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Protein

Probable zinc transporter MSC2

Gene

MSC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably act as a zinc ion transporter moving zinc from the nucleus/endoplasmic reticulum to the cytoplasm. Involved in zinc ion homeostasis and cellular distribution.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular zinc ion homeostasis Source: SGD
  • transmembrane transport Source: SGD
  • zinc II ion transmembrane transport Source: GOC
  • zinc II ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29789-MONOMER.
ReactomeiR-SCE-264876. Insulin processing.
R-SCE-435368. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.4.1. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable zinc transporter MSC2
Alternative name(s):
Meiotic sister chromatid recombination protein 2
Gene namesi
Name:MSC2
Ordered Locus Names:YDR205W
ORF Names:YD8142.02
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR205W.
SGDiS000002613. MSC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Topological domaini28 – 5831LumenalSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Topological domaini80 – 9011CytoplasmicSequence analysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence analysisAdd
BLAST
Topological domaini112 – 13423LumenalSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence analysisAdd
BLAST
Topological domaini156 – 17419CytoplasmicSequence analysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Topological domaini196 – 21924LumenalSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Topological domaini241 – 2444CytoplasmicSequence analysis
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Topological domaini266 – 29833LumenalSequence analysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence analysisAdd
BLAST
Topological domaini320 – 38667CytoplasmicSequence analysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence analysisAdd
BLAST
Topological domaini408 – 41710LumenalSequence analysis
Transmembranei418 – 43821HelicalSequence analysisAdd
BLAST
Topological domaini439 – 45315CytoplasmicSequence analysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence analysisAdd
BLAST
Topological domaini475 – 49117LumenalSequence analysisAdd
BLAST
Transmembranei492 – 51221HelicalSequence analysisAdd
BLAST
Topological domaini513 – 52816CytoplasmicSequence analysisAdd
BLAST
Transmembranei529 – 54921HelicalSequence analysisAdd
BLAST
Topological domaini550 – 56314LumenalSequence analysisAdd
BLAST
Transmembranei564 – 58421HelicalSequence analysisAdd
BLAST
Topological domaini585 – 724140CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: SGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: SGD
  • nuclear membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Probable zinc transporter MSC2PRO_0000206115Add
BLAST

Proteomic databases

MaxQBiQ03455.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZRG17P537353EBI-34990,EBI-28507

Protein-protein interaction databases

BioGridi32255. 25 interactions.
DIPiDIP-5209N.
IntActiQ03455. 2 interactions.
MINTiMINT-493044.

Structurei

3D structure databases

ProteinModelPortaliQ03455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi369 – 37911His-richAdd
BLAST
Compositional biasi643 – 66119His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00630000089781.
HOGENOMiHOG000094005.
InParanoidiQ03455.
KOiK14692.
OMAiENMKGIF.
OrthoDBiEOG7Z95VT.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLQELLAKV PLLLSYPTII LSSNLIVPSH NDLISRAAST SAAEYADEKL
60 70 80 90 100
IFFSTDHAIR LIFLPTFVAS SFNLFAHYFN FINYSSRRKY YVLFTAIYFL
110 120 130 140 150
SILTAIFHPI QSTCITLLII KLLTTADESS PKIALNFKTI LKTFVPFITL
160 170 180 190 200
TLVILRWDPS FDASSGDVNK ISTSLAAYAL LILTLRYASP LILSTLSSSI
210 220 230 240 250
GVVSKDTSVA QHSISRNKRF PLILVLPIFS FVLLYLMTIV NKTYNIQLLM
260 270 280 290 300
VFVFFGCLSI FFLSLKDLFT EDGNQKKGGQ EDEYCRMFDI KYMISYLWLT
310 320 330 340 350
RFTILLTGIM AIVVHFLSFN EITSSIKTDL LSLLFVVVAE YVSSFSNKQP
360 370 380 390 400
DSHSHNHAHH HSHLTDSLPL ENESMFKQMA LNKDTRSIFS FLLLNTAFMF
410 420 430 440 450
VQLLYSFRSK SLGLLSDSLH MALDCTSLLL GLIAGVLTKK PASDKFPFGL
460 470 480 490 500
NYLGTLAGFT NGVLLLGIVC GIFVEAIERI FNPIHLHATN ELLVVATLGL
510 520 530 540 550
LVNLVGLFAF DHGAHDHGGT DNENMKGIFL HILADTLGSV GVVISTLLIK
560 570 580 590 600
LTHWPIFDPI ASLLIGSLIL LSALPLLKST SANILLRLDD KKHNLVKSAL
610 620 630 640 650
NQISTTPGIT GYTTPRFWPT ESGSSGHSHA HTHSHAENHS HEHHHDQKNG
660 670 680 690 700
SQEHPSLVGY IHVQYVDGEN STIIKKRVEK IFENVSIKAW VQVEPQNSTC
710 720
WCRATSMNTI SANPNSLPLQ PIAN
Length:724
Mass (Da):80,578
Last modified:January 16, 2004 - v2
Checksum:i05463664C1CA89E7
GO

Sequence cautioni

The sequence CAA92344.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68194 Genomic DNA. Translation: CAA92344.1. Different initiation.
BK006938 Genomic DNA. Translation: DAA12046.1.
PIRiS61568.
RefSeqiNP_010491.4. NM_001180513.3.

Genome annotation databases

EnsemblFungiiYDR205W; YDR205W; YDR205W.
GeneIDi851786.
KEGGisce:YDR205W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68194 Genomic DNA. Translation: CAA92344.1. Different initiation.
BK006938 Genomic DNA. Translation: DAA12046.1.
PIRiS61568.
RefSeqiNP_010491.4. NM_001180513.3.

3D structure databases

ProteinModelPortaliQ03455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32255. 25 interactions.
DIPiDIP-5209N.
IntActiQ03455. 2 interactions.
MINTiMINT-493044.

Protein family/group databases

TCDBi2.A.4.4.1. the cation diffusion facilitator (cdf) family.

Proteomic databases

MaxQBiQ03455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR205W; YDR205W; YDR205W.
GeneIDi851786.
KEGGisce:YDR205W.

Organism-specific databases

EuPathDBiFungiDB:YDR205W.
SGDiS000002613. MSC2.

Phylogenomic databases

GeneTreeiENSGT00630000089781.
HOGENOMiHOG000094005.
InParanoidiQ03455.
KOiK14692.
OMAiENMKGIF.
OrthoDBiEOG7Z95VT.

Enzyme and pathway databases

BioCyciYEAST:G3O-29789-MONOMER.
ReactomeiR-SCE-264876. Insulin processing.
R-SCE-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

PROiQ03455.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination."
    Thompson D.A., Stahl F.W.
    Genetics 153:621-641(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTANT ANALYSIS.
  4. Erratum
    Thompson D.A., Stahl F.W.
    Genetics 164:1241-1241(2003)
  5. "The yeast gene MSC2, a member of the cation diffusion facilitator family, affects the cellular distribution of zinc."
    Li L., Kaplan J.
    J. Biol. Chem. 276:5036-5043(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiMSC2_YEAST
AccessioniPrimary (citable) accession number: Q03455
Secondary accession number(s): D6VSI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: June 8, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Originally MSC2 was identified in a screen for mutants that show an increase in meiotic unequal sister-chromatid recombination (SCR). MSC2 may also be involved in chromosome instability, rather than SRC.
Present with 1070 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.