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Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

PTH1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.2 Publications

GO - Molecular functioni

  • parathyroid hormone receptor activity Source: UniProtKB
  • peptide hormone binding Source: UniProtKB
  • protein self-association Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160801-MONOMER.
ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).
R-HSA-418555. G alpha (s) signalling events.
SignaLinkiQ03431.
SIGNORiQ03431.

Protein family/group databases

TCDBi9.A.14.4.11. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alternative name(s):
PTH/PTHrP type I receptor
Short name:
PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name:
PTH1 receptor
Gene namesi
Name:PTH1R
Synonyms:PTHR, PTHR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9608. PTH1R.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 188ExtracellularSequence analysisAdd BLAST162
Transmembranei189 – 212Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini213 – 219CytoplasmicSequence analysis7
Transmembranei220 – 239Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini240 – 282ExtracellularSequence analysisAdd BLAST43
Transmembranei283 – 306Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini307 – 320CytoplasmicSequence analysisAdd BLAST14
Transmembranei321 – 342Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini343 – 361ExtracellularSequence analysisAdd BLAST19
Transmembranei362 – 382Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini383 – 409CytoplasmicSequence analysisAdd BLAST27
Transmembranei410 – 428Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini429 – 440ExtracellularSequence analysisAdd BLAST12
Transmembranei441 – 463Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini464 – 593CytoplasmicSequence analysisAdd BLAST130

GO - Cellular componenti

  • apical plasma membrane Source: BHF-UCL
  • basolateral plasma membrane Source: BHF-UCL
  • brush border membrane Source: Ensembl
  • cytoplasm Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • nucleus Source: ProtInc
  • plasma membrane Source: Reactome
  • receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Jansen metaphyseal chondrodysplasia (JMC)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones.
See also OMIM:156400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003582223H → R in JMC; constitutively activated. 3 PublicationsCorresponds to variant rs121434597dbSNPEnsembl.1
Natural variantiVAR_003583410T → P in JMC; constitutively activated. 2 PublicationsCorresponds to variant rs121434598dbSNPEnsembl.1
Natural variantiVAR_038811410T → R in JMC; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant rs121434602dbSNPEnsembl.1
Natural variantiVAR_016064458I → R in JMC. 1 PublicationCorresponds to variant rs121434600dbSNPEnsembl.1
Chondrodysplasia Blomstrand type (BOCD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSevere skeletal dysplasia.
See also OMIM:215045
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016062132P → L in BOCD. 1 PublicationCorresponds to variant rs121434599dbSNPEnsembl.1
Enchondromatosis multiple (ENCHOM)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by multiple formation of enchondromas, benign neoplasms derived from mesodermal cells that form cartilage. Enchondromas remain within the substance of a cartilage or bone. Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma.
See also OMIM:166000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016063150R → C in ENCHOM; Ollier type; unknown pathological significance. 1 PublicationCorresponds to variant rs121434601dbSNPEnsembl.1
Eiken skeletal dysplasia (EISD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare skeletal dysplasia characterized by severely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation.
See also OMIM:600002
Primary failure of tooth eruption (PFE)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.
See also OMIM:125350

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi135I → K: Abolishes hormone binding and homodimerization. 1 Publication1
Mutagenesisi137D → A: Abolishes hormone binding. No effect on homodimerization. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNETi5745.
MalaCardsiPTH1R.
MIMi125350. phenotype.
156400. phenotype.
166000. phenotype.
215045. phenotype.
600002. phenotype.
OpenTargetsiENSG00000160801.
Orphaneti50945. Blomstrand lethal chondrodysplasia.
1077. Dental ankylosis.
79106. Eiken syndrome.
296. Enchondromatosis.
33067. Metaphyseal chondrodysplasia, Jansen type.
PharmGKBiPA33953.

Chemistry databases

ChEMBLiCHEMBL1793.
DrugBankiDB05829. Preotact.
DB06285. Teriparatide.
GuidetoPHARMACOLOGYi331.

Polymorphism and mutation databases

BioMutaiPTH1R.
DMDMi417555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001284527 – 593Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 117Combined sources3 Publications
Disulfide bondi108 ↔ 148Combined sources3 Publications
Disulfide bondi131 ↔ 170Combined sources3 Publications
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Modified residuei551PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ03431.
PRIDEiQ03431.
TopDownProteomicsiQ03431.

2D gel databases

REPRODUCTION-2DPAGEQ03431.

PTM databases

iPTMnetiQ03431.
PhosphoSitePlusiQ03431.

Miscellaneous databases

PMAP-CutDBQ03431.

Expressioni

Tissue specificityi

Expressed in most tissues. Most abundant in kidney, bone and liver.1 Publication

Gene expression databases

BgeeiENSG00000160801.
CleanExiHS_PTH1R.
ExpressionAtlasiQ03431. baseline and differential.
GenevisibleiQ03431. HS.

Organism-specific databases

HPAiHPA007978.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8397094, PubMed:10913300, PubMed:18375760, PubMed:19674967). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (PubMed:19674967, PubMed:20172855).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352224EBI-2860297,EBI-491549

GO - Molecular functioni

  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi111717. 51 interactors.
IntActiQ03431. 2 interactors.
MINTiMINT-258057.
STRINGi9606.ENSP00000321999.

Chemistry databases

BindingDBiQ03431.

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 55Combined sources22
Beta strandi126 – 130Combined sources5
Beta strandi143 – 148Combined sources6
Beta strandi152 – 154Combined sources3
Beta strandi160 – 163Combined sources4
Turni168 – 173Combined sources6
Helixi180 – 185Combined sources6
Helixi188 – 196Combined sources9
Beta strandi588 – 593Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BL1NMR-A168-197[»]
1ET2model-S168-469[»]
1ET3model-S168-469[»]
3C4MX-ray1.95A/B29-187[»]
3H3GX-ray1.94A29-187[»]
3L2JX-ray3.24A/B29-187[»]
4Z8JX-ray0.95B586-593[»]
ProteinModelPortaliQ03431.
SMRiQ03431.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03431.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi474 – 477Important for interaction with G proteins4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiQ03431.
KOiK04585.
OMAiYAGCRVA.
OrthoDBiEOG091G0NF8.
PhylomeDBiQ03431.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK
60 70 80 90 100
RLKEVLQRPA SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG
110 120 130 140 150
SRYRGRPCLP EWDHILCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGATL
260 270 280 290 300
DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG
360 370 380 390 400
CWDLSSGNKK WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLKST LVLMPLFGVH YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP GTPALETLET
560 570 580 590
TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM
Length:593
Mass (Da):66,361
Last modified:October 1, 1993 - v1
Checksum:iDA1400640A6C7F2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti471K → N (PubMed:8397094).Curated1
Sequence conflicti473S → C (PubMed:8397094).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016062132P → L in BOCD. 1 PublicationCorresponds to variant rs121434599dbSNPEnsembl.1
Natural variantiVAR_016063150R → C in ENCHOM; Ollier type; unknown pathological significance. 1 PublicationCorresponds to variant rs121434601dbSNPEnsembl.1
Natural variantiVAR_003582223H → R in JMC; constitutively activated. 3 PublicationsCorresponds to variant rs121434597dbSNPEnsembl.1
Natural variantiVAR_003583410T → P in JMC; constitutively activated. 2 PublicationsCorresponds to variant rs121434598dbSNPEnsembl.1
Natural variantiVAR_038811410T → R in JMC; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant rs121434602dbSNPEnsembl.1
Natural variantiVAR_016064458I → R in JMC. 1 PublicationCorresponds to variant rs121434600dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04308 mRNA. Translation: AAA36525.1.
X68596 mRNA. Translation: CAA48589.1.
U22409
, U22401, U22402, U22403, U22404, U22405, U22406, U22407, U22408 Genomic DNA. Translation: AAB60657.1.
U17418 mRNA. Translation: AAA56774.1.
AY449732 mRNA. Translation: AAR18076.1.
BC112221 mRNA. Translation: AAI12222.1.
BC112247 mRNA. Translation: AAI12248.1.
CCDSiCCDS2747.1.
PIRiI38139. A49191.
RefSeqiNP_000307.1. NM_000316.2.
NP_001171673.1. NM_001184744.1.
XP_016862422.1. XM_017006933.1.
UniGeneiHs.1019.

Genome annotation databases

EnsembliENST00000313049; ENSP00000321999; ENSG00000160801.
ENST00000418619; ENSP00000411424; ENSG00000160801.
ENST00000430002; ENSP00000413774; ENSG00000160801.
ENST00000449590; ENSP00000402723; ENSG00000160801.
GeneIDi5745.
KEGGihsa:5745.
UCSCiuc003cqm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04308 mRNA. Translation: AAA36525.1.
X68596 mRNA. Translation: CAA48589.1.
U22409
, U22401, U22402, U22403, U22404, U22405, U22406, U22407, U22408 Genomic DNA. Translation: AAB60657.1.
U17418 mRNA. Translation: AAA56774.1.
AY449732 mRNA. Translation: AAR18076.1.
BC112221 mRNA. Translation: AAI12222.1.
BC112247 mRNA. Translation: AAI12248.1.
CCDSiCCDS2747.1.
PIRiI38139. A49191.
RefSeqiNP_000307.1. NM_000316.2.
NP_001171673.1. NM_001184744.1.
XP_016862422.1. XM_017006933.1.
UniGeneiHs.1019.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BL1NMR-A168-197[»]
1ET2model-S168-469[»]
1ET3model-S168-469[»]
3C4MX-ray1.95A/B29-187[»]
3H3GX-ray1.94A29-187[»]
3L2JX-ray3.24A/B29-187[»]
4Z8JX-ray0.95B586-593[»]
ProteinModelPortaliQ03431.
SMRiQ03431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111717. 51 interactors.
IntActiQ03431. 2 interactors.
MINTiMINT-258057.
STRINGi9606.ENSP00000321999.

Chemistry databases

BindingDBiQ03431.
ChEMBLiCHEMBL1793.
DrugBankiDB05829. Preotact.
DB06285. Teriparatide.
GuidetoPHARMACOLOGYi331.

Protein family/group databases

TCDBi9.A.14.4.11. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ03431.
PhosphoSitePlusiQ03431.

Polymorphism and mutation databases

BioMutaiPTH1R.
DMDMi417555.

2D gel databases

REPRODUCTION-2DPAGEQ03431.

Proteomic databases

PaxDbiQ03431.
PRIDEiQ03431.
TopDownProteomicsiQ03431.

Protocols and materials databases

DNASUi5745.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313049; ENSP00000321999; ENSG00000160801.
ENST00000418619; ENSP00000411424; ENSG00000160801.
ENST00000430002; ENSP00000413774; ENSG00000160801.
ENST00000449590; ENSP00000402723; ENSG00000160801.
GeneIDi5745.
KEGGihsa:5745.
UCSCiuc003cqm.4. human.

Organism-specific databases

CTDi5745.
DisGeNETi5745.
GeneCardsiPTH1R.
HGNCiHGNC:9608. PTH1R.
HPAiHPA007978.
MalaCardsiPTH1R.
MIMi125350. phenotype.
156400. phenotype.
166000. phenotype.
168468. gene.
215045. phenotype.
600002. phenotype.
neXtProtiNX_Q03431.
OpenTargetsiENSG00000160801.
Orphaneti50945. Blomstrand lethal chondrodysplasia.
1077. Dental ankylosis.
79106. Eiken syndrome.
296. Enchondromatosis.
33067. Metaphyseal chondrodysplasia, Jansen type.
PharmGKBiPA33953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiQ03431.
KOiK04585.
OMAiYAGCRVA.
OrthoDBiEOG091G0NF8.
PhylomeDBiQ03431.
TreeFamiTF315710.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160801-MONOMER.
ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).
R-HSA-418555. G alpha (s) signalling events.
SignaLinkiQ03431.
SIGNORiQ03431.

Miscellaneous databases

EvolutionaryTraceiQ03431.
GeneWikiiParathyroid_hormone_1_receptor.
GenomeRNAii5745.
PMAP-CutDBQ03431.
PROiQ03431.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160801.
CleanExiHS_PTH1R.
ExpressionAtlasiQ03431. baseline and differential.
GenevisibleiQ03431. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTH1R_HUMAN
AccessioniPrimary (citable) accession number: Q03431
Secondary accession number(s): Q2M1U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 176 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.