
Beta strandi289 – 294Combined sources6
Beta strandi298 – 303Combined sources6
Helixi307 – 309Combined sources3
Turni310 – 313Combined sources4
Beta strandi314 – 316Combined sources3
Helixi333 – 345Combined sources13
Beta strandi351 – 355Combined sources5
Helixi373 – 391Combined sources19
Beta strandi396 – 402Combined sources7
Helixi410 – 412Combined sources3
Beta strandi420 – 424Combined sources5
Turni425 – 428Combined sources4
Beta strandi429 – 432Combined sources4
Helixi434 – 445Combined sources12
Beta strandi446 – 449Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QOXX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P2-450[»]
ProteinModelPortaliQ03506.
SMRiQ03506.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03506.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIHMFPSDF KWGVATAAYQ IEGAYNEDGR GMSIWDTFAH TPGKVKNGDN
60 70 80 90 100
GNVACDSYHR VEEDVQLLKD LGVKVYRFSI SWPRVLPQGT GEVNRAGLDY
110 120 130 140 150
YHRLVDELLA NGIEPFCTLY HWDLPQALQD QGGWGSRITI DAFAEYAELM
160 170 180 190 200
FKELGGKIKQ WITFNEPWCM AFLSNYLGVH APGNKDLQLA IDVSHHLLVA
210 220 230 240 250
HGRAVTLFRE LGISGEIGIA PNTSWAVPYR RTKEDMEACL RVNGWSGDWY
260 270 280 290 300
LDPIYFGEYP KFMLDWYENL GYKPPIVDGD MELIHQPIDF IGINYYTSSM
310 320 330 340 350
NRYNPGEAGG MLSSEAISMG APKTDIGWEI YAEGLYDLLR YTADKYGNPT
360 370 380 390 400
LYITENGACY NDGLSLDGRI HDQRRIDYLA MHLIQASRAI EDGINLKGYM
410 420 430 440 450
EWSLMDNFEW AEGYGMRFGL VHVDYDTLVR TPKDSFYWYK GVISRGWLDL
Length:450
Mass (Da):51,303
Last modified:January 23, 2007 - v3
Checksum:iC52C1DB233B72790
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96979 Genomic DNA. Translation: AAA22266.1.
PIRiA48969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96979 Genomic DNA. Translation: AAA22266.1.
PIRiA48969.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QOXX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P2-450[»]
ProteinModelPortaliQ03506.
SMRiQ03506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8328760.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ03506.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBGLA_BACCI
AccessioniPrimary (citable) accession number: Q03506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.