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Protein

Glutamate receptor 1

Gene

GluRIA

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Forms ligand-gated ion channels which are activated by kainate.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-DME-399710. Activation of AMPA receptors.
R-DME-416993. Trafficking of GluR2-containing AMPA receptors.
R-DME-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-DME-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor 1
Alternative name(s):
Glutamate receptor I
Short name:
dGLUR-I
Kainate-selective glutamate receptor
Gene namesi
Name:GluRIA
Synonyms:Glu-RI
ORF Names:CG8442
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004619. GluRIA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 611584ExtracellularSequence analysisAdd
BLAST
Transmembranei612 – 63221HelicalSequence analysisAdd
BLAST
Topological domaini633 – 71078CytoplasmicSequence analysisAdd
BLAST
Transmembranei711 – 73121HelicalSequence analysisAdd
BLAST
Topological domaini732 – 895164ExtracellularSequence analysisAdd
BLAST
Transmembranei896 – 91621HelicalSequence analysisAdd
BLAST
Topological domaini917 – 99175CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: FlyBase
  • ionotropic glutamate receptor complex Source: FlyBase
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 991964Glutamate receptor 1PRO_0000011555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence analysis
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence analysis
Glycosylationi385 – 3851N-linked (GlcNAc...)Sequence analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence analysis
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ03445.
PRIDEiQ03445.

Expressioni

Tissue specificityi

Central nervous system.1 Publication

Developmental stagei

No expression is seen in early embryogenesis, whereas high expression occurs in late embryos. During larval development, expression decreases to undetectable levels in late larvae, resumes at the early pupal stage and gradually increases in late pupae and early adult flies. High levels of expression coincide with major stages of neurogenesis.1 Publication

Gene expression databases

BgeeiFBgn0004619.
GenevisibleiQ03445. DM.

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

IntActiQ03445. 1 interaction.
STRINGi7227.FBpp0076691.

Structurei

3D structure databases

ProteinModelPortaliQ03445.
SMRiQ03445. Positions 40-918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 325Poly-Gln
Compositional biasi367 – 3715Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
InParanoidiQ03445.
KOiK05313.
OMAiAYLHLIC.
OrthoDBiEOG091G11CB.
PhylomeDBiQ03445.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q03445-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHSRLKFLAY LHFICASSIF WPEFSSAQQQ QQTVSLTEKI PLGAIFEQGT
60 70 80 90 100
DDVQSAFKYA MLNHNLNVSS RRFELQAYVD VINTADAFKL SRLICNQFSR
110 120 130 140 150
GVYSMLGAVS PDSFDTLHSY SNTFQMPFVT PWFPEKVLAP SSGLLDFAIS
160 170 180 190 200
MRPDYHQAII DTIQYYGWQS IIYLYDSHDG LLRLQQIYQE LKPGNETFRV
210 220 230 240 250
QMVKRIANVT MAIEFLHTLE DLGRFSKKRI VLDCPAEMAK EIIVQHVRDI
260 270 280 290 300
KLGRRTYHYL LSGLVMDNHW PSDVVEFGAI NITGFRIVDS NRRAVRDFHD
310 320 330 340 350
SRKRLEPSGQ SQSQNAGGPN SLPAISAQAA LMYDAVFVLV EAFNRILRKK
360 370 380 390 400
PDQFRSNHLQ RRSHGGSSSS SATGTNESSA LLDCNTSKGW VTPWEQGEKI
410 420 430 440 450
SRVLRKVEID GLSGEIRFDE DGRRINYTLH VVEMSVNSTL QQVAEWRDDA
460 470 480 490 500
GLLPLHSHNY ASSSRSASAS TGDYDRNHTY IVSSLLEEPY LSLKQYTYGE
510 520 530 540 550
SLVGNDRFEG YCKDLADMLA AQLGIKYEIR LVQDGNYGAE NQYAPGGWDG
560 570 580 590 600
MVGELIRKEA DIAISAMTIT AERERVIDFS KPFMTLGISI MIKKPVKQTP
610 620 630 640 650
GVFSFLNPLS QEIWISVILS YVGVSFVLYF VTRFPPYEWR IVRRPQADST
660 670 680 690 700
AQQPPGIIGG ATLSEPQAHV PPVPPNEFTM LNSFWYSLAA FMQQGCDITP
710 720 730 740 750
PSIAGRIAAA VWWFFTIILI SSYTANLAAF LTVERMVAPI KTPEDLTMQT
760 770 780 790 800
DVNYGTLLYG STWEFFRRSQ IGLHNKMWEY MNANQHHSVH TYDEGIRRVR
810 820 830 840 850
QSKGKYALLV ESPKNEYVNA RPPCDTMKVG RNIDTKGFGV ATPIGSPLRK
860 870 880 890 900
RLNEAVLTLK ENGELLRIRN KWWFDKTECN LDQETSTPNE LSLSNVAGIY
910 920 930 940 950
YILIGGLLLA VIVAIMEFFC RNKTPQLKSP GSNGSAGGVP GMLASSTYQR
960 970 980 990
DSLSDAIMHS QAKLAMQASS EYDERLVGVE LASNVRYQYS M
Length:991
Mass (Da):111,668
Last modified:June 21, 2005 - v2
Checksum:iC8917868ABA06F98
GO
Isoform 2 (identifier: Q03445-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-265: Missing.

Note: No experimental confirmation available.
Show »
Length:726
Mass (Da):81,118
Checksum:i5D98F26A66E54C5F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611M → L in AAA28575 (PubMed:1359540).Curated
Sequence conflicti301 – 3011S → N in AAA28575 (PubMed:1359540).Curated
Sequence conflicti309 – 3168GQSQSQNA → AKAKARTQ in AAA28575 (PubMed:1359540).Curated
Sequence conflicti324 – 3241A → P in AAA28575 (PubMed:1359540).Curated
Sequence conflicti747 – 7471T → A in AAA28575 (PubMed:1359540).Curated
Sequence conflicti759 – 7591Y → H in AAA28575 (PubMed:1359540).Curated
Sequence conflicti916 – 9161M → V in AAA28575 (PubMed:1359540).Curated
Sequence conflicti944 – 9441A → G in AAA28575 (PubMed:1359540).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 265265Missing in isoform 2. 1 PublicationVSP_014219Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97192 mRNA. Translation: AAA28575.1.
AE014296 Genomic DNA. Translation: AAF50652.2.
BT003218 mRNA. Translation: AAO24973.1.
BT050435 mRNA. Translation: ACJ13142.1.
PIRiA46421.
RefSeqiNP_476855.1. NM_057507.4. [Q03445-1]
UniGeneiDm.6460.

Genome annotation databases

EnsemblMetazoaiFBtr0076982; FBpp0076691; FBgn0004619. [Q03445-1]
GeneIDi38742.
KEGGidme:Dmel_CG8442.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97192 mRNA. Translation: AAA28575.1.
AE014296 Genomic DNA. Translation: AAF50652.2.
BT003218 mRNA. Translation: AAO24973.1.
BT050435 mRNA. Translation: ACJ13142.1.
PIRiA46421.
RefSeqiNP_476855.1. NM_057507.4. [Q03445-1]
UniGeneiDm.6460.

3D structure databases

ProteinModelPortaliQ03445.
SMRiQ03445. Positions 40-918.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ03445. 1 interaction.
STRINGi7227.FBpp0076691.

Proteomic databases

PaxDbiQ03445.
PRIDEiQ03445.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076982; FBpp0076691; FBgn0004619. [Q03445-1]
GeneIDi38742.
KEGGidme:Dmel_CG8442.

Organism-specific databases

CTDi38742.
FlyBaseiFBgn0004619. GluRIA.

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
InParanoidiQ03445.
KOiK05313.
OMAiAYLHLIC.
OrthoDBiEOG091G11CB.
PhylomeDBiQ03445.

Enzyme and pathway databases

ReactomeiR-DME-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-DME-399710. Activation of AMPA receptors.
R-DME-416993. Trafficking of GluR2-containing AMPA receptors.
R-DME-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-DME-5694530. Cargo concentration in the ER.

Miscellaneous databases

GenomeRNAii38742.
PROiQ03445.

Gene expression databases

BgeeiFBgn0004619.
GenevisibleiQ03445. DM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGLR1_DROME
AccessioniPrimary (citable) accession number: Q03445
Secondary accession number(s): B6IDJ5, Q86PC2, Q9VRX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 21, 2005
Last modified: September 7, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.