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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Bacillus sp. (strain PS3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi178Copper ACurated1
Metal bindingi219Copper ACurated1
Metal bindingi223Copper ACurated1
Metal bindingi227Copper ACurated1
Binding sitei273Heme (covalent)Curated1
Binding sitei276Heme (covalent)Curated1
Metal bindingi277Iron (heme axial ligand)Curated1
Metal bindingi331Iron (heme axial ligand)Curated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Synonyms:caaA
OrganismiBacillus sp. (strain PS3)
Taxonomic identifieri2334 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23PROSITE-ProRule annotation1 PublicationAdd BLAST23
ChainiPRO_000000605024 – 356Cytochrome c oxidase subunit 2Add BLAST333

Structurei

3D structure databases

ProteinModelPortaliQ03438
SMRiQ03438
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 356Cytochrome cPROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 259Cytochrome c oxidase subunit IIAdd BLAST236

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
PF00034 Cytochrom_C, 1 hit
SUPFAMiSSF46626 SSF46626, 1 hit
SSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit
PS51007 CYTC, 1 hit
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKGLCNWRL FSLFGMMALL LAGCGKPFLS TLQPAGEVAD MQYSLMLLST
60 70 80 90 100
SIMVLVIVVV AIIFVYVVIR FRRRKGEENK IPKQVEGSHK LEIIWTVIPI
110 120 130 140 150
ILLLILAVPT VLTTFKLADV KAMNDKKRDK NTVVVNVRAN QYWWEFEYPD
160 170 180 190 200
YGIITSQDLV VPTNEKVYFN LIASDVKHSF WIPAVGGKMD TNTDNKNQFW
210 220 230 240 250
LVFDQKATDK AGGVFYGKCA ELCGPSHALM DFKVRPLPRD QFDAWVKKMQ
260 270 280 290 300
NAKKPVVTDP VAKEGEAIFN KSCIGCHAVT PLDKRPAQRR TAPNLADFGD
310 320 330 340 350
RERIAGILEH NEENLKKWLR DPNSVKPGNK MAGTYGHLTE EQIDALTKYL

MSLKVE
Length:356
Mass (Da):40,236
Last modified:February 1, 1994 - v1
Checksum:iCAD99B650BFF8342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13955 Genomic DNA Translation: BAA03045.1

Similar proteinsi

Entry informationi

Entry nameiCOX2_BACP3
AccessioniPrimary (citable) accession number: Q03438
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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Main funding by: National Institutes of Health