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Protein

Probable zinc transporter MSC2

Gene

MSC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably act as a zinc ion transporter moving zinc from the nucleus/endoplasmic reticulum to the cytoplasm. Involved in zinc ion homeostasis and cellular distribution.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular zinc ion homeostasis Source: SGD
  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: GO_Central
  • transmembrane transport Source: SGD
  • zinc II ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29789-MONOMER.
ReactomeiR-SCE-264876. Insulin processing.
R-SCE-435368. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.4.1. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable zinc transporter MSC2
Alternative name(s):
Meiotic sister chromatid recombination protein 2
Gene namesi
Name:MSC2
Ordered Locus Names:YDR205W
ORF Names:YD8142.02
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR205W.
SGDiS000002613. MSC2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 58LumenalSequence analysisAdd BLAST31
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 90CytoplasmicSequence analysisAdd BLAST11
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 134LumenalSequence analysisAdd BLAST23
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 174CytoplasmicSequence analysisAdd BLAST19
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 219LumenalSequence analysisAdd BLAST24
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 244CytoplasmicSequence analysis4
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 298LumenalSequence analysisAdd BLAST33
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 386CytoplasmicSequence analysisAdd BLAST67
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 417LumenalSequence analysis10
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 453CytoplasmicSequence analysisAdd BLAST15
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Topological domaini475 – 491LumenalSequence analysisAdd BLAST17
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 528CytoplasmicSequence analysisAdd BLAST16
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 563LumenalSequence analysisAdd BLAST14
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585 – 724CytoplasmicSequence analysisAdd BLAST140

GO - Cellular componenti

  • endoplasmic reticulum Source: SGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: GO_Central
  • integral component of membrane Source: SGD
  • membrane Source: GO_Central
  • nuclear membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061151 – 724Probable zinc transporter MSC2Add BLAST724

Proteomic databases

MaxQBiQ03455.
PRIDEiQ03455.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZRG17P537353EBI-34990,EBI-28507

Protein-protein interaction databases

BioGridi32255. 25 interactors.
DIPiDIP-5209N.
IntActiQ03455. 2 interactors.
MINTiMINT-493044.

Structurei

3D structure databases

ProteinModelPortaliQ03455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi369 – 379His-richAdd BLAST11
Compositional biasi643 – 661His-richAdd BLAST19

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00630000089781.
HOGENOMiHOG000094005.
InParanoidiQ03455.
KOiK14692.
OMAiENMKGIF.
OrthoDBiEOG092C2X9S.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLQELLAKV PLLLSYPTII LSSNLIVPSH NDLISRAAST SAAEYADEKL
60 70 80 90 100
IFFSTDHAIR LIFLPTFVAS SFNLFAHYFN FINYSSRRKY YVLFTAIYFL
110 120 130 140 150
SILTAIFHPI QSTCITLLII KLLTTADESS PKIALNFKTI LKTFVPFITL
160 170 180 190 200
TLVILRWDPS FDASSGDVNK ISTSLAAYAL LILTLRYASP LILSTLSSSI
210 220 230 240 250
GVVSKDTSVA QHSISRNKRF PLILVLPIFS FVLLYLMTIV NKTYNIQLLM
260 270 280 290 300
VFVFFGCLSI FFLSLKDLFT EDGNQKKGGQ EDEYCRMFDI KYMISYLWLT
310 320 330 340 350
RFTILLTGIM AIVVHFLSFN EITSSIKTDL LSLLFVVVAE YVSSFSNKQP
360 370 380 390 400
DSHSHNHAHH HSHLTDSLPL ENESMFKQMA LNKDTRSIFS FLLLNTAFMF
410 420 430 440 450
VQLLYSFRSK SLGLLSDSLH MALDCTSLLL GLIAGVLTKK PASDKFPFGL
460 470 480 490 500
NYLGTLAGFT NGVLLLGIVC GIFVEAIERI FNPIHLHATN ELLVVATLGL
510 520 530 540 550
LVNLVGLFAF DHGAHDHGGT DNENMKGIFL HILADTLGSV GVVISTLLIK
560 570 580 590 600
LTHWPIFDPI ASLLIGSLIL LSALPLLKST SANILLRLDD KKHNLVKSAL
610 620 630 640 650
NQISTTPGIT GYTTPRFWPT ESGSSGHSHA HTHSHAENHS HEHHHDQKNG
660 670 680 690 700
SQEHPSLVGY IHVQYVDGEN STIIKKRVEK IFENVSIKAW VQVEPQNSTC
710 720
WCRATSMNTI SANPNSLPLQ PIAN
Length:724
Mass (Da):80,578
Last modified:January 16, 2004 - v2
Checksum:i05463664C1CA89E7
GO

Sequence cautioni

The sequence CAA92344 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68194 Genomic DNA. Translation: CAA92344.1. Different initiation.
BK006938 Genomic DNA. Translation: DAA12046.1.
PIRiS61568.
RefSeqiNP_010491.4. NM_001180513.3.

Genome annotation databases

EnsemblFungiiYDR205W; YDR205W; YDR205W.
GeneIDi851786.
KEGGisce:YDR205W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68194 Genomic DNA. Translation: CAA92344.1. Different initiation.
BK006938 Genomic DNA. Translation: DAA12046.1.
PIRiS61568.
RefSeqiNP_010491.4. NM_001180513.3.

3D structure databases

ProteinModelPortaliQ03455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32255. 25 interactors.
DIPiDIP-5209N.
IntActiQ03455. 2 interactors.
MINTiMINT-493044.

Protein family/group databases

TCDBi2.A.4.4.1. the cation diffusion facilitator (cdf) family.

Proteomic databases

MaxQBiQ03455.
PRIDEiQ03455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR205W; YDR205W; YDR205W.
GeneIDi851786.
KEGGisce:YDR205W.

Organism-specific databases

EuPathDBiFungiDB:YDR205W.
SGDiS000002613. MSC2.

Phylogenomic databases

GeneTreeiENSGT00630000089781.
HOGENOMiHOG000094005.
InParanoidiQ03455.
KOiK14692.
OMAiENMKGIF.
OrthoDBiEOG092C2X9S.

Enzyme and pathway databases

BioCyciYEAST:G3O-29789-MONOMER.
ReactomeiR-SCE-264876. Insulin processing.
R-SCE-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

PROiQ03455.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSC2_YEAST
AccessioniPrimary (citable) accession number: Q03455
Secondary accession number(s): D6VSI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Originally MSC2 was identified in a screen for mutants that show an increase in meiotic unequal sister-chromatid recombination (SCR). MSC2 may also be involved in chromosome instability, rather than SRC.
Present with 1070 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.