Q03440 (COX4_BACP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 4B
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 4B
Cytochrome c oxidase polypeptide IVB

Gene names

Name:

caaD

Organism

Bacillus PS3 (Thermophilic bacterium PS-3)

Taxonomic identifier

2334 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase bacterial subunit 4 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 110	109	Cytochrome c oxidase subunit 4B		PRO_0000183901
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q03440 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 04A68F25EF2EABB4	FASTA	110	12,864
	10 20 30 40 50 60 MANQTNSGNE RVDLAYRRRK NAEEMRHQMI AFVLMILLTL IAFAAVGYEE FSHWFVVPFI 70 80 90 100 110 LLLAAVQVAF QLYYFMHMSH KGHEFPAMFI YGGVAVMLLL VWAFTTVVWW

References

[1]

"Nucleotide sequence of the gene coding for four subunits of cytochrome c oxidase from the thermophilic bacterium PS3." Ishizuka M., Machida K., Shimada S., Mogi A., Tsuchiya T., Ohmori T., Souma Y., Gonda M., Sone N. J. Biochem. 108:866-873(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-17.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13955 Genomic DNA. Translation: BAA03048.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR014257. Cyt_c_oxidase_su4_bacillaceae. IPR005171. Cyt_c_oxidase_suIV_prok. [Graphical view]
Pfam	PF03626. COX4_pro. 1 hit. [Graphical view]
TIGRFAMs	TIGR02908. CoxD_Bacillus. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COX4_BACP3

Accession

Primary (citable) accession number: Q03440

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program