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Q03405

- UPAR_HUMAN

UniProt

Q03405 - UPAR_HUMAN

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Protein

Urokinase plasminogen activator surface receptor

Gene

PLAUR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei105 – 1062Cleavage; by U-PA
Sitei111 – 1122Cleavage; by U-PA

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. receptor activity Source: UniProtKB
  3. urokinase plasminogen activator receptor activity Source: UniProtKB

GO - Biological processi

  1. attachment of GPI anchor to protein Source: Reactome
  2. blood coagulation Source: UniProtKB
  3. cellular component movement Source: UniProtKB
  4. cellular protein metabolic process Source: Reactome
  5. chemotaxis Source: ProtInc
  6. C-terminal protein lipidation Source: Reactome
  7. fibrinolysis Source: Reactome
  8. post-translational protein modification Source: Reactome
  9. regulation of proteolysis Source: UniProtKB
  10. signal transduction Source: ProtInc
  11. urokinase plasminogen activator signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_1830. Attachment of GPI anchor to uPAR.
REACT_641. Dissolution of Fibrin Clot.

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
Monocyte activation antigen Mo3
CD_antigen: CD87
Gene namesi
Name:PLAUR
Synonyms:MO3, UPAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9053. PLAUR.

Subcellular locationi

Cell membrane 1 Publication. Cell projectioninvadopodium membrane 1 Publication
Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. endoplasmic reticulum lumen Source: Reactome
  3. endoplasmic reticulum membrane Source: Reactome
  4. extracellular vesicular exosome Source: UniProt
  5. extrinsic component of membrane Source: ProtInc
  6. focal adhesion Source: UniProtKB
  7. integral component of membrane Source: UniProtKB
  8. integral component of plasma membrane Source: Ensembl
  9. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 305283Urokinase plasminogen activator surface receptorPRO_0000036090Add
BLAST
Propeptidei306 – 33530Removed in mature formCuratedPRO_0000036091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 46
Disulfide bondi28 ↔ 34
Disulfide bondi39 ↔ 67
Glycosylationi74 – 741N-linked (GlcNAc...)3 Publications
Disulfide bondi93 ↔ 98
Disulfide bondi117 ↔ 144
Disulfide bondi120 ↔ 127
Disulfide bondi137 ↔ 169
Disulfide bondi175 ↔ 192
Glycosylationi184 – 1841N-linked (GlcNAc...)1 Publication
Disulfide bondi193 ↔ 198
Glycosylationi194 – 1941N-linked (GlcNAc...)2 Publications
Disulfide bondi216 ↔ 244
Disulfide bondi219 ↔ 227
Glycosylationi222 – 2221N-linked (GlcNAc...)1 Publication
Disulfide bondi237 ↔ 263
Glycosylationi255 – 2551N-linked (GlcNAc...)1 Publication
Disulfide bondi269 ↔ 287
Disulfide bondi288 ↔ 293
Lipidationi305 – 3051GPI-anchor amidated glycineCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ03405.
PaxDbiQ03405.
PRIDEiQ03405.

Miscellaneous databases

PMAP-CutDBQ03405.

Expressioni

Tissue specificityi

Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Gene expression databases

BgeeiQ03405.
ExpressionAtlasiQ03405. baseline and differential.
GenevestigatoriQ03405.

Organism-specific databases

HPAiHPA050843.

Interactioni

Subunit structurei

Monomer Probable. Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.7 PublicationsCurated

Protein-protein interaction databases

BioGridi111345. 97 interactions.
DIPiDIP-137N.
IntActiQ03405. 4 interactions.
MINTiMINT-1370900.

Structurei

Secondary structure

1
335
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 285
Beta strandi34 – 385
Beta strandi45 – 5410
Beta strandi60 – 689
Beta strandi75 – 817
Beta strandi84 – 9310
Turni96 – 994
Beta strandi116 – 1216
Turni122 – 1309
Beta strandi133 – 1364
Beta strandi138 – 1414
Beta strandi143 – 1508
Beta strandi155 – 1584
Beta strandi164 – 1718
Beta strandi176 – 1838
Beta strandi186 – 1938
Turni196 – 1994
Helixi206 – 2083
Beta strandi211 – 22212
Turni223 – 2253
Beta strandi226 – 2283
Turni229 – 2313
Beta strandi233 – 2386
Beta strandi243 – 2519
Turni252 – 2554
Beta strandi256 – 2649
Helixi266 – 2683
Beta strandi270 – 2734
Helixi275 – 2784
Beta strandi284 – 2885
Turni291 – 2944
Helixi296 – 2983

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YWHX-ray2.70A/C/E/G/I/K/M/O23-335[»]
2FD6X-ray1.90U23-297[»]
2I9BX-ray2.80E/F/G/H23-299[»]
3BT1X-ray2.80U23-303[»]
3BT2X-ray2.50U23-303[»]
3U73X-ray3.19U23-305[»]
3U74X-ray2.39U23-305[»]
4K24X-ray4.50U23-303[»]
ProteinModelPortaliQ03405.
SMRiQ03405. Positions 23-297.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03405.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11492UPAR/Ly6 1Add
BLAST
Domaini115 – 21399UPAR/Ly6 2Add
BLAST
Domaini214 – 30592UPAR/Ly6 3Add
BLAST

Sequence similaritiesi

Contains 3 UPAR/Ly6 domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG41870.
GeneTreeiENSGT00510000049144.
HOVERGENiHBG000245.
InParanoidiQ03405.
KOiK03985.
OMAiTNRTMSY.
OrthoDBiEOG7QRQVG.
PhylomeDBiQ03405.
TreeFamiTF338662.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
[Graphical view]
PfamiPF00021. UPAR_LY6. 3 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q03405-1) [UniParc]FASTAAdd to Basket

Also known as: uPAR1, GPI-anchored

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI
60 70 80 90 100
VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ
110 120 130 140 150
GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH
160 170 180 190 200
WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG FHNNDTFHFL KCCNTTKCNE
210 220 230 240 250
GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT
260 270 280 290 300
HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV
310 320 330
QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
Length:335
Mass (Da):36,978
Last modified:February 1, 1994 - v1
Checksum:iAB1963EA3DC77171
GO
Isoform 2 (identifier: Q03405-2) [UniParc]FASTAAdd to Basket

Also known as: uPAR2, Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     253-335: PKNQSYMVRG...RLWGGTLLWT → RSLWGSWLPCKSTTALRPPCCEEAQATHV

Show »
Length:281
Mass (Da):31,263
Checksum:iE6C580F279FB0316
GO
Isoform 3 (identifier: Q03405-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-202: Missing.
     203-203: I → V

Show »
Length:290
Mass (Da):32,016
Checksum:i60F14E2A2AFB67AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281C → N AA sequence (PubMed:1689240)Curated
Sequence conflicti165 – 1651H → P in AAK31795. 1 PublicationCurated
Sequence conflicti213 – 2131G → E AA sequence (PubMed:7539799)Curated
Sequence conflicti249 – 2491G → D in AAF71751. (PubMed:11051819)Curated
Sequence conflicti252 – 2521E → G in AAF71751. (PubMed:11051819)Curated
Isoform 3 (identifier: Q03405-3)
Sequence conflicti158 – 1581V → I no nucleotide entry (PubMed:8131971)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551E → G.1 Publication
Corresponds to variant rs4251813 [ dbSNP | Ensembl ].
VAR_016322
Natural varianti86 – 861T → A.1 Publication
Corresponds to variant rs399145 [ dbSNP | Ensembl ].
VAR_016323
Natural varianti105 – 1051R → Q.1 Publication
Corresponds to variant rs4251878 [ dbSNP | Ensembl ].
VAR_016324
Natural varianti220 – 2201K → R.1 Publication
Corresponds to variant rs2302524 [ dbSNP | Ensembl ].
VAR_016325
Natural varianti281 – 2811N → K.1 Publication
Corresponds to variant rs4251921 [ dbSNP | Ensembl ].
VAR_016326
Natural varianti297 – 2971D → A.
Corresponds to variant rs16976608 [ dbSNP | Ensembl ].
VAR_052698
Natural varianti317 – 3171L → P.1 Publication
Corresponds to variant rs4760 [ dbSNP | Ensembl ].
VAR_014922

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei158 – 20245Missing in isoform 3. 2 PublicationsVSP_046345Add
BLAST
Alternative sequencei203 – 2031I → V in isoform 3. 2 PublicationsVSP_046346
Alternative sequencei253 – 33583PKNQS…TLLWT → RSLWGSWLPCKSTTALRPPC CEEAQATHV in isoform 2. 2 PublicationsVSP_006715Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51675 mRNA. Translation: CAA35981.1.
M83246 mRNA. Translation: AAA59862.1.
X74039 mRNA. Translation: CAA52191.1.
U09346 Genomic DNA. Translation: AAA17979.1.
U09347 mRNA. Translation: AAA17978.1.
U08839 mRNA. Translation: AAB60333.1.
U09937
, U09931, U09932, U09933, U09935, U09936 Genomic DNA. Translation: AAB60690.1.
AY194849 Genomic DNA. Translation: AAN86351.1.
AK290774 mRNA. Translation: BAF83463.1.
CR456952 mRNA. Translation: CAG33233.1.
AC005525 Genomic DNA. Translation: AAC32739.1.
AC006953 Genomic DNA. Translation: AAD17387.1.
AC006953 Genomic DNA. Translation: AAD17388.1.
CH471126 Genomic DNA. Translation: EAW57220.1.
BC002788 mRNA. Translation: AAH02788.1.
AF257789 mRNA. Translation: AAF71751.1.
AY029180 mRNA. Translation: AAK31795.1.
S78532 Genomic DNA. Translation: AAD14289.1.
CCDSiCCDS12628.1. [Q03405-1]
CCDS33041.1. [Q03405-2]
CCDS33042.1. [Q03405-3]
PIRiI52614.
S12376. A39743.
S39495.
RefSeqiNP_001005376.1. NM_001005376.2. [Q03405-2]
NP_001005377.1. NM_001005377.2. [Q03405-3]
NP_002650.1. NM_002659.3. [Q03405-1]
UniGeneiHs.466871.

Genome annotation databases

EnsembliENST00000221264; ENSP00000221264; ENSG00000011422. [Q03405-3]
ENST00000339082; ENSP00000342049; ENSG00000011422. [Q03405-2]
ENST00000340093; ENSP00000339328; ENSG00000011422. [Q03405-1]
GeneIDi5329.
KEGGihsa:5329.
UCSCiuc002oxd.2. human. [Q03405-2]
uc002oxf.2. human. [Q03405-1]
uc002oxg.2. human. [Q03405-3]

Polymorphism databases

DMDMi465003.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51675 mRNA. Translation: CAA35981.1 .
M83246 mRNA. Translation: AAA59862.1 .
X74039 mRNA. Translation: CAA52191.1 .
U09346 Genomic DNA. Translation: AAA17979.1 .
U09347 mRNA. Translation: AAA17978.1 .
U08839 mRNA. Translation: AAB60333.1 .
U09937
, U09931 , U09932 , U09933 , U09935 , U09936 Genomic DNA. Translation: AAB60690.1 .
AY194849 Genomic DNA. Translation: AAN86351.1 .
AK290774 mRNA. Translation: BAF83463.1 .
CR456952 mRNA. Translation: CAG33233.1 .
AC005525 Genomic DNA. Translation: AAC32739.1 .
AC006953 Genomic DNA. Translation: AAD17387.1 .
AC006953 Genomic DNA. Translation: AAD17388.1 .
CH471126 Genomic DNA. Translation: EAW57220.1 .
BC002788 mRNA. Translation: AAH02788.1 .
AF257789 mRNA. Translation: AAF71751.1 .
AY029180 mRNA. Translation: AAK31795.1 .
S78532 Genomic DNA. Translation: AAD14289.1 .
CCDSi CCDS12628.1. [Q03405-1 ]
CCDS33041.1. [Q03405-2 ]
CCDS33042.1. [Q03405-3 ]
PIRi I52614.
S12376. A39743.
S39495.
RefSeqi NP_001005376.1. NM_001005376.2. [Q03405-2 ]
NP_001005377.1. NM_001005377.2. [Q03405-3 ]
NP_002650.1. NM_002659.3. [Q03405-1 ]
UniGenei Hs.466871.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YWH X-ray 2.70 A/C/E/G/I/K/M/O 23-335 [» ]
2FD6 X-ray 1.90 U 23-297 [» ]
2I9B X-ray 2.80 E/F/G/H 23-299 [» ]
3BT1 X-ray 2.80 U 23-303 [» ]
3BT2 X-ray 2.50 U 23-303 [» ]
3U73 X-ray 3.19 U 23-305 [» ]
3U74 X-ray 2.39 U 23-305 [» ]
4K24 X-ray 4.50 U 23-303 [» ]
ProteinModelPortali Q03405.
SMRi Q03405. Positions 23-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111345. 97 interactions.
DIPi DIP-137N.
IntActi Q03405. 4 interactions.
MINTi MINT-1370900.

Chemistry

BindingDBi Q03405.
ChEMBLi CHEMBL4883.
DrugBanki DB00009. Alteplase.
DB00029. Anistreplase.
DB00015. Reteplase.
DB00031. Tenecteplase.
DB00013. Urokinase.

Polymorphism databases

DMDMi 465003.

Proteomic databases

MaxQBi Q03405.
PaxDbi Q03405.
PRIDEi Q03405.

Protocols and materials databases

DNASUi 5329.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221264 ; ENSP00000221264 ; ENSG00000011422 . [Q03405-3 ]
ENST00000339082 ; ENSP00000342049 ; ENSG00000011422 . [Q03405-2 ]
ENST00000340093 ; ENSP00000339328 ; ENSG00000011422 . [Q03405-1 ]
GeneIDi 5329.
KEGGi hsa:5329.
UCSCi uc002oxd.2. human. [Q03405-2 ]
uc002oxf.2. human. [Q03405-1 ]
uc002oxg.2. human. [Q03405-3 ]

Organism-specific databases

CTDi 5329.
GeneCardsi GC19M044150.
HGNCi HGNC:9053. PLAUR.
HPAi HPA050843.
MIMi 173391. gene.
neXtProti NX_Q03405.
PharmGKBi PA33383.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41870.
GeneTreei ENSGT00510000049144.
HOVERGENi HBG000245.
InParanoidi Q03405.
KOi K03985.
OMAi TNRTMSY.
OrthoDBi EOG7QRQVG.
PhylomeDBi Q03405.
TreeFami TF338662.

Enzyme and pathway databases

Reactomei REACT_1830. Attachment of GPI anchor to uPAR.
REACT_641. Dissolution of Fibrin Clot.

Miscellaneous databases

EvolutionaryTracei Q03405.
GeneWikii Urokinase_receptor.
GenomeRNAii 5329.
NextBioi 20632.
PMAP-CutDB Q03405.
PROi Q03405.
SOURCEi Search...

Gene expression databases

Bgeei Q03405.
ExpressionAtlasi Q03405. baseline and differential.
Genevestigatori Q03405.

Family and domain databases

InterProi IPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
[Graphical view ]
Pfami PF00021. UPAR_LY6. 3 hits.
[Graphical view ]
SMARTi SM00134. LU. 3 hits.
[Graphical view ]
PROSITEi PS00983. LY6_UPAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis."
    Roldan A.L., Cubellis M.V., Masucci M.T., Behrendt N., Lund L.R., Danoe K., Appella E., Blasi F.
    EMBO J. 9:467-474(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 23-33.
  2. "cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator."
    Min H.Y., Semnani R., Mizukami I.F., Watt K., Todd R.F. III, Liu D.Y.
    J. Immunol. 148:3636-3642(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "A novel urokinase receptor on monocyte-like macrophage cell line."
    Bayraktutan U., Jones P.
    Biochem. Soc. Trans. 21:395-395(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator."
    Pyke C., Eriksen J., Solberg H., Schnack Nielsen B., Kristensen P., Lund L.R., Danoe K.
    FEBS Lett. 326:69-74(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. "The structure of the urokinase-type plasminogen activator receptor gene."
    Casey J.R., Petranka J.G., Kottra J., Fleenor D.E., Rosse W.F.
    Blood 84:1151-1156(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 3).
    Tissue: Placenta.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  8. SeattleSNPs variation discovery resource
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-55; ALA-86; GLN-105; ARG-220; LYS-281 AND PRO-317.
  9. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  12. "cDNA cloning and sequencing of human urokinase receptor."
    Zhu F., Jia S., He F.
    Sheng Wu Gong Cheng Xue Bao 16:461-463(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-322 (ISOFORM 1).
    Tissue: Lung cancer.
  13. "Experimental study of anti-metastatic effect of soluble receptor for urokinase plasminogen activator on human breast cancer cells."
    Fu J., Bai X., Wang W., Xi X., Ruan C.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-301 (ISOFORM 1).
  14. "A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene."
    Soravia E., Grebe A., De Luca P., Helin K., Suh T.T., Degen J.L., Blasi F.
    Blood 86:624-635(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
  15. "The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants."
    Behrendt N., Roenne E., Ploug M., Petri T., Loeber D., Nielsen L.S., Schleuning W.-D., Blasi F., Appella E., Danoe K.
    J. Biol. Chem. 265:6453-6460(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  16. "Cell-surface acceleration of urokinase-catalyzed receptor cleavage."
    Hoeyer-Hansen G., Ploug M., Behrendt N., Roenne E., Danoe K.
    Eur. J. Biochem. 243:21-26(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 106-116, CLEAVAGE BY U-PA.
  17. "A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)."
    Duke-Cohan J.S., Morimoto C., Rocker J.A., Schlossman S.F.
    J. Biol. Chem. 270:14107-14114(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 210-230 (ISOFORMS 1/2/3).
    Tissue: Serum.
  18. "Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins."
    Ploug M., Kjalke M., Roenne E., Weidle U., Hoeyer-Hansen G., Danoe K.
    J. Biol. Chem. 268:17539-17546(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, PARTIAL PROTEIN SEQUENCE.
  19. "A urokinase receptor-associated protein with specific collagen binding properties."
    Behrendt N., Jensen O.N., Engelholm L.H., Moertz E., Mann M., Danoe K.
    J. Biol. Chem. 275:1993-2002(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MRC2.
  20. "Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton."
    Artym V.V., Kindzelskii A.L., Chen W.T., Petty H.R.
    Carcinogenesis 23:1593-1601(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FAP, SUBCELLULAR LOCATION.
  21. "Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins."
    Elortza F., Nuehse T.S., Foster L.J., Stensballe A., Peck S.C., Jensen O.N.
    Mol. Cell. Proteomics 2:1261-1270(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  22. "LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration."
    Zhu Y., Bujo H., Yamazaki H., Ohwaki K., Jiang M., Hirayama S., Kanaki T., Shibasaki M., Takahashi K., Schneider W.J., Saito Y.
    Circ. Res. 94:752-758(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SORL1.
  23. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
    Elortza F., Mohammed S., Bunkenborg J., Foster L.J., Nuehse T.S., Brodbeck U., Peck S.C., Jensen O.N.
    J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  24. "Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR."
    Royer-Zemmour B., Ponsole-Lenfant M., Gara H., Roll P., Leveque C., Massacrier A., Ferracci G., Cillario J., Robaglia-Schlupp A., Vincentelli R., Cau P., Szepetowski P.
    Hum. Mol. Genet. 17:3617-3630(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SRPX2.
  25. "Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide."
    Llinas P., Le Du M.H., Gaardsvoll H., Danoe K., Ploug M., Gilquin B., Stura E.A., Menez A.
    EMBO J. 24:1655-1663(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 23-335 OF MUTANT GLN-222 IN COMPLEX WITH PEPTIDE ANTAGONIST, GLYCOSYLATION AT ASN-74; ASN-184; ASN-194 AND ASN-255, DISULFIDE BONDS.
  26. "Structure of human urokinase plasminogen activator in complex with its receptor."
    Huai Q., Mazar A.P., Kuo A., Parry G.C., Shaw D.E., Callahan J., Li Y., Yuan C., Bian C., Chen L., Furie B., Furie B.C., Cines D.B., Huang M.
    Science 311:656-659(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-297 IN COMPLEX WITH PLAU, GLYCOSYLATION AT ASN-74 AND ASN-194, DISULFIDE BONDS.
  27. "Crystal structure of the urokinase receptor in a ligand-free form."
    Xu X., Gardsvoll H., Yuan C., Lin L., Ploug M., Huang M.
    J. Mol. Biol. 416:629-641(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) OF 23-305 OF MUTANT CYS-69 AND CYS-281 ALONE AND IN COMPLEX WITH PLAU, DISULFIDE BONDS, GLYCOSYLATION AT ASN-74 AND ASN-222.

Entry informationi

Entry nameiUPAR_HUMAN
AccessioniPrimary (citable) accession number: Q03405
Secondary accession number(s): A8K409
, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3