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Protein
Submitted name:

Alpha8 subunit of nicotinic acetylcholine receptor

Gene

LOC396120

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha8 subunit of nicotinic acetylcholine receptorImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:LOC396120Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation
  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2520HelicalSequence analysisAdd
BLAST
Transmembranei239 – 26426HelicalSequence analysisAdd
BLAST
Transmembranei270 – 28819HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32324HelicalSequence analysisAdd
BLAST
Transmembranei479 – 50325HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: GO_Central
  • axon Source: AgBase
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: AgBase
  • dendrite Source: AgBase
  • perikaryon Source: AgBase
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1628466.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000015336.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024705.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 238204Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini245 – 495251Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
KOiK04809.
OMAiWIDAYLS.
OrthoDBiEOG091G0R20.
PhylomeDBiQ03481.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTEKCLGFF YSGLCLWASL FLSFFKVSQQ GESQRRLYRD LLRNYNRLER
60 70 80 90 100
PVMNDSQPIV VELQLSLLQI IDVDEKNQVL ITNAWLQMYW VDIYLSWDQY
110 120 130 140 150
EYPGVQNLRF PSDQIWVPDI LLYNSADERF DATFHTNVLV NYSGSCQYIP
160 170 180 190 200
PGILKSTCYI DVRWFPFDVQ KCDLKFGSWT HSGWLIDLQM LEADISNYIS
210 220 230 240 250
NGEWDLVGVP GKRNELYYEC CKEPYPDVTY TITMRRRTLY YGLNLLIPCV
260 270 280 290 300
LISGLALLVF LLPADSGEKI SLGITVLLSL TVFMLLVAEI MPATSDSVPL
310 320 330 340 350
IAQYFASIMV IVGLSVVVTV LVLQFHHHDP QAGKMPRWVR VILLNWCAWF
360 370 380 390 400
LRMKKPGENI KPLSCKYSYP KHHPSLKNTE MNVLPGHQPS NGNMIYSYHT
410 420 430 440 450
MENPCCPQNN DLGSKSGKIT CPLSEDNEHV QKKALMDTIP VIVKILEEVQ
460 470 480 490 500
FIAMRFRKQD EGEEICSEWK FAAAVIDRLC LVAFTLFAII CTFTILMSAP
510
NFIEAVSKDF T
Length:511
Mass (Da):58,705
Last modified:November 1, 1996 - v1
Checksum:i10F362D153EC87A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC192588 Genomic DNA. No translation available.
AC210627 Genomic DNA. No translation available.
X52296 mRNA. Translation: CAA36544.1.
PIRiJH0173.
RefSeqiNP_990532.1. NM_205201.2.
UniGeneiGga.664.

Genome annotation databases

EnsembliENSGALT00000024751; ENSGALP00000024705; ENSGALG00000015336.
GeneIDi396120.
KEGGigga:396120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC192588 Genomic DNA. No translation available.
AC210627 Genomic DNA. No translation available.
X52296 mRNA. Translation: CAA36544.1.
PIRiJH0173.
RefSeqiNP_990532.1. NM_205201.2.
UniGeneiGga.664.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024705.

Chemistry

ChEMBLiCHEMBL1628466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000024751; ENSGALP00000024705; ENSGALG00000015336.
GeneIDi396120.
KEGGigga:396120.

Organism-specific databases

CTDi396120.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
KOiK04809.
OMAiWIDAYLS.
OrthoDBiEOG091G0R20.
PhylomeDBiQ03481.
TreeFamiTF315605.

Gene expression databases

BgeeiENSGALG00000015336.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ03481_CHICK
AccessioniPrimary (citable) accession number: Q03481
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.