Q03466 (EBS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein EBS1

Alternative name(s):
EST1-like BCY1 suppressor 1

Gene names

Name:	EBS1
Ordered Locus Names:	YDR206W
ORF Names:	YD8142.03

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	884 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in telomere maintenance. May be redundant to EST1, a protein associated with the telomerase. Ref.3
Subcellular location	Nucleus Probable. Chromosome › telomere Probable.
Sequence similarities	Belongs to the EST1 family.

Ontologies

Keywords
Cellular component	Chromosome Nucleus Telomere
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of translation Inferred from mutant phenotype PubMed 16467471. Source: SGD nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Inferred from mutant phenotype PubMed 17984081. Source: SGD
Cellular_component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasmic mRNA processing body Inferred from direct assay PubMed 17984081. Source: SGD nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 884	884	Protein EBS1		PRO_0000086907

Sequences

	Sequence		Length	Mass (Da)
	Q03466 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 14482D64E32A1860	FASTA	884	100,000
	10 20 30 40 50 60 MEPSNTQKED LPTAFNGIKS QLNSILKSNQ LFQDYALLNG FLAFVHSKLN AAILTSIESQ 70 80 90 100 110 120 CGKSFAADLD SFDQSSISSI LDFSWESVHY PIFKWFQMWR NYILFEKENK KQQTKFIDFR 130 140 150 160 170 180 KMNSKMLKFF KTVQNFYVNV INTVYKKYDI SVLLPKRIIQ DLKLSDIENT TNVGDILAVK 190 200 210 220 230 240 TFNSSSPLAH LIPTLFHRCL LFLGTAYRYK TLLEEISNKY SISNFKKSLD FFRLASLVLP 250 260 270 280 290 300 SAGETYSQAG AIFLQTGNLG IAVFNFVKGM MTKMPSPVSI KNFGALMVDN KSSLNRSLHT 310 320 330 340 350 360 TIMNTYLQES KGPRTPAKEI LEFYFLGLFG SVWSPTSWRD DTKPNQLNNG IKLRHLENAL 370 380 390 400 410 420 YETMSARYLN NIKTIFHNLI ITIGGFHLLL KRRSDVSAKT LKDLRSNELD YLNFAFKYIA 430 440 450 460 470 480 HILNDIVKES WSENPEVSEI LGMVRIINCW IKANPMVLQY SQSNLEFVNA LAYLINDIVK 490 500 510 520 530 540 KKPSPSFSIT EHIPKRTYWF EEDLMVKGLS FVNFQLSDFD DYEKILEMDH SLDRLIGNPP 550 560 570 580 590 600 LCDKLSASSE MLLRLQAVVN ISSQLLQNNN CGVEWSDNKS RYIFNKKIGF KETVKNSMKT 610 620 630 640 650 660 SKQSNEKAKL QRKNKPSTTN GSISMADLER QMRSSSLDSF SPTMGYSGSS VPMAPDTFNV 670 680 690 700 710 720 KPSGTITGNK VNVELLKIEL SGQNADGAIT NISPGYSNAA ISSSNSTDES SFDLNNILSS 730 740 750 760 770 780 MQQKHAEKSF AKSMQGVNEQ IPANDVCHQA QRPMQGGLYS SQQPSSMSSL NSAYQNASMP 790 800 810 820 830 840 PSASMVSYPY PFLNQQGQGV FPPYNAQNLQ WQSEAYSLKS MNFANPTWLG DQYQTSAPSS 850 860 870 880 AYAQAQRQMF QQPMQQDVGK YMQFPFDAQS NTDSMRGNSR NNMF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA." Zhou J., Hidaka K., Futcher B. Mol. Cell. Biol. 20:1947-1955(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z68194 Genomic DNA. Translation: CAA92345.1. BK006938 Genomic DNA. Translation: DAA12047.1.
PIR	S61569.
RefSeq	NP_010492.3. NM_001180514.3.
3D structure databases
ProteinModelPortal	Q03466.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1297N.
IntAct	Q03466. 14 interactions.
MINT	MINT-388876.
STRING	4932.YDR206W.
Proteomic databases
PaxDb	Q03466.
PeptideAtlas	Q03466.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDR206W; YDR206W; YDR206W.
GeneID	851787.
KEGG	sce:YDR206W. sce:YDR210W-B.
Organism-specific databases
CYGD	YDR206w.
SGD	S000002614. EBS1.
Phylogenomic databases
eggNOG	NOG146635.
GeneTree	ENSGT00530000068698.
KO	K11132.
OMA	WIFANES.
OrthoDB	EOG4R273R.
Gene expression databases
Genevestigator	Q03466.
GermOnline	YDR206W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018834. DNA/RNA-bd_Est1-type. IPR019458. EST1. [Graphical view]
Pfam	PF10374. EST1. 1 hit. PF10373. EST1_DNA_bind. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	969603.

Entry information

Entry name

EBS1_YEAST

Accession

Primary (citable) accession number: Q03466
Secondary accession number(s): D6VSI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program