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Protein

Synaptonemal complex protein 1

Gene

Sycp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:1464329). Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Meiosis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex protein 1
Short name:
SCP-1
Gene namesi
Name:Sycp1
Synonyms:Scp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3794. Sycp1.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome 1 Publication
  • Chromosomecentromere By similarity

  • Note: In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (PubMed:1464329). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (By similarity).By similarity1 Publication

GO - Cellular componenti

  • chromosome, centromeric region Source: UniProtKB-KW
  • nucleus Source: RGD
  • synaptonemal complex Source: RGD
  • transverse filament Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 997997Synaptonemal complex protein 1PRO_0000072365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki296 – 296Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei824 – 8241PhosphoserineCombined sources
Modified residuei940 – 9401PhosphothreonineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ03410.
PRIDEiQ03410.

PTM databases

PhosphoSiteiQ03410.

Expressioni

Tissue specificityi

Testis.1 Publication

Developmental stagei

Expressed exclusively in meiotic prophase cells.1 Publication

Interactioni

Subunit structurei

Homodimer (By similarity). Component of synaptonemal complexes. Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ03410. 1 interaction.
MINTiMINT-7139048.
STRINGi10116.ENSRNOP00000023333.

Structurei

3D structure databases

ProteinModelPortaliQ03410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili108 – 819712Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi118 – 1214Nuclear localization signalSequence analysis
Motifi701 – 7044Nuclear localization signalSequence analysis
Motifi902 – 9054Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi982 – 9909Arg/Lys-rich (basic)

Domaini

Consists of a predicted coiled coil region of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain may have DNA-binding capacity.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH3F. Eukaryota.
ENOG410XZPD. LUCA.
HOGENOMiHOG000154467.
HOVERGENiHBG059062.
InParanoidiQ03410.
KOiK19533.
PhylomeDBiQ03410.

Family and domain databases

InterProiIPR008827. SYCP1.
IPR024835. SYCP1/2.
[Graphical view]
PANTHERiPTHR15607. PTHR15607. 1 hit.
PfamiPF05483. SCP-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQKPFTLF VPPRLSSSQV SAVKPQTAGG DSNYFKTVNK CTEGDFGVPL
60 70 80 90 100
TMSSLSKNRE NIDTDPAFQK LSILPMLEQV ANSGSCHYQE GVNDSDFENS
110 120 130 140 150
EPMSRLYSKL YKEAEKIKKW KVSIESELKQ KENKLQENRK IIEAQRKAIQ
160 170 180 190 200
ELQFENEKVS LKLEEEIQEN KDLIKENNAT RHWCNLLKET CARSAEKTSK
210 220 230 240 250
YEYEREETRQ VYVDLNNNIE KMILAFEELR VQAENARLEM HFKLKEDHEK
260 270 280 290 300
IQHLEEEYQK EVNNKENQVS LLLIQSTEKE NKMKDLTFLL EESRDKANQL
310 320 330 340 350
EEKTKLQDEN LKELNEKKDH LTSELEDIKM SMQRSMSTQK TLEEDLQIAT
360 370 380 390 400
KTIYQLTEEK EAQMEELNKA KTTHSLVVTE LKATTCTLEE LLRTEQQRLE
410 420 430 440 450
NNEDQLKLIT MELQKKSSEL EEMTKFKNNK EVELEELKTI LAEDQKLLDE
460 470 480 490 500
KKQVEKLAEE LQGKEQELTF LLQTREKEIH DLEVQVTVTK TSEEHYLKQV
510 520 530 540 550
EEMKTELEKE KLKNIELTAN SDMLLLENKK LVQEASDMVL ELKKHQEDII
560 570 580 590 600
NCKKQEERML KQIETLEEKE MNLRDELESV RKEFIQQGDE VKCKLDKSEE
610 620 630 640 650
NARSIEYEVL KKEKQMKILE NKCNNLKKQI ENKSKNIEEL HQENKALKKK
660 670 680 690 700
SSAENKQLNA YEIKVNKLEL ELASTKQKFE EMINNYQKEI EIKKISEEKL
710 720 730 740 750
LGEVEKAKAT VDEAVKLQKE IDLRCQHKIA EMVALMEKHK HQYDKIVEER
760 770 780 790 800
DSELGLYKNR EQEQSSAKVA LETELSNIRN ELVSLKKQLE VEKEEKEKLK
810 820 830 840 850
MEQENTAILT DKKDKKIQAS LLESPEATSW KFDSKTTPSQ NISRLSSSMD
860 870 880 890 900
SGKSKDNRDS LRASAKSILS TTVTKEYTVK TPTKKSIYQR ENKYLPTGGS
910 920 930 940 950
NKKRKTVFEF DVNSDSSETT DLLSLVSEED ISNRIYNNNT PDSHLLVKTP
960 970 980 990
KQTPLSLSTP ASFTKFGSLK KMREDRWATI AKIDRKRRLK EAEKLFT
Length:997
Mass (Da):116,511
Last modified:July 15, 1998 - v2
Checksum:i229D59823FD684BE
GO

Sequence cautioni

The sequence CAA48006.1 differs from that shown. Reason: Frameshift at position 6. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67805 mRNA. Translation: CAA48006.1. Frameshift.
PIRiS28061.
RefSeqiNP_036942.1. NM_012810.1.
UniGeneiRn.10420.

Genome annotation databases

GeneIDi25276.
KEGGirno:25276.
UCSCiRGD:3794. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67805 mRNA. Translation: CAA48006.1. Frameshift.
PIRiS28061.
RefSeqiNP_036942.1. NM_012810.1.
UniGeneiRn.10420.

3D structure databases

ProteinModelPortaliQ03410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ03410. 1 interaction.
MINTiMINT-7139048.
STRINGi10116.ENSRNOP00000023333.

PTM databases

PhosphoSiteiQ03410.

Proteomic databases

PaxDbiQ03410.
PRIDEiQ03410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25276.
KEGGirno:25276.
UCSCiRGD:3794. rat.

Organism-specific databases

CTDi6847.
RGDi3794. Sycp1.

Phylogenomic databases

eggNOGiENOG410IH3F. Eukaryota.
ENOG410XZPD. LUCA.
HOGENOMiHOG000154467.
HOVERGENiHBG059062.
InParanoidiQ03410.
KOiK19533.
PhylomeDBiQ03410.

Miscellaneous databases

NextBioi605977.
PROiQ03410.

Family and domain databases

InterProiIPR008827. SYCP1.
IPR024835. SYCP1/2.
[Graphical view]
PANTHERiPTHR15607. PTHR15607. 1 hit.
PfamiPF05483. SCP-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes."
    Meuwissen R.L.J., Offenberg H.H., Dietrich A.J., Riesewijk A., Iersel M., Heyting C.
    EMBO J. 11:5091-5100(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN.
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-824 AND THR-940, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYCP1_RAT
AccessioniPrimary (citable) accession number: Q03410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1998
Last modified: May 11, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.