Q03412 (UNC7_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Innexin unc-7

Alternative name(s):
Uncoordinated protein 7

Gene names

Name:	unc-7
Synonyms:	unc-12, unc-124
ORF Names:	R07D5.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Structural components of the gap junctions. Required for coordinated locomotion.
Subunit structure	Heterooligomer of unc-7 and unc-9 Probable.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential. Cell junction › gap junction.
Developmental stage	Present in all developmental stages but most abundant in L1-L3 larvae.
Sequence similarities	Belongs to the pannexin family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Gap junction Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gap junction assembly Traceable author statement PubMed 8707836. Source: WormBase ion transmembrane transport Inferred from direct assay PubMed 19432959. Source: WormBase locomotion Inferred from mutant phenotype Ref.1. Source: UniProtKB oviposition Inferred from mutant phenotype PubMed 9375655. Source: WormBase regulation of pharyngeal pumping Inferred from mutant phenotype PubMed 12750328. Source: WormBase response to chemical stimulus Inferred from mutant phenotype Ref.1. Source: WormBase
Cellular_component	gap junction Inferred from mutant phenotype Ref.1. Source: UniProtKB integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB neuron projection membrane Inferred from direct assay PubMed 21489288. Source: WormBase
Molecular_function	gap junction hemi-channel activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 522	522	Innexin unc-7		PRO_0000208517
Regions
	Transmembrane	151 – 171	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	320 – 340	21	Helical; Potential
	Transmembrane	405 – 425	21	Helical; Potential
	Compositional bias	20 – 25	6	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	Q03412 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 950D7AFBA9F61120	FASTA	522	60,121
	10 20 30 40 50 60 MLGSSSNPEP PLLSRIIGVP PPPPPRAPTT ALVLRVPTVD SPSKKKQQPD TRNKYQETAL 70 80 90 100 110 120 RDKKTRTPLE KARHLDNLPS YQAQKLLDGS HQLRIDSHHV GSAGHGAGQG HGHKKEFGPA 130 140 150 160 170 180 MILYYLASAF RALYPRLDDD FVDKLNYYYT TTILASFALL VSAKQYVGFP IQCWVPATFT 190 200 210 220 230 240 DAMEQYTENY CWVQNTYWVP MQEDIPREIY SRRNRQIGYY QWVPFILAIE ALLFYVPCIL 250 260 270 280 290 300 WRGLLYWHSG INLQGLVQMA CDARLMDSEI KTRTVYTMAR HMQDEVQLTN IDRQGHSRSC 310 320 330 340 350 360 FSNLQLGANC GRHCGCYVTM LYIGIKVLYS ANVLLQFFLL NHLLGSNDLA YGFSLLKDLM 370 380 390 400 410 420 HAIEWEQTGM FPRVTLCDFE VRVLGNIHRH TVQCVLMINM FNEKIFLFLW FWFLTCGIVT 430 440 450 460 470 480 VCNTMYWILI MFIPSQGMSF VRKYLRVLPD HPAKPIADDV TLRKFTNNFL RKDGVFMLRM 490 500 510 520 ISTHAGELMS SELILALWQD FNNVDRSPTQ FWDAEHGQGT ID

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion." Starich T.A., Herman R.K., Shaw J.E. Genetics 133:527-541(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z19122 Transcribed RNA. Translation: CAA79529.1. Z70685 Genomic DNA. Translation: CAA94607.1.
PIR	T24027.
RefSeq	NP_001257255.1. NM_001270326.1.
UniGene	Cel.17909.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	6239.R07D5.1.
Protein family/group databases
TCDB	1.A.25.1.2. gap junction-forming innexin family.
Proteomic databases
PaxDb	Q03412.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R07D5.1a; R07D5.1a; R07D5.1.
GeneID	181608.
KEGG	cel:CELE_R07D5.1.
UCSC	R07D5.1. c. elegans.
Organism-specific databases
CTD	181608.
WormBase	R07D5.1a; CE06279; WBGene00006747; unc-7.
Phylogenomic databases
eggNOG	NOG74896.
GeneTree	ENSGT00530000064205.
HOGENOM	HOG000017412.
InParanoid	Q03412.
OMA	ACDARLM.
Gene expression databases
ArrayExpress	Q03412.
Family and domain databases
InterPro	IPR000990. Innexin. [Graphical view]
PANTHER	PTHR11893. PTHR11893. 1 hit.
Pfam	PF00876. Innexin. 1 hit. [Graphical view]
PRINTS	PR01262. INNEXIN.
PROSITE	PS51013. PANNEXIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	914640.

Entry information

Entry name

UNC7_CAEEL

Accession

Primary (citable) accession number: Q03412

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project