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Q03466

- EBS1_YEAST

UniProt

Q03466 - EBS1_YEAST

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Protein

Protein EBS1

Gene

EBS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in telomere maintenance. May be redundant to EST1, a protein associated with the telomerase.1 Publication

GO - Biological processi

  1. DNA recombination Source: SGD
  2. negative regulation of translation Source: SGD
  3. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29790-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EBS1
Alternative name(s):
EST1-like BCY1 suppressor 1
Gene namesi
Name:EBS1
Ordered Locus Names:YDR206W
ORF Names:YD8142.03
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR206w.
SGDiS000002614. EBS1.

Subcellular locationi

Nucleus Curated. Chromosometelomere Curated

GO - Cellular componenti

  1. chromosome, telomeric region Source: UniProtKB-KW
  2. cytoplasm Source: SGD
  3. cytoplasmic mRNA processing body Source: SGD
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 884884Protein EBS1PRO_0000086907Add
BLAST

Proteomic databases

MaxQBiQ03466.
PaxDbiQ03466.
PeptideAtlasiQ03466.

Expressioni

Gene expression databases

GenevestigatoriQ03466.

Interactioni

Protein-protein interaction databases

BioGridi32256. 42 interactions.
DIPiDIP-1297N.
IntActiQ03466. 14 interactions.
MINTiMINT-388876.
STRINGi4932.YDR206W.

Structurei

3D structure databases

ProteinModelPortaliQ03466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EST1 family.Curated

Phylogenomic databases

eggNOGiNOG146635.
GeneTreeiENSGT00530000068698.
InParanoidiQ03466.
KOiK11132.
OMAiWIFANES.
OrthoDBiEOG7V76G2.

Family and domain databases

InterProiIPR018834. DNA/RNA-bd_Est1-type.
IPR019458. EST1.
[Graphical view]
PfamiPF10374. EST1. 1 hit.
PF10373. EST1_DNA_bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03466-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPSNTQKED LPTAFNGIKS QLNSILKSNQ LFQDYALLNG FLAFVHSKLN
60 70 80 90 100
AAILTSIESQ CGKSFAADLD SFDQSSISSI LDFSWESVHY PIFKWFQMWR
110 120 130 140 150
NYILFEKENK KQQTKFIDFR KMNSKMLKFF KTVQNFYVNV INTVYKKYDI
160 170 180 190 200
SVLLPKRIIQ DLKLSDIENT TNVGDILAVK TFNSSSPLAH LIPTLFHRCL
210 220 230 240 250
LFLGTAYRYK TLLEEISNKY SISNFKKSLD FFRLASLVLP SAGETYSQAG
260 270 280 290 300
AIFLQTGNLG IAVFNFVKGM MTKMPSPVSI KNFGALMVDN KSSLNRSLHT
310 320 330 340 350
TIMNTYLQES KGPRTPAKEI LEFYFLGLFG SVWSPTSWRD DTKPNQLNNG
360 370 380 390 400
IKLRHLENAL YETMSARYLN NIKTIFHNLI ITIGGFHLLL KRRSDVSAKT
410 420 430 440 450
LKDLRSNELD YLNFAFKYIA HILNDIVKES WSENPEVSEI LGMVRIINCW
460 470 480 490 500
IKANPMVLQY SQSNLEFVNA LAYLINDIVK KKPSPSFSIT EHIPKRTYWF
510 520 530 540 550
EEDLMVKGLS FVNFQLSDFD DYEKILEMDH SLDRLIGNPP LCDKLSASSE
560 570 580 590 600
MLLRLQAVVN ISSQLLQNNN CGVEWSDNKS RYIFNKKIGF KETVKNSMKT
610 620 630 640 650
SKQSNEKAKL QRKNKPSTTN GSISMADLER QMRSSSLDSF SPTMGYSGSS
660 670 680 690 700
VPMAPDTFNV KPSGTITGNK VNVELLKIEL SGQNADGAIT NISPGYSNAA
710 720 730 740 750
ISSSNSTDES SFDLNNILSS MQQKHAEKSF AKSMQGVNEQ IPANDVCHQA
760 770 780 790 800
QRPMQGGLYS SQQPSSMSSL NSAYQNASMP PSASMVSYPY PFLNQQGQGV
810 820 830 840 850
FPPYNAQNLQ WQSEAYSLKS MNFANPTWLG DQYQTSAPSS AYAQAQRQMF
860 870 880
QQPMQQDVGK YMQFPFDAQS NTDSMRGNSR NNMF
Length:884
Mass (Da):100,000
Last modified:November 1, 1996 - v1
Checksum:i14482D64E32A1860
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z68194 Genomic DNA. Translation: CAA92345.1.
BK006938 Genomic DNA. Translation: DAA12047.1.
PIRiS61569.
RefSeqiNP_010492.3. NM_001180514.3.

Genome annotation databases

EnsemblFungiiYDR206W; YDR206W; YDR206W.
GeneIDi851787.
KEGGisce:YDR206W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z68194 Genomic DNA. Translation: CAA92345.1 .
BK006938 Genomic DNA. Translation: DAA12047.1 .
PIRi S61569.
RefSeqi NP_010492.3. NM_001180514.3.

3D structure databases

ProteinModelPortali Q03466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32256. 42 interactions.
DIPi DIP-1297N.
IntActi Q03466. 14 interactions.
MINTi MINT-388876.
STRINGi 4932.YDR206W.

Proteomic databases

MaxQBi Q03466.
PaxDbi Q03466.
PeptideAtlasi Q03466.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR206W ; YDR206W ; YDR206W .
GeneIDi 851787.
KEGGi sce:YDR206W.

Organism-specific databases

CYGDi YDR206w.
SGDi S000002614. EBS1.

Phylogenomic databases

eggNOGi NOG146635.
GeneTreei ENSGT00530000068698.
InParanoidi Q03466.
KOi K11132.
OMAi WIFANES.
OrthoDBi EOG7V76G2.

Enzyme and pathway databases

BioCyci YEAST:G3O-29790-MONOMER.

Miscellaneous databases

NextBioi 969603.

Gene expression databases

Genevestigatori Q03466.

Family and domain databases

InterProi IPR018834. DNA/RNA-bd_Est1-type.
IPR019458. EST1.
[Graphical view ]
Pfami PF10374. EST1. 1 hit.
PF10373. EST1_DNA_bind. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA."
    Zhou J., Hidaka K., Futcher B.
    Mol. Cell. Biol. 20:1947-1955(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiEBS1_YEAST
AccessioniPrimary (citable) accession number: Q03466
Secondary accession number(s): D6VSI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3