Q03405 (UPAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urokinase plasminogen activator surface receptor
Short name=U-PAR
Short name=uPAR

Alternative name(s):
Monocyte activation antigen Mo3
CD_antigen=CD87

Gene names

Name:	PLAUR
Synonyms:	MO3, UPAR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Subunit structure	Monomer Probable. Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Ref.19 Ref.22
Subcellular location	Isoform 1: Cell membrane; Lipid-anchor › GPI-anchor. Isoform 2: Secreted Probable.
Tissue specificity	Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Sequence similarities	Contains 3 UPAR/Ly6 domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
Molecular function	Receptor
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	C-terminal protein lipidation Traceable author statement. Source: Reactome attachment of GPI anchor to protein Traceable author statement. Source: Reactome blood coagulation Non-traceable author statement Ref.4. Source: UniProtKB cellular component movement Non-traceable author statement Ref.1. Source: UniProtKB chemotaxis Traceable author statement PubMed 10749881. Source: ProtInc fibrinolysis Traceable author statement. Source: Reactome regulation of proteolysis Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW cell surface Inferred from direct assay PubMed 12493773. Source: UniProtKB endoplasmic reticulum lumen Traceable author statement. Source: Reactome endoplasmic reticulum membrane Traceable author statement. Source: Reactome extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membrane Traceable author statement Ref.5. Source: ProtInc integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB integral to plasma membrane Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement. Source: Reactome
Molecular_function	U-plasminogen activator receptor activity Non-traceable author statement Ref.1Ref.4. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q03405-1)

Also known as: uPAR1; GPI-anchored;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q03405-2)

Also known as: uPAR2; Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     253-335: PKNQSYMVRG...RLWGGTLLWT → RSLWGSWLPCKSTTALRPPCCEEAQATHV

Isoform 3 (identifier: Q03405-3)

The sequence of this isoform differs from the canonical sequence as follows:
     158-202: Missing.
     203-203: I → V

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

22

Ref.1

Chain

23 – 305

283

Urokinase plasminogen activator surface receptor

PRO_0000036090

Propeptide

306 – 335

30

Removed in mature form Probable

PRO_0000036091

Regions

Domain

23 – 114

92

UPAR/Ly6 1

Domain

115 – 213

99

UPAR/Ly6 2

Domain

214 – 305

92

UPAR/Ly6 3

Sites

Site

105 – 106

2

Cleavage; by U-PA

Site

111 – 112

2

Cleavage; by U-PA

Amino acid modifications

Lipidation

305

1

GPI-anchor amidated glycine Probable

Glycosylation

74

1

N-linked (GlcNAc...) Ref.23 Ref.24 Ref.25

Glycosylation

184

1

N-linked (GlcNAc...) Ref.23

Glycosylation

194

1

N-linked (GlcNAc...) Ref.23 Ref.24

Glycosylation

222

1

N-linked (GlcNAc...) Ref.25

Glycosylation

255

1

N-linked (GlcNAc...) Ref.23

Disulfide bond

25 ↔ 46

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

28 ↔ 34

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

39 ↔ 67

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

93 ↔ 98

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

117 ↔ 144

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

120 ↔ 127

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

137 ↔ 169

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

175 ↔ 192

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

193 ↔ 198

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

216 ↔ 244

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

219 ↔ 227

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

237 ↔ 263

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

269 ↔ 287

Ref.18 Ref.23 Ref.24 Ref.25

Disulfide bond

288 ↔ 293

Ref.18 Ref.23 Ref.24 Ref.25

Natural variations

Alternative sequence

158 – 202

45

Missing in isoform 3.

VSP_046345

Alternative sequence

203

1

I → V in isoform 3.

VSP_046346

Alternative sequence

253 – 335

83

PKNQS…TLLWT → RSLWGSWLPCKSTTALRPPC CEEAQATHV in isoform 2.

VSP_006715

Natural variant

55

1

E → G. Ref.8
Corresponds to variant rs4251813 [ dbSNP | Ensembl ].

VAR_016322

Natural variant

86

1

T → A. Ref.8
Corresponds to variant rs399145 [ dbSNP | Ensembl ].

VAR_016323

Natural variant

105

1

R → Q. Ref.8
Corresponds to variant rs4251878 [ dbSNP | Ensembl ].

VAR_016324

Natural variant

220

1

K → R. Ref.8
Corresponds to variant rs2302524 [ dbSNP | Ensembl ].

VAR_016325

Natural variant

281

1

N → K. Ref.8
Corresponds to variant rs4251921 [ dbSNP | Ensembl ].

VAR_016326

Natural variant

297

1

D → A.
Corresponds to variant rs16976608 [ dbSNP | Ensembl ].

VAR_052698

Natural variant

317

1

L → P. Ref.8
Corresponds to variant rs4760 [ dbSNP | Ensembl ].

VAR_014922

Experimental info

Sequence conflict

28

1

C → N AA sequence Ref.1

Sequence conflict

165

1

H → P in AAK31795. Ref.13

Sequence conflict

213

1

G → E AA sequence Ref.17

Sequence conflict

249

1

G → D in AAF71751. Ref.12

Sequence conflict

252

1

E → G in AAF71751. Ref.12

Isoform 3:

Sequence conflict

158

1

V → I no nucleotide entry Ref.3

Secondary structure

1

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335

Helix Strand Turn

Details...

Beta strand

24 – 28

5

Beta strand

34 – 38

5

Beta strand

45 – 54

10

Beta strand

60 – 68

9

Beta strand

75 – 81

7

Beta strand

84 – 93

10

Turn

96 – 99

4

Beta strand

116 – 121

6

Turn

122 – 130

9

Beta strand

133 – 136

4

Beta strand

138 – 141

4

Beta strand

143 – 150

8

Beta strand

155 – 158

4

Beta strand

164 – 171

8

Beta strand

176 – 183

8

Beta strand

186 – 193

8

Turn

196 – 199

4

Helix

206 – 208

3

Beta strand

211 – 222

12

Turn

223 – 225

3

Beta strand

226 – 228

3

Turn

229 – 231

3

Beta strand

233 – 238

6

Beta strand

243 – 251

9

Turn

252 – 255

4

Beta strand

256 – 264

9

Helix

266 – 268

3

Beta strand

270 – 273

4

Helix

275 – 278

4

Beta strand

284 – 288

5

Turn

291 – 294

4

Helix

296 – 298

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (uPAR1) (GPI-anchored) [UniParc]. Last modified February 1, 1994. Version 1. Checksum: AB1963EA3DC77171	FASTA	335	36,978
	10 20 30 40 50 60 MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI VRLWEEGEEL 70 80 90 100 110 120 ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ GNSGRAVTYS RSRYLECISC 130 140 150 160 170 180 GSSDMSCERG RHQSLQCRSP EEQCLDVVTH WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG 190 200 210 220 230 240 FHNNDTFHFL KCCNTTKCNE GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP 250 260 270 280 290 300 MNQCLVATGT HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV 310 320 330 QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
	Isoform 2 (uPAR2) (Secreted) [UniParc]. Checksum: E6C580F279FB0316	FASTA	281	31,263
	10 20 30 40 50 60 MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI VRLWEEGEEL 70 80 90 100 110 120 ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ GNSGRAVTYS RSRYLECISC 130 140 150 160 170 180 GSSDMSCERG RHQSLQCRSP EEQCLDVVTH WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG 190 200 210 220 230 240 FHNNDTFHFL KCCNTTKCNE GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP 250 260 270 280 MNQCLVATGT HERSLWGSWL PCKSTTALRP PCCEEAQATH V
	Isoform 3 [UniParc]. Checksum: 60F14E2A2AFB67AC	FASTA	290	32,016
	10 20 30 40 50 60 MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI VRLWEEGEEL 70 80 90 100 110 120 ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ GNSGRAVTYS RSRYLECISC 130 140 150 160 170 180 GSSDMSCERG RHQSLQCRSP EEQCLDVVTH WIQEGEEVLE LENLPQNGRQ CYSCKGNSTH 190 200 210 220 230 240 GCSSEETFLI DCRGPMNQCL VATGTHEPKN QSYMVRGCAT ASMCQHAHLG DAFSMNHIDV 250 260 270 280 290 SCCTKSGCNH PDLDVQYRSG AAPQPGPAHL SLTITLLMTA RLWGGTLLWT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis." Roldan A.L., Cubellis M.V., Masucci M.T., Behrendt N., Lund L.R., Danoe K., Appella E., Blasi F. EMBO J. 9:467-474(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 23-33.
[2]	"cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator." Min H.Y., Semnani R., Mizukami I.F., Watt K., Todd R.F. III, Liu D.Y. J. Immunol. 148:3636-3642(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"A novel urokinase receptor on monocyte-like macrophage cell line." Bayraktutan U., Jones P. Biochem. Soc. Trans. 21:395-395(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[4]	"An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator." Pyke C., Eriksen J., Solberg H., Schnack Nielsen B., Kristensen P., Lund L.R., Danoe K. FEBS Lett. 326:69-74(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[5]	"The structure of the urokinase-type plasminogen activator receptor gene." Casey J.R., Petranka J.G., Kottra J., Fleenor D.E., Rosse W.F. Blood 84:1151-1156(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 3). Tissue: Placenta.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[8]	SeattleSNPs variation discovery resource Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-55; ALA-86; GLN-105; ARG-220; LYS-281 AND PRO-317.
[9]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[12]	"cDNA cloning and sequencing of human urokinase receptor." Zhu F., Jia S., He F. Sheng Wu Gong Cheng Xue Bao 16:461-463(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-322 (ISOFORM 1). Tissue: Lung cancer.
[13]	"Experimental study of anti-metastatic effect of soluble receptor for urokinase plasminogen activator on human breast cancer cells." Fu J., Bai X., Wang W., Xi X., Ruan C. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-301 (ISOFORM 1).
[14]	"A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene." Soravia E., Grebe A., De Luca P., Helin K., Suh T.T., Degen J.L., Blasi F. Blood 86:624-635(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
[15]	"The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants." Behrendt N., Roenne E., Ploug M., Petri T., Loeber D., Nielsen L.S., Schleuning W.-D., Blasi F., Appella E., Danoe K. J. Biol. Chem. 265:6453-6460(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[16]	"Cell-surface acceleration of urokinase-catalyzed receptor cleavage." Hoeyer-Hansen G., Ploug M., Behrendt N., Roenne E., Danoe K. Eur. J. Biochem. 243:21-26(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 106-116, CLEAVAGE BY U-PA.
[17]	"A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)." Duke-Cohan J.S., Morimoto C., Rocker J.A., Schlossman S.F. J. Biol. Chem. 270:14107-14114(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 210-230 (ISOFORMS 1/2/3). Tissue: Serum.
[18]	"Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins." Ploug M., Kjalke M., Roenne E., Weidle U., Hoeyer-Hansen G., Danoe K. J. Biol. Chem. 268:17539-17546(1993) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS, PARTIAL PROTEIN SEQUENCE.
[19]	"A urokinase receptor-associated protein with specific collagen binding properties." Behrendt N., Jensen O.N., Engelholm L.H., Moertz E., Mann M., Danoe K. J. Biol. Chem. 275:1993-2002(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MRC2.
[20]	"Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins." Elortza F., Nuehse T.S., Foster L.J., Stensballe A., Peck S.C., Jensen O.N. Mol. Cell. Proteomics 2:1261-1270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[21]	"Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment." Elortza F., Mohammed S., Bunkenborg J., Foster L.J., Nuehse T.S., Brodbeck U., Peck S.C., Jensen O.N. J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[22]	"Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR." Royer-Zemmour B., Ponsole-Lenfant M., Gara H., Roll P., Leveque C., Massacrier A., Ferracci G., Cillario J., Robaglia-Schlupp A., Vincentelli R., Cau P., Szepetowski P. Hum. Mol. Genet. 17:3617-3630(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SRPX2.
[23]	"Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide." Llinas P., Le Du M.H., Gaardsvoll H., Danoe K., Ploug M., Gilquin B., Stura E.A., Menez A. EMBO J. 24:1655-1663(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 23-335 OF MUTANT GLN-222 IN COMPLEX WITH PEPTIDE ANTAGONIST, GLYCOSYLATION AT ASN-74; ASN-184; ASN-194 AND ASN-255, DISULFIDE BONDS.
[24]	"Structure of human urokinase plasminogen activator in complex with its receptor." Huai Q., Mazar A.P., Kuo A., Parry G.C., Shaw D.E., Callahan J., Li Y., Yuan C., Bian C., Chen L., Furie B., Furie B.C., Cines D.B., Huang M. Science 311:656-659(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-297 IN COMPLEX WITH PLAU, GLYCOSYLATION AT ASN-74 AND ASN-194, DISULFIDE BONDS.
[25]	"Crystal structure of the urokinase receptor in a ligand-free form." Xu X., Gardsvoll H., Yuan C., Lin L., Ploug M., Huang M. J. Mol. Biol. 416:629-641(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) OF 23-305 OF MUTANT CYS-69 AND CYS-281 ALONE AND IN COMPLEX WITH PLAU, DISULFIDE BONDS, GLYCOSYLATION AT ASN-74 AND ASN-222.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X51675 mRNA. Translation: CAA35981.1.
M83246 mRNA. Translation: AAA59862.1.
X74039 mRNA. Translation: CAA52191.1.
U09346 Genomic DNA. Translation: AAA17979.1.
U09347 mRNA. Translation: AAA17978.1.
U08839 mRNA. Translation: AAB60333.1.
U09937 , U09931, U09932, U09933, U09935, U09936 Genomic DNA. Translation: AAB60690.1.
AY194849 Genomic DNA. Translation: AAN86351.1.
AK290774 mRNA. Translation: BAF83463.1.
CR456952 mRNA. Translation: CAG33233.1.
AC005525 Genomic DNA. Translation: AAC32739.1.
AC006953 Genomic DNA. Translation: AAD17387.1.
AC006953 Genomic DNA. Translation: AAD17388.1.
CH471126 Genomic DNA. Translation: EAW57220.1.
BC002788 mRNA. Translation: AAH02788.1.
AF257789 mRNA. Translation: AAF71751.1.
AY029180 mRNA. Translation: AAK31795.1.
S78532 Genomic DNA. Translation: AAD14289.1.

IPI

IPI00010676.
IPI00215706.
IPI00215707.

PIR

I52614.
A39743. S12376.
S39495.

RefSeq

NP_001005376.1. NM_001005376.2.
NP_001005377.1. NM_001005377.2.
NP_002650.1. NM_002659.3.

UniGene

Hs.466871.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YWH	X-ray	2.70	A/C/E/G/I/K/M/O	23-335	[»]
2FD6	X-ray	1.90	U	23-297	[»]
2I9B	X-ray	2.80	E/F/G/H	23-299	[»]
3BT1	X-ray	2.80	U	23-303	[»]
3BT2	X-ray	2.50	U	23-303	[»]
3U73	X-ray	3.19	U	23-305	[»]
3U74	X-ray	2.39	U	23-305	[»]

ProteinModelPortal

Q03405.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-137N.

IntAct

Q03405. 4 interactions.

MINT

MINT-1370900.

Polymorphism databases

DMDM

465003.

Proteomic databases

PaxDb

Q03405.

PRIDE

Q03405.

Protocols and materials databases

DNASU

5329.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000221264; ENSP00000221264; ENSG00000011422.
ENST00000339082; ENSP00000342049; ENSG00000011422.
ENST00000340093; ENSP00000339328; ENSG00000011422.

GeneID

5329.

KEGG

hsa:5329.

UCSC

uc002oxd.2. human.
uc002oxf.2. human.
uc002oxg.2. human.

Organism-specific databases

CTD

5329.

GeneCards

GC19M044150.

HGNC

HGNC:9053. PLAUR.

HPA

HPA050843.

MIM

173391. gene.

neXtProt

NX_Q03405.

PharmGKB

PA33383.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG41870.

HOVERGEN

HBG000245.

InParanoid

Q03405.

KO

K03985.

OMA

TNRTMSY.

PhylomeDB

Q03405.

Enzyme and pathway databases

Pathway_Interaction_DB

amb2_neutrophils_pathway. amb2 Integrin signaling.
arf6downstreampathway. Arf6 downstream pathway.
fgf_pathway. FGF signaling pathway.

Reactome

REACT_17015. Metabolism of proteins.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpress

Q03405.

Bgee

Q03405.

Genevestigator

Q03405.

GermOnline

ENSG00000011422. Homo sapiens.

Family and domain databases

InterPro

IPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
[Graphical view]

Pfam

PF00021. UPAR_LY6. 3 hits.
[Graphical view]

SMART

SM00134. LU. 3 hits.
[Graphical view]

PROSITE

PS00983. LY6_UPAR. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q03405.

ChEMBL

CHEMBL4883.

DrugBank

DB00009. Alteplase.
DB00029. Anistreplase.
DB00015. Reteplase.
DB00086. Streptokinase.
DB00031. Tenecteplase.
DB00013. Urokinase.

EvolutionaryTrace

Q03405.

GenomeRNAi

5329.

NextBio

20632.

PMAP-CutDB

Q03405.

SOURCE

Search...

Entry information

Entry name

UPAR_HUMAN

Accession

Primary (citable) accession number: Q03405
Secondary accession number(s): A8K409 , Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 142 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.