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Protein

Cysteine-rich secretory protein 3

Gene

Crisp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein 3
Short name:
CRISP-3
Alternative name(s):
Acidic epididymal glycoprotein 2
Sperm-coating glycoprotein 2
Short name:
SCP 2
Gene namesi
Name:Crisp3
Synonyms:Aeg-2, Aeg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:102552. Crisp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000000626920 – 241Cysteine-rich secretory protein 3Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi132N-linked (GlcNAc...)Sequence analysis1
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi194 ↔ 201PROSITE-ProRule annotation
Disulfide bondi197 ↔ 206PROSITE-ProRule annotation
Disulfide bondi210 ↔ 241PROSITE-ProRule annotation
Disulfide bondi219 ↔ 235PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ03402.
PeptideAtlasiQ03402.
PRIDEiQ03402.

PTM databases

PhosphoSitePlusiQ03402.

Expressioni

Tissue specificityi

Expressed in submandibular gland.

Developmental stagei

Exponential increase between days 25 and 30 after birth.

Inductioni

By androgens.

Gene expression databases

BgeeiENSMUSG00000025433.
CleanExiMM_CRISP3.
GenevisibleiQ03402. MM.

Interactioni

Subunit structurei

Interacts with A1BG (By similarity). Interacts with KNG1 isoform LMW.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026499.

Structurei

3D structure databases

ProteinModelPortaliQ03402.
SMRiQ03402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 170SCPAdd BLAST127
Domaini210 – 241ShKTPROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000236338.
HOVERGENiHBG004184.
InParanoidiQ03402.
KOiK19919.
OMAiCEISAAY.
OrthoDBiEOG091G0D4V.
PhylomeDBiQ03402.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03402-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALMLVLFFL AAVLPPSLLQ DNSQENSLEK LSTSKKSVQE EIVSKHNQLR
60 70 80 90 100
RKVSPSGSDL LNMEWNYDAQ VNAQQRADKC TFSHSPIELR TTNLKCGENL
110 120 130 140 150
FMSSYLVPWS SVIQGWYNES KGLIFGVGPK QNVSVVGHHT QVVWKSNLQV
160 170 180 190 200
ACGVAECPEN PLRYFYVCRY CPVLNYSGHY PSRPYLAYTA RAPCASCPDR
210 220 230 240
CEDGLCTKSC QYKDMSFWCK RLEYVCKHPG LKKRCLATCQ C
Length:241
Mass (Da):27,314
Last modified:October 1, 1993 - v1
Checksum:iD903788B4E4001EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92850 mRNA. Translation: AAA37186.1.
L05560 mRNA. Translation: AAA37461.1.
CH466559 Genomic DNA. Translation: EDL23382.1.
BC022573 mRNA. Translation: AAH22573.1.
BC132536 mRNA. Translation: AAI32537.1.
BC132538 mRNA. Translation: AAI32539.1.
CCDSiCCDS28783.1.
PIRiB49202.
RefSeqiNP_033769.1. NM_009639.2.
UniGeneiMm.14138.

Genome annotation databases

EnsembliENSMUST00000026499; ENSMUSP00000026499; ENSMUSG00000025433.
GeneIDi11572.
KEGGimmu:11572.
UCSCiuc008cog.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92850 mRNA. Translation: AAA37186.1.
L05560 mRNA. Translation: AAA37461.1.
CH466559 Genomic DNA. Translation: EDL23382.1.
BC022573 mRNA. Translation: AAH22573.1.
BC132536 mRNA. Translation: AAI32537.1.
BC132538 mRNA. Translation: AAI32539.1.
CCDSiCCDS28783.1.
PIRiB49202.
RefSeqiNP_033769.1. NM_009639.2.
UniGeneiMm.14138.

3D structure databases

ProteinModelPortaliQ03402.
SMRiQ03402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026499.

PTM databases

PhosphoSitePlusiQ03402.

Proteomic databases

PaxDbiQ03402.
PeptideAtlasiQ03402.
PRIDEiQ03402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026499; ENSMUSP00000026499; ENSMUSG00000025433.
GeneIDi11572.
KEGGimmu:11572.
UCSCiuc008cog.1. mouse.

Organism-specific databases

CTDi10321.
MGIiMGI:102552. Crisp3.

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000236338.
HOVERGENiHBG004184.
InParanoidiQ03402.
KOiK19919.
OMAiCEISAAY.
OrthoDBiEOG091G0D4V.
PhylomeDBiQ03402.
TreeFamiTF316148.

Miscellaneous databases

ChiTaRSiCrisp3. mouse.
PROiQ03402.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025433.
CleanExiMM_CRISP3.
GenevisibleiQ03402. MM.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIS3_MOUSE
AccessioniPrimary (citable) accession number: Q03402
Secondary accession number(s): A2RTK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.