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Protein

Glutathione S-transferase 2

Gene

GST2

Organism
Dianthus caryophyllus (Carnation) (Clove pink)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601Glutathione; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei112 – 1121GlutathioneBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 2 (EC:2.5.1.18)
Alternative name(s):
GST class-zeta
Gene namesi
Name:GST2
OrganismiDianthus caryophyllus (Carnation) (Clove pink)
Taxonomic identifieri3570 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesCaryophyllaceaeDianthus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›145›145Glutathione S-transferase 2PRO_0000186032Add
BLAST

Proteomic databases

PRIDEiQ03425.

Expressioni

Developmental stagei

Senescing flowers.

Inductioni

Accumulates in response to the phytohormone ethylene.

Structurei

3D structure databases

ProteinModelPortaliQ03425.
SMRiQ03425. Positions 8-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8882GST N-terminalAdd
BLAST
Domaini93 – ›145›53GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 226Glutathione bindingBy similarity
Regioni72 – 732Glutathione bindingBy similarity
Regioni116 – 1183Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Zeta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q03425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSETQKMQ LYSYSSSSCA WRVRIALHLK GLDFEYKAVD LLKGEHLTPE
60 70 80 90 100
FLKLNPLGYV PALVHGDIVI ADSLAIIMYL EEKFPENPLL PRDLQKRALN
110 120 130 140
YQAANIVASN IQPFQNLAVL NYIEEKLGSD EKLSWANHHI KKGFS
Length:145
Mass (Da):16,447
Last modified:October 1, 1993 - v1
Checksum:iEEF49C6143D796B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei145 – 1451

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05916 Genomic DNA. Translation: AAA51450.1.
PIRiS33629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05916 Genomic DNA. Translation: AAA51450.1.
PIRiS33629.

3D structure databases

ProteinModelPortaliQ03425.
SMRiQ03425. Positions 8-115.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ03425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of an ethylene-responsive glutathione S-transferase gene cluster in carnation."
    Itzhaki H., Woodson W.R.
    Plant Mol. Biol. 22:43-58(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. White Sim.
    Tissue: Petal.

Entry informationi

Entry nameiGSTZ2_DIACA
AccessioniPrimary (citable) accession number: Q03425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.