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Q03435

- NHP10_YEAST

UniProt

Q03435 - NHP10_YEAST

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Protein
Non-histone protein 10
Gene
NHP10, HMO2, YDL002C, YD8119.05C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi94 – 15865HMG box
Add
BLAST

GO - Molecular functioni

  1. DNA end binding Source: SGD
  2. heteroduplex DNA loop binding Source: SGD
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. double-strand break repair Source: SGD
  2. nucleosome mobilization Source: SGD
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29433-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone protein 10
Alternative name(s):
High mobility group protein 2
Gene namesi
Name:NHP10
Synonyms:HMO2
Ordered Locus Names:YDL002C
ORF Names:YD8119.05C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL002c.
SGDiS000002160. NHP10.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Ino80 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 203202Non-histone protein 10
PRO_0000048567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ03435.
PaxDbiQ03435.
PeptideAtlasiQ03435.

Expressioni

Gene expression databases

GenevestigatoriQ03435.

Interactioni

Subunit structurei

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IES1P435795EBI-12010,EBI-22775
IES3Q123453EBI-12010,EBI-35758
IES5P400605EBI-12010,EBI-22617
INO80P5311511EBI-12010,EBI-24019

Protein-protein interaction databases

BioGridi32052. 322 interactions.
DIPiDIP-1387N.
IntActiQ03435. 28 interactions.
MINTiMINT-388714.
STRINGi4932.YDL002C.

Structurei

3D structure databases

ProteinModelPortaliQ03435.
SMRiQ03435. Positions 76-160.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5648.
HOGENOMiHOG000001026.
KOiK11680.
OMAiAYLLFCE.
OrthoDBiEOG70KH25.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03435-1 [UniParc]FASTAAdd to Basket

« Hide

MSVEEKKRRL EELKDQNVVL GLAIQRSRLS VKRLKLEYGV LLERLESRIE    50
LDPELNCEDP LPTLASFKQE LLTKPFRKSK TKRHKVKERD PNMPKRPTNA 100
YLLYCEMNKE RIRQNGSLDV TRDLAEGWKN LNEQDRKPYY KLYSEDRERY 150
QMEMEIYNKK ISNIDADDDK EENEQKIKNN EEGSSTKVAD SKGGEDGSLV 200
SSN 203
Length:203
Mass (Da):23,857
Last modified:November 1, 1996 - v1
Checksum:iEE6F488F78D32415
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48008 Genomic DNA. Translation: CAA88059.1.
BK006938 Genomic DNA. Translation: DAA11846.1.
PIRiS50980.
RefSeqiNP_010282.3. NM_001180061.3.

Genome annotation databases

EnsemblFungiiYDL002C; YDL002C; YDL002C.
GeneIDi851562.
KEGGisce:YDL002C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48008 Genomic DNA. Translation: CAA88059.1 .
BK006938 Genomic DNA. Translation: DAA11846.1 .
PIRi S50980.
RefSeqi NP_010282.3. NM_001180061.3.

3D structure databases

ProteinModelPortali Q03435.
SMRi Q03435. Positions 76-160.
ModBasei Search...

Protein-protein interaction databases

BioGridi 32052. 322 interactions.
DIPi DIP-1387N.
IntActi Q03435. 28 interactions.
MINTi MINT-388714.
STRINGi 4932.YDL002C.

Proteomic databases

MaxQBi Q03435.
PaxDbi Q03435.
PeptideAtlasi Q03435.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL002C ; YDL002C ; YDL002C .
GeneIDi 851562.
KEGGi sce:YDL002C.

Organism-specific databases

CYGDi YDL002c.
SGDi S000002160. NHP10.

Phylogenomic databases

eggNOGi COG5648.
HOGENOMi HOG000001026.
KOi K11680.
OMAi AYLLFCE.
OrthoDBi EOG70KH25.

Enzyme and pathway databases

BioCyci YEAST:G3O-29433-MONOMER.

Miscellaneous databases

NextBioi 968998.

Gene expression databases

Genevestigatori Q03435.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Characterization of a high mobility group 1/2 homolog in yeast."
    Lu J., Kobayashi R., Brill S.J.
    J. Biol. Chem. 271:33678-33685(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
    Shen X., Ranallo R., Choi E., Wu C.
    Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNHP10_YEAST
AccessioniPrimary (citable) accession number: Q03435
Secondary accession number(s): D6VRY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1750 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi