Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable zinc transporter MSC2

Gene

MSC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably act as a zinc ion transporter moving zinc from the nucleus/endoplasmic reticulum to the cytoplasm. Involved in zinc ion homeostasis and cellular distribution.1 Publication

Miscellaneous

Originally MSC2 was identified in a screen for mutants that show an increase in meiotic unequal sister-chromatid recombination (SCR). MSC2 may also be involved in chromosome instability, rather than SRC.
Present with 1070 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular zinc ion homeostasis Source: SGD
  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: GO_Central
  • transmembrane transport Source: SGD
  • zinc II ion transport Source: SGD

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29789-MONOMER
ReactomeiR-SCE-264876 Insulin processing
R-SCE-435368 Zinc efflux and compartmentalization by the SLC30 family

Protein family/group databases

TCDBi2.A.4.4.1 the cation diffusion facilitator (cdf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Probable zinc transporter MSC2
Alternative name(s):
Meiotic sister chromatid recombination protein 2
Gene namesi
Name:MSC2
Ordered Locus Names:YDR205W
ORF Names:YD8142.02
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR205W
SGDiS000002613 MSC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 58LumenalSequence analysisAdd BLAST31
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 90CytoplasmicSequence analysisAdd BLAST11
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 134LumenalSequence analysisAdd BLAST23
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 174CytoplasmicSequence analysisAdd BLAST19
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 219LumenalSequence analysisAdd BLAST24
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 244CytoplasmicSequence analysis4
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 298LumenalSequence analysisAdd BLAST33
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 386CytoplasmicSequence analysisAdd BLAST67
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 417LumenalSequence analysis10
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 453CytoplasmicSequence analysisAdd BLAST15
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Topological domaini475 – 491LumenalSequence analysisAdd BLAST17
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 528CytoplasmicSequence analysisAdd BLAST16
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 563LumenalSequence analysisAdd BLAST14
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585 – 724CytoplasmicSequence analysisAdd BLAST140

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061151 – 724Probable zinc transporter MSC2Add BLAST724

Proteomic databases

MaxQBiQ03455
PaxDbiQ03455
PRIDEiQ03455

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZRG17P537353EBI-34990,EBI-28507

Protein-protein interaction databases

BioGridi3225582 interactors.
DIPiDIP-5209N
IntActiQ03455 3 interactors.
MINTiQ03455
STRINGi4932.YDR205W

Structurei

3D structure databases

ProteinModelPortaliQ03455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi369 – 379His-richAdd BLAST11
Compositional biasi643 – 661His-richAdd BLAST19

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00630000089781
HOGENOMiHOG000094005
InParanoidiQ03455
KOiK14692
OMAiENMKGIF
OrthoDBiEOG092C2X9S

Family and domain databases

Gene3Di1.20.1510.101 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

Q03455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLQELLAKV PLLLSYPTII LSSNLIVPSH NDLISRAAST SAAEYADEKL
60 70 80 90 100
IFFSTDHAIR LIFLPTFVAS SFNLFAHYFN FINYSSRRKY YVLFTAIYFL
110 120 130 140 150
SILTAIFHPI QSTCITLLII KLLTTADESS PKIALNFKTI LKTFVPFITL
160 170 180 190 200
TLVILRWDPS FDASSGDVNK ISTSLAAYAL LILTLRYASP LILSTLSSSI
210 220 230 240 250
GVVSKDTSVA QHSISRNKRF PLILVLPIFS FVLLYLMTIV NKTYNIQLLM
260 270 280 290 300
VFVFFGCLSI FFLSLKDLFT EDGNQKKGGQ EDEYCRMFDI KYMISYLWLT
310 320 330 340 350
RFTILLTGIM AIVVHFLSFN EITSSIKTDL LSLLFVVVAE YVSSFSNKQP
360 370 380 390 400
DSHSHNHAHH HSHLTDSLPL ENESMFKQMA LNKDTRSIFS FLLLNTAFMF
410 420 430 440 450
VQLLYSFRSK SLGLLSDSLH MALDCTSLLL GLIAGVLTKK PASDKFPFGL
460 470 480 490 500
NYLGTLAGFT NGVLLLGIVC GIFVEAIERI FNPIHLHATN ELLVVATLGL
510 520 530 540 550
LVNLVGLFAF DHGAHDHGGT DNENMKGIFL HILADTLGSV GVVISTLLIK
560 570 580 590 600
LTHWPIFDPI ASLLIGSLIL LSALPLLKST SANILLRLDD KKHNLVKSAL
610 620 630 640 650
NQISTTPGIT GYTTPRFWPT ESGSSGHSHA HTHSHAENHS HEHHHDQKNG
660 670 680 690 700
SQEHPSLVGY IHVQYVDGEN STIIKKRVEK IFENVSIKAW VQVEPQNSTC
710 720
WCRATSMNTI SANPNSLPLQ PIAN
Length:724
Mass (Da):80,578
Last modified:January 16, 2004 - v2
Checksum:i05463664C1CA89E7
GO

Sequence cautioni

The sequence CAA92344 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68194 Genomic DNA Translation: CAA92344.1 Different initiation.
BK006938 Genomic DNA Translation: DAA12046.1
PIRiS61568
RefSeqiNP_010491.4, NM_001180513.3

Genome annotation databases

EnsemblFungiiYDR205W; YDR205W; YDR205W
GeneIDi851786
KEGGisce:YDR205W

Similar proteinsi

Entry informationi

Entry nameiMSC2_YEAST
AccessioniPrimary (citable) accession number: Q03455
Secondary accession number(s): D6VSI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: March 28, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome