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Protein

Urokinase plasminogen activator surface receptor

Gene

PLAUR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein domain specific binding Source: AgBase
  • receptor activity Source: UniProtKB
  • receptor binding Source: AgBase
  • urokinase plasminogen activator receptor activity Source: UniProtKB

GO - Biological processi

  • attachment of GPI anchor to protein Source: Reactome
  • blood coagulation Source: UniProtKB
  • chemotaxis Source: ProtInc
  • fibrinolysis Source: Reactome
  • movement of cell or subcellular component Source: UniProtKB
  • negative regulation of apoptotic process Source: CACAO
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: CACAO
  • negative regulation of intrinsic apoptotic signaling pathway Source: CACAO
  • positive regulation of DNA binding Source: CACAO
  • positive regulation of epidermal growth factor receptor signaling pathway Source: CACAO
  • positive regulation of protein phosphorylation Source: CACAO
  • positive regulation of release of cytochrome c from mitochondria Source: CACAO
  • regulation of proteolysis Source: UniProtKB
  • signal transduction Source: ProtInc
  • urokinase plasminogen activator signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011422-MONOMER.
ReactomeiR-HSA-162791. Attachment of GPI anchor to uPAR.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-75205. Dissolution of Fibrin Clot.
SIGNORiQ03405.

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
Monocyte activation antigen Mo3
CD_antigen: CD87
Gene namesi
Name:PLAUR
Synonyms:MO3, UPAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9053. PLAUR.

Subcellular locationi

  • Cell membrane 1 Publication
  • Cell projectioninvadopodium membrane 1 Publication

  • Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.1 Publication
Isoform 1 :
  • Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity
Isoform 2 :
  • Secreted By similarity

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • endoplasmic reticulum lumen Source: Reactome
  • endoplasmic reticulum membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extrinsic component of membrane Source: ProtInc
  • focal adhesion Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: Ensembl
  • invadopodium membrane Source: UniProtKB-SubCell
  • plasma membrane Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5329.
OpenTargetsiENSG00000011422.
PharmGKBiPA33383.

Chemistry databases

ChEMBLiCHEMBL4883.
DrugBankiDB00009. Alteplase.
DB00029. Anistreplase.
DB00015. Reteplase.
DB00031. Tenecteplase.
DB00013. Urokinase.

Polymorphism and mutation databases

BioMutaiPLAUR.
DMDMi465003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003609023 – 305Urokinase plasminogen activator surface receptorAdd BLAST283
PropeptideiPRO_0000036091306 – 335Removed in mature formCuratedAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 463 Publications
Disulfide bondi28 ↔ 343 Publications
Disulfide bondi39 ↔ 673 Publications
Glycosylationi74N-linked (GlcNAc...)3 Publications1
Disulfide bondi93 ↔ 983 Publications
Disulfide bondi117 ↔ 1443 Publications
Disulfide bondi120 ↔ 1273 Publications
Disulfide bondi137 ↔ 1693 Publications
Disulfide bondi175 ↔ 1923 Publications
Glycosylationi184N-linked (GlcNAc...)1 Publication1
Disulfide bondi193 ↔ 1983 Publications
Glycosylationi194N-linked (GlcNAc...)2 Publications1
Disulfide bondi216 ↔ 2443 Publications
Disulfide bondi219 ↔ 2273 Publications
Glycosylationi222N-linked (GlcNAc...)1 Publication1
Disulfide bondi237 ↔ 2633 Publications
Glycosylationi255N-linked (GlcNAc...)1 Publication1
Disulfide bondi269 ↔ 2873 Publications
Disulfide bondi288 ↔ 2933 Publications
Lipidationi305GPI-anchor amidated glycineCurated1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei105 – 106Cleavage; by U-PA2
Sitei111 – 112Cleavage; by U-PA2

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ03405.
MaxQBiQ03405.
PaxDbiQ03405.
PeptideAtlasiQ03405.
PRIDEiQ03405.

PTM databases

iPTMnetiQ03405.
PhosphoSitePlusiQ03405.
SwissPalmiQ03405.

Miscellaneous databases

PMAP-CutDBQ03405.

Expressioni

Tissue specificityi

Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Gene expression databases

BgeeiENSG00000011422.
ExpressionAtlasiQ03405. baseline and differential.
GenevisibleiQ03405. HS.

Organism-specific databases

HPAiCAB073533.
HPA050843.

Interactioni

Subunit structurei

Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.Curated7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANGP039505EBI-716505,EBI-525291

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein domain specific binding Source: AgBase
  • receptor binding Source: AgBase

Protein-protein interaction databases

BioGridi111345. 105 interactors.
DIPiDIP-137N.
IntActiQ03405. 9 interactors.
MINTiMINT-1370900.
STRINGi9606.ENSP00000339328.

Chemistry databases

BindingDBiQ03405.

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 28Combined sources5
Beta strandi34 – 38Combined sources5
Beta strandi45 – 54Combined sources10
Beta strandi60 – 68Combined sources9
Beta strandi75 – 81Combined sources7
Beta strandi84 – 93Combined sources10
Turni96 – 99Combined sources4
Beta strandi116 – 121Combined sources6
Turni122 – 130Combined sources9
Beta strandi133 – 136Combined sources4
Beta strandi138 – 141Combined sources4
Beta strandi143 – 150Combined sources8
Beta strandi155 – 158Combined sources4
Beta strandi164 – 171Combined sources8
Beta strandi176 – 183Combined sources8
Beta strandi186 – 193Combined sources8
Turni196 – 199Combined sources4
Helixi206 – 208Combined sources3
Beta strandi211 – 222Combined sources12
Turni223 – 225Combined sources3
Beta strandi226 – 228Combined sources3
Turni229 – 231Combined sources3
Beta strandi233 – 238Combined sources6
Beta strandi243 – 251Combined sources9
Turni252 – 255Combined sources4
Beta strandi256 – 264Combined sources9
Helixi266 – 268Combined sources3
Beta strandi270 – 273Combined sources4
Helixi275 – 278Combined sources4
Beta strandi284 – 288Combined sources5
Turni291 – 294Combined sources4
Helixi296 – 298Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWHX-ray2.70A/C/E/G/I/K/M/O23-335[»]
2FD6X-ray1.90U23-297[»]
2I9BX-ray2.80E/F/G/H23-299[»]
3BT1X-ray2.80U23-303[»]
3BT2X-ray2.50U23-303[»]
3U73X-ray3.19U23-305[»]
3U74X-ray2.39U23-305[»]
4K24X-ray4.50U23-303[»]
4QTIX-ray3.00U23-305[»]
ProteinModelPortaliQ03405.
SMRiQ03405.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03405.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 114UPAR/Ly6 1Add BLAST92
Domaini115 – 213UPAR/Ly6 2Add BLAST99
Domaini214 – 305UPAR/Ly6 3Add BLAST92

Sequence similaritiesi

Contains 3 UPAR/Ly6 domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJ50. Eukaryota.
ENOG410Z47S. LUCA.
GeneTreeiENSGT00510000049144.
HOVERGENiHBG000245.
InParanoidiQ03405.
KOiK03985.
OMAiVERGCAH.
OrthoDBiEOG091G0FQ6.
PhylomeDBiQ03405.
TreeFamiTF338662.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 2 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q03405-1) [UniParc]FASTAAdd to basket
Also known as: uPAR1, GPI-anchored

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI
60 70 80 90 100
VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ
110 120 130 140 150
GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH
160 170 180 190 200
WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG FHNNDTFHFL KCCNTTKCNE
210 220 230 240 250
GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT
260 270 280 290 300
HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV
310 320 330
QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
Length:335
Mass (Da):36,978
Last modified:February 1, 1994 - v1
Checksum:iAB1963EA3DC77171
GO
Isoform 2 (identifier: Q03405-2) [UniParc]FASTAAdd to basket
Also known as: uPAR2, Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     253-335: PKNQSYMVRG...RLWGGTLLWT → RSLWGSWLPCKSTTALRPPCCEEAQATHV

Show »
Length:281
Mass (Da):31,263
Checksum:iE6C580F279FB0316
GO
Isoform 3 (identifier: Q03405-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-202: Missing.
     203-203: I → V

Show »
Length:290
Mass (Da):32,016
Checksum:i60F14E2A2AFB67AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28C → N AA sequence (PubMed:1689240).Curated1
Sequence conflicti165H → P in AAK31795 (Ref. 13) Curated1
Sequence conflicti213G → E AA sequence (PubMed:7539799).Curated1
Sequence conflicti249G → D in AAF71751 (PubMed:11051819).Curated1
Sequence conflicti252E → G in AAF71751 (PubMed:11051819).Curated1
Isoform 3 (identifier: Q03405-3)
Sequence conflicti158V → I no nucleotide entry (PubMed:8131971).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01632255E → G.1 PublicationCorresponds to variant rs4251813dbSNPEnsembl.1
Natural variantiVAR_01632386T → A.1 PublicationCorresponds to variant rs399145dbSNPEnsembl.1
Natural variantiVAR_016324105R → Q.1 PublicationCorresponds to variant rs4251878dbSNPEnsembl.1
Natural variantiVAR_016325220K → R.1 PublicationCorresponds to variant rs2302524dbSNPEnsembl.1
Natural variantiVAR_016326281N → K.1 PublicationCorresponds to variant rs4251921dbSNPEnsembl.1
Natural variantiVAR_052698297D → A.Corresponds to variant rs16976608dbSNPEnsembl.1
Natural variantiVAR_014922317L → P.1 PublicationCorresponds to variant rs4760dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046345158 – 202Missing in isoform 3. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_046346203I → V in isoform 3. 2 Publications1
Alternative sequenceiVSP_006715253 – 335PKNQS…TLLWT → RSLWGSWLPCKSTTALRPPC CEEAQATHV in isoform 2. 2 PublicationsAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51675 mRNA. Translation: CAA35981.1.
M83246 mRNA. Translation: AAA59862.1.
X74039 mRNA. Translation: CAA52191.1.
U09346 Genomic DNA. Translation: AAA17979.1.
U09347 mRNA. Translation: AAA17978.1.
U08839 mRNA. Translation: AAB60333.1.
U09937
, U09931, U09932, U09933, U09935, U09936 Genomic DNA. Translation: AAB60690.1.
AY194849 Genomic DNA. Translation: AAN86351.1.
AK290774 mRNA. Translation: BAF83463.1.
CR456952 mRNA. Translation: CAG33233.1.
AC005525 Genomic DNA. Translation: AAC32739.1.
AC006953 Genomic DNA. Translation: AAD17387.1.
AC006953 Genomic DNA. Translation: AAD17388.1.
CH471126 Genomic DNA. Translation: EAW57220.1.
BC002788 mRNA. Translation: AAH02788.1.
AF257789 mRNA. Translation: AAF71751.1.
AY029180 mRNA. Translation: AAK31795.1.
S78532 Genomic DNA. Translation: AAD14289.1.
CCDSiCCDS12628.1. [Q03405-1]
CCDS33041.1. [Q03405-2]
CCDS33042.1. [Q03405-3]
PIRiI52614.
S12376. A39743.
S39495.
RefSeqiNP_001005376.1. NM_001005376.2. [Q03405-2]
NP_001005377.1. NM_001005377.2. [Q03405-3]
NP_001287966.1. NM_001301037.1.
NP_002650.1. NM_002659.3. [Q03405-1]
UniGeneiHs.466871.

Genome annotation databases

EnsembliENST00000221264; ENSP00000221264; ENSG00000011422. [Q03405-3]
ENST00000339082; ENSP00000342049; ENSG00000011422. [Q03405-2]
ENST00000340093; ENSP00000339328; ENSG00000011422. [Q03405-1]
GeneIDi5329.
KEGGihsa:5329.
UCSCiuc002oxd.3. human. [Q03405-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51675 mRNA. Translation: CAA35981.1.
M83246 mRNA. Translation: AAA59862.1.
X74039 mRNA. Translation: CAA52191.1.
U09346 Genomic DNA. Translation: AAA17979.1.
U09347 mRNA. Translation: AAA17978.1.
U08839 mRNA. Translation: AAB60333.1.
U09937
, U09931, U09932, U09933, U09935, U09936 Genomic DNA. Translation: AAB60690.1.
AY194849 Genomic DNA. Translation: AAN86351.1.
AK290774 mRNA. Translation: BAF83463.1.
CR456952 mRNA. Translation: CAG33233.1.
AC005525 Genomic DNA. Translation: AAC32739.1.
AC006953 Genomic DNA. Translation: AAD17387.1.
AC006953 Genomic DNA. Translation: AAD17388.1.
CH471126 Genomic DNA. Translation: EAW57220.1.
BC002788 mRNA. Translation: AAH02788.1.
AF257789 mRNA. Translation: AAF71751.1.
AY029180 mRNA. Translation: AAK31795.1.
S78532 Genomic DNA. Translation: AAD14289.1.
CCDSiCCDS12628.1. [Q03405-1]
CCDS33041.1. [Q03405-2]
CCDS33042.1. [Q03405-3]
PIRiI52614.
S12376. A39743.
S39495.
RefSeqiNP_001005376.1. NM_001005376.2. [Q03405-2]
NP_001005377.1. NM_001005377.2. [Q03405-3]
NP_001287966.1. NM_001301037.1.
NP_002650.1. NM_002659.3. [Q03405-1]
UniGeneiHs.466871.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWHX-ray2.70A/C/E/G/I/K/M/O23-335[»]
2FD6X-ray1.90U23-297[»]
2I9BX-ray2.80E/F/G/H23-299[»]
3BT1X-ray2.80U23-303[»]
3BT2X-ray2.50U23-303[»]
3U73X-ray3.19U23-305[»]
3U74X-ray2.39U23-305[»]
4K24X-ray4.50U23-303[»]
4QTIX-ray3.00U23-305[»]
ProteinModelPortaliQ03405.
SMRiQ03405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111345. 105 interactors.
DIPiDIP-137N.
IntActiQ03405. 9 interactors.
MINTiMINT-1370900.
STRINGi9606.ENSP00000339328.

Chemistry databases

BindingDBiQ03405.
ChEMBLiCHEMBL4883.
DrugBankiDB00009. Alteplase.
DB00029. Anistreplase.
DB00015. Reteplase.
DB00031. Tenecteplase.
DB00013. Urokinase.

PTM databases

iPTMnetiQ03405.
PhosphoSitePlusiQ03405.
SwissPalmiQ03405.

Polymorphism and mutation databases

BioMutaiPLAUR.
DMDMi465003.

Proteomic databases

EPDiQ03405.
MaxQBiQ03405.
PaxDbiQ03405.
PeptideAtlasiQ03405.
PRIDEiQ03405.

Protocols and materials databases

DNASUi5329.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221264; ENSP00000221264; ENSG00000011422. [Q03405-3]
ENST00000339082; ENSP00000342049; ENSG00000011422. [Q03405-2]
ENST00000340093; ENSP00000339328; ENSG00000011422. [Q03405-1]
GeneIDi5329.
KEGGihsa:5329.
UCSCiuc002oxd.3. human. [Q03405-1]

Organism-specific databases

CTDi5329.
DisGeNETi5329.
GeneCardsiPLAUR.
HGNCiHGNC:9053. PLAUR.
HPAiCAB073533.
HPA050843.
MIMi173391. gene.
neXtProtiNX_Q03405.
OpenTargetsiENSG00000011422.
PharmGKBiPA33383.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ50. Eukaryota.
ENOG410Z47S. LUCA.
GeneTreeiENSGT00510000049144.
HOVERGENiHBG000245.
InParanoidiQ03405.
KOiK03985.
OMAiVERGCAH.
OrthoDBiEOG091G0FQ6.
PhylomeDBiQ03405.
TreeFamiTF338662.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011422-MONOMER.
ReactomeiR-HSA-162791. Attachment of GPI anchor to uPAR.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-75205. Dissolution of Fibrin Clot.
SIGNORiQ03405.

Miscellaneous databases

EvolutionaryTraceiQ03405.
GeneWikiiUrokinase_receptor.
GenomeRNAii5329.
PMAP-CutDBQ03405.
PROiQ03405.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011422.
ExpressionAtlasiQ03405. baseline and differential.
GenevisibleiQ03405. HS.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 2 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPAR_HUMAN
AccessioniPrimary (citable) accession number: Q03405
Secondary accession number(s): A8K409
, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 181 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.