Reviewed, UniProtKB/Swiss-Prot Q03403 (TFF2_HUMAN)

Names and origin

Protein names

Recommended name:
    Trefoil factor 2
Alternative name(s):
    Spasmolytic polypeptide
      Short name=SP
    Spasmolysin

Gene names

Name:	TFF2
Synonyms:	SML1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains By similarity.
Subcellular location	Secreted.
Tissue specificity	Stomach.
Sequence similarities	Contains 2 P-type (trefoil) domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Repeat Signal
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	digestion Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 129	106	Trefoil factor 2		PRO_0000023460
Regions
	Domain	29 – 73	45	P-type 1
	Domain	79 – 122	44	P-type 2
Amino acid modifications
	Disulfide bond	29 ↔ 127		By similarity
	Disulfide bond	31 ↔ 58		By similarity
	Disulfide bond	42 ↔ 57		By similarity
	Disulfide bond	52 ↔ 69		By similarity
	Disulfide bond	81 ↔ 107		By similarity
	Disulfide bond	91 ↔ 106		By similarity
	Disulfide bond	101 ↔ 118		By similarity
Natural variations
	Natural variant	3	1	R → W: dbSNP rs7277409.		VAR_053564
Experimental info
	Sequence conflict	1 – 19	19	MGRRD…LGLCA → RHGTARRPAPGSAPRPGAMC Ref.1
	Sequence conflict	122	1	K → N in CAA35995. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q03403-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 6A296A11AD9CCC5D	FASTA	129	14,284
	10 20 30 40 50 60 MGRRDAQLLA ALLVLGLCAL AGSEKPSPCQ CSRLSPHNRT NCGFPGITSD QCFDNGCCFD 70 80 90 100 110 120 SSVTGVPWCF HPLPKQESDQ CVMEVSDRRN CGYPGISPEE CASRKCCFSN FIFEVPWCFF PKSVEDCHY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma." Tomasetto C., Rio M.C., Gautier C., Wolf C., Hareuveni M., Chambon P., Lathe R. EMBO J. 9:407-414(1990) [PubMed: 2303034] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Stomach.
[2]	"The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3." Seib T., Blin N., Hilgert K., Seifert M., Theisinger B., Engel M., Dooley S., Zang K.D., Welter C. Genomics 40:200-202(1997) [PubMed: 9070946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region." Berry A., Scott H.S., Kudoh J., Talior I., Korostishevsky M., Wattenhofer M., Guipponi M., Barras C., Rossier C., Shibuya K., Wang J., Kawasaki K., Asakawa S., Minoshima S., Shimizu N., Antonarakis S.E., Bonne-Tamir B. Genomics 68:22-29(2000) [PubMed: 10950923] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	X51698 mRNA. Translation: CAA35995.1. U47292 , U47289, U47290, U47291 Genomic DNA. Translation: AAB05397.1. AB038162 Genomic DNA. Translation: BAB13730.1. BC032820 mRNA. Translation: AAH32820.1.
IPI	IPI00010675.
PIR	S12371.
RefSeq	NP_005414.1.
UniGene	Hs.2979
3D structure databases
HSSP	HSSP built from PDB template 1PCP based on UniProtKB P01359.
SMR	Q03403. Positions 24-129.
ModBase	Search...
Proteomic databases
PeptideAtlas	Q03403.
PRIDE	Q03403.
Genome annotation databases
Ensembl	ENSG00000160181. Homo sapiens. [Contig view]
GeneID	7032.
KEGG	hsa:7032.
Organism-specific databases
GeneCards	GC21M042639.
HGNC	HGNC:11756. TFF2.
MIM	182590. gene.
PharmGKB	PA36471.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q03403.
HOVERGEN	Q03403.
OMA	Q03403. FPGITSD.
Gene expression databases
ArrayExpress	Q03403.
Bgee	Q03403.
CleanEx	HS_TFF2.
GermOnline	ENSG00000160181. Homo sapiens.
Family and domain databases
InterPro	IPR000519. P_trefoil. IPR017994. P_trefoil_chordata. IPR017957. P_trefoil_CS. [Graphical view]
Pfam	PF00088. Trefoil. 2 hits. [Graphical view]
PRINTS	PR00680. PTREFOIL.
SMART	SM00018. PD. 2 hits. [Graphical view]
PROSITE	PS00025. P_TREFOIL_1. 2 hits. PS51448. P_TREFOIL_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	27473.
SOURCE	Search...

Entry information

Entry name

TFF2_HUMAN

Accession

Primary (citable) accession number: Q03403
Secondary accession number(s): Q15854

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)