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Protein

Trefoil factor 2

Gene

TFF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chemokine-mediated signaling pathway Source: GO_Central
  • digestion Source: ProtInc
  • wound healing Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 2
Alternative name(s):
Spasmolysin
Spasmolytic polypeptide
Short name:
SP
Gene namesi
Name:TFF2
Synonyms:SML1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:11756. TFF2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7032.
OpenTargetsiENSG00000160181.
PharmGKBiPA36471.

Polymorphism and mutation databases

BioMutaiTFF2.
DMDMi2833194.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002346024 – 129Trefoil factor 2Add BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 127PROSITE-ProRule annotation
Disulfide bondi31 ↔ 58PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi52 ↔ 69PROSITE-ProRule annotation
Disulfide bondi81 ↔ 107PROSITE-ProRule annotation
Disulfide bondi91 ↔ 106PROSITE-ProRule annotation
Disulfide bondi101 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ03403.
PeptideAtlasiQ03403.
PRIDEiQ03403.

PTM databases

iPTMnetiQ03403.
PhosphoSitePlusiQ03403.

Expressioni

Tissue specificityi

Stomach.

Gene expression databases

BgeeiENSG00000160181.
CleanExiHS_TFF2.
GenevisibleiQ03403. HS.

Organism-specific databases

HPAiCAB025834.
HPA036705.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FCRL4Q96PJ53EBI-4314702,EBI-4314687

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112890. 1 interactor.
IntActiQ03403. 2 interactors.
STRINGi9606.ENSP00000291526.

Structurei

3D structure databases

ProteinModelPortaliQ03403.
SMRiQ03403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 73P-type 1PROSITE-ProRule annotationAdd BLAST45
Domaini79 – 122P-type 2PROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Contains 2 P-type (trefoil) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IZEH. Eukaryota.
ENOG410Y3PX. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000253928.
HOVERGENiHBG004363.
InParanoidiQ03403.
OMAiCVMEVSA.
OrthoDBiEOG091G0XBT.
PhylomeDBiQ03403.
TreeFamiTF336092.

Family and domain databases

CDDicd00111. Trefoil. 2 hits.
Gene3Di4.10.110.10. 2 hits.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 2 hits.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 2 hits.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 2 hits.
PROSITEiPS00025. P_TREFOIL_1. 2 hits.
PS51448. P_TREFOIL_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRDAQLLA ALLVLGLCAL AGSEKPSPCQ CSRLSPHNRT NCGFPGITSD
60 70 80 90 100
QCFDNGCCFD SSVTGVPWCF HPLPKQESDQ CVMEVSDRRN CGYPGISPEE
110 120
CASRKCCFSN FIFEVPWCFF PKSVEDCHY
Length:129
Mass (Da):14,284
Last modified:November 1, 1997 - v2
Checksum:i6A296A11AD9CCC5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 19MGRRD…LGLCA → RHGTARRPAPGSAPRPGAMC (PubMed:2303034).CuratedAdd BLAST19
Sequence conflicti122K → N in CAA35995 (PubMed:2303034).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0535643R → W.Corresponds to variant rs7277409dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51698 mRNA. Translation: CAA35995.1.
U47292
, U47289, U47290, U47291 Genomic DNA. Translation: AAB05397.1.
AB038162 Genomic DNA. Translation: BAB13730.1.
BC032820 mRNA. Translation: AAH32820.1.
CCDSiCCDS13684.1.
PIRiS12371.
RefSeqiNP_005414.1. NM_005423.4.
UniGeneiHs.2979.

Genome annotation databases

EnsembliENST00000291526; ENSP00000291526; ENSG00000160181.
GeneIDi7032.
KEGGihsa:7032.
UCSCiuc002zaw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51698 mRNA. Translation: CAA35995.1.
U47292
, U47289, U47290, U47291 Genomic DNA. Translation: AAB05397.1.
AB038162 Genomic DNA. Translation: BAB13730.1.
BC032820 mRNA. Translation: AAH32820.1.
CCDSiCCDS13684.1.
PIRiS12371.
RefSeqiNP_005414.1. NM_005423.4.
UniGeneiHs.2979.

3D structure databases

ProteinModelPortaliQ03403.
SMRiQ03403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112890. 1 interactor.
IntActiQ03403. 2 interactors.
STRINGi9606.ENSP00000291526.

PTM databases

iPTMnetiQ03403.
PhosphoSitePlusiQ03403.

Polymorphism and mutation databases

BioMutaiTFF2.
DMDMi2833194.

Proteomic databases

PaxDbiQ03403.
PeptideAtlasiQ03403.
PRIDEiQ03403.

Protocols and materials databases

DNASUi7032.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291526; ENSP00000291526; ENSG00000160181.
GeneIDi7032.
KEGGihsa:7032.
UCSCiuc002zaw.4. human.

Organism-specific databases

CTDi7032.
DisGeNETi7032.
GeneCardsiTFF2.
HGNCiHGNC:11756. TFF2.
HPAiCAB025834.
HPA036705.
MIMi182590. gene.
neXtProtiNX_Q03403.
OpenTargetsiENSG00000160181.
PharmGKBiPA36471.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZEH. Eukaryota.
ENOG410Y3PX. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000253928.
HOVERGENiHBG004363.
InParanoidiQ03403.
OMAiCVMEVSA.
OrthoDBiEOG091G0XBT.
PhylomeDBiQ03403.
TreeFamiTF336092.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160181-MONOMER.

Miscellaneous databases

GeneWikiiTrefoil_factor_2.
GenomeRNAii7032.
PROiQ03403.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160181.
CleanExiHS_TFF2.
GenevisibleiQ03403. HS.

Family and domain databases

CDDicd00111. Trefoil. 2 hits.
Gene3Di4.10.110.10. 2 hits.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 2 hits.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 2 hits.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 2 hits.
PROSITEiPS00025. P_TREFOIL_1. 2 hits.
PS51448. P_TREFOIL_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFF2_HUMAN
AccessioniPrimary (citable) accession number: Q03403
Secondary accession number(s): Q15854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.