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Protein
Submitted name:

Alpha8 subunit of nicotinic acetylcholine receptor

Gene

CHRNA8

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha8 subunit of nicotinic acetylcholine receptorImported
Gene namesi
Name:CHRNA8Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation
  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei239 – 264HelicalSequence analysisAdd BLAST26
Transmembranei270 – 288HelicalSequence analysisAdd BLAST19
Transmembranei300 – 323HelicalSequence analysisAdd BLAST24
Transmembranei479 – 503HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

  • axon Source: AgBase
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: AgBase
  • dendrite Source: AgBase
  • integral component of membrane Source: UniProtKB-KW
  • perikaryon Source: AgBase
  • postsynaptic membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000015336.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024705.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 238Neur_chan_LBDInterPro annotationAdd BLAST204
Domaini245 – 495Neur_chan_membInterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
KOiK04809.
OMAiTDIYLSW.
OrthoDBiEOG091G0R20.
TreeFamiTF315605.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTEKCLGFF YSGLCLWASL FLSFFKVSQQ GESQRRLYRD LLRNYNRLER
60 70 80 90 100
PVMNDSQPIV VELQLSLLQI IDVDEKNQVL ITNAWLQMYW VDIYLSWDQY
110 120 130 140 150
EYPGVQNLRF PSDQIWVPDI LLYNSADERF DATFHTNVLV NYSGSCQYIP
160 170 180 190 200
PGILKSTCYI DVRWFPFDVQ KCDLKFGSWT HSGWLIDLQM LEADISNYIS
210 220 230 240 250
NGEWDLVGVP GKRNELYYEC CKEPYPDVTY TITMRRRTLY YGLNLLIPCV
260 270 280 290 300
LISGLALLVF LLPADSGEKI SLGITVLLSL TVFMLLVAEI MPATSDSVPL
310 320 330 340 350
IAQYFASIMV IVGLSVVVTV LVLQFHHHDP QAGKMPRWVR VILLNWCAWF
360 370 380 390 400
LRMKKPGENI KPLSCKYSYP KHHPSLKNTE MNVLPGHQPS NGNMIYSYHT
410 420 430 440 450
MENPCCPQNN DLGSKSGKIT CPLSEDNEHV QKKALMDTIP VIVKILEEVQ
460 470 480 490 500
FIAMRFRKQD EGEEICSEWK FAAAVIDRLC LVAFTLFAII CTFTILMSAP
510
NFIEAVSKDF T
Length:511
Mass (Da):58,705
Last modified:November 1, 1996 - v1
Checksum:i10F362D153EC87A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC192588 Genomic DNA. No translation available.
AC210627 Genomic DNA. No translation available.
X52296 mRNA. Translation: CAA36544.1.
PIRiJH0173.
RefSeqiNP_990532.1. NM_205201.2.
UniGeneiGga.664.

Genome annotation databases

EnsembliENSGALT00000024751; ENSGALP00000024705; ENSGALG00000015336.
GeneIDi396120.
KEGGigga:396120.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ03481_CHICK
AccessioniPrimary (citable) accession number: Q03481
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported