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Protein

6-phospho-alpha-glucosidase 2

Gene

LSEI_2684

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Mn2+By similarityNote: Binds 1 divalent metal ion per subunit. Mn2+.By similarity
  • NAD+By similarityNote: Binds 1 NAD+ per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96SubstrateBy similarity1
Sitei112Increases basicity of active site TyrBy similarity1
Binding sitei150SubstrateBy similarity1
Metal bindingi172ManganeseBy similarity1
Active sitei173Proton donorBy similarity1
Metal bindingi202ManganeseBy similarity1
Active sitei267Proton acceptorBy similarity1
Binding sitei287SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 73NADBy similarityAdd BLAST67

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Manganese, Metal-binding, NAD

Protein family/group databases

CAZyiGH4. Glycoside Hydrolase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-alpha-glucosidase 2 (EC:3.2.1.122)
Gene namesi
Ordered Locus Names:LSEI_2684
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001651 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003892051 – 4616-phospho-alpha-glucosidase 2Add BLAST461

Structurei

3D structure databases

ProteinModelPortaliQ034G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 4 family.Curated

Phylogenomic databases

HOGENOMiHOG000239810.
KOiK01232.
OMAiAENGYLT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR019802. GlycHydrolase_4_CS.
IPR001088. Glyco_hydro_4.
IPR022616. Glyco_hydro_4_C.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02056. Glyco_hydro_4. 1 hit.
PF11975. Glyco_hydro_4C. 1 hit.
[Graphical view]
PRINTSiPR00732. GLHYDRLASE4.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
PROSITEiPS01324. GLYCOSYL_HYDROL_F4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q034G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQNKQFSIV IAGGGSTYTA GIVMMLLENA ERFPLRALKL YDIDEERQAT
60 70 80 90 100
IAEAIAIELK EKAPAIDFTW TTDPQTAFTD VDFCFAHIRS GGYKMREQDE
110 120 130 140 150
KIPLKHHVVG QETCGPGGIA YGMRSIGDII ELIDFIEKYS PDCWMLNYSN
160 170 180 190 200
PASIVAEACR RLRPDAKILN ICDMPVGTQR RMSQIIGLQP KDLEVRYFGM
210 220 230 240 250
NHFGWWTSVK DKAGNEYLPQ IRDYVAHHGY LTQIEVDTQH MDASWQATHK
260 270 280 290 300
KAQDLLAVDP HYLPNTYLKY YLYPDYVVAH SDPDYTRANE VEDGREKCVF
310 320 330 340 350
SAAQKIIDAG TSDVGSFPID SHASFIVDLA CAIAFNTHER MLLIVENNGA
360 370 380 390 400
VANIDDNIMV EVPCIVGKDG AEPLTQGKIP MFQRGMILNQ AMVEKLVVDA
410 420 430 440 450
WINHDYQELW QALTLSKTLP SAQVAKEVLD DLIEANREYW PELKHDEHEV
460
HLISESAVSE I
Length:461
Mass (Da):52,030
Last modified:November 14, 2006 - v1
Checksum:iF96D99955DA75E84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ71403.1.
RefSeqiWP_011674973.1. NC_008526.1.
YP_807845.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ71403; ABJ71403; LSEI_2684.
GeneIDi4421236.
KEGGilca:LSEI_2684.
PATRICi22209078. VBILacCas62221_2628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ71403.1.
RefSeqiWP_011674973.1. NC_008526.1.
YP_807845.1. NC_008526.1.

3D structure databases

ProteinModelPortaliQ034G9.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH4. Glycoside Hydrolase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ71403; ABJ71403; LSEI_2684.
GeneIDi4421236.
KEGGilca:LSEI_2684.
PATRICi22209078. VBILacCas62221_2628.

Phylogenomic databases

HOGENOMiHOG000239810.
KOiK01232.
OMAiAENGYLT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR019802. GlycHydrolase_4_CS.
IPR001088. Glyco_hydro_4.
IPR022616. Glyco_hydro_4_C.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02056. Glyco_hydro_4. 1 hit.
PF11975. Glyco_hydro_4C. 1 hit.
[Graphical view]
PRINTSiPR00732. GLHYDRLASE4.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
PROSITEiPS01324. GLYCOSYL_HYDROL_F4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAGL2_LACC3
AccessioniPrimary (citable) accession number: Q034G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: November 14, 2006
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.