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Q03438

- COX2_BACP3

UniProt

Q03438 - COX2_BACP3

Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Bacillus sp. (strain PS3)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.
    Heme group.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi178 – 1781Copper ACurated
    Metal bindingi219 – 2191Copper ACurated
    Metal bindingi223 – 2231Copper ACurated
    Metal bindingi227 – 2271Copper ACurated
    Binding sitei273 – 2731Heme (covalent)Curated
    Binding sitei276 – 2761Heme (covalent)Curated
    Metal bindingi277 – 2771Iron (heme axial ligand)Curated
    Metal bindingi331 – 3311Iron (heme axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Oxidase aa(3) subunit 2
    Gene namesi
    Name:ctaC
    Synonyms:caaA
    OrganismiBacillus sp. (strain PS3)
    Taxonomic identifieri2334 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Chaini24 – 356333Cytochrome c oxidase subunit 2PRO_0000006050Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ03438.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini260 – 35697Cytochrome cPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 259236Cytochrome c oxidase subunit IIAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cytochrome c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    1.10.760.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR009056. Cyt_c-like_dom.
    IPR003088. Cyt_c_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    PF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46626. SSF46626. 1 hit.
    SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    PS51007. CYTC. 1 hit.
    PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q03438-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKGLCNWRL FSLFGMMALL LAGCGKPFLS TLQPAGEVAD MQYSLMLLST    50
    SIMVLVIVVV AIIFVYVVIR FRRRKGEENK IPKQVEGSHK LEIIWTVIPI 100
    ILLLILAVPT VLTTFKLADV KAMNDKKRDK NTVVVNVRAN QYWWEFEYPD 150
    YGIITSQDLV VPTNEKVYFN LIASDVKHSF WIPAVGGKMD TNTDNKNQFW 200
    LVFDQKATDK AGGVFYGKCA ELCGPSHALM DFKVRPLPRD QFDAWVKKMQ 250
    NAKKPVVTDP VAKEGEAIFN KSCIGCHAVT PLDKRPAQRR TAPNLADFGD 300
    RERIAGILEH NEENLKKWLR DPNSVKPGNK MAGTYGHLTE EQIDALTKYL 350
    MSLKVE 356
    Length:356
    Mass (Da):40,236
    Last modified:February 1, 1994 - v1
    Checksum:iCAD99B650BFF8342
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13955 Genomic DNA. Translation: BAA03045.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13955 Genomic DNA. Translation: BAA03045.1 .

    3D structure databases

    ProteinModelPortali Q03438.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    1.10.760.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR009056. Cyt_c-like_dom.
    IPR003088. Cyt_c_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46626. SSF46626. 1 hit.
    SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    PS51007. CYTC. 1 hit.
    PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the gene coding for four subunits of cytochrome c oxidase from the thermophilic bacterium PS3."
      Ishizuka M., Machida K., Shimada S., Mogi A., Tsuchiya T., Ohmori T., Souma Y., Gonda M., Sone N.
      J. Biochem. 108:866-873(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-48.

    Entry informationi

    Entry nameiCOX2_BACP3
    AccessioniPrimary (citable) accession number: Q03438
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3