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Q03438 (COX2_BACP3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene names
Name:ctaC
Synonyms:caaA
OrganismBacillus PS3 (Thermophilic bacterium PS-3)
Taxonomic identifier2334 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Heme group.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Contains 1 cytochrome c domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.1
Chain24 – 356333Cytochrome c oxidase subunit 2
PRO_0000006050

Regions

Transmembrane45 – 6521Helical; Potential
Transmembrane93 – 11321Helical; Potential
Domain260 – 35697Cytochrome c
Region24 – 259236Cytochrome c oxidase subunit II

Sites

Metal binding1781Copper A Probable
Metal binding2191Copper A Probable
Metal binding2231Copper A Probable
Metal binding2271Copper A Probable
Metal binding2771Iron (heme axial ligand) Probable
Metal binding3311Iron (heme axial ligand) Probable
Binding site2731Heme (covalent) Probable
Binding site2761Heme (covalent) Probable

Sequences

Sequence LengthMass (Da)Tools
Q03438 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: CAD99B650BFF8342

FASTA35640,236
        10         20         30         40         50         60 
MNKGLCNWRL FSLFGMMALL LAGCGKPFLS TLQPAGEVAD MQYSLMLLST SIMVLVIVVV 

        70         80         90        100        110        120 
AIIFVYVVIR FRRRKGEENK IPKQVEGSHK LEIIWTVIPI ILLLILAVPT VLTTFKLADV 

       130        140        150        160        170        180 
KAMNDKKRDK NTVVVNVRAN QYWWEFEYPD YGIITSQDLV VPTNEKVYFN LIASDVKHSF 

       190        200        210        220        230        240 
WIPAVGGKMD TNTDNKNQFW LVFDQKATDK AGGVFYGKCA ELCGPSHALM DFKVRPLPRD 

       250        260        270        280        290        300 
QFDAWVKKMQ NAKKPVVTDP VAKEGEAIFN KSCIGCHAVT PLDKRPAQRR TAPNLADFGD 

       310        320        330        340        350 
RERIAGILEH NEENLKKWLR DPNSVKPGNK MAGTYGHLTE EQIDALTKYL MSLKVE

« Hide

References

[1]"Nucleotide sequence of the gene coding for four subunits of cytochrome c oxidase from the thermophilic bacterium PS3."
Ishizuka M., Machida K., Shimada S., Mogi A., Tsuchiya T., Ohmori T., Souma Y., Gonda M., Sone N.
J. Biochem. 108:866-873(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-48.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D13955 Genomic DNA. Translation: BAA03045.1.

3D structure databases

ProteinModelPortalQ03438.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c_dom.
IPR003088. Cyt_c_I.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
[Graphical view]
SUPFAMSSF49503. Cupredoxin. 1 hit.
SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
SSF46626. Cytochrome_c. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_BACP3
AccessionPrimary (citable) accession number: Q03438
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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