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Q034G9

- PAGL2_LACC3

UniProt

Q034G9 - PAGL2_LACC3

Protein

6-phospho-alpha-glucosidase 2

Gene

LSEI_2684

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate.

    Cofactori

    Binds 1 divalent metal ion per subunit. Manganese By similarity.By similarity
    Binds 1 NAD+ per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961SubstrateBy similarity
    Sitei112 – 1121Increases basicity of active site TyrBy similarity
    Binding sitei150 – 1501SubstrateBy similarity
    Metal bindingi172 – 1721ManganeseBy similarity
    Active sitei173 – 1731Proton donorBy similarity
    Metal bindingi202 – 2021ManganeseBy similarity
    Active sitei267 – 2671Proton acceptorBy similarity
    Binding sitei287 – 2871SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 7367NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. maltose-6'-phosphate glucosidase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Manganese, Metal-binding, NAD

    Enzyme and pathway databases

    BioCyciLCAS321967:GH4S-2681-MONOMER.

    Protein family/group databases

    CAZyiGH4. Glycoside Hydrolase Family 4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phospho-alpha-glucosidase 2 (EC:3.2.1.122)
    Gene namesi
    Ordered Locus Names:LSEI_2684
    OrganismiLactobacillus casei (strain ATCC 334)
    Taxonomic identifieri321967 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001651: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4614616-phospho-alpha-glucosidase 2PRO_0000389205Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi321967.LSEI_2684.

    Structurei

    3D structure databases

    ProteinModelPortaliQ034G9.
    SMRiQ034G9. Positions 5-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 4 family.Curated

    Phylogenomic databases

    eggNOGiCOG1486.
    HOGENOMiHOG000239810.
    KOiK01232.
    OMAiCHTRANE.
    OrthoDBiEOG632D2X.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR019802. GlycHydrolase_4_CS.
    IPR001088. Glyco_hydro_4.
    IPR022616. Glyco_hydro_4_C.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02056. Glyco_hydro_4. 1 hit.
    PF11975. Glyco_hydro_4C. 1 hit.
    [Graphical view]
    PRINTSiPR00732. GLHYDRLASE4.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    PROSITEiPS01324. GLYCOSYL_HYDROL_F4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q034G9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQNKQFSIV IAGGGSTYTA GIVMMLLENA ERFPLRALKL YDIDEERQAT    50
    IAEAIAIELK EKAPAIDFTW TTDPQTAFTD VDFCFAHIRS GGYKMREQDE 100
    KIPLKHHVVG QETCGPGGIA YGMRSIGDII ELIDFIEKYS PDCWMLNYSN 150
    PASIVAEACR RLRPDAKILN ICDMPVGTQR RMSQIIGLQP KDLEVRYFGM 200
    NHFGWWTSVK DKAGNEYLPQ IRDYVAHHGY LTQIEVDTQH MDASWQATHK 250
    KAQDLLAVDP HYLPNTYLKY YLYPDYVVAH SDPDYTRANE VEDGREKCVF 300
    SAAQKIIDAG TSDVGSFPID SHASFIVDLA CAIAFNTHER MLLIVENNGA 350
    VANIDDNIMV EVPCIVGKDG AEPLTQGKIP MFQRGMILNQ AMVEKLVVDA 400
    WINHDYQELW QALTLSKTLP SAQVAKEVLD DLIEANREYW PELKHDEHEV 450
    HLISESAVSE I 461
    Length:461
    Mass (Da):52,030
    Last modified:November 14, 2006 - v1
    Checksum:iF96D99955DA75E84
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ71403.1.
    RefSeqiWP_011674973.1. NC_008526.1.
    YP_807845.1. NC_008526.1.

    Genome annotation databases

    EnsemblBacteriaiABJ71403; ABJ71403; LSEI_2684.
    GeneIDi4421236.
    KEGGilca:LSEI_2684.
    PATRICi22209078. VBILacCas62221_2628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ71403.1 .
    RefSeqi WP_011674973.1. NC_008526.1.
    YP_807845.1. NC_008526.1.

    3D structure databases

    ProteinModelPortali Q034G9.
    SMRi Q034G9. Positions 5-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321967.LSEI_2684.

    Protein family/group databases

    CAZyi GH4. Glycoside Hydrolase Family 4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ71403 ; ABJ71403 ; LSEI_2684 .
    GeneIDi 4421236.
    KEGGi lca:LSEI_2684.
    PATRICi 22209078. VBILacCas62221_2628.

    Phylogenomic databases

    eggNOGi COG1486.
    HOGENOMi HOG000239810.
    KOi K01232.
    OMAi CHTRANE.
    OrthoDBi EOG632D2X.

    Enzyme and pathway databases

    BioCyci LCAS321967:GH4S-2681-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR019802. GlycHydrolase_4_CS.
    IPR001088. Glyco_hydro_4.
    IPR022616. Glyco_hydro_4_C.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02056. Glyco_hydro_4. 1 hit.
    PF11975. Glyco_hydro_4C. 1 hit.
    [Graphical view ]
    PRINTSi PR00732. GLHYDRLASE4.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    PROSITEi PS01324. GLYCOSYL_HYDROL_F4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 334.
    2. "The sim operon facilitates the transport and metabolism of sucrose isomers in Lactobacillus casei ATCC 334."
      Thompson J., Jakubovics N., Abraham B., Hess S., Pikis A.
      J. Bacteriol. 190:3362-3373(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiPAGL2_LACC3
    AccessioniPrimary (citable) accession number: Q034G9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3