Reviewed, UniProtKB/Swiss-Prot Q03402 (CRIS3_MOUSE)

Names and origin

Protein names

Recommended name:
    Cysteine-rich secretory protein 3
      Short name=CRISP-3
Alternative name(s):
    Acidic epididymal glycoprotein 2
    Sperm-coating glycoprotein 2
      Short name=SCP 2

Gene names

Name:	Crisp3
Synonyms:	Aeg-2, Aeg2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens.
Subcellular location	Note: Stored in secretory granules of granular convoluted tubules cells.
Tissue specificity	Expressed in submandibular gland.
Developmental stage	Exponential increase between days 25 and 30 after birth.
Induction	By androgens.
Sequence similarities	Belongs to the CRISP family.

Ontologies

Keywords
Domain	Signal
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 241	222	Cysteine-rich secretory protein 3		PRO_0000006269
Amino acid modifications
	Glycosylation	118	1	N-linked (GlcNAc...) Potential
	Glycosylation	132	1	N-linked (GlcNAc...) Potential
	Glycosylation	175	1	N-linked (GlcNAc...) Potential
	Disulfide bond	194 ↔ 201		By similarity
	Disulfide bond	197 ↔ 206		By similarity
	Disulfide bond	210 ↔ 241		By similarity
	Disulfide bond	219 ↔ 235		By similarity
	Disulfide bond	226 ↔ 239		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q03402-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: D903788B4E4001EF	FASTA	241	27,314
	10 20 30 40 50 60 MALMLVLFFL AAVLPPSLLQ DNSQENSLEK LSTSKKSVQE EIVSKHNQLR RKVSPSGSDL 70 80 90 100 110 120 LNMEWNYDAQ VNAQQRADKC TFSHSPIELR TTNLKCGENL FMSSYLVPWS SVIQGWYNES 130 140 150 160 170 180 KGLIFGVGPK QNVSVVGHHT QVVWKSNLQV ACGVAECPEN PLRYFYVCRY CPVLNYSGHY 190 200 210 220 230 240 PSRPYLAYTA RAPCASCPDR CEDGLCTKSC QYKDMSFWCK RLEYVCKHPG LKKRCLATCQ C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule." Mizuki N., Kasahara M. Mol. Cell. Endocrinol. 89:25-32(1992) [PubMed: 1301383] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Submandibular gland.
[2]	"Transcripts for cysteine-rich secretory protein-1 (CRISP-1; DE/AEG) and the novel related CRISP-3 are expressed under androgen control in the mouse salivary gland." Haendler B., Kraetzschmar J., Theuring F., Schleuning W.-D. Endocrinology 133:192-198(1993) [PubMed: 8319566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Submandibular gland.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M92850 mRNA. Translation: AAA37186.1. L05560 mRNA. Translation: AAA37461.1. BC022573 mRNA. Translation: AAH22573.1.
IPI	IPI00132197.
PIR	B49202.
RefSeq	NP_033769.1.
UniGene	Mm.14138
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000025433. Mus musculus. [Contig view]
GeneID	11572.
KEGG	mmu:11572.
Organism-specific databases
MGI	MGI:102552. Crisp3.
Phylogenomic databases
HOGENOM	Q03402.
HOVERGEN	Q03402.
OMA	Q03402. TARAPCA.
Gene expression databases
ArrayExpress	Q03402.
Bgee	Q03402.
CleanEx	MM_CRISP3.
GermOnline	ENSMUSG00000025433. Mus musculus.
Family and domain databases
InterPro	IPR001283. Allrgn_V5/Tpx1. IPR018244. Allrgn_V5/Tpx1_CS. IPR013871. Cysteine_rich_secretory. IPR014044. SCP-like_extracellular. [Graphical view]
PANTHER	PTHR10334. Allrgn_V5/Tpx1. 1 hit.
Pfam	PF08562. Crisp. 1 hit. PF00188. SCP. 1 hit. [Graphical view]
PRINTS	PR00837. V5TPXLIKE.
ProDom	PD000542. Allrgn_V5/Tpx1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00198. SCP. 1 hit. [Graphical view]
PROSITE	PS01009. CRISP_1. 1 hit. PS01010. CRISP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	279094.
SOURCE	Search...

Entry information

Entry name

CRIS3_MOUSE

Accession

Primary (citable) accession number: Q03402

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)