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Protein

DNA excision repair protein ERCC-6

Gene

ERCC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.3 Publications
Isoform 2: Like isoform 1, it is involved in repair of DNA damage, acting on its own or synergistically with isoform 1. May bind to PiggyBac transposable elements known as MER85 scattered in the genome and may therefore regulate the expression of nearby genes. Able to stimulate the antiviral response and modulate the expression of genes involved in metabolism regulation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi532 – 539ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • chromatin binding Source: UniProtKB
  • DNA binding Source: UniProtKB
  • DNA-dependent ATPase activity Source: UniProtKB
  • helicase activity Source: UniProtKB-KW
  • protein complex binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • protein tyrosine kinase activator activity Source: MGI

GO - Biological processi

  • activation of JNKK activity Source: Ensembl
  • activation of JUN kinase activity Source: Ensembl
  • base-excision repair Source: UniProtKB
  • DNA repair Source: UniProtKB
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  • multicellular organism growth Source: Ensembl
  • photoreceptor cell maintenance Source: Ensembl
  • positive regulation of DNA-templated transcription, elongation Source: UniProtKB
  • positive regulation of gene expression, epigenetic Source: Reactome
  • pyrimidine dimer repair Source: Ensembl
  • regulation of DNA-templated transcription, elongation Source: UniProtKB
  • response to gamma radiation Source: Ensembl
  • response to oxidative stress Source: UniProtKB
  • response to superoxide Source: Ensembl
  • response to toxic substance Source: Ensembl
  • response to UV Source: UniProtKB
  • response to UV-B Source: Ensembl
  • response to X-ray Source: Ensembl
  • transcription-coupled nucleotide-excision repair Source: UniProtKB
  • transcription elongation from RNA polymerase I promoter Source: Ensembl
  • transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER).
R-HSA-6782135. Dual incision in TC-NER.
R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-HSA-73762. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA excision repair protein ERCC-6 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase ERCC6
Cockayne syndrome protein CSB
Gene namesi
Name:ERCC6
Synonyms:CSB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:3438. ERCC6.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Cockayne syndrome B (CSB)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by cutaneous sensitivity to sunlight, abnormal and slow growth, cachectic dwarfism, progeroid appearance, progressive pigmentary retinopathy and sensorineural deafness. There is delayed neural development and severe progressive neurologic degeneration resulting in mental retardation. Two clinical forms are recognized: in the classical form or Cockayne syndrome type 1, the symptoms are progressive and typically become apparent within the first few years or life; the less common Cockayne syndrome type 2 is characterized by more severe symptoms that manifest prenatally. Cockayne syndrome shows some overlap with certain forms of xeroderma pigmentosum. Unlike xeroderma pigmentosum, patients with Cockayne syndrome do not manifest increased freckling and other pigmentation abnormalities in the skin and have no significant increase in skin cancer.
See also OMIM:133540
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_001218670R → W in CSB. 2 PublicationsCorresponds to variant rs202080674dbSNPEnsembl.1
Natural variantiVAR_063511680N → D in CSB. 1 Publication1
Natural variantiVAR_063512686W → C in CSB. 1 PublicationCorresponds to variant rs751292948dbSNPEnsembl.1
Natural variantiVAR_063513687S → L in CSB. 1 Publication1
Natural variantiVAR_001219851W → R in CSB. 2 PublicationsCorresponds to variant rs368728467dbSNPEnsembl.1
Natural variantiVAR_001220957V → G in CSB. 2 Publications1
Natural variantiVAR_0012211042P → L in CSB. 2 Publications1
Cerebro-oculo-facio-skeletal syndrome 1 (COFS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome.
See also OMIM:214150
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063514871L → P in COFS1. 1 Publication1
Natural variantiVAR_063515987L → P in COFS1. 1 PublicationCorresponds to variant rs121917905dbSNPEnsembl.1
De Sanctis-Cacchione syndrome (DSC)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome consisting of xeroderma pigmentosum associated with severe neurological and developmental involvement. In addition to the clinical signs of xeroderma pigmentosum, patients present with mental retardation, dwarfism, gonadal hypoplasia, microcephaly and various neurologic complications of early onset.
See also OMIM:278800
Macular degeneration, age-related, 5 (ARMD5)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
See also OMIM:613761
UV-sensitive syndrome 1 (UVSS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by cutaneous photosensitivity and mild freckling in the absence of neurological abnormalities or skin tumors.
See also OMIM:600630
Premature ovarian failure 11 (POF11)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
See also OMIM:616946
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q03468-2)
Natural varianti746G → D in POF11, the mutation results in weaker cellular response to DNA damage as indicated by delayed recruitement of mutant protein to DNA damaged sites, interaction with RNA polymerase II is not affected either after UV or H(2)O(2) damage. 2 Publications1
Natural varianti1056V → I in POF11, the mutation results in weaker cellular response to DNA damage as indicated by delayed recruitement of mutant protein to DNA damaged sites, interaction with RNA polymerase II is not affected either after UV or H(2)O(2) damage. 2 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1427 – 1428LL → GG: Fails to bind polyubiquitin chains. 1 Publication2

Keywords - Diseasei

Age-related macular degeneration, Cataract, Cockayne syndrome, Deafness, Disease mutation, Dwarfism, Mental retardation, Premature ovarian failure, Xeroderma pigmentosum

Organism-specific databases

DisGeNETi2074.
MalaCardsiERCC6.
MIMi133540. phenotype.
214150. phenotype.
278800. phenotype.
600630. phenotype.
613761. phenotype.
616946. phenotype.
OpenTargetsiENSG00000225830.
Orphaneti279. Age-related macular degeneration.
90321. Cockayne syndrome type 1.
90322. Cockayne syndrome type 2.
90324. Cockayne syndrome type 3.
1466. COFS syndrome.
178338. UV-sensitive syndrome.
PharmGKBiPA27852.

Polymorphism and mutation databases

BioMutaiERCC6.
DMDMi416959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743141 – 1493DNA excision repair protein ERCC-6Add BLAST1493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170N6-methylated lysine; by EHMT21 Publication1
Modified residuei297N6-methylated lysine; by EHMT21 Publication1
Modified residuei448N6-methylated lysine; by EHMT21 Publication1
Modified residuei486PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei1054N6-methylated lysine; by EHMT21 Publication1
Modified residuei1142PhosphoserineCombined sources1
Modified residuei1348PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated at the C-terminus. Ubiquitination by the CSA complex leads to ERCC6 proteasomal degradation in a UV-dependent manner. Stabilized following interaction with KIAA1530/UVSSA, which promotes recruitment of deubiquitinating enzyme USP7, leading to deubiquitination of ERCC6 thereby preventing UV-induced degradation of ERCC6 by the proteasome.5 Publications

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ03468.
MaxQBiE7EV46.
Q03468.
PaxDbiQ03468.
PeptideAtlasiQ03468.
PRIDEiQ03468.

PTM databases

iPTMnetiQ03468.
PhosphoSitePlusiQ03468.

Expressioni

Tissue specificityi

Expressed in heart, ovary, but not in granulosa cells.1 Publication

Gene expression databases

BgeeiENSG00000225830.
CleanExiHS_ERCC6.
ExpressionAtlasiQ03468. baseline and differential.
GenevisibleiQ03468. HS.

Interactioni

Subunit structurei

Homodimer. Binds DNA. Interacts with ERCC8. Interacts with a subunit of RNA polymerase II TFIIH. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with KIAA1530/UVSSA.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ERCC8Q13216-12EBI-295284,EBI-596556

GO - Molecular functioni

  • protein complex binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108386. 52 interactors.
DIPiDIP-193N.
IntActiQ03468. 18 interactors.
MINTiMINT-1193928.
STRINGi9606.ENSP00000348089.

Structurei

Secondary structure

11493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi93 – 96Combined sources4
Helixi102 – 104Combined sources3
Helixi109 – 155Combined sources47

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CVOX-ray1.85A84-160[»]
ProteinModelPortaliQ03468.
SMRiQ03468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini519 – 695Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST177
Domaini843 – 1002Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1400 – 1428Ubiquitin-binding domain (UBD)Add BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi466 – 481Nuclear localization signalSequence analysisAdd BLAST16
Motifi646 – 649DEGH box4
Motifi1038 – 1055Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi356 – 394Asp/Glu-rich (acidic)Add BLAST39
Compositional biasi442 – 446Gly-rich5

Domaini

A C-terminal ubiquitin-binding domain (UBD) is essential for transcription-coupled nucleotide excision repair to proceed.1 Publication

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
KOG0387. Eukaryota.
ENOG410XP4Z. LUCA.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00590000083118.
HOGENOMiHOG000170952.
HOVERGENiHBG051502.
InParanoidiQ03468.
KOiK10841.
OMAiEGTRIPH.
OrthoDBiEOG091G03VL.
PhylomeDBiQ03468.
TreeFamiTF101236.
TF328011.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q03468-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNEGIPHSS QTQEQDCLQS QPVSNNEEMA IKQESGGDGE VEEYLSFRSV
60 70 80 90 100
GDGLSTSAVG CASAAPRRGP ALLHIDRHQI QAVEPSAQAL ELQGLGVDVY
110 120 130 140 150
DQDVLEQGVL QQVDNAIHEA SRASQLVDVE KEYRSVLDDL TSCTTSLRQI
160 170 180 190 200
NKIIEQLSPQ AATSRDINRK LDSVKRQKYN KEQQLKKITA KQKHLQAILG
210 220 230 240 250
GAEVKIELDH ASLEEDAEPG PSSLGSMLMP VQETAWEELI RTGQMTPFGT
260 270 280 290 300
QIPQKQEKKP RKIMLNEASG FEKYLADQAK LSFERKKQGC NKRAARKAPA
310 320 330 340 350
PVTPPAPVQN KNKPNKKARV LSKKEERLKK HIKKLQKRAL QFQGKVGLPK
360 370 380 390 400
ARRPWESDMR PEAEGDSEGE ESEYFPTEEE EEEEDDEVEG AEADLSGDGT
410 420 430 440 450
DYELKPLPKG GKRQKKVPVQ EIDDDFFPSS GEEAEAASVG EGGGGGRKVG
460 470 480 490 500
RYRDDGDEDY YKQRLRRWNK LRLQDKEKRL KLEDDSEESD AEFDEGFKVP
510 520 530 540 550
GFLFKKLFKY QQTGVRWLWE LHCQQAGGIL GDEMGLGKTI QIIAFLAGLS
560 570 580 590 600
YSKIRTRGSN YRFEGLGPTV IVCPTTVMHQ WVKEFHTWWP PFRVAILHET
610 620 630 640 650
GSYTHKKEKL IRDVAHCHGI LITSYSYIRL MQDDISRYDW HYVILDEGHK
660 670 680 690 700
IRNPNAAVTL ACKQFRTPHR IILSGSPMQN NLRELWSLFD FIFPGKLGTL
710 720 730 740 750
PVFMEQFSVP ITMGGYSNAS PVQVKTAYKC ACVLRDTINP YLLRRMKSDV
760 770 780 790 800
KMSLSLPDKN EQVLFCRLTD EQHKVYQNFV DSKEVYRILN GEMQIFSGLI
810 820 830 840 850
ALRKICNHPD LFSGGPKNLK GLPDDELEED QFGYWKRSGK MIVVESLLKI
860 870 880 890 900
WHKQGQRVLL FSQSRQMLDI LEVFLRAQKY TYLKMDGTTT IASRQPLITR
910 920 930 940 950
YNEDTSIFVF LLTTRVGGLG VNLTGANRVV IYDPDWNPST DTQARERAWR
960 970 980 990 1000
IGQKKQVTVY RLLTAGTIEE KIYHRQIFKQ FLTNRVLKDP KQRRFFKSND
1010 1020 1030 1040 1050
LYELFTLTSP DASQSTETSA IFAGTGSDVQ TPKCHLKRRI QPAFGADHDV
1060 1070 1080 1090 1100
PKRKKFPASN ISVNDATSSE EKSEAKGAEV NAVTSNRSDP LKDDPHMSSN
1110 1120 1130 1140 1150
VTSNDRLGEE TNAVSGPEEL SVISGNGECS NSSGTGKTSM PSGDESIDEK
1160 1170 1180 1190 1200
LGLSYKRERP SQAQTEAFWE NKQMENNFYK HKSKTKHHSV AEEETLEKHL
1210 1220 1230 1240 1250
RPKQKPKNSK HCRDAKFEGT RIPHLVKKRR YQKQDSENKS EAKEQSNDDY
1260 1270 1280 1290 1300
VLEKLFKKSV GVHSVMKHDA IMDGASPDYV LVEAEANRVA QDALKALRLS
1310 1320 1330 1340 1350
RQRCLGAVSG VPTWTGHRGI SGAPAGKKSR FGKKRNSNFS VQHPSSTSPT
1360 1370 1380 1390 1400
EKCQDGIMKK EGKDNVPEHF SGRAEDADSS SGPLASSSLL AKMRARNHLI
1410 1420 1430 1440 1450
LPERLESESG HLQEASALLP TTEHDDLLVE MRNFIAFQAH TDGQASTREI
1460 1470 1480 1490
LQEFESKLSA SQSCVFRELL RNLCTFHRTS GGEGIWKLKP EYC
Length:1,493
Mass (Da):168,416
Last modified:October 1, 1993 - v1
Checksum:i285257E2AEC071AC
GO
Isoform 2 (identifier: Q03468-2) [UniParc]FASTAAdd to basket
Also known as: CSB-PGBD31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     466-1061: RRWNKLRLQD...KRKKFPASNI → SPKMPRTLSL...VKCSVEYHTE
     1062-1493: Missing.

Note: Major transcript, generated by alternative splicing of ERCC6 exon 5 to a domesticated PiggyBac transposon, PGBD3, located within ERCC6 intron 5. The fusion protein consists of the N-terminal 465 residues of ERCC6 tethered to the entire PGBD3 sequence.2 Publications
Show »
Length:1,061
Mass (Da):119,487
Checksum:i542A37356E38C376
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054153134R → W.1 PublicationCorresponds to variant rs148095899dbSNPEnsembl.1
Natural variantiVAR_001216255K → T.1 Publication1
Natural variantiVAR_001217399G → D.2 PublicationsCorresponds to variant rs2228528dbSNPEnsembl.1
Natural variantiVAR_016301425D → A.1 PublicationCorresponds to variant rs4253046dbSNPEnsembl.1
Natural variantiVAR_016302446G → D.1 PublicationCorresponds to variant rs4253047dbSNPEnsembl.1
Natural variantiVAR_036021591P → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036022652R → L in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_001218670R → W in CSB. 2 PublicationsCorresponds to variant rs202080674dbSNPEnsembl.1
Natural variantiVAR_063511680N → D in CSB. 1 Publication1
Natural variantiVAR_063512686W → C in CSB. 1 PublicationCorresponds to variant rs751292948dbSNPEnsembl.1
Natural variantiVAR_063513687S → L in CSB. 1 Publication1
Natural variantiVAR_001219851W → R in CSB. 2 PublicationsCorresponds to variant rs368728467dbSNPEnsembl.1
Natural variantiVAR_063514871L → P in COFS1. 1 Publication1
Natural variantiVAR_016303942T → M.1 PublicationCorresponds to variant rs2228525dbSNPEnsembl.1
Natural variantiVAR_001220957V → G in CSB. 2 Publications1
Natural variantiVAR_063515987L → P in COFS1. 1 PublicationCorresponds to variant rs121917905dbSNPEnsembl.1
Natural variantiVAR_0163041002Y → C.1 PublicationCorresponds to variant rs4253206dbSNPEnsembl.1
Natural variantiVAR_0360231038R → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0012211042P → L in CSB. 2 Publications1
Natural variantiVAR_0012221095P → R.3 PublicationsCorresponds to variant rs4253208dbSNPEnsembl.1
Natural variantiVAR_0012231097M → V.2 PublicationsCorresponds to variant rs2228526dbSNPEnsembl.1
Natural variantiVAR_0360241119E → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0360251119E → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0012241213R → G.3 PublicationsCorresponds to variant rs2228527dbSNPEnsembl.1
Natural variantiVAR_0374361220T → I.Corresponds to variant rs34704611dbSNPEnsembl.1
Natural variantiVAR_0163051230R → P.1 PublicationCorresponds to variant rs4253211dbSNPEnsembl.1
Natural variantiVAR_0163061308V → L.1 PublicationCorresponds to variant rs2229761dbSNPEnsembl.1
Natural variantiVAR_0163071322G → V.1 PublicationCorresponds to variant rs4253219dbSNPEnsembl.1
Natural variantiVAR_0374371355D → E.Corresponds to variant rs34917815dbSNPEnsembl.1
Natural variantiVAR_0163081372G → R.1 PublicationCorresponds to variant rs4253227dbSNPEnsembl.1
Natural variantiVAR_0163091382G → R.1 PublicationCorresponds to variant rs4253228dbSNPEnsembl.1
Natural variantiVAR_0163101410G → R.1 PublicationCorresponds to variant rs4253229dbSNPEnsembl.1
Natural variantiVAR_0012251413Q → R.2 PublicationsCorresponds to variant rs2228529dbSNPEnsembl.1
Natural variantiVAR_0163111441T → I.1 PublicationCorresponds to variant rs4253230dbSNPEnsembl.1
Isoform 2 (identifier: Q03468-2)
Natural varianti746G → D in POF11, the mutation results in weaker cellular response to DNA damage as indicated by delayed recruitement of mutant protein to DNA damaged sites, interaction with RNA polymerase II is not affected either after UV or H(2)O(2) damage. 2 Publications1
Natural varianti1056V → I in POF11, the mutation results in weaker cellular response to DNA damage as indicated by delayed recruitement of mutant protein to DNA damaged sites, interaction with RNA polymerase II is not affected either after UV or H(2)O(2) damage. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058677466 – 1061RRWNK…PASNI → SPKMPRTLSLHEITDLLETD DSIEASAIVIQPPENATAPV SDEESGDEEGGTINNLPGSL LHTAAYLIQDGSDAESDSDD PSYAPKDDSPDEVPSTFTVQ QPPPSRRRKMTKILCKWKKA DLTVQPVAGRVTAPPNDFFT VMRTPTEILELFLDDEVIEL IVKYSNLYACSKGVHLGLTS SEFKCFLGIIFLSGYVSVPR RRMFWEQRTDVHNVLVSAAM RRDRFETIFSNLHVADNANL DPVDKFSKLRPLISKLNERC MKFVPNETYFSFDEFMVPYF GRHGCKQFIRGKPIRFGYKF WCGATCLGYICWFQPYQGKN PNTKHEEYGVGASLVLQFSE ALTEAHPGQYHFVFNNFFTS IALLDKLSSMGHQATGTVRK DHIDRVPLESDVALKKKERG TFDYRIDGKGNIVCRWNDNS VVTVASSGAGIHPLCLVSRY SQKLKKKIQVQQPNMIKVYN QFMGGVDRADENIDKYRASI RGKKWYSSPLLFCFELVLQN AWQLHKTYDEKPVDFLEFRR RVVCHYLETHGHPPEPGQKG RPQKRNIDSRYDGINHVIVK QGKQTRCAECHKNTTFRCEK CDVALHVKCSVEYHTE in isoform 2. 1 PublicationAdd BLAST596
Alternative sequenceiVSP_0586781062 – 1493Missing in isoform 2. 1 PublicationAdd BLAST432

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04791 mRNA. Translation: AAA52397.1.
AY204752 Genomic DNA. Translation: AAO13487.1.
AC073366 Genomic DNA. No translation available.
AL138760 Genomic DNA. Translation: CAH70291.1.
CH471187 Genomic DNA. Translation: EAW93094.1.
CH471187 Genomic DNA. Translation: EAW93097.1.
CCDSiCCDS7229.1.
PIRiA44224.
RefSeqiNP_000115.1. NM_000124.3.
UniGeneiHs.49063.

Genome annotation databases

EnsembliENST00000355832; ENSP00000348089; ENSG00000225830.
GeneIDi2074.
KEGGihsa:2074.
UCSCiuc001jhs.6. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Allelic variations of the XP genes
Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04791 mRNA. Translation: AAA52397.1.
AY204752 Genomic DNA. Translation: AAO13487.1.
AC073366 Genomic DNA. No translation available.
AL138760 Genomic DNA. Translation: CAH70291.1.
CH471187 Genomic DNA. Translation: EAW93094.1.
CH471187 Genomic DNA. Translation: EAW93097.1.
CCDSiCCDS7229.1.
PIRiA44224.
RefSeqiNP_000115.1. NM_000124.3.
UniGeneiHs.49063.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CVOX-ray1.85A84-160[»]
ProteinModelPortaliQ03468.
SMRiQ03468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108386. 52 interactors.
DIPiDIP-193N.
IntActiQ03468. 18 interactors.
MINTiMINT-1193928.
STRINGi9606.ENSP00000348089.

PTM databases

iPTMnetiQ03468.
PhosphoSitePlusiQ03468.

Polymorphism and mutation databases

BioMutaiERCC6.
DMDMi416959.

Proteomic databases

EPDiQ03468.
MaxQBiE7EV46.
Q03468.
PaxDbiQ03468.
PeptideAtlasiQ03468.
PRIDEiQ03468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355832; ENSP00000348089; ENSG00000225830.
GeneIDi2074.
KEGGihsa:2074.
UCSCiuc001jhs.6. human.

Organism-specific databases

CTDi2074.
DisGeNETi2074.
GeneCardsiERCC6.
GeneReviewsiERCC6.
HGNCiHGNC:3438. ERCC6.
MalaCardsiERCC6.
MIMi133540. phenotype.
214150. phenotype.
278800. phenotype.
600630. phenotype.
609413. gene.
613761. phenotype.
616946. phenotype.
neXtProtiNX_Q03468.
OpenTargetsiENSG00000225830.
Orphaneti279. Age-related macular degeneration.
90321. Cockayne syndrome type 1.
90322. Cockayne syndrome type 2.
90324. Cockayne syndrome type 3.
1466. COFS syndrome.
178338. UV-sensitive syndrome.
PharmGKBiPA27852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
KOG0387. Eukaryota.
ENOG410XP4Z. LUCA.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00590000083118.
HOGENOMiHOG000170952.
HOVERGENiHBG051502.
InParanoidiQ03468.
KOiK10841.
OMAiEGTRIPH.
OrthoDBiEOG091G03VL.
PhylomeDBiQ03468.
TreeFamiTF101236.
TF328011.

Enzyme and pathway databases

ReactomeiR-HSA-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER).
R-HSA-6782135. Dual incision in TC-NER.
R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-HSA-73762. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

ChiTaRSiERCC6. human.
GeneWikiiERCC6.
GenomeRNAii101243544.
2074.
PROiQ03468.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000225830.
CleanExiHS_ERCC6.
ExpressionAtlasiQ03468. baseline and differential.
GenevisibleiQ03468. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERCC6_HUMAN
AccessioniPrimary (citable) accession number: Q03468
Secondary accession number(s): D3DX94, E7EV46, Q5W0L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 184 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.