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Protein

CCAAT/enhancer-binding protein delta

Gene

Cebpd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:1714459). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein delta
Short name:
C/EBP delta
Alternative name(s):
Transcription factor CELF
Gene namesi
Name:Cebpd
Synonyms:Celf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi2328. Cebpd.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 268267CCAAT/enhancer-binding protein deltaPRO_0000076623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Cross-linki120 – 120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ03484.
PRIDEiQ03484.

PTM databases

iPTMnetiQ03484.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

GenevisibleiQ03484. RN.

Interactioni

Subunit structurei

Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064025.

Structurei

3D structure databases

ProteinModelPortaliQ03484.
SMRiQ03484. Positions 188-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25464bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni195 – 22228Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni226 – 25429Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISXQ. Eukaryota.
ENOG4111HWR. LUCA.
GeneTreeiENSGT00530000063192.
HOVERGENiHBG050879.
InParanoidiQ03484.
KOiK10050.
OMAiVPNLELC.
OrthoDBiEOG7R56TQ.
PhylomeDBiQ03484.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALFSLDS PARGAPWPTE PAAFYEPGRV GKPGRGPEPG DLGEPGSTTP
60 70 80 90 100
AMYDDESAID FSAYIDSMAA VPTLELCHDE IFADLFNSNH KAAGAGSLEL
110 120 130 140 150
LQGGPTRPPG VGSIARGPLK REPDWGDGDA PGSLLPAQVA VCAQTVVSLA
160 170 180 190 200
AAAQPTPPTS PEPPRGSPGP SLAPGPVREK GAGKRGPDRG SPEYRQRRER
210 220 230 240 250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLASLRQF
260
FKELPSPPFL PPTGTDCR
Length:268
Mass (Da):28,600
Last modified:October 1, 1996 - v1
Checksum:iEF12ABA104C7B9F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65149 mRNA. Translation: AAA40913.1.
PIRiB39429.
RefSeqiNP_037286.1. NM_013154.2.
UniGeneiRn.202620.
Rn.6975.

Genome annotation databases

EnsembliENSRNOT00000074586; ENSRNOP00000064025; ENSRNOG00000050869.
GeneIDi25695.
KEGGirno:25695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65149 mRNA. Translation: AAA40913.1.
PIRiB39429.
RefSeqiNP_037286.1. NM_013154.2.
UniGeneiRn.202620.
Rn.6975.

3D structure databases

ProteinModelPortaliQ03484.
SMRiQ03484. Positions 188-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064025.

PTM databases

iPTMnetiQ03484.

Proteomic databases

PaxDbiQ03484.
PRIDEiQ03484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074586; ENSRNOP00000064025; ENSRNOG00000050869.
GeneIDi25695.
KEGGirno:25695.

Organism-specific databases

CTDi1052.
RGDi2328. Cebpd.

Phylogenomic databases

eggNOGiENOG410ISXQ. Eukaryota.
ENOG4111HWR. LUCA.
GeneTreeiENSGT00530000063192.
HOVERGENiHBG050879.
InParanoidiQ03484.
KOiK10050.
OMAiVPNLELC.
OrthoDBiEOG7R56TQ.
PhylomeDBiQ03484.

Miscellaneous databases

PROiQ03484.

Gene expression databases

GenevisibleiQ03484. RN.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of transcription factors that bind to the cAMP responsive region of the substance P precursor gene. cDNA cloning of a novel C/EBP-related factor."
    Kageyama R., Sasai Y., Nakanishi S.
    J. Biol. Chem. 266:15525-15531(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiCEBPD_RAT
AccessioniPrimary (citable) accession number: Q03484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.